Impact of the Young Athletes Program on Young Children with Autism Spectrum Disorders in Quincy Public Schools

The Center for Social Development and Education (CSDE) and the College of Education and Human Development (CEHD) are supporting the implementation of the Young Athletes (YA) program for preschool children with Autism Spectrum Disorder (ASD) in Quincy Public Schools. 50-73% of children with ASD have significant motor delays compared to normative peers. Concerns include: Delays in overall gross motor skills, including manual dexterity, balance, gait, motor coordination, and ball handling skills.Motor development appears to slow for two- and three-year-old children with ASD. Young Athletes is a theoretically-based program designed to improve the motor development of children with disabilities (ages 3-7) through various motor activities. Clinical trials conducted by CSDE (Favazza et al., 2013) indicated that the Young Athletes program significantly improved the motor skills of young children with disabilities

Camp Shriver – A Free Inclusive Summer Sports Camp for Children with and without Disabilities

Camp Shriver at UMass Boston is in its 9th year, providing a free and fully inclusive summer recreational program for children in the communities of Boston and Quincy. Having served almost 1,000 campers, Camp Shriver at UMass Boston reaches out to children and families who have few opportunities, particularly families of children with disabilities

Helping Developing Countries Implement the Young Athletes Program

The Center for Social Development and Education is implementing Young Athletes (YA), a motor play program, in five developing countries: Kenya, Romania, Malawi, Venezuela, and Tanzania. Young Athletes is a theoretically-based program designed to improve the motor development of children with disabilities (ages 3-7) through various motor activities. Clinical trials conducted by CSDE (Favazza et al., 2013) indicate that the Young Athletes program significantly improves the motor skills of children with disabilities. The program is now being introduced internationally to address the needs of children in developing countries

Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.

Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to our understanding of cell replication and vitality. The proliferation of whole genome sequencing represents an unprecedented opportunity to glean new insights into telomere biology on a previously unimaginable scale. To this end, a number of approaches for estimating telomere length from whole-genome sequencing data have been proposed. Here we present Telomerecat, a novel approach to the estimation of telomere length. Previous methods have been dependent on the number of telomeres present in a cell being known, which may be problematic when analysing aneuploid cancer data and non-human samples. Telomerecat is designed to be agnostic to the number of telomeres present, making it suited for the purpose of estimating telomere length in cancer studies. Telomerecat also accounts for interstitial telomeric reads and presents a novel approach to dealing with sequencing errors. We show that Telomerecat performs well at telomere length estimation when compared to leading experimental and computational methods. Furthermore, we show that it detects expected patterns in longitudinal data, repeated measurements, and cross-species comparisons. We also apply the method to a cancer cell data, uncovering an interesting relationship with the underlying telomerase genotype

Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.

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GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests. ICP is associated with an increased risk of adverse outcomes, including spontaneous preterm birth and stillbirth. Whilst rare mutations affecting hepatobiliary transporters contribute to the aetiology of ICP, the role of common genetic variation in ICP has not been systematically characterised to date. Here, we perform genome-wide association studies (GWAS) and meta-analyses for ICP across three studies including 1138 cases and 153,642 controls. Eleven loci achieve genome-wide significance and have been further investigated and fine-mapped using functional genomics approaches. Our results pinpoint common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements as contributing mechanisms to ICP susceptibility

Helping Developing Countries Implement the Young Athletes Program

The Center for Social Development and Education is implementing Young Athletes (YA), a motor play program, in five developing countries: Kenya, Romania, Malawi, Venezuela, and Tanzania. Young Athletes is a theoretically-based program designed to improve the motor development of children with disabilities (ages 3-7) through various motor activities. Clinical trials conducted by CSDE (Favazza et al., 2013) indicate that the Young Athletes program significantly improves the motor skills of children with disabilities. The program is now being introduced internationally to address the needs of children in developing countries

Absence of Smad3 Induces Neutrophil Migration after Cutaneous Irradiation : Possible Contribution to Subsequent Radioprotection

Our previous work showed that 6 weeks after cutaneous irradiation, mice null (knockout, KO) for Smad3, a cytoplasmic downstream mediator of transforming growth factor-β, demonstrate less epidermal acanthosis and dermal inflammation than wild-type (WT) Smad3 mice. Analysis of the kinetics of inflammation showed that 6 to 8 hours after skin irradiation, there was a transient sevenfold increase in neutrophil influx in Smad3 KO mice compared with WT. Herein we describe bone marrow transplantation and skin grafting between WT and KO mice to assess the contribution of the neutrophil genotype compared with that of irradiated skin to the induction of neutrophil migration after irradiation. Results from bone marrow transplantation showed that WT marrow transplanted into KO mice enhanced neutrophil migration 6 to 8 hours after irradiation by 3.2-fold compared with KO marrow in WT mice. KO skin grafted onto either WT or KO animals showed a sixfold elevation of neutrophils after irradiation compared with grafted WT skin. These results suggest that the genotype of the irradiated skin, rather than the inflammatory cell, controls neutrophil influx. Circulating neutrophils, increased in WT mice after injection of granulocyte colony-stimulating factor, resulted in increased neutrophil migration to the skin 6 to 8 hours after irradiation and less skin damage 6 weeks after irradiation compared with untreated WT mice. Thus, early responses, including enhanced neutrophil influx, appear to contribute to subsequent cutaneous radioprotection