Fibrosi Polmonare Idiopatica: valutazione della progressione e della prognosi dopo la pubblicazione delle linee guida ATS/ERS/JRS/ALAT 2011.

La fibrosi polmonare idiopatica è una patologia interstiziale cronica e progressiva ad eziologia sconosciuta. Le linee guida ATS/ERS/JRS/ALAT 2011 hanno confermato l’assenza di terapie mediche e la necessità di indirizzare i pazienti a protocolli sperimentali quando disponibili e alle liste di trapianto. Obiettivo dello studio: valutazione della progressione e della prognosi dei pazienti con Fibrosi Polmonare Idiopatica suddivisi in base al pattern HRCT come suggerito dalle linee guida ATS/ERS/JRS/ALAT 2011. Materiali e metodi: 61 pazienti seguiti dalla UO di Pneumologia 1 dell’ AOUP per fibrosi polmonare idiopatica (IPF) sono stati suddivisi in tre gruppi (UIP, Possible UIP, Non UIP) in base alle caratteristiche HRCT basali, come suggerito dalle linee guida 2011. I pazienti sono stati sottoposti a valutazioni cliniche, funzionali e strumentali al momento della diagnosi e seguiti nel tempo. Successivamente sono state calcolate la progressione delle alterazioni funzionali e HRCT e la mortalità (Kaplan- Mayer) nei tre gruppi di pazienti. Risultati: L’analisi dei dati HRCT ha mostrato un incremento significativo nel tempo dello score fibrotico nel gruppo UIP e Non UIP , dell’ honeycombing nel gruppo UIP e Non UIP, del numero di lobi interessati da bronchiectasie da trazione nel gruppo UIP e Possible UIP e delle anomalie complessive nel gruppo UIP. L’FVC% si riduceva nel tempo in tutti e tre i gruppi, l’SVC% nel gruppo UIP e Non UIP, la TLC% nel gruppo UIP e Possible UIP, la DLCO% nel gruppo UIP. Nel gruppo UIP non si dimostravano differenze del tasso di mortalità in base al valore basale degli indici funzionali, mentre la sopravvivenza risultava maggiore nei pazienti con score fibrotico basale inferiore a 40, anomalie complessive inferiori a 40 o con un numero di lobi interessati da bronchiectasie inferiori a 3 all’ HRCT basale. Conclusioni: Nel nostro studio i criteri HRCT delle linee guida 2011 sono risultati accurati nella stratificazione dei pazienti con fibrosi polmonare idiopatica. Le alterazioni HRTC (score fibrotico, anomalie complessive e lobi interessati da bronchiectasie) inoltre erano predittive per la sopravvivenza

Perceiving oneself. Outcomes of an exploratory survey with the PBL at the University

The university is undoubtedly a privileged place for participation, confrontation, and continuous educational investment. A place where students are actively encouraged to reason and solve problems by autonomously obtaining and drawing on all the necessary information sources. The study describes the exploratory survey conducted with a sample of 38 students, enrolled in the first year of the Master's Degree Course in Pedagogical Sciences (LM-85) at the University of Palermo, in the academic year 2022-23, on the training value of the problem-based learning (PBL) teaching methodology. The research focuses on the degree of satisfaction the students had during the PBL activities and their self-perception, in terms of skills (problem-solving, decision-making, team working and critical thinking) and the impact these will have on their personal and professional growth

Innovative Energy Approach for Design and Sizing of Electric Vehicle Charging Infrastructure

In Italy, the availability of service areas (SAs) equipped with charging stations (CSs) for electric vehicles (EVs) on highways is limited in comparison to the total number of service areas. The scope of this work is to create a prototype and show a different approach to assessing the number of inlets required on highways. The proposed method estimates the energy requirements for the future electric fleet on highways. It is based on an energy conversion that starts with the fuel sold in the highway network and ends with the number of charging inlets. A proposed benchmark method estimates energy requirements for the electric fleet using consolidated values and statistics about refueling attitudes, with factors for range correction and winter conditions. The results depend on assumptions about future car distribution, with varying numbers of required inlets. The analysis revealed that vehicle traffic is a critical factor in determining the number of required charging inlets, with significant variance between different SAs. This study highlights the necessity of incorporating factors like weather, car charging power, and the future EV range into these estimations. The findings are useful for planning EV charging infrastructure, especially along major traffic routes and in urban areas with high-range vehicles relying on High-Power DC (HPDC) charging. The model’s applicability to urban scenarios can be improved by considering the proportion of energy recharged at the destination. A key limitation is the lack of detailed origin–destination (OD) highway data, leading to some uncertainty in the calculated range ratio coefficient and underscoring the need for future research to refine this model

Nessuno resta indietro: La Bellezza del Service Learning

La chiusura delle scuole che ha provocato un incremento significativo della povertà educativa ha sollecitato l’opportunità di pro-gettare interventi integrati di service learning per favorire il recupero e il potenziamento dei minori in difficoltà. 869 studenti del Corso di Laurea Magistrale in Scienze della Formazione Primaria dell’Università degli Studi di Palermo, sono stati coinvolti nella progettazione e nella realizzazione di percorsi didattici mirati, rivolti agli alunni “fragili” di 33 scuole palermitane. Complessiva-mente sono state erogate 60.000 ore in DAD di attività di recupero e di potenziamento dell’apprendimento di alunni della scuola primaria di Palermo. Le attività didattiche sfidanti hanno favorito la stimolazione cognitiva e lo sviluppo della motivazione per l’apprendimento. Il progetto di Service Learning ha così portato alla riscoperta della bellezza dell’inclusione, dell’integrazione e della responsabilità civica.School closures due to COVID-19 have brought significant disruptions to education. Service-learning interventions have offered significant opportunities to reduce and reverse the long-term negative effects and to empower the recovery process of pupils in difficulty. The study was carried out with 869 students enrolled in the Primary Education Sciences master’s degree course at the University of Palermo. The participants have been involved in the planning and implementation of targeted educational courses de-signed for the “fragile” pupils from 33 different schools in Palermo. The primary level pupils were provided with a total of 60.000 hours of recovery and learning enhancement activities in remote mode. Challenging teaching activities fostered cognitive and learning development of the pupils. The results reveal that the service-learning project led to the rediscovery of the beauty of inclusion, integration, and civic responsibility

Metabolomic approach to profile functional and metabolic changes in heart failure

Heart failure (HF) is characterized by a series of adaptive changes in energy metabolism. The use of metabolomics enables the parallel assessment of a wide range of metabolites. In this study, we appraised whether metabolic changes correlate with HF severity, assessed as an impairment of functional contractility, and attempted to interpret the role of metabolic changes in determining systolic dysfunction

Uso específico de ISCI durante a nutrição enteral noturna em criança com diabetes tipo 1, tireoidite de Hashimoto e síndrome de Down

The management of insulin therapy in diabetic patients who have comorbidities that involve nutritional aspects, is a major challenge for diabetes care teams. In diabetic patients with compromised nutritional status, artificial nutrition, both enteral or parenteral, may help in the treatment of chronic and acute diseases, leading to better and faster recover of the health status but, if not adequately associated with insulin therapy, it may negatively affect blood glucose levels and lead to poorer metabolic control. In particular, evidence-based recommendations for the treatment of diabetic patients during enteral nutrition therapy are not currently available and, therefore, medical practices are often based on case reports, rather than outcomes of research. We report our experience with a diabetic patient receiving nocturnal enteral feeding due to comorbidities and malnutrition, who was followed up at our centre and precociously treated with continuous subcutaneous insulin infusion after the onset of type 1 diabetes. There is great need for adequately powered randomized controlled trials to provide scientific evidence for the insulin treatment of diabetic patients undergoing enteral feeding

Performance of the diamond active target prototype for the PADME experiment at the DAΦ\PhiNE BTF

The PADME experiment at the DA$\Phi$NE Beam-Test Facility (BTF) is designed to search for the gauge boson of a new $\rm U(1)$ interaction in the process e$^+$e$^-\rightarrow\gamma$+$\rm A'$, using the intense positron beam hitting a light target. The $\rm A'$, usually referred as dark photon, is assumed to decay into invisible particles of a secluded sector and it can be observed by searching for an anomalous peak in the spectrum of the missing mass measured in events with a single photon in the final state. The measurement requires the determination of the 4-momentum of the recoil photon, performed by a homogeneous, highly segmented BGO crystals calorimeter. A significant improvement of the missing mass resolution is possible using an active target capable to determine the average position of the positron bunch with a resolution of less than 1 mm. This report presents the performance of a real size $\rm (2x2 cm^2)$ PADME active target made of a thin (50 $\mu$m) diamond sensor, with graphitic strips produced via laser irradiation on both sides. The measurements are based on data collected in a beam test at the BTF in November 2015.Comment: 7 pages, 10 figure

A rapid high-performance liquid chromatography-tandem mass spectrometry assay for unambiguous detection of different milk species employed in cheese manufacturing

n/