1,371 research outputs found
Wavefront sensing with a brightest pixel selection algorithm
Astronomical adaptive optics systems with open-loop deformable mirror control
have recently come on-line. In these systems, the deformable mirror surface is
not included in the wavefront sensor paths, and so changes made to the
deformable mirror are not fed back to the wavefront sensors. This gives rise to
all sorts of linearity and control issues mainly centred on one question: Has
the mirror taken the shape requested? Non-linearities in wavefront measurement
and in the deformable mirror shape can lead to significant deviations in mirror
shape from the requested shape. Here, wavefront sensor measurements made using
a brightest pixel selection method are discussed along with the implications
that this has for open-loop AO systems. Discussion includes elongated laser
guide star spots and also computational efficiency.Comment: 10 pages, 12 figures, accepted by MNRA
Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18.
Positron emission tomography (PET) is unique in that it allows quantification of biochemical processes in vivo, but difficulties with preparing suitably labelled radiotracers limit its scientific and diagnostic applications. Aromatic [(18)F]fluorination of drug-like small molecules is particularly challenging as their functional group compositions often impair the labelling efficiency. Herein, we report a new strategy for incorporation of (18)F into highly functionalized aromatic compounds using sulfonium salts as leaving groups. The method is compatible with pharmacologically relevant functional groups, including aliphatic amines and basic heterocycles. Activated substrates react with [(18)F]fluoride at room temperature, and with heating the reaction proceeds in the presence of hydrogen bond donors. Furthermore, the use of electron rich spectator ligands allows efficient and regioselective [(18)F]fluorination of non-activated aromatic moieties. The method provides a broadly applicable route for (18)F labelling of biologically active small molecules, and offers immediate practical benefits for drug discovery and imaging with PET
Review and optimization of housing and husbandry of anemonefishes for use in research
As anemonefishes of the genus Amphiprion are emerging as a model organism for marine science, it is critical to have standardization in housing and husbandry protocols for research laboratories. Here, we conducted a literature review, a questionnaire survey, and two experiments regarding the housing and husbandry of anemonefishes for use in research. The literature review identified the need for standardization and optimization of multiple variables including tank volume, diet composition, and lighting type for the housing of broodstock pairs. The questionnaire survey was completed by 27 laboratories, with a 45% response rate, across 11 different countries in Europe, North America, Asia, and Australia. Results from the survey confirmed the need for standardization or optimization of laboratory protocols. The experimental manipulation of housing of Amphiprion percula was conducted over a 3-month period, where reproduction was monitored for 8 breeding pairs housed in large, 120-liter (30-gallon) tanks versus 7 breeding pairs housed in small, 9-liter (2-gallon) tanks. Results suggest that reproductive output was significantly reduced among breeding pairs in experimental 9-liter tanks when compared to those housed in standard 120-liter tanks. The experimental manipulation of husbandry of A. percula was conducted over a 3-month period, where reproduction was monitored across 19 breeding pairs on a high ration diet (1 mL scoop of pellets) versus 15 breeding pairs on a low ration diet (0.5 mL scoop of pellets). Results suggest that reproductive output was significantly reduced among breeding pairs on a low ration diet when compared to those on a high ration diet. Although the experimental 9-liter tanks were likely below the optimum for reproductive output, the fact that reproduction still occurred suggests that the fish will reproduce in tanks smaller than 120 liters and that 20-75 liter tanks may be the best option for housing large numbers of A. percula and similar species. The reproductive output of broodstock pairs fed a high ration diet is similar to that seen in the wild, and provision of higher quality foods (e.g., cuttlefish, shrimp, fish eggs, etc.) beyond commercial pellets may enhance survival of larvae. In conclusion, our research suggests that the anemonefish research community should be discussing the optimization and standardization of housing and husbandry or, minimally, recognize that housing and husbandry influence a wide range of traits and will influence the results and conclusions drawn from experiments
An aperture masking mode for the MICADO instrument
MICADO is a near-IR camera for the Europea ELT, featuring an extended field
(75" diameter) for imaging, and also spectrographic and high contrast imaging
capabilities. It has been chosen by ESO as one of the two first-light
instruments. Although it is ultimately aimed at being fed by the MCAO module
called MAORY, MICADO will come with an internal SCAO system that will be
complementary to it and will deliver a high performance on axis correction,
suitable for coronagraphic and pupil masking applications. The basis of the
pupil masking approach is to ensure the stability of the optical transfer
function, even in the case of residual errors after AO correction (due to non
common path errors and quasi-static aberrations). Preliminary designs of pupil
masks are presented. Trade-offs and technical choices, especially regarding
redundancy and pupil tracking, are explained.Comment: SPIE 2014 Proceeding -- Montrea
Artists’ Studio Archives Managing Your Studio Practice & Building a Creative Legacy Revised Edition (2022): A Comprehensive Guide for Artists & Their Assistants
This guide is based on real-life scenarios and best practices in managing an art studio archive. It will aid artists in every career stage, from emerging artists to late-career artists; the yet-to- be-discovered and the well-established. Increasing productivity in the studio with good documentation helps artists better prepare to sell work and secure grant funding, as well as manage better the legal and financial aspects of an artistic practice
Artist\u27 Studio Archives: Managing Personal Collections & Creative Legacies
A guide for artists, their assistants, and others managing and preserving an artist\u27s studio archives
Ultimate performance of Quantum Well Infrared Photodetectors in the tunneling regime
Thanks to their wavelength diversity and to their excellent uniformity,
Quantum Well Infrared Photodetectors (QWIP) emerge as potential candidates for
astronomical or defense applications in the very long wavelength infrared
(VLWIR) spectral domain. However, these applications deal with very low
backgrounds and are very stringent on dark current requirements. In this paper,
we present the full electro-optical characterization of a 15 micrometer QWIP,
with emphasis on the dark current measurements. Data exhibit striking features,
such as a plateau regime in the IV curves at low temperature (4 to 25 K). We
show that present theories fail to describe this phenomenon and establish the
need for a fully microscopic approach
Magnetic and electronic properties of lithium cobalt oxide substituted by nickel
[Abstract] We measured susceptibility, electron-spin resonance, magnetization and electrical conductivity of LiCo1−yNiyO2 powders synthesized by wet-chemistry method using succinic acid as chelating agent. We found unusual properties in the nickel-rich LiCo0.2Ni0.8O2, which shows several resonance lines as a function of the temperature in the range 3.5–300 K. The signal at low magnetic field is attributed to the magnetic domains in the nanostructured sample. The two other lines correspond to the typical ferromagnetic signal observed in powdered compounds. In the temperature range 120–300 K, the unique ESR line centered at 315 mT is the paramagnetic signal with a gyromagnetic factor g=2.12, which is in good agreement with the presence of a high concentration of Ni3+ (3d7) ions. In the nickel-rich oxide, LiNi0.8Co0.2O2, the magnetic data are qualitatively well-described by the model proposed by Drillon and Panissod for a 3D ferromagnetic order.Spanish and French Foreign Office; HF 1999-0101Spanish and French Foreign Office; PAI Picasso 00717T
The Center of Excellence Model for Information Services (CLIR pub 163)
In 2013, The Andrew W. Mellon Foundation awarded a group of librarians from ARL\u27s Research Library Leadership Fellows program a planning grant to examine the center of excellence (CoE) model for information services. Used in a variety of industries, CoEs are designed to attract the most talented researchers in a particular field, enhance collaboration, and improve access to the resources needed for their research. The planning grant was awarded to determine whether the CoE model could serve as a means to provide the new services required for the effective use of digital information.
This report describes the team\u27s approach to examining the feasibility of CoEs in the library setting. The team conducted preliminary investigations of more than 100 centers, which they narrowed to 35 for in-depth research. Interviews were conducted with staff at 19 centers and 7 funding organizations. In their conclusion, the team advises developing networks of expertise or expert networks, instead of CoEs, and provides a series of recommendations for building such networks
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