175-jähriges Jubiläum der Universität Stuttgart : Reden anlässlich des Festakts am 9. Juli 2004

Inhalt: Programm Festakt zum 175-jährigen Jubiläum der Universität Stuttgart, Freitag, 9. Juli 2004, 17.00 Uhr im Hegelsaal des Kultur- und Kongresszentrums Liederhalle, Stuttgart (S. 7) - Frisch, Dieter (Prof. Dr.-Ing., Rektor der Universität Stuttgart): Begrüßung (S. 9) - Hoffmann, Claus Dieter (1. Vorsitzender der Vereinigung von Freunden der Universität Stuttgart): Grußwort (S. 19) - Teufel, Erwin (Ministerpräsident des Landes Baden-Württemberg): Festansprache (S. 25

Gene Expression Profiling of Mono- and Co-Culture Models of the Respiratory Tract Exposed to Crystalline Quartz under Submerged and Air-Liquid Interface Conditions

In vitro lung cell models like air-liquid interface (ALI) and 3D cell cultures have advanced greatly in recent years, being especially valuable for testing advanced materials (e.g., nanomaterials, fibrous substances) when considering inhalative exposure. Within this study, we established submerged and ALI cell culture models utilizing A549 cells as mono-cultures and co-cultures with differentiated THP-1 (dTHP-1), as well as mono-cultures of dTHP-1. After ALI and submerged exposures towards α-quartz particles (Min-U-Sil5), with depositions ranging from 15 to 60 µg/cm(2), comparison was made with respect to their transcriptional cellular responses employing high-throughput RT-qPCR. A significant dose- and time-dependent induction of genes coding for inflammatory proteins, e.g., IL-1A, IL-1B, IL-6, IL-8, and CCL22, as well as genes associated with oxidative stress response such as SOD2, was observed, even more pronounced in co-cultures. Changes in the expression of similar genes were more pronounced under submerged conditions when compared to ALI exposure in the case of A549 mono-cultures. Hereby, the activation of the NF-κB signaling pathway and the NLRP3 inflammasome seem to play an important role. Regarding genotoxicity, neither DNA strand breaks in ALI cultivated cells nor a transcriptional response to DNA damage were observed. Altogether, the toxicological responses depended considerably on the cell culture model and exposure scenario, relevant to be considered to improve toxicological risk assessment

Comparing α-Quartz-Induced Cytotoxicity and Interleukin-8 Release in Pulmonary Mono- and Co-Cultures Exposed under Submerged and Air-Liquid Interface Conditions

The occupational exposure to particles such as crystalline quartz and its impact on the respiratory tract have been studied extensively in recent years. For hazard assessment, the development of physiologically more relevant in-vitro models, i.e., air-liquid interface (ALI) cell cultures, has greatly progressed. Within this study, pulmonary culture models employing A549 and differentiated THP-1 cells as mono-and co-cultures were investigated. The different cultures were exposed to α-quartz particles (Min-U-Sil5) with doses ranging from 15 to 66 µg/cm(2) under submerged and ALI conditions and cytotoxicity as well as cytokine release were analyzed. No cytotoxicity was observed after ALI exposure. Contrarily, Min-U-Sil5 was cytotoxic at the highest dose in both submerged mono- and co-cultures. A concentration-dependent release of interleukin-8 was shown for both exposure types, which was overall stronger in co-cultures. Our findings showed considerable differences in the toxicological responses between ALI and submerged exposure and between mono- and co-cultures. A substantial influence of the presence or absence of serum in cell culture media was noted as well. Within this study, the submerged culture was revealed to be more sensitive. This shows the importance of considering different culture and exposure models and highlights the relevance of communication between different cell types for toxicological investigations

Hermann Schmalzried : Reden anlässlich der Verleihung der Ehrenpromotion (Dr. rer. nat. E. h.) an Prof. Dr. rer. nat. Hermann Schmalzried durch die Universität Stuttgart am 17. Januar 2003

Inhalt: Fritsch, Dieter (Prof.Dr.-Ing., Rektor der Universität Stuttgart): Begrüßung anlässlich der Verleihung der Würde eines Dr. rer. nat. E. h. an Herrn Prof. Dr. rer. nat. Hermann Schmalzried - Bertagnolli, Helmut (Prof. Dr. rer. nat., Dekan der Fakultät 3 Chemie der Universität Stuttgart): Rede anlässlich der Ehrenpromotion von Herrn Prof. Hermann Schmalzried - Maier, Joachim (Prof. Dr., Max-Planck-Institut für Festkörperforschung): In Sachen Hermann Schmalzried - eine Laudatio - Schmalzried, Hermann (Prof. Dr. rer. nat., emeritus): Die Universität als Lebensfor

International Evaluation of the Finnish Geospatial Research Institute, FGI

This is the report of an international panel for the 2022 Evaluation of the Finnish Geospatial Research Institute (FGI). The Ministry of Agriculture and Forestry commissioned a team of proven scientists and science managers to review the FGI's activities and competencies and make recommendations for the coming years. The evaluation panel focused their work on 1) the quality of research and expert work of FGI, 2) FGI's societal impacts and relevance to society (public sector, private companies, citizens), 3) FGI's activity and leadership in research collaboration and networks and 4) foresight and innovativeness of FGI's activities. The evaluation panel prepared a description of FGI's strengths, weaknesses, threats and opportunities. In addition, the panel made suggestions and recommendations for further development of FGI's research and expert work

Zum Gedenken an Otto Graf, universeller Bauforscher in Stuttgart. Abschiedsvorlesung von Prof. Dr.-Ing. H. W. Reinhardt

Inhalt: Reinhardt, H.-W.: Otto Graf, Rückschau im Licht von heute (Abschiedsvorlesung am 4. Juli 2006), S. 7 - 41; Gehlen, Christoph: Rede des Direktors der Materialprüfungsanstalt Universität Stuttgart (MPA-Stuttgart / Otto-Graf-Institut (FMPA)) zur Verabschiedung von Herrn Prof. Dr.-Ing. H.-W. Reinhardt am 4. Juli 2006, S. 43 - 55; Thielen, Gerd: Kurze Ansprache des stv. Sprechers des Deutschen Ausschusses für Stahlbeton (DAfStb), S. 57 - 59; Eligehausen, Rolf: Ansprache des stv. Geschäftsführenden Institutsdirektors, S. 61 - 67; Fritsch, Dieter: Grußwort des Rektors der Universität Stuttgart aus Anlass der Abschiedsvorlesung von Herrn Prof. Dr.-Ing. Hans-Wolf Reinhardt, S. 69 - 75; Lebenslauf Hans-Wolf Reinhardt, S. 76; Lebenslauf Otto Graf, S. 77; Aus der Presse, S. 78; Die Autoren, S. 7