NBI and Laryngeal Papillomatosis: A Diagnostic Challenge: A Systematic Review

Narrow-band imaging (NBI) represents a valid aid in laryngeal squamous cell carcinoma (LSCC) diagnosis for detecting vascular changes. However, LSCC and laryngeal papillomatosis (LP) show similar vascular patterns that may lead to misdiagnosis and improper treatment. This review aims to deepen this NBI limit in order to stress a careful preoperative evaluation of laryngeal lesions. The research was carried out on PubMed, Web of Science and Scopus databases using specific keywords. The topic of research was assessed by these parameters: accuracy, sensitivity, specificity, and positive and negative predictive values. This review included only five articles: they demonstrated that NBI is better than white-light endoscopy in detecting LSCC and LP. They also reported that LP is frequently mistaken for LSCC, resulting in high rates of false positives using NBI. This is the first review that emphasized this NBI limitation in distinguishing between LP and LSCC in cases of a type V pattern of intraepithelial papillary capillary loop. Although NBI application increased the rate of early cancer detection, LP reduces NBI accuracy. This drawback may lead to misdiagnosis and improper treatment. Our advice is to be careful in cases of type V pattern on NBI and to research LP epithelial and clinical features because it could be a pitfall

Papillomavirus Infection and Prevention: How Much Does the Sicilian Population Know? An Observational Study

Human papillomavirus is a sexually transmitted virus that is responsible not only for uterine cervical cancer, but also for the oral and oropharyngeal cancers. In this latter case, the virus indiscriminately affects both sexes at any age. Vaccination plays a key role in preventing infection and its possible consequences. Therefore, this study aimed to assess the degree of awareness of papillomavirus infection and its possible prevention in the Sicilian population. A prospective observational study was carried out on the Sicilian population through a self-administered questionnaire, consisting of 10 multiple-choice questions. The survey lasted from June 2021 to December 2021. A total of 844 respondents were included: 60.90% were female and 53.55% were aged between 21 and 30 years. Most of the surveyed population knew about the virus and the existence of the vaccine, however, many of them did not know about virus's effects on the oral and oropharyngeal sites (49.17%), or about the indication for vaccination for males (39.69%). Oral and oropharyngeal papillomavirus-related cancers are an increasingly frequent finding, especially in young adults. Therefore, it is necessary and quite mandatory to educate the population about the risks that certain voluptuous habits may cause, with the help of general practitioners, schools, social media, and social networks

Software Development in the Post-PC Era: Towards Software Development as a Service

Abstract. Software systems affect all aspects of our modern life andare revolutionizing the way we live. Over the years, software developmenthas evolved to meet the needs of new types of applications and toembrace new technological disruptions. Today, we witness the rise of mobilitywhere the role of the conventional high-specification PC is declining.Some refer to this era as the Post-PC era. This technological shift,powered by a key enabling technology - cloud computing, has opened new opportunities for human advancement (e.g. the Internet of Things).Consequently, the evolving landscape of software systems drives the need for new methods for conceiving them. Such methods need to a) address the challenges and requirements of this era and b) embrace the benefitsof new technological breakthroughs. In this paper, we list the characteristics of the Post-PC era from the software development perspective. In addition, we describe three motivating trends of software development processes. Then, we derive a list of requirements for the future software development approach from the characteristics of the Post-PC era and from the motivating trends. Finally, we propose a reference architecturefor cloud-based software process enactment as an enabler for Software Development as a Service (SDaaS). The architecture is thefirst step to address the needs that we have identified

Design and in-house validation of a portable system for the determination of free acidity in virgin olive oil

Nutritional and healthy values are well known properties of virgin olive oil (VOO). The product quality, in terms of belonging to a specific quality grade (extra virgin, virgin, lampante), is defined by a set of chemical-physical and sensory measurements. According to the official regulation of the European Union (EU Reg. 1348/2013)the free acidity is the first parameter that has to be determined by analysts; it gives information about the quality of the olives used to produce the VOO as well as the hydrolytic state of VOO just produced and stored. The official procedure is based on an acid-base titration that needs to be carried out in a chemical laboratory. In this paper a portable battery-operated electronic system to measure olive oil free acidity is presented: the system can be used for quick \u201cin situ\u201d tests in a production environment (olive oil mills or packaging centers)by people without particular training. The working principle of the system is based on the creation of an emulsion between oil and a hydroalcoholic solution: the free acidity is estimated on the value of the emulsion electrical conductance. The proposed system has been calibrated and in-house validated showing good results in terms of limit of detection and quantification, precision and accuracy. Moreover, a good correlation (R 2adj = 0.97)with free acidity data obtained applying the official method on 30 olive oil samples belonging to different commercial categories (extra virgin, virgin and lampante olive oil)has been evidenced

Representation of safety standards with semantic technologies used in industrial environments

Proceedings of: 36th International Conference on Computer Safety, Reliability, and Security, (SAFECOMP 2017). Trento, Italy, September 13-15, 2017Understanding and following safety standards with their text can be difficult. Ambiguity and inconsistency, among other issues, can easily arise. As a solution, several authors argue for the explicit representation of the standards with models, which can be created with semantic technologies such as ontologies. However, this possibility has received little attention. The few authors that have addressed it have also only dealt with a subset of safety standard aspects and have used technologies not usually applied for critical systems engineering. As a first step towards addressing these issues, this position paper presents our initial work on the representation of safety standards with Knowledge Manager, a tool used in industrial environments that exploits semantic technologies to manage domain information. The proposal also builds on prior work on the specification of safety compliance needs with a holistic generic metamodel. We describe how to use Knowledge Manager to specify the concepts and relationships of the metamodel for a given safety standard, and discuss the application and benefits of the corresponding representation.The research leading to this paper has received funding from the AMASS project (H2020-ECSEL no. 692474; Spain’s MINECO ref. PCIN-2015-262)

Potential of the Oxidized Form of the Oleuropein Aglycon to Monitor the Oil Quality Evolution of Commercial Extra-Virgin Olive Oils

The quality of commercially available extra-virgin olive oils (VOOs) of different chemical compositions was evaluated as a function of storage (12 months), simulating market storage conditions, to find reliable and early markers of the virgin olive oil (VOOs) quality status in the market. By applying a D-optimal design using the Most Descriptive Compound (MDC) algorithm, 20 virgin olive oils were selected. The initial concentrations of oleic acid, hydrophilic phenols, and a-tocopherol in the 20 VOOs ranged from 58.2 to 80.5%, 186.7 to 1003.2 mg/kg, and 170.7-300.6 mg/kg, respectively. K-270, increment K, (E, E)-2.4-decadienal and (E)-2-decenal, and the oxidative form of the oleuropein aglycon (3,4-DHPEA-EA-OX) reflected the VOO quality status well, with 3,4-DHPEA-EA-OX being the most relevant and quick index for simple monitoring of the "extra-virgin" commercial shelf-life category. Its HPLC-DAD evaluation is easy because of the different wavelength absorbances of the oxidized and non-oxidized form (3,4-DHPEA-EA), respectively, at 347 and 278 nm