Evaluación de impactos del cambio climático en especies bioindicadoras o de interés forestal en España

El Cambio Climático es un proceso que ya está afectando a España. Uno de sus efectos más notables es la alteración del paisaje debido a cambios estructurales en la vegetación. La expresión de este Cambio se produce a través de procesos de decaimiento y muerte, por causas bióticas y abióticas, de las formaciones forestales más significativas. En este contexto, es previsible un desplazamiento de los cinturones de vegetación al alterarse los pisos bioclimáticos de vegetación. Existen metodologías para estimar la dirección e intensidad de estos procesos; una de ellas se expondrá en este artículo

Análisis sobre el crecimiento e impacto social de la propiedad horizontal en el municipio de Madrid en los últimos 7 Años

Documentar el impacto social de la propiedad horizontal en Madrid – CundinamarcaEl presente proyecto de investigación, busca analizar los factores que han incidido en el crecimiento de la propiedad horizontal del municipio de Madrid y con mayor notoriedad en los últimos 7 años, los proyectos de construcción de conjuntos residenciales y/o mixtos por parte de diferentes constructoras han tomado tanta fuerza que se han convertido en un tipo de vivienda atractivo para las familias por ser más asequibles que las casas tradicionales, dado que se cuentan con subsidios por parte del gobierno y las cajas de compensación, alivios financieros, tasa fresh VIS y presuntamente más seguros para vivir. Como afirma Velez(2006) “Señala que la propiedad horizontal constituye la expresión más moderna y versátil del derecho de dominio sobre los bienes inmuebles en el contexto nacional. El poblamiento de los grandes y pequeños núcleos urbanos ha estado estrecha y directamente referenciado en las normas sobre la propiedad por pisos.” (pág. 1) Sin embargo, todo este movimiento poblacional, la convivencia entre vecinos, las adaptaciones entre varias culturas y generaciones, entre otros temas sociales ¿Traerán consigo también consecuencias o impactos sociales a nivel municipal? Hablando en este caso específico del municipio de Madrid Cundinamarca donde se centra el foco de información. Precisamente, es por eso la intención de buscar todas las herramientas y recursos necesarios para encontrar respuestas afines al tema de investigación. El método a emplear en el trabajo de investigación será la combinación del método cuantitativo y cualitativo donde la recolección de la información será por medio de encuestas otorgadas por los habitantes del sector objetivo se establecerá un cuestionario de preguntas para luego realizarle el tratamiento estadístico a estos datos y por otra parte analizaremos la información CORPORACIÓN UNIVERSITARIA MINUTO DE DIOS RECTORÍA CUNDINAMARCA- CENTRO REGIONAL MADRID www.uniminuto.edu 7 cualitativa mediante una entrevista estructurada hacia el secretario de gobierno del Municipio de Madrid Cundinamarca para tener en cuenta el punto de vista de las entidades de control frente al tema que es objeto de investigación. Teniendo esta información analizaremos las variables que arroje tanto las encuestas como la entrevista para responder la pregunta problema de este estudio que se refiere al análisis sobre el crecimiento e impacto de la propiedad horizontal en el municipio de Madrid en los últimos 7 años. El presente estudio pretende realizar una mirada crítica a los cambios que han surgido desde el 2016 hasta la actualidad con la llegada de estos habitantes al municipio y determinar cuál ha sido el incremento de la PH y la huella que han dejado en el municipio. Dentro de las limitantes la más relevante es el difícil acceso a la persona que se encarga de la Secretaria De Gobierno del municipio de Madrid Cundinamarca debido a su agenda tan congestionada dada la importancia de su carg

Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome

Ribosomes and protein synthesis have been reported to be altered in the cerebral cortex at advanced stages of Alzheimer's disease (AD). Modifications in the hippocampus with disease progression have not been assessed. Sixty-seven cases including middle-aged (MA) and AD stages I-VI were analyzed. Nucleolar chaperones nucleolin, nucleophosmin and nucleoplasmin 3, and upstream binding transcription factor RNA polymerase I gene (UBTF) mRNAs are abnormally regulated and their protein levels reduced in AD. Histone modifications dimethylated histone H3K9 (H3K9me2) and acetylated histone H3K12 (H3K12ac) are decreased in CA1. Nuclear tau declines in CA1 and dentate gyrus (DG), and practically disappears in neurons with neurofibrillary tangles. Subunit 28 ribosomal RNA (28S rRNA) expression is altered in CA1 and DG in AD. Several genes encoding ribosomal proteins are abnormally regulated and protein levels of translation initiation factors eIF2 a, eIF3h and eIF5, and elongation factor eEF2, are altered in the CA1 region in AD. These findings show alterations in the protein synthesis machinery in AD involving the nucleolus, nucleus and ribosomes in the hippocampus in AD some of them starting at first stages (I-II) preceding neuron loss. These changes may lie behind reduced numbers of dendritic branches and reduced synapses of CA1 and DG neurons which cause hippocampal atroph

An analysis of the similarities in the ATR-FTIR spectra from Argania spinosa, Rosa rubiginosa and Elaeis guineensis oils

The attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) spectra of the essential oil from Rosa rubiginosa L. seeds and the vegetable oils from Argania spinosa L. kernel and Elaeis guineensis Jacq. pulp show important similitudes that hamper their identification by vibrational spectroscopy techniques if they are not complemented with well-established methods such as gas chromatography. Nevertheless, the observed similarities in structure-composition-traditional uses between Argania spinosa and Rosa rubiginosa oils suggest that they could be interchangeable when skin physicians, dermatologic-surgeons or cosmetologists perceive in their practice that one of the oils produces an allergic reaction or other side effects, although further activity studies are needed

Vibrational analysis and thermal behavior of Salvia hispanica, Nigella sativa and Papaver somniferum seeds

Producción CientíficaIntroduction: Salvia hispanica L., Nigella sativa L. and Papaver somniferum L. are involved in opiate-dependent behavior. It is known that the seeds of these three herbs contain high amounts of antioxidants, which are helpful in disease prevention, but further research is needed on some of their other phytochemical components (terpene alkaloids, benzoquinones and others), which are claimed to affect human opioid receptors. Methods: Seeds from the three afore mentioned plants have been studied by ATR-FTIR vibrational spectroscopy and thermo analytical techniques (TG/DTG, DTA and DSC). Results: The infrared spectrum has confirmed the presence of the ester carbonyl of terpenoid alkaloids (such as nigellamine) and the fully conjugated cyclic dione structure of quinones (e.g., thymoquinone). As regards the thermal stability of these seeds, small differences have been observed in their thermal profiles (endothermic effects at around 333ºC for chia, 268ºC for black cumin and 319ºC for poppy seeds), which can be ascribed to their different content in carbohydrates. Conclusions: The functional groups of the main active constituents and the thermal behavior of these three seeds have been elucidated

Crude and refined oils from Elaeis guineensis: Facile characterization by FTIR and thermal analysis techniques

From an industrial perspective, fast characterization of raw materials provides an important tool for preventing manufacturing problems and contributes to assure the quality of the final products. In this work, several fast, cheap, and simple methods (Fourier transform infrared spectroscopy (FTIR) and various thermoanalytical techniques) were used for screening and characterization of crude and refined palm oils and other palm-derived products. The FTIR spectra allowed for ready distinction between mesocarp-derived products and those obtained from the kernel. The same applied to high-temperature differential scanning calorimetry (DSC) and differential thermal analysis (DTA) thermograms and the low-temperature DSC curves, in which the peak values and the presence or absence of certain peaks also permitted to differentiate among the various oils and fractions. Correspondences of mesocarp-derived oils with olein and kernel-derived oils with stearin were confirmed by both analytical methods and from the crystallization study. The relationship between the triglyceride composition and the FTIR and thermal profiles of the various palm-derived products has potential to be utilized as a facile quality control method in mill plants and laboratories

Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson’s disease

Mean ratio of the number of nucleolar staining and the total number of neurons (ratio SD) visualized with haematoxylin and eosin and immunohistochemistry to NPM1 and NPM3 in the substantia nigra at stages 1, 3, 4, and 5 of PD. Percentage (%) of nucleolus staining and total neurons. No significant differences are seen regarding the ratios of NPM3 nucleolar staining along disease progression. However, NPM1 immunohistochemistry reveals a significant decrease between PD1 and PD5 (P ≤ 0.05 One-way Anova) (DOC 28 kb

On the probable composition of ‘Jamaican stone’ aphrodisiac

Producción CientíficaA dangerous aphrodisiac, commonly known as ‘Jamaican stone’, banned by the U.S. Food and Drug Administration, has been studied by vibrational spectroscopy in order to solve the controversy on its composition. The results of the ATR-FTIR analysis revealed the presence of the a-pyrone ring, which is characteristic of bufadienolides from toad venom and bulbs of squill (Drimia maritima (L.) Stearn). This conclusion was reached after a comparative study with the spectra for phytochemicals derived from gambir and cat’s claw, two Uncaria species also preconized as aphrodisiacs and deemed as possible constituents of the ‘stone’. Owing to their physiologic similarities to digoxin, bufadienolides have been shown to produce a toxic profile similar to that of digoxin, although the lack one of the side chains found on digoxin should allow the use of hemodialysis to treat ‘Jamaican stone’ overdose

Furfural, 5-HMF, acid-soluble lignin and sugar contents in C. ladanifer and E. arborea lignocellulosic biomass hydrolysates obtained from microwave-assisted treatments in different solvents

Cistus ladanifer L. and Erica arborea L. are the two most representative shrub species from the Iberian Peninsula. With a view to their valorization, their biomass hydrolysate components, obtained from microwave-assisted treatments with choline chloride/urea - HNO3 10%, N,N-dimethylacetamide/NaHCO3 and N,N-dimethylacetamide/CH3OK as solvents, have been measured using a spectrophotometric method. Concentrations of furfural and 5-(hydroxymethyl)furfural (5-HMF) in the filtrate have been determined after reduction with NaBH4. The production of total sugars, reducing sugars and non-reducing sugars has also been assessed. The obtained results support the choice of microwave-assisted choline chloride/urea deep eutectic solvent in acid media as the preferred method (over the polar aprotic solvent-based alternatives) for the extraction of lignin, furfural, 5-HMF and sugars from C. ladanifer and E. arborea biomass, attaining the best production yields for 60¿min exposure times. Another is the case if the aim of the treatments is to recovery sugars from both shrubs for subsequent enzymatic saccharification: the very low 5-HMF contents resulting from the dimetylacetamide systems (especially is association with CH3OK) make them highly advantageous as compared to the traditional method using NaOH

Phlebotomine mortality effect of systemic insecticides administered to dogs

BACKGROUND: Zoonotic visceral leishmaniasis (ZVL) caused by Leishmania (Leishmania) infantum is an important disease in humans and dogs. Different mammal species are reservoirs but dogs are considered to be the main one. Phlebotomine sand flies are the proven vector. Four systemic insecticides approved for their use in dogs were previously selected based on their potential to be used in endemic countries as part of the control programs of ZVL. These insecticides are proved to be safe and effective against the on-label insects and parasites, but there is no information about their activity against phlebotomine sand flies. METHODS: The phlebotomine mortality of four systemic insecticides in dogs was evaluated using two randomized clinical trials. For the first trial, thirty dogs were randomly allocated into five groups: four treatments and one control, of equal size. The treatments evaluated were: Guardian(R)SR, Elanco (moxidectin); Comfortis(R), Elanco (spinosad); Bravecto(R), Merck Animal Health (fluralaner); and NexGard(R), Merial (afoxolaner). Blood from dogs was taken at days 2, 4, 21 and 31 post-treatment (trial 1). The compound that showed the highest efficacy was selected for a second trial (trial 2) with 20 dogs sampled at days 0, 2, 4, 7, 14, 18, 32, 39, 51 and 84 post-treatment. Membrane feeding bioassays with Phlebotomus papatasi were used to evaluate the phlebotomine mortality efficacy of the different treatments. Phlebotomine mortality was observed every 24 h following the membrane feeding during 5 days. A mixed model for a negative binomial logistic regression, and a Cox proportional hazard mixed model were used to estimate phlebotomine mortality due to different treatments. RESULTS: Fluralaner was the only compound that showed significant phlebotomine mortality. Fluralaner maintained the phlebotomine mortality between 60-80% for 30 days after treatment. In trial 1 we found that fluralaner increased the risk of death by 1.9 times (95% CI: 1.02-3.6) and 1.7 times (95% CI: 1.09-2.6) at days 2 and 4 after treatment. The Cox model resulted in an increase of 1.47 (95% CI: 1.1-1.96) times in hazard risk at day 2 and 1.89 (95% CI: 1.35-2.45) at day 4 after treatment. In trial 2 we found that fluralaner increased the risk of death by 1.64 times (95% CI: 1.16-2.54) and 1.97 times (95% CI: 1.23-3.17) at days 14 and 32. The hazard risk was also increased by 1.92 (95% CI: 1.4-2.64) times at day 14 after treatment. Phlebotomine survival including all experimental days was significantly lower in the fluralaner group in both trials. CONCLUSIONS: A single oral treatment of fluralaner in dogs induces phlebotomine mortality. Systemic insecticides in dogs should be considered as a potential preventive measure of ZVL