Health Line App

Es tracta d'una app mòbil de millora d'hàbits d'alimentació, amb la finalitat de millorar els hàbits alimentosos i donar idees a l'hora de cuinar a diari, fer la compra etc...El context de l'aplicació serà el de poder obtenir receptes recomanades en funció dels ingredients que tenim a la nevera en aquest moment, (és a dir introdueixo per exemple arròs i pollastre i em proposa diferents receptes amb aquests ingredients), a la vegada amb fitxa de detall de la recepta. D'altra banda, una calculadora de calories per grams o quantitats que calculi l'ingredient que vulguem és a dir una mena de seguiment calòric o taula de calories, al seu torn disposaríem d'un calendari amb la dieta que vulguem seguir per setmana (esmorzar, dinar, sopar.. els menjars que desitgem fer al dia), amb l'objectiu d'observar si ens saltem o complim amb assiduïtat els menjars del dia. Per últim, es podran crear llistes de la compra per a reduir despeses i tenir ben controlat el que es necessita. L'aplicació serà duta a terme amb el framework Ionic i serà compatible amb Android i iOs. En conclusió, es tracta d'una idea original que té una clara orientació al públic "sa" i és potencialment utilitzable en el dia a dia ja que ens facilita molt la feinaIt is a mobile app for improving eating habits, with the objetive of improving nutritional habits and giving ideas when it comes to cooking daily, doing the shopping, etc. The context of the application will be to be able to get recommended recipes based on the ingredients we have in the fridge right now (that is, I introduce for example rice and chicken and proposes different recipes with these ingredients), at the same time with recipe detail sheet. On the other hand, a calculator of calories per grams or quantities that calculate the ingredient we want, that is, a kind of calorie tracking or calorie chart, in turn we would have a calendar with the diet we want to follow per week ( breakfast, lunch, dinner ... the meals that we want to make daily), with the aim of observing if we skip or regularly fulfill the meals of the day. Lastly, shopping lists can be created to reduce costs and have what you need well controlled. The application will be carried out with the Ionic framework and will be compatible with Android and iOS. In conclusion, this is an original idea that has a clear orientation to the "healthy" public and is potentially usable in the day to day as it facilitates us a lot of work.Se trata de una app móvil de mejora de hábitos de alimentación, con el fin de mejorar los hábitos alimenticios y dar ideas en la hora de cocinar a diario, hacer la compra etc...El contexto de la aplicación será el de poder obtener recetas recomendadas en función de los ingredientes que tenemos a la nevera en este momento, (es decir introduzco por ejemplo arroz y pollo y me propone diferentes recetas con estos ingredientes), a la vegada con ficha de detalle de la receta. Por otro lado, una calculadora de calorías por gramos o cantidades que calcule el ingrediente que queramos es decir un tipo de seguimiento calórico o tabla de calorías, a su vez dispondríamos de un calendario con la dieta que queramos seguir por semana (almuerzo, comida, cenar.. las comidas que deseamos hacer en el día), con el objetivo de observar si nos saltamos o cumplimos con asiduidad las comidas del día. Por último, se podrán crear listas de la compra para reducir gastos y tener muy controlado el que se necesita. La aplicación será llevada a cabo con el framework Ionic y será compatible con Android y iOs. En conclusión, se trata de una idea original que tiene una clara orientación al público "sano" y es potencialmente utilizable en el día a día puesto que nos facilita mucho el trabajo

The nanomechanics of neurotoxina proteins reveals common features at the start of the neurodegeneration cascade.

1 pags. -- 56th Annual Meeting of the Biophysical-Society, FEB 25-29, 2012, San Diego, CAAmyloidogenic neurodegenerative diseases are incurable conditions caused by specific largely disordered proteins. However, the underlying molecular mechanism remains elusive. A favored hypothesis postulates that a critical conformational change in the monomer (an ideal therapeutic target) in these ‘‘neurotoxic proteins’’ triggers the pathogenic cascade. Using force spectroscopy with unequivocal singlemolecule identification we demonstrate a rich conformational polymorphism at their monomer level. This polymorphism strongly correlates with amyloidogenesis and neurotoxicity: it is absent in a fibrillization-incompetent mutant, favored by familial-disease mutations and diminished by a surprisingly promiscuous inhibitor of the monomeric b-conformational change and neurodegeneration. The demonstrated ability to inhibit the conformational heterogeneity of these proteins by a single pharmacological agent reveals common features in the monomer and suggests a common pathway to diagnose, prevent, halt or reverse multiple neurodegenerative disease

Common Features at the Start of the Neurodegeneration Cascade

A single-molecule study reveals that neurotoxic proteins share common structural features that may trigger neurodegeneration, thus identifying new targets for therapy and diagnosis

The nanomechanics of neurotoxic proteins reveals common features at the start of the neurodegeneration cascade

Trabajo presentado en el 56th Annual Meeting-Biophysical Society, celebrado en Washington (Estados Unidos) del 25 al 29 de febrero de 2012.Amyloidogenic neurodegenerative diseases are incurable conditions caused by specific largely disordered proteins. However, the underlying molecular mechanism remains elusive. A favored hypothesis postulates that a critical conformational change in the monomer (an ideal therapeutic target) in these ‘‘neurotoxic proteins’’ triggers the pathogenic cascade. Using force spectroscopy with unequivocal single-molecule identification we demonstrate a rich conformational polymorphism at their monomer level. This polymorphism strongly correlates with amyloidogenesis and neurotoxicity: it is absent in a fibrillization-incompetent mutant, favored by familial-disease mutations and diminished by a surprisingly promiscuous inhibitor of the monomeric b-conformational change and neurodegeneration. The demonstrated ability to inhibit the conformational heterogeneity of these proteins by a single pharmacological agent reveals common features in the monomer and suggests a common pathway to diagnose, prevent, halt or reverse multiple neurodegenerative disease

Validation of artificial neural networks as a methodology for donor-recipient matching for liver transplantation.

In 2014, we reported a model for donor-recipient (D-R) matching in liver transplantation (LT) based on artificial neural networks (ANNs) from a Spanish multicenter study (Model for Allocation of Donor and Recipient in España [MADR-E]). The aim is to test the ANN-based methodology in a different European health care system in order to validate it. An ANN model was designed using a cohort of patients from King's College Hospital (KCH; n = 822). The ANN was trained and tested using KCH pairs for both 3- and 12-month survival models. End points were probability of graft survival (correct classification rate [CCR]) and nonsurvival (minimum sensitivity [MS]). The final model is a rule-based system for facilitating the decision about the most appropriate D-R matching. Models designed for KCH had excellent prediction capabilities for both 3 months (CCR-area under the curve [AUC] = 0.94; MS-AUC = 0.94) and 12 months (CCR-AUC = 0.78; MS-AUC = 0.82), almost 15% higher than the best obtained by other known scores such as Model for End-Stage Liver Disease and balance of risk. Moreover, these results improve the previously reported ones in the multicentric MADR-E database. In conclusion, the use of ANN for D-R matching in LT in other health care systems achieved excellent prediction capabilities supporting the validation of these tools. It should be considered as the most advanced, objective, and useful tool to date for the management of waiting lists. Liver Transplantation 24 192-203 2018 AASLD

Something about us : postgrau en Il·lustració creativa i tècniques de comunicació visual, postgrau en Il·lustració per a publicacions infantils i juvenils, 2020-2021

Durant aquest curs hem conviscut amb la incertesa, i hem mirat més que mai cap al nostre interior. Cadascú ha viscut la seva pròpia experiència, i per això busquem connectar amb els altres a través de les nostres diferents vivències i mirades. Be part of US. Be part of our collective explosion: “SOMETHING ABOUT US”. “SOMETHING ABOUT US” és el reflex de la realitat que ens ha tocat compartir. Ens parla de la singularitat i la mirada individual que cadascú ha aportat a aquest oment. És una exposició col·lectiva que mostra els treballs dels estudiants dels postgraus en Il·lustració creativa i tècniques de comunicació visual i en Il·lustració per a publicacions infantils i juvenils d’EINA realitzats durant el curs 2020-2021. A l’exposició es presenten projectes que funcionen també com a experiències individuals i col·lectives i que connecten amb el paper de l’il·lustrador en l’actualitat. Ens agradaria compartir amb tots vosaltres aquestes reflexions. Aquest catàleg aplega les diferents realitats i mirades de tots els estudiants de diferents indrets de món com Holanda, Itàlia, Iran, epública Dominicana, Uruguai, i múltiples llocs d’Espanya. Tal com comenten els participants: “Busquem la connexió entre les nostres diferents històries. Be part of us!”.y hemos mirado más que nunca hacia nuestro interior. Cada uno ha vivido su propia experiencia, y por ello buscamos conectar con los demás a través de nuestras diferentes vivencias y miradas. Be part of US. Be part of our collective explosion: “SOMETHING ABOUT US”. “SOMETHING ABOUT US” es el reflejo de la realidad que nos ha tocado compartir. Nos habla de la singularidad y la mirada individual que cada uno ha aportado a este momento. Es una exposición colectiva que muestra los trabajos de los estudiantes de los postgrados en Ilustración creativa y técnicas de comunicación visual y en Ilustración para publicaciones infantiles y juveniles de EINA realizados durante el curso 2020-2021. En la exposición se presentan proyectos que funcionan también como experiencias individuales y colectivas y que conectan con el papel del ilustrador en la actualidad. Nos gustaría compartir con todos vosotros estas reflexiones. Este catálogo reúne las diferentes realidades y iradas de todos los estudiantes de diferentes lugares de mundo como Holanda, Italia, Irán, República ominicana, Uruguay, y múltiples lugares de España. Tal y como comentan los participantes: Buscamos la conexión entre nuestras diferentes historias. Be part of us!”.During this course, we have lived with uncertainty, and we have looked inwards more than ever. Each of us has lived our own experience, and so we have sought to connect with others through our different experiences and perspectives. Be part of US. Be part of our collective explosion: SOMETHING ABOUT US”. “SOMETHING ABOUT US” reflects the reality we share. It tells us about the singularity and the individual look that each one of us has brought to this moment. It is a collective exhibition that shows the work of the students of the postgraduate courses in Creative Illustration and Visual Communication Techniques and in Illustration for Children’s and Teenagers’ Publications at EINA carried out during the academic year 2020-2021. The exhibition presents projects that also function as individual and collective experiences and that connect with the role of the illustrator today. We would like to share these reflections with all of you. This catalogue brings together the different realities and views of all the students from different parts of the world such as Holland, Italy, Iran, Dominican Republic, Uruguay, and many parts of Spain. As the participants comment: “We are looking for the connection between our different stories. Be part of us!”

Summary of the nanomechanical analysis of NPs.

<p>SMFS experiments were performed on pFS-2 polyprotein constructs, although the data reported only refer to the guest NPs. The calculation of the associated experimental errors is described in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001335#pbio.1001335.s018" target="_blank">Text S1</a> and they are only indicated when they are different to zero. Due to the small number of events, the frequency of hM conformers in the NPs (a subset of the M set, operationally defined with a high <i>F</i> cut off) is not statistically significant. However it correlates very well with the %M. Furthermore, statistical analysis shows that, with the exception of polyQ tracts (for which the number of M, events is too low), the differences in the %M events for NP guests are statistically significant for the following pairs: NP and non-NP, NP and familial NP, NP (except for Arc Aβ42) and NP+QBP1. These differences are not statistically significant for the following pairs: Aβ42 and Aβ42+SV111, Arc Aβ42 and Arc Aβ42+QBP1, and non NPs. The numbers in parenthesis are half of the 95% confidence interval for the %M (or NM, modeled as a Bernoulli distribution) while the numbers after ± are the SMFS experimental errors. Note that the % numbers here are the estimation for the population while the % numbers in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001335#pbio-1001335-g002" target="_blank">Figures 2</a>–<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001335#pbio-1001335-g003" target="_blank"></a><a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001335#pbio-1001335-g004" target="_blank"></a><a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001335#pbio-1001335-g005" target="_blank">5</a> correspond to the raw samples.</p><p><i>n</i>, sample size. NM, no force peaks detected: <i>F</i>≤20 pN; M, at least one force peak: <i>F</i>>20 pN; hM, subset of M conformers with at least one force peak with <i>F</i>≥400 pN.</p

Nanomechanical analysis of α-synuclein.

<p>Δ<i>L</i>_c (left) and <i>F</i> (right) histograms of pFS-2 polyproteins carrying α-synuclein. The wt protein (first row) exhibits a wide-range polymorphism ranging from NM conformers (orange bars) to M conformers (red bars), including some hM conformers. Familial-disease mutations A30P and A53T increase the number of M and hM conformers of α-synuclein when compared to the wt. Treatment with QBP1 peptide (20 µM <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001335#pbio.1001335-Tomita1" target="_blank">[42]</a>) reduces the formation of M and hM conformers in A53T α-synuclein. TEM images of the amyloid fibers formed by ubi+A53T α-synuclein are shown on the right in which amyloid fibers are clearly not formed in the presence of QBP1 (top image). From bottom to top, the scale bars correspond to 0.45 and 0.6 µm, respectively. Examples of hM conformers of A30P and A53T α-synuclein are shown in the inset.</p

Nanomechanical analysis of NPs using the pFS-2 strategy.

<p>(A) Top: Schematic representation of the pFS-2 polyprotein <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001335#pbio.1001335-Oroz1" target="_blank">[30]</a> carrying a guest NP (in orange) mechanically protected within a carrier module (C, in gray), flanked by ubiquitin repeats (U, in black). Bottom: cartoon representations of the two carrier-guest constructions used in this study: ubiquitin (left, PDB code 1d3z) and titin I27 (right, PDB code 1tit). The images were prepared by VMD 1.8.6 <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001335#pbio.1001335-Humphrey1" target="_blank">[58]</a>. The hydrogen bonds of the mechanical clamp in both carriers are indicated by black bars <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001335#pbio.1001335-CarrinVzquez2" target="_blank">[51]</a>. (B) Representative force-extension recordings of pFS-2+Sup35NM. Using this strategy, we can unambiguously resolve a variety of conformations adopted by Sup35NM, ranging from a typical NM conformation (top trace, in orange), to M conformations with different degrees of mechanical stability (in red), including hM conformers (bottom). This color code will be maintained throughout the rest of the article. On the basis of our carrier-guest design, the carrier module must always unfold completely (“a” is Δ<i>L</i>_c for the carrier module) before the force can access and stretch the guest NP, resulting in its unfolding (“b” and “c” represent the Δ<i>L</i>_c for NM and M regions of the NP, respectively). The sum of b+c corresponds to the complete unfolding of the NP. The pFS-2 vector also contains an NM region, represented as a coil (a fragment of titin N2B <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001335#pbio.1001335-Oroz1" target="_blank">[30]</a>) that can act as a spacer to avoid the noisy proximal region of the force-extension recordings, a major problem in SMFS.</p