Räumliche und zeitliche Visualisierung als Smart-City-Planungswerkzeug

Die steigende Bevölkerung und der starke Zuzug in die urbanen Ballungsräume ist eine große Herausforderung für die Akteure der Planungswelt. Um ressourcenschonende Planungen voranzutreiben, ist eine innere Entwicklung der urbanen Systeme zielführend. Dabei ist neben der Aufspürung und Nutzung von Flächenreserven, die Nutzung und der Ausbau bestehender Versorgungsinfrastruktursysteme eine Möglichkeit für nachhaltige Entwicklungen. Dies stellt eine komplexe Planungsaufgabe für Planer und Entscheidungsträger dar, die das Zusammenwirken von Planungsakteuren unterschiedlichster Domänen erfordert. Innerhalb des interdisziplinären Forschungsprojektes URBEM (Urbanes Energie- und Mobilitätssystem) wurde ein visuelles Planungs- und Entscheidungsunterstützungswerkzeug, die URBEMVisualisierung, entwickelt. Diese webbasierte Umgebung bietet eine Arbeits- und Kommunikationsplattform für Domänenexperten und Stakeholder zur Unterstützung komplexer Planungsprozesse. Die URBEMVisualisierung erlaubt domänenspezifische Simulationsergebnisse räumlich zu verorten, visuelle Übersichten zu generieren und ein urbanes Gesamtsystem mit Hilfe der räumlichen Überlagerung von Informationen unterschiedlichster Versorgungsträgerstrukturen im Bereich Energie und Mobilität zu untersuchen. Dies bietet den Planern eine Grundlage um Probleme im Raum und in der Zeit fest zu machen und gezielte Maßnahmen zur Entwicklung smarter Lebensräume aufzuzeigen. Die Möglichkeiten der URBEM Visualisierung werden im folgenden Beitrag anhand von Modellergebnissen aus der Domäne Mobilität illustriert

Object-guided Spatial Attention in Touch: Holding the Same Object with Both Hands Delays Attentional Selection

Abstract Previous research has shown that attention to a specific location on a uniform visual object spreads throughout the entire object. Here we demonstrate that, similar to the visual system, spatial attention in touch can be object guided. We measured event-related brain potentials to tactile stimuli arising from objects held by observers' hands, when the hands were placed either near each other or far apart, holding two separate objects, or when they were far apart but holding a common object. Observers covertly oriented their attention to the left, to the right, or to both hands, following bilaterally presented tactile cues indicating likely tactile target location(s). Attentional modulations for tactile stimuli at attended compared to unattended locations were present in the time range of early somatosensory components only when the hands were far apart, but not when they were near. This was found to reflect enhanced somatosensory processing at attended locations rather than suppressed processing at unattended locations. Crucially, holding a common object with both hands delayed attentional selection, similar to when the hands were near. This shows that the proprioceptive distance effect on tactile attentional selection arises when distant event locations can be treated as separate and unconnected sources of tactile stimulation, but not when they form part of the same object. These findings suggest that, similar to visual attention, both space- and object-based attentional mechanisms can operate when we select between tactile events on our body surface.</jats:p

Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study

Extracts made from the leaves of the mango food plant (Mangifera indica L., Anacardiaceae) have a long history of medicinal usage, most likely due to particularly high levels of the polyphenol mangiferin. In rodent models, oral mangiferin protects cognitive function and brain tissue from a number of challenges and modulates cerebro-electrical activity. Recent evidence has confirmed the latter effect in healthy humans following a mangiferin-rich mango leaf extract using quantitative electroencephalography (EEG). The current study therefore investigated the effects of a single dose of mango leaf extract, standardised to contain &gt;60 mangiferin (Zynamite&reg;), on cognitive function and mood. This study adopted a double-blind, placebo-controlled cross-over design in which 70 healthy young adults (18 to 45 years) received 300 mg mango leaf extract and a matched placebo, on separate occasions, separated by at least 7 days. On each occasion, cognitive/mood assessments were undertaken pre-dose and at 30 min, 3 h and 5 h post-dose using the Computerised Mental Performance Assessment System (COMPASS) assessment battery and the Profile of Mood States (POMS). The results showed that a single dose of 300 mg mango leaf extract significantly improved performance accuracy across the tasks in the battery, with domain-specific effects seen in terms of enhanced performance on an &lsquo;Accuracy of Attention&rsquo; factor and an &lsquo;Episodic Memory&rsquo; factor. Performance was also improved across all three tasks (Rapid Visual Information Processing, Serial 3s and Serial 7s subtraction tasks) that make up the Cognitive Demand Battery sub-section of the assessment. All of these cognitive benefits were seen across the post-dose assessments (30 min, 3 h, 5 h). There were no interpretable treatment related effects on mood. These results provide the first demonstration of cognition enhancement following consumption of mango leaf extract and add to previous research showing that polyphenols and polyphenol rich extracts can improve brain function

The First Focused Hard X-ray Images of the Sun with NuSTAR

We present results from the the first campaign of dedicated solar observations undertaken by the \textit{Nuclear Spectroscopic Telescope ARray} ({\em NuSTAR}) hard X-ray telescope. Designed as an astrophysics mission, {\em NuSTAR} nonetheless has the capability of directly imaging the Sun at hard X-ray energies ($>$3~keV) with an increase in sensitivity of at least two magnitude compared to current non-focusing telescopes. In this paper we describe the scientific areas where \textit{NuSTAR} will make major improvements on existing solar measurements. We report on the techniques used to observe the Sun with \textit{NuSTAR}, their limitations and complications, and the procedures developed to optimize solar data quality derived from our experience with the initial solar observations. These first observations are briefly described, including the measurement of the Fe K-shell lines in a decaying X-class flare, hard X-ray emission from high in the solar corona, and full-disk hard X-ray images of the Sun.Comment: 11 pages, accepted to Ap

Gender-specific expression of ubiquitin-specific peptidase 9 modulates tau expression and phosphorylation: possible implications for tauopathies

Public transcriptomics studies have shown that several genes display pronounced gender differences in their expression in the human brain, which may influence the manifestations and risk for neuronal disorders. Here we apply a transcriptome-wide analysis to discover genes with gender-specific expression and significant alterations in public post mortem brain tissue from Alzheimer’s disease (AD) patients compared to controls. We identify the sex-linked ubiquitin specific peptidase 9 (USP9) as an outstanding candidate gene with highly significant expression differences between the genders and male-specific under-expression in AD. Since previous studies have shown that USP9 can modulate the phosphorylation of the AD-associated protein MAPT, we investigate functional associations between USP9 and MAPT in further detail. After observing a high positive correlation between the expression of USP9 and MAPT in the public transcriptomics data, we show that USP9 knockdown results in significantly decreased MAPT expression in a DU145 cell culture model and a concentration-dependent decrease for the MAPT orthologs mapta and maptb in a zebrafish model. From the analysis of microarray and qRT-PCR experiments for the knockdown in DU145 cells and prior knowledge from the literature, we derive a data-congruent model for a USP9-dependent regulatory mechanism modulating MAPT expression via BACH1 and SMAD4. Overall, the analyses suggest USP9 may contribute to molecular gender differences observed in tauopathies and provide a new target for intervention strategies to modulate MAPT expression

Temperature-Induced Increase in Methane Release from Peat Bogs: A Mesocosm Experiment

Peat bogs are primarily situated at mid to high latitudes and future climatic change projections indicate that these areas may become increasingly wetter and warmer. Methane emissions from peat bogs are reduced by symbiotic methane oxidizing bacteria (methanotrophs). Higher temperatures and increasing water levels will enhance methane production, but also methane oxidation. To unravel the temperature effect on methane and carbon cycling, a set of mesocosm experiments were executed, where intact peat cores containing actively growing Sphagnum were incubated at 5, 10, 15, 20, and 25°C. After two months of incubation, methane flux measurements indicated that, at increasing temperatures, methanotrophs are not able to fully compensate for the increasing methane production by methanogens. Net methane fluxes showed a strong temperature-dependence, with higher methane fluxes at higher temperatures. After removal of Sphagnum, methane fluxes were higher, increasing with increasing temperature. This indicates that the methanotrophs associated with Sphagnum plants play an important role in limiting the net methane flux from peat. Methanotrophs appear to consume almost all methane transported through diffusion between 5 and 15°C. Still, even though methane consumption increased with increasing temperature, the higher fluxes from the methane producing microbes could not be balanced by methanotrophic activity. The efficiency of the Sphagnum-methanotroph consortium as a filter for methane escape thus decreases with increasing temperature. Whereas 98% of the produced methane is retained at 5°C, this drops to approximately 50% at 25°C. This implies that warming at the mid to high latitudes may be enhanced through increased methane release from peat bogs

Impacts of stratospheric sulfate geoengineering on global solar photovoltaic and concentrating solar power resource

In recent years, the idea of geoengineering, artificially modifying the climate to reduce global temperatures, has received increasing attention due to the lack of progress in reducing global greenhouse gas emissions. Stratospheric sulfate injection (SSI) is a geoengineering method proposed to reduce planetary warming by reflecting a proportion of solar radiation back into space that would otherwise warm the surface and lower atmosphere. We analyze results from the HadGEM2-CCS climate model with stratospheric emissions of 10 Tg yr-1 of SO2, designed to offset global temperature rise by around 1°C. A reduction in concentrating solar power (CSP) output of 5.9% on average over land is shown under SSI compared to a baseline future climate change scenario (RCP4.5) due to a decrease in direct radiation. Solar photovoltaic (PV) energy is generally less affected as it can use diffuse radiation, which increases under SSI, at the expense of direct radiation. Our results from HadGEM2-CCS are compared to the GEOSCCM chemistry-climate model from the Geoengineering Model Intercomparison Project (GeoMIP), with 5 Tg yr-1 emission of SO2. In many regions, the differences predicted in solar energy output between the SSI and RCP4.5 simulations are robust, as the sign of the changes for both the HadGEM2-CCS and GEOSCCM models agree. Furthermore, the sign of the total and direct annual mean radiation changes evaluated by HadGEM2-CCS agree with the sign of the multi-model mean changes of an ensemble of GeoMIP models over the majority of the world

A Review of Interventions to Reduce Mechanical Restraint and Seclusion among Adult Psychiatric Inpatients

Objective: This review examines nature and effectiveness of interventions to reduce the use of mechanical restraint and seclusion among adult psychiatric inpatients. Method: Electronic searches were conducted to locate post-1960 empirical studies of restraint and seclusion reduction in English. A total of 36 studies were identified, mostly from the USA. Analysis was conducted using a structured data extraction tool. Results: The majority of studies reported reduced levels or mechanical restraint and/or seclusion, but the standard of evidence was poor. There were no randomised trials. Most were retrospective studies of official records before and after the intervention was introduced, with varying follow-up periods. The interventions were diverse, but tended to include one or more of the following: new restraint and/or seclusion policies, staffing changes, staff training, review procedures and crisis management initiatives. The research was unable to address which of these elements was most effective. There was also evidence that some improved outcomes were achieved by substituting restraint or seclusion for each other or for alternatives forms of containment (medication in particular). Nurses’ attitudes, skills and approach to patient care were absent from the literature. Conclusions: Interventions probably can reduce the use of restraint and seclusion, but better designed research is required to demonstrate their effectiveness conclusively. More attention should also be paid to understanding how interventions work, particularly from the perspective of nursing staff. This is essential to the successful implementation of restraint and seclusion interventions across different psychiatric settings and treatment populations