1,621 research outputs found
Four-decade trends in lymph node status of patients with vulvar squamous cell carcinoma in northern Italy
On the electromagnetic energy resolution of Cherenkov-fiber calorimeters
Electromagnetic calorimeters which sample the Cherenkov radiation of shower particles in optical fibers operate in a markedly different manner from calorimeters which rely on the dE/dx of shower particles. The well-understood physics of electromagnetic shower development is applied to the case of Cherenkov-fiber calorimetry (also known as quartz fiber calorimetry) and the results of systematically performed studies are considered in detail to derive an understanding of the critical parameters involved in energy measurement using such calorimeters. A quantitative parameterization of Cherenkov-fiber calorimetry electromagnetic energy resolution is proposed and compared with existing experimental results
Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia
From Uterus to Brain: An Update on Epidemiology, Clinical Features, and Treatment of Brain Metastases From Gestational Trophoblastic Neoplasia
In this review, we provide the state of the art about brain metastases (BMs) from gestational trophoblastic neoplasia (GTN), a rare condition. Data concerning the epidemiology, clinical presentation, innovations in therapeutic modalities, and outcomes of GTN BMs are comprehensively presented with particular attention to the role of radiotherapy, neurosurgery, and the most recent chemotherapy regimens. Good response rates have been achieved thanks to multi-agent chemotherapy, but brain involvement by GTNs entails significant risks for patients’ health since sudden and extensive intracranial hemorrhages are possible. Moreover, despite the evolution of treatment protocols, a small proportion of these patients ultimately develops a resistant disease. To tackle this unmet clinical need, immunotherapy has been recently proposed. The role of this novel option for this subset of patients as well as the achieved results so far are also discussed
Superficially invasive vulvar squamous cell carcinoma: A 37-year-long experience of a tertiary referral center
Is there a place for immune checkpoint inhibitors in vulvar neoplasms? A state of the art review
Vulvar cancer (VC) is a rare neoplasm, usually arising in postmenopausal women, although human papilloma virus (HPV)-associated VC usually develop in younger women. Incidences of VCs are rising in many countries. Surgery is the cornerstone of early-stage VC management, whereas therapies for advanced VC are multimodal and not standardized, combining chemotherapy and radiotherapy to avoid exenterative surgery. Randomized controlled trials (RCTs) are scarce due to the rarity of the disease and prognosis has not improved. Hence, new therapies are needed to improve the outcomes of these patients. In recent years, improved knowledge regarding the crosstalk between neoplastic and tumor cells has allowed researchers to develop a novel therapeutic approach exploiting these molecular interactions. Both the innate and adaptive immune systems play a key role in anti-tumor immunesurveillance. Immune checkpoint inhibitors (ICIs) have demonstrated efficacy in multiple tumor types, improving survival rates and disease outcomes. In some gynecologic cancers (e.g., cervical cancer), many studies are showing promising results and a growing interest is emerging about the potential use of ICIs in VC. The aim of this manuscript is to summarize the latest developments in the field of VC immunoncology, to present the role of state-of-the-art ICIs in VC management and to discuss new potential immunotherapeutic approaches
A new measurement of J/psi suppression in Pb-Pb collisions at 158 GeV per nucleon
We present a new measurement of J/psi production in Pb-Pb collisions at 158
GeV/nucleon, from the data sample collected in year 2000 by the NA50
Collaboration, under improved experimental conditions with respect to previous
years. With the target system placed in vacuum, the setup was better adapted to
study, in particular, the most peripheral nuclear collisions with unprecedented
accuracy. The analysis of this data sample shows that the (J/psi)/Drell-Yan
cross-sections ratio measured in the most peripheral Pb-Pb interactions is in
good agreement with the nuclear absorption pattern extrapolated from the
studies of proton-nucleus collisions. Furthermore, this new measurement
confirms our previous observation that the (J/psi)/Drell-Yan cross-sections
ratio departs from the normal nuclear absorption pattern for semi-central Pb-Pb
collisions and that this ratio persistently decreases up to the most central
collisions.Comment: 19 pages, 10 figures. Submitted to Eur. Phys. J.
Quartz fiber calorimetry
The fundamentals of a new electromagnetic and hadronic sampling calorimetry based on the detection of Cherenkov light generated in quartz optical fibers are presented. Optical fibers transport light only in a selected angular range which results in a non-obvious and absolutely unique characteristic for this new technique: showers of very narrow visible energy. In addition, the technique is characterized by radiation resistance measured in Gigarads and nanosecond signal duration. Combined, these properties make quartz fiber calorimetry a very promising technique for high intensity heavy ion experiments and for the high pseudorapidity regions of high intensity collider experiments. The results of beam tests and simulations are used to illustrate the basic properties and peculiar characteristics of this recent development
J/psi azimuthal anisotropy relative to the reaction plane in Pb-Pb collisions at 158 GeV per nucleon
The J/ azimuthal distribution relative to the reaction plane has been
measured by the NA50 experiment in Pb-Pb collisions at 158 GeV/nucleon. Various
physical mechanisms related to charmonium dissociation in the medium created in
the heavy ion collision are expected to introduce an anisotropy in the
azimuthal distribution of the observed J/ mesons at SPS energies. Hence,
the measurement of J/ elliptic anisotropy, quantified by the Fourier
coefficient v of the J/ azimuthal distribution relative to the
reaction plane, is an important tool to constrain theoretical models aimed at
explaining the anomalous J/ suppression observed in Pb-Pb collisions. We
present the measured J/ yields in different bins of azimuthal angle
relative to the reaction plane, as well as the resulting values of the Fourier
coefficient v as a function of the collision centrality and of the
J/ transverse momentum. The reaction plane has been estimated from the
azimuthal distribution of the neutral transverse energy detected in an
electromagnetic calorimeter. The analysis has been performed on a data sample
of about 100 000 events, distributed in five centrality or p
sub-samples. The extracted v values are significantly larger than zero
for non-central collisions and are seen to increase with p.Comment: proceedings of HP08 conference corrected a typo in one equatio
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