354 research outputs found

    Quality of Service Centric Web Service Composition: Assessing Composition Impact Scale towards Fault Proneness

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    Service composition in service oriented architecture is an important activity. In regard to achieve the quality of service and secured activities from the web service compositions, they need to be verified about their impact towards fault proneness before deploying that service composition. Henceforth, here in this paper, we devised a novel statistical approach to assess the service composition impact scale towards fault proneness. The devised model explores the higher and lower ranges of the service composition impact scale, which is from the knowledge of earlier compositions that are notified as fault prone

    ABCC6 is a basolateral plasma membrane protein

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    RATIONALE:: ABCC6 plays a crucial role in ectopic calcification; mutations of the gene cause pseudoxanthoma elasticum and general arterial calcification of infancy. To elucidate the role of ABCC6 in cellular physiology and disease, it is crucial to establish the exact subcellular localization of the native ABCC6 protein. OBJECTIVE:: In a recent article in Circulation Research, ABCC6 was reported to localize to the mitochondria-associated membrane and not the plasma membrane. As the suggested mitochondrial localization is inconsistent with published data and the presumed role of ABCC6, we performed experiments to determine the cellular localization of ABCC6 in its physiological environment. METHODS AND RESULTS:: We performed immunofluorescent labeling of frozen mouse and human liver sections, as well as primary hepatocytes. We used several different antibodies recognizing human and mouse ABCC6. Our results unequivocally show that ABCC6 is in the basolateral membrane of hepatocytes and is not associated with the mitochondria, mitochondria-associated membrane, or the endoplasmic reticulum. CONCLUSIONS:: Our findings support the model that ABCC6 is in the basolateral membrane, mediating the sinusoidal efflux of a metabolite from the hepatocytes to systemic circulation. © 2013 American Heart Association, Inc

    An Exactly Conservative Integrator for the n-Body Problem

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    The two-dimensional n-body problem of classical mechanics is a non-integrable Hamiltonian system for n > 2. Traditional numerical integration algorithms, which are polynomials in the time step, typically lead to systematic drifts in the computed value of the total energy and angular momentum. Even symplectic integration schemes exactly conserve only an approximate Hamiltonian. We present an algorithm that conserves the true Hamiltonian and the total angular momentum to machine precision. It is derived by applying conventional discretizations in a new space obtained by transformation of the dependent variables. We develop the method first for the restricted circular three-body problem, then for the general two-dimensional three-body problem, and finally for the planar n-body problem. Jacobi coordinates are used to reduce the two-dimensional n-body problem to an (n-1)-body problem that incorporates the constant linear momentum and center of mass constraints. For a four-body choreography, we find that a larger time step can be used with our conservative algorithm than with symplectic and conventional integrators.Comment: 17 pages, 3 figures; to appear in J. Phys. A.: Math. Ge

    Influence de différents niveaux de rayonnement UV sur la physiologie, le taux de pigments et la composition des baies, cépage Riesling

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    Changes in the stratospheric ozone concentration causes UV-radiation to increase. The response to UV-B radiation on the organ and cellular level is mainly an increase in the formation of UV-absorbing compounds meant to decrease UV-radiation penetration into the tissue. Some key enzymes involved in flavonoid biosynthesis and the phenyl-propanoid pathway have been shown to be up-regulated by UV-radiation, as are levels of key antioxidants glutathione and ascorbate, whereas carotenoid pigment formation and the incorporation of nitrogen into amino acids can be inhibited. Since components such as flavonoids, amino acids and carotenoids are important constituents of grapes with a marked effect on flavour development, some influence of altered UV-radiation can be expected. We investigated these possible effects under field conditions by selectively attenuating various portions of the light spectrum in the UV-part with polyester and di- and tri-acetate films and exposing the entire canopy or parts thereof to these conditions during berry development. We evaluated skin pigment composition using a non-destructive spectro-photometric technique. There was a strong UV-induced shift towards the formation of red and brown pigment components without affecting sugar levels. Chlorophyll degradation in the berry skin proceeded faster in the high UV-radiation treatments and this could be assessed for non-destructively by measuring berry fluorescence. Amino acid concentration was reduced under high levels of UV-B radiation and both the total bound glycosidic secondary metabolites and phenolics were increased. There were some effects noticeable on fermentation velocity and the retention of free and bound aromatic components in the wineinfo:eu-repo/semantics/publishedVersio

    The Relativistic Factor in the Orbital Dynamics of Point Masses

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    There is a growing population of relativistically relevant minor bodies in the Solar System and a growing population of massive extrasolar planets with orbits very close to the central star where relativistic effects should have some signature. Our purpose is to review how general relativity affects the orbital dynamics of the planetary systems and to define a suitable relativistic correction for Solar System orbital studies when only point masses are considered. Using relativistic formulae for the N body problem suited for a planetary system given in the literature we present a series of numerical orbital integrations designed to test the relevance of the effects due to the general theory of relativity in the case of our Solar System. Comparison between different algorithms for accounting for the relativistic corrections are performed. Relativistic effects generated by the Sun or by the central star are the most relevant ones and produce evident modifications in the secular dynamics of the inner Solar System. The Kozai mechanism, for example, is modified due to the relativistic effects on the argument of the perihelion. Relativistic effects generated by planets instead are of very low relevance but detectable in numerical simulations
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