Experimental evaluation of anti-inflammatory, antinociceptive and antipyretic activities of clove oil inmice

Background: Clove oil of Eugenia caryophyllata (Myrtaceae) is a light yellowish fluid obtained from dried flower buds. Clove oil is used traditionally to relieve toothache.Aim: The aim of the present work was to study the anti-inflammatory, antinociceptive and antipyretic potential of clove oil in mice.Methods: Analgesic activity was examined using acetic-acid-induced abdominal constrictions and the hot plate test. Carrageenan-induced paw edema and brewer’s-yeast-induced pyrexia were used to investigate the anti-inflammatory activity and the antipyretic effects, respectively. The oil was administered intraperitoneally (i.p.) at a dose of 33 mg/kg body weight and the effects were compared with reference drugs.Results: In the antinociceptive test, mice treated with clove oil exhibited significantly decreased acetic-acidinducedwrithing movements by a maximum of 87.7% (p<0.01) compared with a decrease of 77.7% (p<0.01) in response to aspirin injection (100 mg/kg, intraperitoneal, i.p.). Similarly, in the hot plate test, clove oil significantly increased the reaction latency to pain after 60 min by 82.3% (p<0.05) compared with morphine value of 91.7% (p<0.01). In addition, clove oil and indomethacin produced anti-inflammatory effects, as demonstrated by respectively 50.6% (p<0.05) and 70.4% (p<0.01) inhibition of mouse paw edema induced by carrageenan. Furthermore, clove oil significantly attenuated the hyperthermia induced by yeast at ΔT-max by 2.7oC (p<0.001), and time of peak effects was 30-180 min compared with a paracetamol value ΔT-max of 3.2oC (p<0.001). The estimated i.p. LD50 of clove oil was 161.9 mg/kg. Phytochemical screening of the oil showed the presence of eugenol.Conclusion: The present findings demonstrate the potential pharmacological properties of clove oil and provide further a support for its reported use in folk medicine.Keywords: Eugenia caryophyllata; clove oil; eugenol; antinociceptive; anti-inflammatory; antipyretic; mic

Synthesis of New Series of Pyrazoline, and Study their Kinetics and Reaction Mechanism

A new series of novel pyrazoline compounds were synthesized by addition of thiosemicarbazide to the 2,6-dibenzylidenecyclohexanone (Chalcone) and its para substituted derivatives. This study was conducted for four purposes. Firstly, a series of five membered ring pyrazoline compounds were synthesized and the structure of all new products obtained are supported by spectral data (1H-NMR, 13CNMR, IR and UV-Vis.), and the effect of substituents were studied. Secondly, the reaction kinetics of the new synthesized compounds were studied to investigate the reaction mechanism pathway and order of the reaction; it was found that, the reaction undergoes via Claisen route of mechanism with first-order reaction. Thirdly, the thermodynamics of the reaction were studied, the rate of the reaction, Arrhenius parameters (A), and thermodynamic parameters for activation includes (free energies (Ea), entropies (ΔS#), and Gibbs free energy (ΔG#) were estimated. Finally, the compensation effect was also studied, and found the same pathway for all of the synthesized pyrazoline compounds

POD‐identification reduced order model of linear transport equations for control purposes

Intrusive reduced order modeling techniques require access to the solver's discretization and solution algorithm, which are not available for most computational fluid dynamics codes. Therefore, a nonintrusive reduction method that identifies the system matrix of linear fluid dynamical problems with a least-squares technique is presented. The methodology is applied to the linear scalar transport convection-diffusion equation for a 2D square cavity problem with a heated lid. The (time-dependent) boundary conditions are enforced in the obtained reduced order model (ROM) with a penalty method. The results are compared and the accuracy of the ROMs is assessed against the full order solutions and it is shown that the ROM can be used for sensitivity analysis by controlling the nonhomogeneous Dirichlet boundary conditions

SISTEM INFORMASI E-LEARNING PADA SMA NEGERI 16 PALEMBANG BERBASIS WEB

SMA Negeri 16 adalah institut pendidikan yang berdiri sejak 1997 dan berlokasi di jalan Lebak Murni Sako Palembang. SMA Negeri 16 saat ini dipimpin oleh ibu Dra. Sri Asmuniah, M.Si kini memasuki angkatan ke-15 dengan jumlah siswa sebanyak 733 siswa. Dalam kegiatannya penyampaian berbagai informasi kegiatan sekolah dan kepada para siswa mengalami kesulitan dikarenakan cara penyampaian informasi melalui edaran dan penyampaian tugas,materi pembelajaran dikelas kesulitan menjangkau siswa yang berhalangan hadir. Tujuan penelitian skripsi ini adalah untuk merancang bangun sistem informasi e-learning yang berfokus pada kegiatan belajar mengajar sehingga dapat mempermudah pihak sekolah dalam menyampaikan informasi penting mengenai acara kegiatan sekolah dan kegiatan belajar. Metodologi yang digunakan adalah metodologi RUP. Metodologi ini memiliki 4 fase antara lain : inception (permulaan), elaboration (perluasan/perencanaan), construction (konstruksi), transition (transisi). Dalam merancang penulis menggunakan bahasa pemrogram PHP dan Sql. Hasil rancang bangun sistem informasi ini diharapkan dapat mempermudah dan mempercepat kegiatan belajar di SMA Negeri 16 Palembang

A Combined Conjugate Gradient Quasi-Newton Method with Modification BFGS Formula

The conjugate gradient and Quasi-Newton methods have advantages and drawbacks, as although quasi-Newton algorithm has more rapid convergence than conjugate gradient, they require more storage compared to conjugate gradient algorithms. In 1976, Buckley designed a method that combines the CG method with QN updates, which is better than that observed for conjugate gradient algorithms but not as good as the quasi-Newton approach. This type of method is called the preconditioned conjugate gradient (PCG) method. In this paper, we introduce two new preconditioned conjugate gradient (PCG) methods that combine conjugate gradient with a new update of quasi-Newton methods. The new quasi-Newton method satisfied the positive define, and the direction of the new preconditioned conjugate gradient is descent direction. In numerical results, it is showing the new preconditioned conjugate gradient method is more effective on several high-dimension test problems than standard preconditioning

An experimental method to identify neurogenic and myogenic active mechanical states of intestinal motility

Excitatory and inhibitory enteric neural input to intestinal muscle acting on ongoing myogenic activity determines the rich repertoire of motor patterns involved in digestive function. The enteric neural activity cannot yet be established during movement of intact intestine in vivo or in vitro. We propose the hypothesis that is possible to deduce indirectly, but reliably, the state of activation of the enteric neural input to the muscle from measurements of the mechanical state of the intestinal muscle. The fundamental biomechanical model on which our hypothesis is based is the “three-element model” proposed by Hill. Our strategy is based on simultaneous video recording of changes in diameters and intraluminal pressure with a fiber-optic manometry in isolated segments of rabbit colon. We created a composite spatiotemporal map (DPMap) from diameter (DMap) and pressure changes (PMaps). In this composite map rhythmic myogenic motor patterns can readily be distinguished from the distension induced neural peristaltic contractions. Plotting the diameter changes against corresponding pressure changes at each location of the segment, generates “orbits” that represent the state of the muscle according to its ability to contract or relax actively or undergoing passive changes. With a software developed in MatLab, we identified twelve possible discrete mechanical states and plotted them showing where the intestine actively contracted and relaxed isometrically, auxotonically or isotonically, as well as where passive changes occurred or was quiescent. Clustering all discrete active contractions and relaxations states generated for the first time a spatio-temporal map of where enteric excitatory and inhibitory neural input to the muscle occurs during physiological movements. Recording internal diameter by an impedance probe proved equivalent to measuring external diameter, making possible to further develop similar strategy in vivo and humans.Australian National Health and Medical Research Counci