9 research outputs found
CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative
Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research
The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients
Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation
⁹⁰Sr and ⁸⁹Sr in seawater off Japan as a consequence of the Fukushima Dai-ichi nuclear accident
The impact of the earthquake and tsunami on the east coast of Japan on 11 March 2011 caused a loss of power at the Fukushima Dai-ichi nuclear power plant (NPP) that resulted in one of the most important releases of artificial radioactivity into the environment. Although several works were devoted to evaluating the atmospheric dispersion of radionuclides, the impact of the discharges to the ocean has been less investigated. Here we evaluate the distribution of Fukushima-derived ⁹⁰Sr (n = 57) and ⁸⁹Sr (n = 19) throughout waters 30-600 km offshore in June 2011. Concentrations of ⁹⁰Sr and ⁸⁹Sr in both surface waters and shallow profiles ranged from 0.8±0.2 to 85±3 Bqm⁻³ and from 19±6 to 265±74 Bqm⁻³, respectively. Because of its short half-life, all measured ⁸⁹Sr was due to the accident, while the ⁹⁰Sr concentrations can be compared to the background levels in the Pacific Ocean of about 1.2 Bqm⁻³. Fukushima-derived radiostrontium was mainly detected north of Kuroshio Current, as this was acting as a southern boundary for transport. The highest activities were associated with near-shore eddies, and larger inventories were found in the closest stations to Fukushima NPP. The data evidence a major influence of direct liquid discharges of radiostrontium compared to the atmospheric deposition. Existing ¹³⁷Cs data reported from the same samples allowed us to establish a ⁹⁰Sr / ¹³⁷Cs ratio of 0.0256±0.0006 in seawater off Fukushima, being significantly different than that of the global atmospheric fallout (i.e., 0.63) and may be used in future studies to track waters coming from the east coast of Japan. Liquid discharges of ⁹⁰Sr to the ocean were estimated, resulting in an inventory of 53±1 TBq of ⁹⁰Sr in the inshore study area in June 2011 and total releases of ⁹⁰Sr ranging from 90 to 900 TBq, depending upon the reported estimates of ¹³⁷Cs releases that are considered
Gestão Patrimonial na Câmara Municipal de Itapoá
Orientador : Joel Souza e SilvaProjeto (especialização) - Universidade Federal do Paraná, Setor de Ciências Sociais Aplicadas, Curso de Especialização em Gestão Pública MunicipalInclui referênciasResumo : O presente projeto trata do controle patrimonial na Câmara Municipal de Itapoá. A Câmara de Itapoá é uma Câmara de pequeno porte, que passou a fazer o controle de seus bens há pouco tempo e vem enfrentando problemas na regularização de tal controle. Com as novas normas de contabilidade aplicadas ao setor público, o controle patrimonial passou a ser parte fundamental na Administração pública. Durante a análise na Câmara, verificou-se que a maior parte dos problemas relacionados com a gestão patrimonial é devido à falta de padronização dos procedimentos de controle, onde muitas vezes algumas etapas não eram efetuadas. Assim, este trabalho propõe a criação de uma normativa com cinco etapas obrigatórias, Aquisição, cadastro, responsabilização/distribuição, movimentação e inventário, a serem seguidas na aquisição de qualquer Bem patrimonial. Estas etapas visam a padronização dos procedimentos. Com a implantação da proposta, espera-se que os problemas referentes a falta de controle patrimonial sejam resolvidos e que o controle passe a ser mais efetivo
cDf International Congress : proceedings : actes, actas : actes, Barcelona Jun. 2013
El Congrés Internacional coupDefouet Barcelona 2013 ha estat una iniciativa de l'Art Nouveau European Route – Ruta Europea del Modernisme, organitzada per l'Institut del Paisatge Urbà de l'Ajuntament de Barcelona i el grup de recerca GRACMON de la Universitat de BarcelonaCoordinació: Lluís Bosch, Mireia Freixa.[eng] In 2013 the magazine coupDefouet reached its first decade of existence. As a way of celebrating this, the Art Nouveau European Route – the association of cities and other local institutions for the promotion and diffusion of Art Nouveau heritage that created the magazine – organised a magnificent international congress as a framework for scientific exchange and raising public awareness. The first coupDefouet International Congress on Art Nouveau was held in Barcelona, the city from which coupDefouet is published and one of the undisputable world capitals of Art Nouveau. This volume of the Singularitats series comprises the proceedings of that event.[cat] L’any 2013 va fer deu anys de l’aparició de coupDefouet, la revista de la Ruta Europea del Modernisme, una associació de municipis i altres entitats locals per a la promoció i la difusió del patrimoni modernista o Art Nouveau. Per commemorar-ho, s’organitzà un congrés internacional amb l’objectiu de contribuir al coneixement científic i la difusió d’aquest moviment artístic. El primer Congrés Internacional coupDefouet se celebrà a Barcelona, la ciutat en què s’edita coupDefouet i una de les capitals indiscutibles de l’Art Nouveau. En aquest volum de Singularitats s’apleguen les actes d’aquell esdeveniment