SERVQUAL Model with Interrelated Dimensions. The Case of The Pharmacy in Mexico

This research is focused on understanding the interrelation between the different dimen- sions of the SERVQUAL model in the pharmaceutical area, which have differences in per- ceptions of service domains depending on the cultures in which they are immersed. To study the proposed relationships, we collect data of 100 pharmacy customers of Mex- ico and use SEM to test the relationship between SERVQUAL dimensions, purchase fre- quency, gender, and quality perception. Our results show that the SERVQUAL dimensions are interrelated, SERVQUAL dimen- sions and gender predict the perception of quality but not the purchase frequency. These results provide key information in order to understand in a better way the service quality in the pharmaceutical area. We develop a theoretical framework that is based on interrelationships between the dif- ferent dimensions of SERVQUAL, assuming that they are not independent of each other. This way of understanding SERVQUAL dimensions can provide relevant information to un- derstand better how individual perceptions affect the service quality in the pharmaceutical area.Esta investigación se centra en comprender la interrelación entre las diferentes dimensiones del modelo SERVQUAL en el área farmacéutica, que presentan diferencias en las percepciones de los dominios de servicio en función de las culturas en las que se encuentran inmersas. Para estudiar las relaciones propuestas, recopilamos datos de 100 clientes de farmacia de México y usamos SEM para probar la relación entre las dimensiones de SERVQUAL, la frecuencia de compra, el género y la percepción de calidad. Nuestros resultados muestran que las dimensiones de SERVQUAL están interrelacionadas, las dimensiones de SERVQUAL y el género predicen la percepción de calidad pero no la frecuencia de compra. Estos resultados brindan información clave para comprender de mejor manera la calidad del servicio en el área farmacéutica. Desarrollamos un marco teórico que se basa en las interrelaciones entre las diferentes dimensiones de SERVQUAL, asumiendo que no son independientes entre sí. Esta forma de entender las dimensiones de SERVQUAL puede proporcionar información relevante para comprender mejor cómo las percepciones individuales afectan la calidad del servicio en el área farmacéutica

La expresión génica hipotalámica de la enzima Citocromo P450scc en ratas hembras es regulada positivamente por estrógeno y negativamente por progesterona

Los neuroesteroides son potentes moléculas modulatorias sintetizadas en sistema nervioso central y cuya actividad se restringe a dicho ámbito. En su síntesis participan enzimas del grupo del citocromo P450 (CP450) enzimas que no pertenecen a dicho grupo. En este trabajo se estudia la expresión génica de CP450scc a nivel de hipotálamo medio basal (HMB) de ratas hembra en diferentes condiciones hormonales, y se lo relaciona con su eventual regulación a través de esteroides gonadales, particularmente estrógenos y progesterona. Se proporciona evidencia de que existe una expresión diferencial en HMB, y que dicha expresión se encuentra positivamente modulada por estrógenos, y negativamente modulada por progesterona.Neurosteroids are extremely potent modulatory molecules synthesized in the central nervous system (CNS), whose activity is limited to that ambit. Several types on enzimatic molecules participate of their synthesis, like enzymes related to the cytochrome P450 (CP450) and others not vinculated to this group. In this paper we study the gene expression of CP450scc in the mediobasal hypothalamus (MBH) of female rats under differents hormonal condition, and its eventual relationship with estrogen and progesterone regulation of that expression. Evidence is presented regarding differential gene expression of CP450scc in the MBH, as well as evidence related to its positive regulation by estrogen and negative regulation by progesterone.Fil: Giuliani, Fernando. Consejo Nacional de Investigaciones Científicas y TécnicasFil: Yunes, Roberto. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Departamento de PatologíaFil: Cabrera, Ricardo. Universidad de Mendoza. Facultad de Ciencias de la Salu

Relation between circuit current and plasma current density in plasma discharges with dielectric media

The theoretical derivation of the relation between moving charges in the plasma and external circuit current was first established on a firm basis by Sato1 for the case of a discharge with constant applied voltage between bare electrodes. The generalization to time varying applied voltages was established by Morrow and Sato2 , still considering bare electrodes. In the present work we extend the latter derivation to include general devices with arbitrarily arranged linear dielectric media, and multiple electrodes with time dependent voltages, of interest, for instance, for a Dielectric Barrier Discharge (DBD). In particular, the present derivation determines a general, practical expression for the reactive term present in Morrow and Sato formula. Using the expression derived we show how in simple DBD geometries usual circuit approximations of the plasma discharge can be obtained and its validity justified. Also, we consider the determination of the internal plasma current from the measurement of the external circuit current for a cylindrical DBD operated with helium at atmospheric pressure. Finally, we apply the theory to a three-electrode device in order to relate electric measurements to volume integrals on the plasma that were shown to be useful in order to quantify species production by electron impact.Fil: Giuliani, Leandro Estanislao. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaFil: Grondona, Diana Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaFil: Minotti, Fernando Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentin

La docencia en la psicología social comunitaria: algunos problemas

The process of development of community psychology shows a growing methodological and theoretical complexity. In such process, a permanent critical reflection based on the experience obtained in the community and on the research conducted in the different themes that support such discipline, has been generated. The authors' line of work is supported on a permanent accivity within the communities' context as well as on me teaching field, maintaining a constant concern about the compromise acquired with the communities and about the discipline itself. Within this same scenario, some elements related to the formation of community psychologists are revised as a results of the importance of the role such psychologists must play, as well as of the need for formation programs that maintain high-quality standards. Considering our teaching experience, we present some topics that result critical in the teaching of community psychology, such as the difficulty to level the academic periods with communities' "rhythms;" the reciprocal nature of the process of familiarization; the students' reach of compromise; the role of the graduate individual sustained by the traditional college formation, and his/her opposition to the rendering of knowledge, as proposed by the discipline itself, among others.El proceso de desarrollo de la psicología comunitaria muestra una creciente complejidad teórica y metodológica. En ese proceso se ha generado una permanente reflexión crítica basada en la experiencia comunitaria y en la investigación de las diferentes áreas temáticas que sustentan las propuestas de la disciplina. Nuestra línea de trabajo se fundamenta en un quehacer sostenido en el contexto de las comunidades y en el campo de la docencia, manteniendo una preocupación permanente tanto por el compromiso con las comunidades como con la disciplina. Dentro de este panorama, se revisan algunos elementos relativos a la formación de los/las psicólogos/as comunitarios/as, en función de la importancia que tiene dentro del marco de la disciplina el rol que debe desempeñar este profesional de la psicología, así como de la necesidad de un alto nivel de capacitación. En este trabajo se exponen, a partir de nuestra experiencia docente, algunos tópicos que resultan críticos en la docencia de la psicología comunitaria, tales como la dificultad de armonizar los lapsos académicos con los «ritmos» de la comunidad; el carácter recíproco del proceso de familiarización; el alcance del compromiso en los estudiantes; el rol del profesional sustentado por la formación universitaria tradicional y su oposición a la «desprofesionalización» o entrega de conocimientos, propuesta por la disciplina, entre otros

Pharmacological effect of one icv dose of Allopregnanolone in female rat: behavioural profile

We have previously observed that intracerebroventricular allopregnanolone (ALLO) injection produced an anxiolytic effect and inhibited sexual receptivity when the test was performed in a separate manner. Also, ALLO reverts learning deficit in female rats in the hippocampi. To study the behavioral effects of an acute treatment with ALLO in the right lateral ventricle we used two approaches: a- A battery test to analyze the anxiety and mating behavior. And b- The avoidance test and novel object recognition test to evaluate its effect on memory and learning. Ovariectomized rats were injected with estrogen and progesterone. After it ALLO or vehicle were administered into the right lateral ventricle. To reach the objective (a) rats were put in a sequential battery test in the next order: 1-Open field. 2- Plus maze task. 3- Mating behavior. For the aim (b) it was performed a Novel Object Recognition Test and Step-down Inhibitory Avoidance Task. ALLO did not affect locomotors-exploratory behavior. Animals treated with ALLO, spent more time and had more entries into the open arm in a plus maze task and lordosis quotient was lower than in the control group. ALLO increased the latency in step down test and had no effects on discrimination index test in NORT. Here we demonstrated that one pharmacological dose of ALLO in ovariectomized primed rats is enough to generate all changes observed in the battery test. Moreover, the acute treatment with ALLO in lateral ventricle enhanced the memory acquisition in an avoidance task.Fil: Pelegrina, Laura Tatiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Escudero, Carla Gimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Giuliani, Fernando Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: García Menéndez, Sebastián Marcelo Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Laconi, Myriam Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentin

Model of the boundary layer of a vacuum-arc magnetic filter

A model is developed to describe the electrostatic boundary layer in a positively biased magnetic filter in filtered arcs with low collisionality. The set of equations used includes the electron momentum equation, with an anomalous collision term due to micro-instabilities leading to Bohm diffusion, electron mass conservation, and Poisson equation. Analytical solutions are obtained, valid for the regimes of interest, leading to an explicit expression to determine the electron density current to the filter wall as a function of the potential of the filter and the ratio of electron density at the plasma to that at the filter wall. Using a set of planar and cylindrical probes it is verified experimentally that the mentioned ratio of electron densities remains reasonably constant for different magnetic field values and probe bias, which allows to obtain a closed expression for the current. Comparisons are made with the experimentally determined current collected at different sections of a positively biased straight filter.Fil: Minotti, Fernando Oscar. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Instituto de Fisica del Plasma; Argentina;Fil: Giuliani, Leandro Estanislao. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Instituto de Fisica del Plasma; Argentina;Fil: Grondona, Diana Elena. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Instituto de Fisica del Plasma; Argentina;Fil: Della Torre, H.. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Instituto de Fisica del Plasma; Argentina;Fil: Kelly, Hector Juan. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Instituto de Fisica del Plasma; Argentina

Sushi domain-containing protein 4 controls synaptic plasticity and motor learning

Fine control of protein stoichiometry at synapses underlies brain function and plasticity. How proteostasis is controlled independently for each type of synaptic protein in a synapse-specific and activity-dependent manner remains unclear. Here, we show that Susd4, a gene coding for a complement-related transmembrane protein, is expressed by many neuronal populations starting at the time of synapse formation. Constitutive loss-of-function of Susd4 in the mouse impairs motor coordination adaptation and learning, prevents long-term depression at cerebellar synapses, and leads to misregulation of activity-dependent AMPA receptor subunit GluA2 degradation. We identified several proteins with known roles in the regulation of AMPA receptor turnover, in particular ubiquitin ligases of the NEDD4 subfamily, as SUSD4 binding partners. Our findings shed light on the potential role of SUSD4 mutations in neurodevelopmental diseases.Agence Nationale de la Recherche ANR 9139SAMA90010901Agence Nationale de la Recherche ANR-15-CE37-0001-01ATIP-AVENIR RSE11005JSAEcole des Neurosciences de ParisFondation pour la Recherche Medicale DEQ20150331748Fondation pour la Recherche Medicale DEQ20140329514H2020 European Research Council SynID 724601Idex PSL ANR-10-IDEX-0001-02 PSL*Labex ANR-11-IDEX-0004-02Labex Memolife ANR-10-LABX-5

La estimulación gabaérgica del núcleo septal lateral del cerebro de ratas macho incrementa la respuesta agresiva frente a estímulos neutros

El núcleo septal lateral forma parte de estructuras subcorticales del cerebro. La destrucción de dicho núcleo genera lo que se conoce como síndrome de furia septal. En este trabajo demostramos que el agonista GABAérgico muscimol, en dosis no sedativas, indujo una “inhibición del miedo" en ratas macho de la cepa Sprague- Dawley, asociada a un aumento de respuestas agresivas a objetos habitualmente neutros. Estos resultados, sumados al hecho de que el núcleo septal lateral participa en diversas entidades psiquiátricas, hace que sea interesante aportar al conocimiento de su función apelando a moduladores que se sabe están presentes en el en dicha estructura del sistema nervioso central.Destruction of lateral septum –a nucleus located in subcortical regions of the anterior brain– has been related to an entity known as rage septal syndrome. In the present paper we demonstrate that the direct GABAergic agonist muscimol produces “fear inhibition" when tested at non-sedative doses in Sprague-Dawley male rats. This phenomenon is also supported by an increase of aggressive behaviors directed to otherwise neutral objects. Since the septal lateral has been involved in several psychiatric diseases, it appears as potentially interesting to contribute to the knowledge of its function by taking advantage of eventual modulators known to be present in the nucleus.Fil: Nanfaro, Federico. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Área Farmacología.Fil: Bazzocchini, Vanesa. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Área Farmacología.Fil: Vega, Adriana. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Área Farmacología.Fil: Giuliani, Fernando. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Área Farmacología.Fil: Laconi, Miriam. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Área Farmacología.Fil: Casas, Sebastián.Fil: Escudero, Carla. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Área Farmacología.Fil: Cabrera, Ricardo. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Área Farmacología.Fil: Yunes, Roberto. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Área Farmacología

Growth of preterm infants at the time of global obesity

Preterm birth, 90% of which occurs between 32 and <37 weeks' gestation,1 2 is a complex heterogeneous syndrome interlinked with the stillbirth and intrauterine growth restriction syndromes. Its phenotypes are associated with different gains in neonatal weight, morbidity and mortality, and perhaps body composition, growth and development. Preterm birth is related to several aetiologies, although nearly 30% of all preterm births are not associated with any maternal/pregnancy conditions or fetal growth restriction