68 research outputs found

    Influence of masonry infill on the seismic performance of concentrically braced frames

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    This paper presents an experimental and analytical study to investigate the effect of masonry infill on the seismic performance of special Concentrically Braced Frames (CBFs). Cyclic lateral load tests are conducted on three half-scale specimens including two special CBFs with and without masonry infill and a moment resisting steel frame with masonry infill for comparison purposes. Companion analyses are performed to study the influence of masonry infill on the potential rupture of gusset plates and top-seat angle connections by using detailed FE models validated with experimental results. It is shown that the presence of masonry infill could increase the lateral stiffness and load carrying capacity of the special CBF by 33% and 41%, respectively. However, the interaction between masonry infill and the frame significantly increased the strain demands and failure potential of the connections. The results of the experimental tests and analytical simulations indicate that ignoring the influence of masonry infill in the seismic design process of CBFs results in a premature fracture of the connection weld lines and a significant reduction in the deformation capacity and ductility of the frame. This can adversely influence the seismic performance of the structure under strong earthquakes. The results of this study compare well with the damage observations after the 2003 earthquake in Bam, Iran

    Evaluating the capability of a critical state constitutive model to predict the collapse potential of loose sand

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    Many catastrophic flow failures in granular soil slopes are believed to be caused by a rise in pore water pressure associated with substantial loss of soil shear strength. This failure mechanism is known as prefailure instability or static liquefaction. Constant shear (CS) and consolidated undrained (CU) triaxial tests can reproduce stress paths, in which such instability may occur before reaching the failure. In the present study, a previously proposed critical state constitutive model was first used to simulate the behavior of loose saturated sand in CU tests. It was then employed to predict the instability of loose sand subjected to the CS loading. Under such loading, loose dry sand initially experience small volume increase, and then start to contract substantially. In saturated sand, such contractions can lead to the generation of pore water pressure and sudden decrease of shear strength. The capability of the model to predict the onset of the volume contraction and collapse potential of loose dry sand was examined by comparing the model predictions with experimental results of CS tests. The comparison showed that the effect of initial void ratio, consolidation and deviatoric stresses on behavior of loose dry sand can be well predicted by the model

    Analytical study on the seismic performance of steel braced frames with masonry infill

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    Special Concentrically Braced Frames (CBFs) are widely used as efficient lateral-load resisting systems in seismic regions. In this study, experimentally validated FE models are used to investigate the effects of masonry infill and gusset-plate configuration on the seismic performance of CBFs. It is shown that the presence of masonry infill can increase the initial stiffness and ultimate strength of CBFs by up to 35% and 52%, respectively. However, the frame-infill interaction imposes high plastic strain demands at the horizontal re-entrant corner of gusset plate connections, which may lead to premature failure of fillet welds under strong earthquakes. While using tapered gusset plates can significantly increase the fracture potential at fillet welds, gusset plates with elliptical clearance of eight times the plate thickness can lead to up to 54% lower equivalent plastic strain demands at both gusset plate connections and brace elements. While the effects of masonry infill are usually ignored in the seismic design process, the results highlight the importance of considering those effects in the seismic design of CBF elements and gusset plate connections

    Mn L3,2 X-ray Absorption Spectroscopy And Magnetic Circular Dichroism In Ferromagnetic (Ga,Mn)P

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    We have measured the X-ray absorption (XAS) and X-ray magnetic circular dichroism (XMCD) at the Mn L3,2 edges in ferromagnetic Ga1-xMnxP films for 0.018<x<0.042. Large XMCD asymmetries at the L3 edge indicate significant spin-polarization of the density of states at the Fermi energy. The spectral shapes of the XAS and XMCD are nearly identical with those for Ga1-xMnxAs indicating that the hybridization of Mn d states and anion p states is similar in the two materials. Finally, compensation with sulfur donors not only lowers the ferromagnetic Curie temperature but also reduces the spin polarization of the hole states.Comment: 2 pages, 1 figure; To appear in the Proceedings of the 28th International Conference on the Physics of Semiconductors (ICPS-28, Vienna, Austria, July 24-28, 2006

    Intelligent Monitoring System for Bird Behavior Study

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    Until now, the best way to obtain relevant information about the behaviour of animals is capturing them. However, the procedure to capture individuals cause them stress and introduces an effect on the measurement that can affect the behaviour of the animals. To solve this problems this paper describes a novel intelligent motoring system for birds breeding in nest boxes. This system is based in a network of smart-nest boxes that allows access to the acquired data all over the world through internet. A prototype of the proposed system has been implemented for the evaluation of a lesser kestrel breeding colony in Southern Spain. This prototype has offered in a short time more valuable information that several years of manual captures. This prototype has demonstrated that the proposed system allows short and log time animal behaviour evaluation without interferences or causing stress.Junta de Andalucía P06-RNM-01712Junta de Andalucía P06-RNM-04588Junta de Andalucía P07-TIC-02476Junta de Andalucía TIC-570

    A cross-over experiment to investigate possible mechanisms for lower BMIs in people who habitually eat breakfast

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    © 2015 Macmillan Publishers Limited. The body mass index (BMI) of breakfast eaters is frequently reported to be lower compared with that of breakfast skippers. This is not explained by differences in energy intakes, indicating there may be other mechanisms serving to drive this paradoxical association between breakfast and BMI. This study aimed to investigate the effect of eating breakfast versus morning fasting on measures predominantly of metabolism in lean and overweight participants who habitually eat or skip breakfast.Subjects/Methods:Participants (n=37) were recruited into four groups on the basis of BMI (lean and overweight) and breakfast habit (breakfast eater and breakfast skipper). Participants were randomly assigned to a breakfast experimental condition, breakfast eating or no breakfast, for 7 days and then completed the alternative condition. At the end of each breakfast experimental condition, measurements were made before and after a high carbohydrate breakfast of 2274±777 kJ or a rest period. Resting metabolic rate, thermic effect of food (TEF), blood glucose, insulin and leptin levels were recorded. Hunger and 'morningness' were assessed and pedometers worn.Results:Lean participants had lower fasting insulin levels (P=0.045) and higher insulin concentrations following breakfast (P=0.001). BMI and breakfast habit did not interact with the experimental breakfast condition, with the exception of hunger ratings; breakfast eaters were hungrier in the mornings compared with breakfast skippers in the no breakfast condition (P=0.001).Conclusions:There is little evidence from this study for a metabolic-based mechanism to explain lower BMIs in breakfast eaters.Published versio

    Dietary factors associated with metabolic syndrome in Brazilian adults

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    <p>Abstract</p> <p>Background</p> <p>Metabolic Syndrome (MS) is defined as the association of numerous factors that increase cardiovascular risk and diet is one of the main factors related to increase the MS in the population. This study aimed to evaluate the association of diet on the presence of MS in an adult population sample.</p> <p>Methodology</p> <p>305 adults were clinically screened to participate in a lifestyle modification program. Anthropometric assessments included waist circumference (WC), body fat and calculated BMI (kg/m<sup>2</sup>) and muscle-mass index (MMI kg/m<sup>2</sup>). Dietary intake was estimated by 24 h dietary recall. Fasting blood was used for biochemical analysis. MS was diagnosed using NCEP-ATPIII (2001) criteria with adaptation for glucose (≥ 100 mg/dL). Logistic regression (Odds ratio) was performed in order to determine the odds ratio for developing MS according to dietary intake.</p> <p>Results</p> <p>An adequate intake of fruits, OR = 0.52 (CI:0.28-0.98), and an intake of more than 8 different items in the diet (variety), OR = 0.31 (CI:0.12-0.79) showed to be a protective factor against a diagnosis of MS. Saturated fat intake greater than 10% of total caloric value represented a risk for MS diagnosis, OR = 2.0 (1.04-3.84).</p> <p>Conclusion</p> <p>Regarding the dietary aspect, a risk factor for MS was higher intake of saturated fat, and protective factors were high diet variety and adequate fruit intake.</p

    Molecular mechanisms and cellular functions of cGAS-STING signalling

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    The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes (STING), detects pathogenic DNA to trigger an innate immune reaction involving a strong type I interferon response against microbial infections. Notably however, besides sensing microbial DNA, the DNA sensor cGAS can also be activated by endogenous DNA, including extranuclear chromatin resulting from genotoxic stress and DNA released from mitochondria, placing cGAS–STING as an important axis in autoimmunity, sterile inflammatory responses and cellular senescence. Initial models assumed that co-localization of cGAS and DNA in the cytosol defines the specificity of the pathway for non-self, but recent work revealed that cGAS is also present in the nucleus and at the plasma membrane, and such subcellular compartmentalization was linked to signalling specificity of cGAS. Further confounding the simple view of cGAS–STING signalling as a response mechanism to infectious agents, both cGAS and STING were shown to have additional functions, independent of interferon response. These involve non-catalytic roles of cGAS in regulating DNA repair and signalling via STING to NF-κB and MAPK as well as STING-mediated induction of autophagy and lysosome- dependent cell death. We have also learnt that cGAS dimers can multimerize and undergo liquid–liquid phase separation to form biomolecular condensates that could importantly regulate cGAS activation. Here, we review the molecular mechanisms and cellular functions underlying cGAS–STING activation and signalling, particularly highlighting the newly emerging diversity of this signalling pathway and discussing how the specificity towards normal, damage-induced and infection-associated DNA could be achieved
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