1,742 research outputs found
Full-rotation singularity-safe workspace for kinematically redundant parallel robots
This paper introduces and computes a novel type of work-space for kinematically redundant parallel robots that defines the regionin which the end-effector can make full rotations without coming close tosingular configurations; it departs from the traditional full-rotation dex-terous workspace, which considers full rotations without encounteringsingularities but does not take into account the performance problemsresulting from closeness to these locations. Kinematically redundant ar-chitectures have the advantage of being able to be reconfigured withoutchanging the pose of the end-effector, thus being capable of avoidingsingularities and being suitable for applications where high dexterityis required. Knowing the workspace of these robots in which the end-effector is able to complete full, smooth rotations is a key design aspectto improve performance; however, since this singularity-safe workspaceis generally small, or even non-existent, in most parallel manipulators,its characterisation and calculation have not received attention in theliterature. The proposed workspace for kinematically redundant robotsis introduced using a planar parallel architecture as a case study; the for-mulation works by treating the manipulator as two halves, calculatingthe full-rotation workspace of the end-effector for each half whilst ensur-ing singularity conditions are not approached or met, and then findingthe intersection of both regions. The method is demonstrated ontwoexample robot instances, and a numerical analysis is also carried out asa comparison
Testing Hardy nonlocality proof with genuine energy-time entanglement
We show two experimental realizations of Hardy ladder test of quantum
nonlocality using energy-time correlated photons, following the scheme proposed
by A. Cabello \emph{et al.} [Phys. Rev. Lett. \textbf{102}, 040401 (2009)].
Unlike, previous energy-time Bell experiments, these tests require precise
tailored nonmaximally entangled states. One of them is equivalent to the
two-setting two-outcome Bell test requiring a minimum detection efficiency. The
reported experiments are still affected by the locality and detection
loopholes, but are free of the post-selection loophole of previous energy-time
and time-bin Bell tests.Comment: 5 pages, revtex4, 6 figure
Negative refraction and the spectral filtering of terahertz radiation by a photonic crystal prism
We demonstrate how micromachined photonic crystals can be used to negatively refract terahertz frequency light. The photonic crystals, which are constructed from conventional dielectric materials, manipulate the incident beam via interaction with their photonic bands. Consequently, we show that different components of a broadband beam incident on the structure may be positively or negatively refracted, depending upon its frequency and that the structure can be used as an effective spectral filter of THz radiation
Local context effects during emotional item directed forgetting in younger and older adults
This paper explored the differential sensitivity young and older adults exhibit to the local context of items entering memory. We examined trial-to-trial performance during an item directed forgetting task for positive, negative, and neutral (or baseline) words each cued as either to-be-remembered (TBR) or to-be-forgotten (TBF). This allowed us to focus on how variations in emotional valence (independent of arousal) and instruction (TBR vs. TBF) of the previous item (trial n-1) impacted memory for the current item (trial n) during encoding. Different from research showing impairing effects of emotional arousal, both age groups showed a memorial boost for stimuli when preceded by items high in positive or negative valence relative to those preceded by neutral items. This advantage was particularly prominent for neutral trial n items that followed emotional items suggesting that, regardless of age, neutral memories may be strengthened by a local context that is high in valence. A trending age difference also emerged with older adults showing greater sensitivity when encoding instructions changed between trial n-1 and n. Results are discussed in light of age-related theories of cognitive and emotional processing, highlighting the need to consider the dynamic, moment-to-moment fluctuations of these systems
Measurement of two-halo neutron transfer reaction p(Li,Li)t at 3 MeV
The p(\nuc{11}{Li},\nuc{9}{Li})t reaction has been studied for the first time
at an incident energy of 3 MeV delivered by the new ISAC-2 facility at
TRIUMF. An active target detector MAYA, build at GANIL, was used for the
measurement. The differential cross sectionshave been determined for
transitions to the \nuc{9}{Li} ground andthe first excited states in a wide
range of scattering angles. Multistep transfer calculations using different
\nuc{11}{Li} model wave functions, shows that wave functions with strong
correlations between the halo neutrons are the most successful in reproducing
the observation.Comment: 6 pages, 3 figures, submitted to Physical Review Letter
Scaling of the distribution of fluctuations of financial market indices
We study the distribution of fluctuations over a time scale (i.e.,
the returns) of the S&P 500 index by analyzing three distinct databases.
Database (i) contains approximately 1 million records sampled at 1 min
intervals for the 13-year period 1984-1996, database (ii) contains 8686 daily
records for the 35-year period 1962-1996, and database (iii) contains 852
monthly records for the 71-year period 1926-1996. We compute the probability
distributions of returns over a time scale , where varies
approximately over a factor of 10^4 - from 1 min up to more than 1 month. We
find that the distributions for 4 days (1560 mins) are
consistent with a power-law asymptotic behavior, characterized by an exponent
, well outside the stable L\'evy regime . To
test the robustness of the S&P result, we perform a parallel analysis on two
other financial market indices. Database (iv) contains 3560 daily records of
the NIKKEI index for the 14-year period 1984-97, and database (v) contains 4649
daily records of the Hang-Seng index for the 18-year period 1980-97. We find
estimates of consistent with those describing the distribution of S&P
500 daily-returns. One possible reason for the scaling of these distributions
is the long persistence of the autocorrelation function of the volatility. For
time scales longer than days, our results are
consistent with slow convergence to Gaussian behavior.Comment: 12 pages in multicol LaTeX format with 27 postscript figures
(Submitted to PRE May 20, 1999). See
http://polymer.bu.edu/~amaral/Professional.html for more of our work on this
are
Prospects for Observations of Pulsars and Pulsar Wind Nebulae with CTA
The last few years have seen a revolution in very-high gamma-ray astronomy
(VHE; E>100 GeV) driven largely by a new generation of Cherenkov telescopes
(namely the H.E.S.S. telescope array, the MAGIC and MAGIC-II large telescopes
and the VERITAS telescope array). The Cherenkov Telescope Array (CTA) project
foresees a factor of 5 to 10 improvement in sensitivity above 0.1 TeV,
extending the accessible energy range to higher energies up to 100 TeV, in the
Galactic cut-off regime, and down to a few tens GeV, covering the VHE photon
spectrum with good energy and angular resolution. As a result of the fast
development of the VHE field, the number of pulsar wind nebulae (PWNe) detected
has increased from one PWN in the early '90s to more than two dozen firm
candidates today. Also, the low energy threshold achieved and good sensitivity
at TeV energies has resulted in the detection of pulsed emission from the Crab
Pulsar (or its close environment) opening new and exiting expectations about
the pulsed spectra of the high energy pulsars powering PWNe. Here we discuss
the physics goals we aim to achieve with CTA on pulsar and PWNe physics
evaluating the response of the instrument for different configurations.Comment: accepted for publication in Astroparticle Physic
Label-free segmentation of co-cultured cells on a nanotopographical gradient
The function and fate of cells is influenced by many different factors, one of which is surface topography of the support culture substrate. Systematic studies of nanotopography and cell response have typically been limited to single cell types and a small set of topographical variations. Here, we show a radical expansion of experimental throughput using automated detection, measurement, and classification of co-cultured cells on a nanopillar array where feature height changes continuously from planar to 250 nm over 9 mm. Individual cells are identified and characterized by more than 200 descriptors, which are used to construct a set of rules for label-free segmentation into individual cell types. Using this approach we can achieve label-free segmentation with 84% confidence across large image data sets and suggest optimized surface parameters for nanostructuring of implant devices such as vascular stents
Phase III randomised trial comparing paclitaxel/carboplatin with paclitaxel/cisplatin in patients with advanced non-small-cell lung cancer: a cooperative multinational trial
Background: The combination of paclitaxel with cisplatin or carboplatin has significant activity in non-small-cell lung cancer (NSCLC). This phase III study of chemotherapy-naïve advanced NSCLC patients was designed to assess whether response rate in patients receiving a paclitaxel/carboplatin combination was similar to that in patients receiving a paclitaxel/cisplatin combination. Paclitaxel was given at a dose of 200 mg/m2 (3-h intravenous infusion) followed by either carboplatin at an AUC of 6 or cisplatin at a dose of 80 mg/m2, all repeated every 3 weeks. Survival, toxicity and quality of life were also compared. Patients and methods: Patients were randomised to receive one of the two combinations, stratified according to centre, performance status, disease stage and histology. The primary analyses of response rate and survival were carried out on response-evaluable patients. Survival was also analysed for all randomised patients. Toxicity analyses were carried out on all treated patients. Results: A total of 618 patients were randomised. The two treatment arms were well balanced with regard to gender (83% male), age (median 58 years), performance status (83% ECOG 0-1), stage (68% IV, 32% IIIB) and histology (38% squamous cell carcinoma). In the paclitaxel/carboplatin arm, 306 patients received a total of 1311 courses (median four courses, range 1-10 courses) while in the paclitaxel/cisplatin arm, 302 patients received a total of 1321 courses (median four courses, range 1-10 courses). In only 76% of courses, carboplatin was administered as planned at an AUC of 6, while in 96% of courses, cisplatin was given at the planned dose of 80 mg/m2. The response rate was 25% (70 of 279) in the paclitaxel/carboplatin arm and 28% (80 of 284) in the paclitaxel/cisplatin arm (P = 0.45). Responses were reviewed by an independent radiological committee. For all randomised patients, median survival was 8.5 months in the paclitaxel/carboplatin arm and 9.8 months in the paclitaxel/cisplatin arm [hazard ratio 1.20, 90% confidence interval (CI) 1.03-1.40]; the 1-year survival rates were 33% and 38%, respectively. On the same dataset, a survival update after 22 months of additional follow-up yielded a median survival of 8.2 months in the paclitaxel/carboplatin arm and 9.8 months in the paclitaxel/cisplatin arm (hazard ratio 1.22, 90% CI 1.06-1.40; P = 0.019); the 2-year survival rates were 9% and 15%, respectively. Excluding neutropenia and thrombocytopenia, which were more frequent in the paclitaxel/carboplatin arm, and nausea/vomiting and nephrotoxicity, which were more frequent in the paclitaxel/cisplatin arm, the rate of severe toxicities was generally low and comparable between the two arms. Overall quality of life (EORTC QLQ-C30 and LC-13) was also similar between the two arms. Conclusions: This is the first trial comparing carboplatin and cisplatin in the treatment of advanced NSCLC. Although paclitaxel/carboplatin yielded a similar response rate, the significantly longer median survival obtained with paclitaxel/cisplatin indicates that cisplatin-based chemotherapy should be the first treatment optio
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