Simulation of two-phase air–liquid flows in a closed bioreactor loop: Numerical modeling, experiments, and verification

Improvements in technology for the production of microbial biomass from natural gas, which have been gaining importance in recent years, require the development and optimization of energy-efficient bioreactor designs. The most advanced methods for developing and scaling up industrial biotechnological processes rely on detailed hydrodynamic modeling, in addition to classical approaches, as the main tool for analysis and large-scale transfer of experimental information. This paper presents the results of a simulation of flows in a bioreactor circuit using the latest mathematical methods and numerical flow analysis tools for two-phase bubble flows based on experimental data. © 2022 The Authors. Mathematical Methods in the Applied Sciences published by John Wiley & Sons, Ltd.Ural Branch, Russian Academy of Sciences, UB RASComputations were performed using the Uran supercomputer hosted by UB RAS. Open access funding enabled and organized by Projekt DEAL

Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level

Genetic associations between variants on chromosome 5p13 and 8q24 and gastric cancer (GC) have been previously reported in the Asian population. We aimed to replicate these findings and to characterize the associations at the genome and transcriptome level. We performed a fine-mapping association study in 1926 GC patients and 2012 controls of European descent using high dense SNP marker sets on both chromosomal regions. Next, we performed expression quantitative trait locus (eQTL) analyses using gastric transcriptome data from 143 individuals focusing on the GC associated variants. On chromosome 5p13 the strongest association was observed at rs6872282 (P = 2.53 × 10-04) and on chromosome 8q24 at rs2585176 (P = 1.09 × 10-09). On chromosome 5p13 we found cis-eQTL effects with an upregulation of PTGER4 expression in GC risk allele carrier (P = 9.27 × 10-11). On chromosome 8q24 we observed cis-eQTL effects with an upregulation of PSCA expression in GC risk allele carrier (P = 2.17 × 10-47). In addition, we found trans-eQTL effects for the same variants on 8q24 with a downregulation of MBOAT7 expression in GC risk allele carrier (P = 3.11 × 10-09). In summary, we confirmed and refined the previously reported GC associations at both chromosomal regions. Our data point to shared etiological factors between Asians and Europeans. Furthermore, our data imply an upregulated expression of PTGER4 and PSCA as well as a downregulated expression of MBOAT7 in gastric tissue as risk-conferring GC pathomechanisms

Визначення несучої здатності сталезалізобетонних нерозрізних балок з гнучкими анкерами

The article investigates the carrying capacity of reinforced concrete beams theoretically. The data obtained from the calculations compared with the values obtained experimentally during the tests. Also a nomogram of the selection of the required number of flexible anchors for the perception of longitudinal forces in the beam is constructed, depending on the class of concrete and the number of double-leaf reinforced concrete beams.В статье исследованы теоретическим методом несущую способность сталежелезобетонных балок. Полученные по расчетам данные сравнению с экспериментально полученными во время испытаний значениями. Также построена номограмма подбора необходимого количества гибких анкеров для восприятия продольных сил в балке в зависимости от класса бетона и номера двутавра сталежелезобетонные балки.У статті досліджено теоретичним методом несучу здатність сталезалізобетонних балок. Отримані за розрахунками дані порівняні з експериментально отриманими під час випробувань значеннями. Також побудована номограма підбору необхідної кількості гнучких анкерів для сприйняття поздовжніх сил у балці в залежності від класу бетону та номеру двотавру сталезалізобетонної балки

Sex differences in the prevalence of Helicobacter pylori infection: an individual participant data pooled analysis (StoP Project)

Background Helicobacter pylori (H. pylori) infection is more frequent among men, though the magnitude of the association might be inaccurate due to potential misclassification of lifetime infection and publication bias. Moreover, infection is common, and most studies are cross-sectional. Thus, prevalence ratios (PRs) may be easier to interpret than odds ratios (ORs). Aim The aim of this study was to quantify the association between sex and H. pylori infection using controls from 14 studies from the Stomach Cancer Pooling (StoP) Project. Participants and methods H. pylori infection was defined based on IgG serum antibody titers or multiplex serology. Participants were also classified as infected if gastric atrophy was present, based on histological examination or serum pepsinogen (PG) levels (PG I 6470 and PG I/II ratio 643). Summary ORs and PRs, adjusted for age, social class and smoking, and corresponding 95% confidence intervals (CIs), were estimated through random-effects meta-analysis. Results Men had significantly higher OR (OR: 1.33, 95% CI: 1.04\u20131.70) and PR (PR: 1.05, 95% CI: 1.00\u20131.10) of infection, with stronger associations among hospital-based or older controls. Results were similar when considering the presence of gastric atrophy to define infection status, particularly among participants older than 65 years. Conclusion This collaborative pooled-analysis supports an independent effect of sex on the prevalence of H. pylori infection, while minimizing misclassification of lifetime infection status and publication bias