152 research outputs found

    Determinantes del comercio entre Ecuador y los países integrantes de la Unión Europea

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    This paper seeks to identify the significant variables in trade between Ecuador and the European Union. Through literature review, we highlight the importance of this work to expose the existing commercial relationship between the European Union and the countries of Latin America and the Caribbean, especially with Ecuador. The results of gravity models highlight the importance of migration, trade liberalization and population, while pointing the insignificance of variables such as distance, religion and language.El presente trabajo busca identificar las variables significativas en el comercio entre Ecuador y la Unión Europea. Por medio de la revisión de la literatura, resaltamos la importancia del presente trabajo al exponer la relación comercial existente entre la Unión Europea y los países de América Latina y el Caribe, especialmente con Ecuador. Los resultados de los modelos de gravedad resaltan la importancia de la migración, la apertura comercial y la población, mientras que señalan la insignificancia de variables como la distancia, la religión e idioma

    Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?

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    SLE can affect any part of the gastrointestinal (GI) tract. GI symptoms are reported to occur in >50% of SLE patients. To describe the GI manifestations of SLE in the RELESSER (Registry of SLE Patients of the Spanish Society of Rheumatology) cohort and to determine whether these are associated with a more severe disease, damage accrual and a worse prognosis. METHODS: We conducted a nationwide, retrospective, multicentre, cross-sectional cohort study of 3658 SLE patients who fulfil =4 ACR-97 criteria. Data on demographics, disease characteristics, activity (SLEDAI-2K or BILAG), damage (SLICC/ACR/DI) and therapies were collected. Demographic and clinical characteristics were compared between lupus patients with and without GI damage to establish whether GI damage is associated with a more severe disease. RESULTS: From 3654 lupus patients, 3.7% developed GI damage. Patients in this group (group 1) were older, they had longer disease duration, and were more likely to have vasculitis, renal disease and serositis than patients without GI damage (group 2). Hospitalizations and mortality were significantly higher in group 1. Patients in group 1 had higher modified SDI (SLICC Damage Index). The presence of oral ulcers reduced the risk of developing damage in 33% of patients. CONCLUSION: Having GI damage is associated with a worse prognosis. Patients on a high dose of glucocorticoids are at higher risk of developing GI damage which reinforces the strategy of minimizing glucocorticoids. Oral ulcers appear to decrease the risk of GI damage. © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology

    Outpatient Parenteral Antibiotic Treatment vs Hospitalization for Infective Endocarditis: Validation of the OPAT-GAMES Criteria

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    Gestión del conocimiento: perspectiva multidisciplinaria. Volumen 12

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    El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 12, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro cuenta con el apoyo de los grupos de investigación: Universidad Sur del Lago “Jesús María Semprúm” (UNESUR), Zulia – Venezuela; Universidad Politécnica Territorial de Falcón Alonso Gamero (UPTAG), Falcón – Venezuela; Universidad Politécnica Territorial de Mérida Kleber Ramírez (UPTM), Mérida – Venezuela; Universidad Guanajuato (UG) - Campus Celaya - Salvatierra - Cuerpo Académico de Biodesarrollo y Bioeconomía en las Organizaciones y Políticas Públicas (C.A.B.B.O.P.P), Guanajuato – México; Centro de Altos Estudios de Venezuela (CEALEVE), Zulia – Venezuela, Centro Integral de Formación Educativa Especializada del Sur (CIFE - SUR) - Zulia - Venezuela, Centro de Investigaciones Internacionales SAS (CIN), Antioquia - Colombia.y diferentes grupos de investigación del ámbito nacional e internacional que hoy se unen para estrechar vínculos investigativos, para que sus aportes científicos formen parte de los libros que se publiquen en formatos digital e impreso

    Clinical practice guideline for treatment of type 2 diabetes mellitus : therapeutic targets

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    Introducción: Está demostrado que alcanzar y mantener una hemoglobina glicosilada (HbA1c) del 7% reduce la incidencia de complicaciones micro y macrovasculares en adultos jóvenes con diabetes mellitus tipo 2 (DMT2). Se ha propuesto que esta meta de manejo debe individualizarse en pacientes mayores de 65 años de edad o en aquellos con antecedente de enfermedad cardiovascular; sin embargo, la evidencia es discutida. Objetivos: Definir los potenciales riesgos y beneficios de la terapia intensificada para DMT2 buscando valores de HbA1 <7% en pacientes mayores de 65 años, con comobilidades significativas y sin estas, y en grupos de pacientes con eventos cardiovasculares previos. Métodos: Se elaboró la guía de práctica clínica, siguiendo los lineamientos de la guía metodológica del Ministerio de Salud y Protección Social colombiano. Se revisó la evidencia disponible de forma sistemática y se formularon las recomendaciones utilizando la metodología GRADE. Conclusiones: En los pacientes con DMT2 mayores de 65 años y en aquellos con antecedente de enfermedad cardiovascular, se recomienda no intensificar el manejo para alcanzar valores de HbA1c cercanos a lo normal (< 6,5 %). Las metas de manejo en el grupo de mayores de 65 años deberán definirse para cada paciente de forma individual de acuerdo con una valoración integral que tenga en cuenta su riesgo de hipoglucemia y pronóstico vital.Artículo original1-9Introduction: It is demonstrated that reach and maintaina glycated hemoglobin (HbA1c) of 7% reduce the incidence of macro and micro vascular complications in young adults with type 2 diabetes. It has been proposed that this therapeutic goal must be individualized in patients older than 65 years or in those with previous cardiovascular disease, however the evidence supporting this adjustment is controversial. Aim: To define the risk and benefits of intensified therapy to achieve HbA1 <7% in DMT2 patients older than 65 years, with or without significant comorbidities, and in patients with previous cardiovascular events. Methods: A clinical practice guide has been developed following the broad outline of the methodological guide from the Colombian Ministry of Health and Social Welfare, with the aim of systematically gathering scientific evidenceand formulating recommendations using the GRADE methodology. Conclusions: In patients with DMT2 who are older than 65 years of age, and in those with antecedents of cardiovascular disease it is recommended not to intensify treatment to reach HbA1c values close to normal (<6,5% HbA1c). The therapeutic goals in patients older than 65 years should be individualized according with an integral evaluation considering hypoglycemia risk andlife-threatening situation

    Buen vivir : ¿alternativa postcapitalista?

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    La concepción del Buen Vivir se propone desnudar y superar los errores y las limitaciones de la matriz de pensamiento eurocentrista, de una determinada narrativa de la modernidad y del capitalismo como única forma posible de pensar y vivir. Ello se encuentra asociado a las diversas nociones y teorías tradicionales del progreso y el desarrollo que se sustentan en el crecimiento exponencial de bienes y servicios lo cual supone la explotación ilimitada de los recursos naturales y humanos que existen en el planeta. Para alcanzar los beneficios que presume la distribución de los frutos de este crecimiento económico persistente, se elaboran políticas, planes y programas de desarrollo, proceso reforzado por un conjunto de instancias financieras, de capacitación y transferencia de conocimientos desde el mundo desarrollado hacia el mundo en vías de desarrollo. Descargar al final de la página la convocatoria para Polis Nº 42

    Relationship between damage clustering and mortality in systemic lupus erythematosus in early and late stages of the disease: cluster analyses in a large cohort from the Spanish Society of Rheumatology Lupus Registry.

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    To identify patterns (clusters) of damage manifestations within a large cohort of SLE patients and evaluate the potential association of these clusters with a higher risk of mortality. This is a multicentre, descriptive, cross-sectional study of a cohort of 3656 SLE patients from the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics Damage Index. Using cluster analysis, groups of patients with similar patterns of damage manifestations were identified. Then, overall clusters were compared as well as the subgroup of patients within every cluster with disease duration shorter than 5 years. Three damage clusters were identified. Cluster 1 (80.6% of patients) presented a lower amount of individuals with damage (23.2 vs 100% in clusters 2 and 3, P In a large cohort of SLE patients, cardiovascular and musculoskeletal damage manifestations were the two dominant forms of damage to sort patients into clinically meaningful clusters. Both in early and late stages of the disease, there was a significant association of these clusters with an increased risk of mortality. Physicians should pay special attention to the early prevention of damage in these two systems

    Memorias del primer Simposio Nacional de Ciencias Agronómicas

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    Primer simposio nacional de Ciencias Agronómicas: El renacer del espacio de discusión científica para el Agro colombiano
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