Adrenal myelolipoma: A rare tumor of adrenal gland

Bu çalışma, 21-24 Ekim 2021 tarihlerinde düzenlenen 5. Ulusal Ürogenital Kanserler Kongresi‘nde bildiri olarak sunulmuştur.Myelolipomlar hematopoetik hücreler ile iç içe matür adipöz dokudan oluşan adrenal bezin nadir görülen benign ve hormonal olarak inaktif tümörleridir. Adrenal kortikal tümörler içerisinde ikinci sıklıkta görülürler. Bu tümörler genellikle görüntüleme işlemleri sırasında insidental olarak saptanırlar. Otopsi serilerinde insidansı yaklaşık olarak %0.08-0.2 arasında değişmektedir. Patogenezleri belirsiz olmakla birlikte primer olayın enfeksiyon, kronik stres veya adrenal bez dejenerasyonuna bağlı retiküloendotelyal hücrelerde meydana gelen met aplastik değişiklikler olduğu düşünülmektedir. Genellikle tek taraflı adrenal kitle olarak görülürler ve bu tümörlerin büyük kısmı asemptomatiktir. Nadiren 4 cm’den büyük kitle yapısı oluştururlar. Bu tümörlerde malign transformasyon bildirilmemiştir. Ancak benign tümörler olmalarına rağmen diğer adrenal tümörlerden ayırıcı tanısının yapılması önemlidir. Burada karın ağrısı ve kabızlık şikayetleriyle başvuran 40 yaşında erkek hastada yapılan tetkikler sırasında saptanan sağ adrenal bez yerleşimli myelolipom olgusu sunulmuştur ve myelolipomları n klinikopatolojik özellikleri gözden geçirilmiştir.Myelolipomas are rare benign and hormonally inactive tumors of the adrenal gland consisting of mature adipose tissue intertwined with hematopoietic cells. They are the second most common adrenal cortical tumors. These tumors are usually detected incidentally during imaging procedures. Its incidence in autopsy series varies between approximately 0.08-0.2%. Although their pathogenesis is uncertain, the primary event is thought to be metaplastic changes in reticuloendothelial cells due to infection, chronic stress, or adrenal gland degeneration. They are generally seen as unilateral adrenal masses and most of these tumors are asymptomatic. They rarely form a mass structure larger than 4 cm. Malignant transformation has not been reported in these tumors. However, although they are benign tumors, their differential diagnosis from other adrenal tumors is important. Here, a 40-year-old male patient presenting with the complaints of abdominal pain and constipation is presented with a case of right adrenal gland myelolipoma and the clinicopathological features of myelolipomas are reviewed

Do Renal Cysts Affect the Success of Extracorporeal Shockwave Lithotripsy? A Retrospective Comparative Study

The aim of this study was to assess the effect of simple renal cysts on extracorporeal shockwave lithotripsy (SWL) in patients with calyceal renal calculi. Patients with simple renal cysts >35 mm and ipsilateral renal calculi 40 years that had renal calculi 0.05), which was 33.3% in group 1 and 68.2% in the control group (P=0.017). The presence of renal cysts in a patient with calculi requires that an individualized treatment plan be devised, so as to provide the patient with the most effective treatment

LRIG2 mutations cause urofacial syndrome

Urofacial syndrome (UFS) (or Ochoa syndrome) is an autosomal-recessive disease characterized by congenital urinary bladder dysfunction, associated with a significant risk of kidney failure, and an abnormal facial expression upon smiling, laughing, and crying. We report that a subset of UFS-affected individuals have biallelic mutations in LRIG2, encoding leucine-rich repeats and immunoglobulin-like domains 2, a protein implicated in neural cell signaling and tumorigenesis. Importantly, we have demonstrated that rare variants in LRIG2 might be relevant to nonsyndromic bladder disease. We have previously shown that UFS is also caused by mutations in HPSE2, encoding heparanase-2. LRIG2 and heparanase-2 were immunodetected in nerve fascicles growing between muscle bundles within the human fetal bladder, directly implicating both molecules in neural development in the lower urinary tract

Nation-wide analysis of the impact of Covid-19 pandemic on daily urology practice in Turkey

Objective To present a nation-wide analysis of the workload of urology departments in Turkey week-by-week during Covid-19 pandemic