183 research outputs found

    Experimentally feasible measures of distance between quantum operations

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    We present two measures of distance between quantum processes based on the superfidelity, introduced recently to provide an upper bound for quantum fidelity. We show that the introduced measures partially fulfill the requirements for distance measure between quantum processes. We also argue that they can be especially useful as diagnostic measures to get preliminary knowledge about imperfections in an experimental setup. In particular we provide quantum circuit which can be used to measure the superfidelity between quantum processes. As the behavior of the superfidelity between quantum processes is crucial for the properties of the introduced measures, we study its behavior for several families of quantum channels. We calculate superfidelity between arbitrary one-qubit channels using affine parametrization and superfidelity between generalized Pauli channels in arbitrary dimensions. Statistical behavior of the proposed quantities for the ensembles of quantum operations in low dimensions indicates that the proposed measures can be indeed used to distinguish quantum processes.Comment: 9 pages, 4 figure

    Bimanual Movement Characteristics and Real-World Performance Following Hand-Arm Bimanual Intensive Therapy in Children with Unilateral Cerebral Palsy

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    The purpose of this study was to quantify characteristics of bimanual movement intensity during 30 h of hand-arm bimanual intensive therapy (HABIT) and bimanual performance (activities and participation) in real-world settings using accelerometers in children with unilateral cerebral palsy (UCP). Twenty-five children with UCP participated in a 30 h HABIT program. Data were collected from bilateral wrist-worn accelerometers during 30 h of HABIT to quantify the movement intensity and three days pre- and post-HABIT to assess real-world performance gains. Movement intensity and performance gains were measured using six standard accelerometer-derived variables. Bimanual capacity (body function and activities) was assessed using standardized hand function tests. We found that accelerometer variables increased significantly during HABIT, indicating increased bimanual symmetry and intensity. Post-HABIT, children demonstrated significant improvements in all accelerometer metrics, reflecting real-world performance gains. Children also achieved significant and clinically relevant changes in hand capacity following HABIT. Therefore, our findings suggest that accelerometers can objectively quantify bimanual movement intensity during HABIT. Moreover, HABIT enhances hand function as well as activities and participation in real-world situations in children with UCP

    Low dose cranial irradiation-induced cerebrovascular damage is reversible in mice

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    BACKGROUND: High-dose radiation-induced blood-brain barrier breakdown contributes to acute radiation toxicity syndrome and delayed brain injury, but there are few data on the effects of low dose cranial irradiation. Our goal was to measure blood-brain barrier changes after low (0.1 Gy), moderate (2 Gy) and high (10 Gy) dose irradiation under in vivo and in vitro conditions. METHODOLOGY: Cranial irradiation was performed on 10-day-old and 10-week-old mice. Blood-brain barrier permeability for Evans blue, body weight and number of peripheral mononuclear and circulating endothelial progenitor cells were evaluated 1, 4 and 26 weeks postirradiation. Barrier properties of primary mouse brain endothelial cells co-cultured with glial cells were determined by measurement of resistance and permeability for marker molecules and staining for interendothelial junctions. Endothelial senescence was determined by senescence associated ÎČ-galactosidase staining. PRINCIPLE FINDINGS: Extravasation of Evans blue increased in cerebrum and cerebellum in adult mice 1 week and in infant mice 4 weeks postirradiation at all treatment doses. Head irradiation with 10 Gy decreased body weight. The number of circulating endothelial progenitor cells in blood was decreased 1 day after irradiation with 0.1 and 2 Gy. Increase in the permeability of cultured brain endothelial monolayers for fluorescein and albumin was time- and radiation dose dependent and accompanied by changes in junctional immunostaining for claudin-5, ZO-1 and ÎČ-catenin. The number of cultured brain endothelial and glial cells decreased from third day of postirradiation and senescence in endothelial cells increased at 2 and 10 Gy. CONCLUSION: Not only high but low and moderate doses of cranial irradiation increase permeability of cerebral vessels in mice, but this effect is reversible by 6 months. In-vitro experiments suggest that irradiation changes junctional morphology, decreases cell number and causes senescence in brain endothelial cells

    A hybrid decision support system for analyzing challenges of the agricultural supply chain

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    Agricultural supply chain management includes all the events involved in moving products of the agricultural sector from the field to the customer, and is a crucial aspect ensuring the rich contribution of the agricultural sector to the economic growth of the nation. The purpose of this paper is to add value to the present knowledge base by ascertaining the challenges of the agricultural supply chain in India on the basis of a thorough literature survey and the Delphi technique. Following this, the decision-making trial and evaluation laboratory approach was used to model the identified challenges, explore the cause–effect interrelationship, and to develop the systematic hierarchical structures of challenges through an interpretive structural modeling methodology. The implementation of the approach in the Indian context led to the inference that two factors, namely limited integration among the national agricultural markets, and limited agricultural market infrastructure were the most important ones. The integrated model obtained as an output of this study intends to guide the agricultural policy- and decision-makers to improve the performance of the agricultural supply chain in India. Also, some essential recommendations have been given to improve the efficiency of the agricultural supply chain management
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