Risk and protective factors for release in outpatients with schizophrenia

eposterWe aim to determine risk and protective factors influencing relapse incidence in outpatient with schizophrenia. A longitudinal, observational study was done with outpatients with schizophrenia (F20) or schizoaffective disorder (F25)(DMS-IV and ICD-10), without hospitalization during the previous 6 months. The patients were consecutively included into the study to received oral (O-A) or long-acting injectable (depot-A) antipsychotics. Clinical stage evolution, compliance, efficacy and safety assessments (including PANSS, CGI-SSI, hospitalization rates, and adverse events) were recorded before and after 6 and 12 months of treatment. Results: 60 outpatients (aged 34.5±8.9, male 73%), 75% schizophrenia and 25% schizoaffective disorder diagnosis, 68.3% fewer than 15 years of schizophrenia evolution, 76.7% fewer than 5 times previous hospitalizations were treated with O-A (41.7%) or depot-A (58.3%) antipsychotics for at least one year. Depot-A treated patients showed a significant higher compliance compared to O-A patients during the all following time, lower PANSS (total, positive and negative) scores and CGI-SSI score (p<0.01), and a delayed relapse incidence and re-hospitalization to more than 1 year in the 48% of patients (relapse % depot/% oral) after 6 months 22.9%/52.0%, and after 12 months 48.6%/4.0%. Conclusion: There were protective factors which delayed relapse incidence in schizophrenia: Use of sustained-release preparations, family support. There were risk factors for occurrence of relapse in schizophrenia: cocaine, heroin and alcohol consumption, absence of family support, greater severity of patients assessed through CGI-SI, male sex, age older than 25 years and long-term evolution of the disorder.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Análisis de compuestos perfluorados en suero sanguíneo mediante microextracción con disolventes supramoleculares y cromatografía líquida/espectrometría de masas con trampa iónica

III Encuentro sobre Nanociencia y Nanotecnología de Investigadores y Tecnólogos Andaluce

Avatars and Cartoons reduce anxiety in pediatric inpatients

Avatars and Cartoons reduce anxiety in pediatric inpatients I Bellido1, MV Bellido2, A Gomez-Luque3. 1University of Malaga, Pharmacology and Clinical Therapeutics, Spain, 2Regional University Hospital, Malaga, Surgery Service, Spain, 3Virgen de la Victoria University Hospital, Malaga, Anaesthesia Service, Spain Background and aim: Pain induces fear, stress and anxiety in young children. Avatars and cartoons explaining analgesic and sedative drugs administration routes may reduce children’s anxiety in young children. We quantify the possible antianxiety effect of avatars and cartoons explaining analgesic and sedative drug’s administration routes to inpatients children. Methods: A prospective, aleatorized, controlled study (blinded for the analyser) in inpatients children (< 6 years old) was done. Clinical stage, diagnostic, surgery, anaesthesia and all treatment procedures were recorded. Anxiety (STAIC test) was recorded before and 5 h and 24 h after drugs administration. A 15 minutes movie with avatars and cartoons explaining how the analgesic and sedative drugs were going to be administered was use in 120 children (movie group) and was compared to other group that could not see the movie (control group n=120). Results: Children, N=240, aged 3-6 years, 4.5±1 years old, 55% male, treated in emergency 50%, surgery (31.3%) and intensities care unit (18.8%) were enrolled. The drugs routes administration were oral (25%), intramuscular (29.6%), intravenous (39.6%), inhalatory (3.8%), others (2.1%). Children saw part or the full movie an average of 5.2±2.1 times. At 24 h of follow-up anxiety was higher in control than in movie group (8.5±3 vs. 4.3±1.6, p<0.05, Student t test). Children of the control group wept, complained, and called their parents during more time than movie group. Conclusion: The use of avatars and cartoons to explain analgesics and sedative drugs routes administration to inpatients young children reduced children’s anxiety.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Inequality in mortality in pre-industrial Southern Europe during an epidemic episode : socio-economic determinants (eighteenth - nineteenth centuries Spain)

The objective of this study is to gain more comprehensive knowledge about social inequality in mortality in pre-industrial periods. With this aim, we have reconstructed the life courses of the inhabitants of the town of Vera in south-east Spain for the period 1797-1812 in order to estimate the influence of socio-economic status on ordinary and extraordinary mortality, given that, during this period, the town suffered from several epidemic outbreaks of yellow fever. As a result of these outbreaks, around a quarter of the town's population died. The results obtained indicate social inequality in mortality at least from the end of the eighteenth century. Although the differences are higher in mortality caused by non-infectious diseases or ill-defined causes, the coefficients also show a certain social gradient in mortality derived from infectious diseases. However, with respect to this latter type of mortality, the place of residence - seems to have a greater influence on the chances of survival than socio-economic status

Propofol induce higher amnesic effect than sevoflurane and isoflurane anaesthesia in the rat

Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Development and Evaluation of a Python Telecare System Based on a Bluetooth Body Area Network

This paper presents a prototype of a telemonitoring system, based on a BAN (Body Area Network) that is integrated by a Bluetooth (BT) pulse oximeter, a GPS (Global Positioning System) unit, and a smartphone. The smartphone is the hardware platformfor running a Python software thatmanages the Bluetooth piconet formed by the sensors. Thus the smartphone forwards the data received from the Bluetooth devices, encoded into JSON (JavaScript Object Notation), to a central server. This server provides universal access to the information of the patient’s location and health status through a web application based on AJAX (Asynchronous JavaScript and XML) technology. Additionally, for the described prototype, the study presents some performance analyses about several topics that are of great interest for the applicability of the prototype: (i) the technique used to forward the patient’s location and health status, (ii) the power consumption of the smartphone (which is compared with the measurements of an equivalent software developed for Java Micro Edition platform), and (iii) the web browser compatibility of the web application developed for the control and monitoring of the patients.Ministerio de Educación y Ciencia TEC2009-13763-C02-0

Prototyping of a Remote Monitoring System for a medical Personal Area Network using Python

This paper presents a prototype developed in Python of a pervasive mobile health system aimed at monitoring a patient in indoor and outdoor environments continuously. The system is based on a Bluetooth PAN (Personal Area Network), worn by the patient, whose master node, a smartphone, collects information about patient's location and health status and detects emergency situations. These data are sent to a central server through Wi-Fi or GPRSIUMTS, which allows physicians to get access to patient data and configure the PAN sensors remotely using a conventional web browser.Ministerio de Educación y Ciencia TEC2006-12211- C02-01/TC

Trans-oligomerization of duplicated aminoacyl-tRNA synthetases maintains genetic code fidelity under stress

Aminoacyl-tRNA synthetases (aaRSs) play a key role in deciphering the genetic message by producing charged tRNAs and are equipped with proofreading mechanisms to ensure correct pairing of tRNAs with their cognate amino acid. Duplicated aaRSs are very frequent in Nature, with 25,913 cases observed in 26,837 genomes. The oligomeric nature of many aaRSs raises the question of how the functioning and oligomerization of duplicated enzymes is organized. We characterized this issue in a model prokaryotic organism that expresses two different threonyl-tRNA synthetases, responsible for Thr-tRNAThr synthesis: one accurate and constitutively expressed (T1) and another (T2) with impaired proofreading activity that also generates mischarged Ser-tRNAThr. Low zinc promotes dissociation of dimeric T1 into monomers deprived of aminoacylation activity and simultaneous induction of T2, which is active for aminoacylation under low zinc. T2 either forms homodimers or heterodimerizes with T1 subunits that provide essential proofreading activity in trans. These findings evidence that in organisms with duplicated genes, cells can orchestrate the assemblage of aaRSs oligomers that meet the necessities of the cell in each situation. We propose that controlled oligomerization of duplicated aaRSs is an adaptive mechanism that can potentially be expanded to the plethora of organisms with duplicated oligomeric aaRSs.Ministerio de Economía y Competitividad BFU2010–19544, BFU2013–44686-

Metaheuristic approaches for optimal broadcasting design in metropolitan MANETs

11th International Conference on Computer Aided Systems Theory. Las Palmas de Gran Canaria, Spain, February 12-16, 2007Mobile Ad-hoc Networks (MANETs) are composed of a set of communicating devices which are able to spontaneously interconnect without any pre-existing infrastructure. In such scenario, broadcasting becomes an operation of tremendous importance for the own existence and operation of the network. Optimizing a broadcasting strategy in MANETs is a multiobjective problem accounting for three goals: reaching as many stations as possible, minimizing the network utilization, and reducing the duration of the operation itself. This research, which has been developed within the OPLINK project (http://oplink.lcc.uma.es), faces a wide study about this problem in metropolitan MANETs with up to seven different advanced multiobjective metaheuristics. They all compute Pareto fronts of solutions which empower a human designer with the ability of choosing the preferred configuration for the network. The quality of these fronts is evaluated by using the hypervolume metric. The obtained results show that the SPEA2 algorithm is the most accurate metaheuristic for solving the broadcasting problem.Publicad