Non-clinical outcomes of antiretroviral therapy for HIV/AIDS in developing countries: a systematic literature review

The impacts of antiretroviral therapy on quality of life, mental health, labor productivity, and economic wellbeing for people living with HIV/AIDS in developing countries are only beginning to be measured. We conducted a systematic literature review to analyze the effect of antiretroviral therapy (ART) on these non-clinical indicators in developing countries and assess the state of research on these topics. Both qualitative and quantitative studies were included, as were peer-reviewed articles, gray literature, and conference abstracts and presentations. Findings are reported from 12 full-length articles, 7 abstracts, and 1 presentation (representing 16 studies). Compared to HIV-positive patients not yet on treatment, patients on ART reported significant improvements in physical, emotional and mental health and daily function. Work performance improved and absenteeism decreased, with the most dramatic changes occurring in the first three months of treatment and then leveling off. Little research has been done on the impact of ART on household wellbeing, with modest changes in child and family wellbeing within households where adults are receiving ART reported so far. Studies from developing countries have not yet assessed non-clinical outcomes of therapy beyond the first year; therefore, longitudinal outcomes are still unknown. As ART roll out extends throughout high HIV prevalence, low-resource countries and is sustained over years and decades, both positive and adverse non-clinical outcomes need to be empirically measured and qualitatively explored in order to support patient adherence and maximize treatment benefits

Non-clinical outcomes of antiretroviral therapy for HIV/AIDS in developing countries: a systematic literature review

This repository item contains a single issue of the Health and Development Discussion Papers, an informal working paper series that began publishing in 2002 by the Boston University Center for Global Health and Development. It is intended to help the Center and individual authors to disseminate work that is being prepared for journal publication or that is not appropriate for journal publication but might still have value to readers.The impacts of antiretroviral therapy on quality of life, mental health, labor productivity, and economic wellbeing for people living with HIV/AIDS in developing countries are only beginning to be measured. We conducted a systematic literature review to analyze the effect of antiretroviral therapy (ART) on these non-clinical indicators in developing countries and assess the state of research on these topics. Both qualitative and quantitative studies were included, as were peer-reviewed articles, gray literature, and conference abstracts and presentations. Findings are reported from 12 full-length articles, 7 abstracts, and 1 presentation (representing 16 studies). Compared to HIV-positive patients not yet on treatment, patients on ART reported significant improvements in physical, emotional and mental health and daily function. Work performance improved and absenteeism decreased, with the most dramatic changes occurring in the first three months of treatment and then leveling off. Little research has been done on the impact of ART on household wellbeing, with modest changes in child and family wellbeing within households where adults are receiving ART reported so far. Studies from developing countries have not yet assessed non-clinical outcomes of therapy beyond the first year; therefore, longitudinal outcomes are still unknown. As ART roll out extends throughout high HIV prevalence, low-resource countries and is sustained over years and decades, both positive and adverse non-clinical outcomes need to be empirically measured and qualitatively explored in order to support patient adherence and maximize treatment benefits

Nitrogen abundances in giant stars of the globular cluster NGC 6752

We present N abundances for 21 bright giants in the globular cluster NGC 6752 based on high-resolution UVES spectra of the 3360A NH lines. We confirm that the Stromgren c1 index traces the N abundance and find that the star-to-star N abundance variation is 1.95 dex, at the sample's luminosity. We find statistically significant correlations, but small amplitude variations, between the abundances of N and alpha-, Fe-peak, and s-process elements. Analyses using model atmospheres with appropriate N, O, Na, and Al abundances would strengthen, rather than mute, these correlations. If the small variations of heavy elements are real, then the synthesis of the N anomalies must take place in stars which also synthesize alpha-, Fe-peak, and s-process elements. These correlations offer support for contributions from both AGB and massive stars to the globular cluster abundance anomalies.Comment: Accepted for publication in Ap

Olfactory Orientation and Navigation in Humans.

Although predicted by theory, there is no direct evidence that an animal can define an arbitrary location in space as a coordinate location on an odor grid. Here we show that humans can do so. Using a spatial match-to-sample procedure, humans were led to a random location within a room diffused with two odors. After brief sampling and spatial disorientation, they had to return to this location. Over three conditions, participants had access to different sensory stimuli: olfactory only, visual only, and a final control condition with no olfactory, visual, or auditory stimuli. Humans located the target with higher accuracy in the olfaction-only condition than in the control condition and showed higher accuracy than chance. Thus a mechanism long proposed for the homing pigeon, the ability to define a location on a map constructed from chemical stimuli, may also be a navigational mechanism used by humans

I Had to Do the Reading: A Phenomenological Case Study of College English Students

The purposes of this qualitative phenomenological case study were to investigate multiple student experiences in a general elective introduction to literature course when music was added as an autonomously structured assignment. Music and song lyrics are no strangers to the classroom setting, but there is a gap in the literature examining the space where students can create meaningful links between music they enjoy and assigned course readings in college English. Informed by social constructivism and English studies theories this study was designed to investigate any impact that autonomously driven music-link assignments may have on students. The structured assignments were called music-link assignments. The music-link assignments were designed to encourage student criticality while interacting with an assigned reading and locating a link to a song of their choosing. Study documents included semi-structured and informal interviews, artifacts including music-link assignments that include an experiential portion for student reflection, and reflections taken in class during small group class discussions. Data and findings from this study indicated that many students cited positive affects in their experience, a greater feeling of agency in the class, and relatability to the assigned readings. Also, some students noted difficulty in completing the assignments. Overall, this study demonstrates the need for further research in combining facets of popular culture, such as music, in different content areas, and settings

Expanding the Role of Maryland Community Colleges in K-12 Teacher Preparation: Benefits and Costs of Implementing the Associate of Arts in Teaching (AAT) Degree

This study uses benefit-cost analysis to compare three alternative scenarios for implementing the Associate of Arts in Teaching (AAT) degree in Maryland community colleges. The first policy scenario is that community colleges retain their traditional role in K-12 teacher preparation by providing lower-division transfer courses and programs for undergraduate students who are seeking to transfer into teacher education programs at four-year institutions (historical role for Maryland community colleges). The second policy scenario is that community colleges expand their traditional role in K-12 teacher preparation by offering the AAT degree in addition to providing lower-division transfer courses and programs (current role for Maryland community colleges). The third policy scenario is that community colleges offer the AAT degree as the exclusive lower-division requirement for students seeking admission into teacher preparation programs at four-year colleges and universities (hypothetical future role for Maryland community colleges). Drawing on the seminal work of Schultz (1963) and Becker (1964; 1975; 1993), human capital theory serves as the guiding theoretical framework for this study. The three policy scenarios under consideration in this benefit-cost analysis were designed to increase a particular type of human capital investment by providing opportunities for community college students to enter the teacher preparation pipeline in higher education. This study examines the benefits and costs that are associated with each of these three alternatives to explore which policy provides the greatest net benefit to the State of Maryland

The emittance of space radiator materials measured at elevated temperatures

The spectral emittances of textured space radiator materials between 1.7 and 14.7 micrometer have been evaluated at room temperature and elevated temperature (630 C) in air. Heating in air caused a permanent increase in spectral emittance for all materials tested: HCl/ion beam textured 304 stainless steel, untextured Ti (6 percent Al, 4 percent V), and sandblasted Ti (6 percent Al, 4 percent V). Changes in the surface chemistry and/or surface morphology of these materials were also observed. Elevated temperature spectral emittance was measured in an argon atmosphere and compared to the measurements in air. Similarity between the room temperature and elevated temperature spectral emittance measurements was also investigated, and limited agreement was found

Consequences of cell-to-cell P-glycoprotein transfer on acquired multidrug resistance in breast cancer: a cell population dynamics model

Cancer is a proliferation disease affecting a genetically unstable cell population, in which molecular alterations can be somatically inherited by genetic, epigenetic or extragenetic transmission processes, leading to a cooperation of neoplastic cells within tumoral tissue. The efflux protein P-glycoprotein (P gp) is overexpressed in many cancer cells and has known capacity to confer multidrug resistance to cytotoxic therapies. Recently, cell-to-cell P-gp transfers have been shown. Herein, we combine experimental evidence and a mathematical model to examine the consequences of an intercellular P-gp trafficking in the extragenetic transfer of multidrug resistance from resistant to sensitive cell subpopulations. We report cell-to-cell transfers of functional P-gp in co-cultures of a P-gp overexpressing human breast cancer MCF-7 cell variant, selected for its resistance towards doxorubicin, with the parental sensitive cell line. We found that P-gp as well as efflux activity distribution are progressively reorganized over time in co-cultures analyzed by flow cytometry. A mathematical model based on a Boltzmann type integro-partial differential equation structured by a continuum variable corresponding to P-gp activity describes the cell populations in co-culture. The mathematical model elucidates the population elements in the experimental data, specifically, the initial proportions, the proliferative growth rates, and the transfer rates of P-gp in the sensitive and resistant subpopulations. We confirmed cell-to-cell transfer of functional P-gp. The transfer process depends on the gradient of P-gp expression in the donor-recipient cell interactions, as they evolve over time. Extragenetically acquired drug resistance is an additional aptitude of neoplastic cells which has implications in the diagnostic value of P-gp expression and in the design of chemotherapy regimensComment: 13 pages, 8 figures, 1 tabl