159 research outputs found
PTPN22 gene polymorphism in Takayasu's arteritis
Objective. Takayasu's arteritis (TA) is a chronic, rare granulomatous panarteritis of unknown aetiology involving mainly the aorta and its major branches. In this study, genetic susceptibility to TA has been investigated by screening the functional single nucleotide polymorphism (SNP) of PTPN22 gene encoding the lymphoid-specific protein tyrosine phosphatase. Methods. Totally, 181 patients with TA and 177 healthy controls are genotyped by PCR-RFLP method for the SNP rs2476601 (A/G) of PTPN22 gene. Polymorphic region was amplified by PCR and digested with Xcm I enzyme. Results. Detected frequencies of heterozygous genotype (AG) were 5.1% (9/177) in control group and 3.8% (7/181) in TA group (P = 0.61, odds ratio: 0.75, 95% CI: 0.3, 2.0). No association with angiographic type, vascular involvement or prognosis of TA was observed either. Conclusion. The distribution of PTPN22 polymorphism did not reveal any association with TA in Turkey. © The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved
In situ thrombosis in pulmonary arterial aneurysms due to Behçetâs disease and efficacy of ımmunosuppressive therapy
Intestinal Perforations in Behçetâs Disease
Behçetâs disease accompanied by intestinal involvement is called intestinal Behçetâs disease. The intestinal ulcers of Behçetâs disease are usually multiple and scattered and tend to perforate easily, so that many patients require emergency operation. The aim of this study is to determine the extent of surgical resection necessary to prevent reperforation and to point out the findings of concurrent oral and genital ulcers and multiple intestinal perforations in all patients of our series. During a 25-year study period, information of 125 Behçetâs disease cases was gathered. Among the 82 patients who were diagnosed with intestinal Behçetâs disease, 22 cases had intestinal perforations needing emergency laparotomy. We investigated and analyzed these cases according to the patientsâ demographic characteristics, clinical presentations, laboratory data, and surgical outcome. There were 14 men and 8 women ranging from 22 to 65 years of age. Nine cases were diagnosed preoperatively, and the diagnoses were confirmed in all 22 cases during the surgical intervention. Surgical resection was performed in every patient, with right hemicolectomy and ileocecal resection in 11 cases, partial ileum resection in 8 cases with two reperforations, and ileocecal resection in 3 cases with one reperforation
Dislexia e ensino-aprendizagem de lĂngua portuguesa : um estudo de caso
Monografia (graduação)âUniversidade de BrasĂlia, Instituto de Letras, 2013.Esta pesquisa trata da dislexia e do ensino-aprendizagem de LĂngua Portuguesa para dislĂ©xicos, com base em um estudo de caso com estudante dislĂ©xico da rede pĂșblica de ensino do Plano Piloto. Dentre as questĂ”es abordadas, estĂŁo as definiçÔes da dislexia, seus tipos e possĂveis tratamentos, alĂ©m da discussĂŁo do espaço que tal distĂșrbio de aprendizagem tem na educação, a sugestĂŁo de inclusĂŁo da dislexia na Educação Especial e, consequentemente, nas salas de recursos e a adequação da metodologia de ensino, baseada na exploração dos gĂȘneros textuais e dos multiletramentos, dentro da perspectiva Sociointeracionista de Vygotsky e da proposta de professor libertador, de Paulo Freire
Fungalâderived cues promote ocular autoimmunity through a Dectinâ2/Card9âmediated mechanism
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