Sense of belonging as perceived by two third grade students.

This study investigated the sense of belonging as perceived by two third grade students. Two informants in a small midwestem public school were used in this qualitative study. Data was collected through interviews, observations, informant journals, and a researcher reflection journal. It was discovered that these informants believe that a sense of humor, class participation, compliments, and non-verbal facial expressions contribute to a child feeling a sense of belonging in the classroom. Further research needs to be completed to determine other factors that contribute to a child’s sense of belonging in the classroom, as well as other settings within the school. Research also needs to be completed regarding compliments as a component of a child’s sense of belonging

Note it: aplicació gamificada per la pràctica de dictats musicals

Treballs Finals de Grau d'Enginyeria Informàtica, Facultat de Matemàtiques, Universitat de Barcelona, Any: 2019, Director: Anna Puig Puig[en] Note it will be a gamified application with the goal to serve as a support in the practice of melodic dictations the academic field. This application’s target audience are music students between 11 and 13 years old with a music studies level around first year of "grau mitjà de música". The main objective of this project is to design and develop this application that offers the necessary tools for users to be able to do dictations and see their results. Among the most important requirements of the application there is designing and implementing a sheet music editor and implementing methods to automatically correct user’s dictations. Teachers, through a web platform, will be able to assign dictations to their students and to receive the results of the dictations made by their students

Glucose and fructose have sugar-specific effects in both liver and skeletal muscle in vivo: a role for liver fructokinase.

We examined glucose and fructose effects on serine phosphorylation levels of a range of proteins in rat liver and muscle cells. For this, healthy adult rats were subjected to either oral glucose or fructose loads. A mini-array system was utilized to determine serine phosphorylation levels of liver and skeletal muscle proteins. A glucose oral load of 125 mg/100 g body weight (G 1/2) did not induce changes in phosphorylated serines of the proteins studied. Loading with 250 mg/100 g body weight of fructose (Fr), which induced similar glycemia levels as G 1/2, significantly increased serine phosphorylation of liver cyclin D3, PI3 kinase/p85, ERK-2, PTP2 and clusterin. The G 1/2 increased serine levels of the skeletal muscle proteins cyclin H, Cdk2, IRAK, total PKC, PTP1B, c-Raf 1, Ras and the β-subunit of the insulin receptor. The Fr induced a significant increase only in muscle serine phosphorylation of PI3 kinase/p85. The incubation of isolated rat hepatocytes with 10 mM glucose for 5 min significantly increased serine phosphorylation of 31 proteins. In contrast, incubation with 10 mM fructose produced less intense effects. Incubation with 10 mM glucose plus 75 µM fructose counteracted the effects of the incubation with glucose alone, except those on Raf-1 and Ras. Less marked effects were detected in cultured muscle cells incubated with 10 mM glucose or 10 mM glucose plus 75 µM fructose. Our results suggest that glucose and fructose act as specific functional modulators through a general mechanism that involves liver-generated signals, like micromolar fructosemia, which would inform peripheral tissues of the presence of either glucose- or fructose-derived metabolites

Targeting antitumoral proteins to breast cancer by local administration of functional inclusion bodies

Altres ajuts de l'Instituto de Salud Carlos III: PI15/00272, PI1702242FIS i #PI16/01224Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44-targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44 tumor cells in culture, and upon local administration, promote destruction of tumoral tissue in orthotropic mouse models of human breast cancer. These findings support the concept of bacterial inclusion bodies as versatile protein materials suitable for application in chronic diseases that, like cancer, can benefit from a local slow release of therapeutic protein

Targeting antitumoral proteins to breast cancer by local administration of functional inclusion bodies

Biofabrication; Cancer therapy; Functional amyloidsBiofabricación; Terapia contra el cáncer; Amiloides funcionalesBiofabricació; Teràpia contra el càncer; Amiloides funcionalsTwo structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44-targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44+ tumor cells in culture, and upon local administration, promote destruction of tumoral tissue in orthotropic mouse models of human breast cancer. These findings support the concept of bacterial inclusion bodies as versatile protein materials suitable for application in chronic diseases that, like cancer, can benefit from a local slow release of therapeutic proteins.This study has been supported by La Fundacio Marato TV3 and NanoCanTri (CIBER-BBN) to E.V. and I.A., and partially by ISCIII (PI15/00272 and PI1702242 co-founded by Fondo Europeo de Desarrollo Regional (FEDER), to E.V. and S.S., respectively), and Agencia Estatal de Investigacion (AEI) and FEDER (BIO2016-76063-R, AEI/FEDER, UE), AGAUR (2017SGR-229) and CIBER-BBN (VENOM4CANCER) granted to A.V. Protein production and DLS have been partially performed by the ICTS "NANBIOSIS," more specifically by the Protein Production Platform of CIBER-BBN/IBB () and the Biomaterial Processing and Nanostructuring Unit (), respectively. Biodistribution and immunohistochemistry assays were performed at the ICTS "NANBIOSIS," specifically by U20/FVPR (). L.S.-G. was supported by predoctoral fellowship from AGAUR (2018FI_B2_00051). L.S. was supported by the European Research Council (CoG #617473) and the Instituto de Salud Carlos III (FIS #PI16/01224). J.S.-F. was supported by an AECC post-doctoral fellowship. A.V. received an ICREA ACADEMIA awar

The effects of neuromuscular electrical stimulation for dysphagia in opercular syndrome: a case study

A 76-year-old man with opercular syndrome characterized by complete bilateral loss of voluntary control of facial, lingual, pharyngeal and masticatory muscles is presented with focus on the severe dysphagia. Three years earlier the patient had experienced two strokes resulting in opercular syndrome with severe dysphagia. Despite initial logopedic dysphagia treatment, swallowing did not improve. A new treatment for dysphagia, consisting of neuromuscular electrical stimulation was applied on the patient. He returned to oral feeding. Clinical and treatment observations are reported

Guia per a la implementació territorial de projectes de millora en l’atenció a la complexitat

Pacients crònics complexos; Atenció a la cronicitat avançada; Ruta assistencial de la complexitatPacientes crónicos complejos; Atención a la cronicidad avanzada; Ruta asistencial de la complejidadComplex chronic patients; Attention to advanced chronicity; Complexity care routeEls objectius d’aquesta guia són: definir les característiques, les estratègies d’identificació i el model genèric d’atenció de PCC i MACA i aportar una visió pragmàtica de la implementació d’iniciatives de base territorial per a l’atenció d’aquests pacients

Characterization, improvement and application of plant elicitor peptides as new control tools against plant pathogens

La família de les Rosaceae comprèn espècies d’alta rellevància econòmica, com ho són les espècies de fruiters de clima temperat, ornamentals i medicinals. El seu cultiu, però, es veu limitat per la propagació de diversos fitopatògens, com ara la Xanthomonas arboricola pv. pruni (Xap). Aquest és l’agent responsable de la taca bacteriana dels fruiters de pinyol, la qual compromet la producció d’aquests cultius i provoca pèrdues econòmiques significants. El control d’aquesta malaltia es basa en l’ús de compostos del coure, als quals se’ls hi atribueix toxicitat vegetal, soques bacterianes resistents al coure i contaminació de l’ambient. A conseqüència, es planteja una necessitat global de noves estratègies més eficients i sostenibles que permetin el control de la taca bacteriana.Programa de Doctorat en Tecnologi

Diversity of plant defense elicitor peptides within the Rosaceae

Abstract Background Plant elicitor peptides (Peps) are endogenous molecules that induce and amplify the first line of inducible plant defense, known as pattern-triggered immunity, contributing to protect plants against attack by bacteria, fungi and herbivores. Pep topic application and transgenic expression have been found to enhance disease resistance in a small number of model plant-pathogen systems. The action of Peps relies on perception by specific receptors, so displaying a family-specific activity. Recently, the presence and activity of Peps within the Rosaceae has been demonstrated. Here we characterized the population of Pep sequences within the economically important plant family of Rosaceae, with special emphasis on the Amygdaleae and Pyreae tribes, which include the most relevant edible species such as apple, pear and peach, and numerous ornamental and wild species (e.g. photinia, firethorn and hawthorn). Results The systematic experimental search for Pep and the corresponding precursor PROPEP sequences within 36 Amygdaleae and Pyreae species, and 100 cultivars had a highly homogeneous pattern, with two tribe-specific Pep types per plant, i.e. Pep1 and Pep2 (Amygdaleae) or Pep3 and Pep4 (Pyreae). Pep2 and Pep3 are highly conserved, reaching identity percentages similar to those of genes used in plant phylogenetic analyses, while Pep1 and Pep4 are somewhat more variable, with similar values to the corresponding PROPEPs. In contrast to Pep3 and Pep4, Pep1 and Pep2 sequences of different species paralleled their phylogenetic relationships, and putative ancestor sequences were identified. The large amount of sequences allowed refining of a C-terminal consensus sequence that would support the protective activity of Pep1–4 in a Prunus spp. and Xanthomonas arboricola pv. pruni system. Moreover, tribe-specific consensus sequences were deduced at the center and C-terminal regions of Peps, which might explain the higher protection efficiencies described upon topic treatments with Peps from the same tribe. Conclusions The present study substantially enhances the knowledge on Peps within the Amygdaleae and Pyreae species. It can be the basis to design and fine-tune new control tools against important plant pathogens affecting Prunus, Pyrus and Malus species

Diversity of plant defense elicitor peptides within the Rosaceae

Plant elicitor peptides (Peps) are endogenous molecules that induce and amplify the first line of inducible plant defense, known as pattern-triggered immunity, contributing to protect plants against attack by bacteria, fungi and herbivores. Pep topic application and transgenic expression have been found to enhance disease resistance in a small number of model plant-pathogen systems. The action of Peps relies on perception by specific receptors, so displaying a family-specific activity. Recently, the presence and activity of Peps within the Rosaceae has been demonstrated. Here we characterized the population of Pep sequences within the economically important plant family of Rosaceae, with special emphasis on the Amygdaleae and Pyreae tribes, which include the most relevant edible species such as apple, pear and peach, and numerous ornamental and wild species (e.g. photinia, firethorn and hawthorn)This work was supported by the Spanish MINECO AGL2013–41405-R and the FP7 KBBE.2013.1.2–04 with reference 613678 (DROPSA