The psychosocial impact of assistive device scale: Italian validation in a cohort of nonambulant people with neuromotor disorders

The importance of adaptive seating system on body structure and function is widely accepted, but its impact on psychosocial aspects needs more consideration by health professionals. This article describes the Italian validation of the Psychosocial Impact of Assistive Device Scale (IT-PIADS) for non-ambulant people with neuromotor disorders. Once agreement has been given by the original authors, the scale was translated and adapted to the Italian culture. The IT-PIADS was administered to different wheelchairs users with heterogeneous diagnosis. The internal consistency and test-retest reliability were examined. Its concurrent validity was evaluated with the Italian version of the WheelCon-M-SF. The IT-PIADS was administered to 87 subjects. Cronbach's α was 0.92 (p < 0.05), and the testretest reliability (ICC) for competence, adaptability and self-esteem subscales were 0.96, 0.90, 0.93 respectively. The Pearson correlation coefficient of the IT-PIADS with the WheelCon-M-I-SF scores showed significant data for competence and adaptability subscales. Psychosocial perception on assistive devices can be reliably measure. The IT-PIADS showed good psychometric properties and it is possible to confirm its validity for clinical and research purposes. Nevertheless, before using this measure with greater confidence, further psychometric properties tests of the IT-PIADS are recommended

Behavioral interactions between terrestrial salamanders and spiders: competition or intraguild predation? Behavioral interactions between terrestrial salamanders and spiders: competition or intraguild predation?

Several studies suggest that small terrestrial salamanders are important regulators of leaf litter arthropod communities, and likely contribute to ecosystem processes such as decomposition and nutrient cycling. Despite the recognition that salamanders have the potential to strongly affect ecosystem function through both direct and indirect pathways, little is known regarding the nature of interactions between small vertebrates and the large, predatory arthropods with which they share both microhabitat and prey. Our study was designed to explore interactions between Eastern Red-backed Salamanders, Plethodon cinereus, and spiders in the genus Wadotes in an eastern North American temperate forest ecosystem. We were particularly interested in teasing apart behaviors such as territoriality and intraguild predation in an attempt to determine specifically which interaction is most likely responsible for the observed negative relationship between salamander and spider abundance at our field site. Field data indicate that P. cinereus and large syntopic spiders exhibit negative spatial associations in the microhabitat beneath cover objects, a possible indication of interspecific territoriality. In our laboratory experiments, resident salamanders displayed agonistic postures similarly toward both intruding conspecifics and spiders, suggesting that salamanders may perceive large intruding spiders as competitors. Finally, we observed no injuries to individual P. cinereus or adult spiders even though occasional chases and bites by both were recorded during the behavioral trials. We found no evidence that adults or juveniles of P. cinereus were envenomated by adult Wadotes spp., and there were no instances of intra-guild predation in this study. Multiple lines of evidence from this study, and others, suggest that the primary interaction between individuals of P. cinereus and large spiders is competitive in nature rather than predatory. We suggest that the cost associated with intraguild predation on salamanders with noxious skin secretions may preclude them from being preyed upon by spiders

The RMS Survey: Ammonia and water maser analysis of massive star forming regions

The Red MSX Source (RMS) survey has identified a sample of ~1200 massive young stellar objects (MYSOs), compact and ultra compact HII regions from a sample of ~2000 MSX and 2MASS colour selected sources. We have used the 100 m Green Bank telescope to search for 22-24 GHz water maser and ammonia (1,1), (2,2) and (3,3) emission towards ~600 RMS sources located within the northern Galactic plane. We have identified 308 H2O masers which corresponds to an overall detection rate of ~50%. Abridged: We detect ammonia emission towards 479 of these massive young stars, which corresponds to ~80%. Ammonia is an excellent probe of high density gas allowing us to measure key parameters such as gas temperatures, opacities, and column densities, as well as providing an insight into the gas kinematics. The average kinetic temperature, FWHM line width and total NH3 column density for the sample are approximately 22 K, 2 km/s and 2x10^{15} cm^{-2}, respectively. We find that the NH3 (1,1) line width and kinetic temperature are correlated with luminosity and finding no underlying dependence of these parameters on the evolutionary phase of the embedded sources, we conclude that the observed trends in the derived parameters are more likely to be due to the energy output of the central source and/or the line width-clump mass relationship. The velocities of the peak H2O masers and the NH3 emission are in excellent agreement with each other, which would strongly suggest an association between the dense gas and the maser emission. Moreover, we find the bolometric luminosity of the embedded source and the isotropic luminosity of the H2O maser are also correlated. We conclude from the correlations of the cloud and water maser velocities and the bolometric and maser luminosity that there is a strong dynamical relationship between the embedded young massive star and the H2O maser.Comment: 17 pages and 17 figures and 8 tables. Tables\,2 and 5 and full versions of Figs. 3 and 7 are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.125.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A

Minimum weight design of axially compressed ring and stringer stiffened cylindrical shells

Minimum weight design of axially compressed ring and stringer stiffened cylindrical shell

Stalagmite water content as a proxy for drip water supply in tropical and subtropical areas

In this pilot study water was extracted from samples of two Holocene stalagmites from Socotra Island, Yemen, and one Eemian stalagmite from southern continental Yemen. The amount of water extracted per unit mass of stalagmite rock, termed "water yield" hereafter, serves as a measure of its total water content. Based on direct correlation plots of water yields and δ18Ocalcite and on regime shift analyses, we demonstrate that for the studied stalagmites the water yield records vary systematically with the corresponding oxygen isotopic compositions of the calcite (δ18Ocalcite). Within each stalagmite lower δ18Ocalcite values are accompanied by lower water yields and vice versa. The δ18Ocalcite records of the studied stalagmites have previously been interpreted to predominantly reflect the amount of rainfall in the area; thus, water yields can be linked to drip water supply. Higher, and therefore more continuous drip water supply caused by higher rainfall rates, supports homogeneous deposition of calcite with low porosity and therefore a small fraction of water-filled inclusions, resulting in low water yields of the respective samples. A reduction of drip water supply fosters irregular growth of calcite with higher porosity, leading to an increase of the fraction of water-filled inclusions and thus higher water yields. The results are consistent with the literature on stalagmite growth and supported by optical inspection of thin sections of our samples. We propose that for a stalagmite from a dry tropical or subtropical area, its water yield record represents a novel paleo-climate proxy recording changes in drip water supply, which can in turn be interpreted in terms of associated rainfall rates

Designing and conducting qualitative research across countries and cultures: challenges for inclusiveness and rigour

Qualitative research is fundamental to understanding the nature and complexity of human phenomena. While cultural and psychometric validations exist for quantitative tools, the same cannot be said of qualitative ones. There are other many challenges when conducting a multinational qualitative study, which includes different cultural and linguistic 'biases'. This paper presents some key issues that researchers may encounter when designing and developing multinational and multicultural qualitative studies, and also provides some strategies to overcome difficulties and ensure rigour

ICELUS: Investigating strategy switching for throughput maximization to a mobile sink

Wireless sensor networks offer a pragmatic solution for monitoring in a variety of scenarios. For efficient and practical data gathering, especially in large-scale systems deployed in inaccessible areas, unmanned vehicles are becoming a compelling solution. The added infrastructure flexibility comes at the cost of limited contact time between the mobile entity and the stationary devices. The channel fading caused by mobility further decreases the data yield.We address this challenge by analysing the relevant classes of data transfer schemes and identifying adaptation conditions that enable the selection of the best fitting strategy. The result of this analysis, ICELUS, provides an integrated protocol that exploits the available communication resources. © 2016 IFIP

IRIS: Efficient Visualization, Data Analysis and Experiment Management for Wireless Sensor Networks

The design of ubiquitous computing environments is challenging, mainly due to the unforeseeable impact of real-world environments on the system performance. A crucial step to validate the behavior of these systems is to perform in-field experiments under various conditions. We introduce IRIS, an experiment management and data processing tool allowing the definition of arbitrary complex data analysis applications. While focusing on Wireless Sensor Networks, IRIS supports the seamless integration of heterogeneous data gathering technologies. The resulting flexibility and extensibility enable the definition of various services, from experiment management and performance evaluation to user-specific applications and visualization. IRIS demonstrated its effectiveness in three real-life use cases, offering a valuable support for in-field experimentation and development of customized applications for interfacing the end user with the system

Mir34a constrains pancreatic carcinogenesis

Several studies have shown that over 70 different microRNAs are aberrantly expressed in pancreatic ductal adenocarcinoma (PDAC), affecting proliferation, apoptosis, metabolism, EMT and metastasis. The most important genetic alterations driving PDAC are a constitutive active mutation of the oncogene Kras and loss of function of the tumour suppressor Tp53 gene. Since the MicroRNA 34a (Mir34a) is a direct target of Tp53 it may critically contribute to the suppression of PDAC. Mir34a is epigenetically silenced in numerous cancers, including PDAC, where Mir34a down-regulation has been associated with poor patient prognosis. To determine whether Mir34a represents a suppressor of PDAC formation we generated an in vivo PDAC-mouse model harbouring pancreas-specific loss of Mir34a (Kras(G12D);Mir34a(Delta/Delta)). Histological analysis of Kras(G12D);Mir34a(Delta/Delta) mice revealed an accelerated formation of pre-neoplastic lesions and a faster PDAC development, compared to Kras(G12D) controls. Here we show that the accelerated phenotype is driven by an early up-regulation of the pro-inflammatory cytokines TNFA and IL6 in normal acinar cells and accompanied by the recruitment of immune cells. Our results imply that Mir34a restrains PDAC development by modulating the immune microenvironment of PDAC, thus defining Mir34a restauration as a potential therapeutic strategy for inhibition of PDAC development

Relationship between Helicobacter pylori Virulence Genes and Clinical Outcomes in Saudi Patients

Helicobacter pylori has been strongly associated with gastritis, gastric and duodenal ulcers, and it is a risk factor for gastric cancer. Two major virulence factors of H. pylori have been described: the cytotoxin-associated gene product (cagA) and the vacuolating toxin (vacA). Since considerable geographic diversity in the prevalence of H. pylori virulence factors has been reported, the aim of this work was to determine if there is a significant correlation between different H. pylori virulence genes (cagA and vacA) in 68 patients, from Saudi Arabia, and gastric clinical outcomes. H. pylor was recognized in cultures of gastric biopsies. vacA and cagA genes were detected by polymerase chain reaction (PCR). The cagA gene was obtained with 42 isolates (61.8%). The vacA s- and m- region genotypes were determined in all strains studied. Three genotypes were found: s1/m1 (28%), s1/m2 (40%) and s2/m2 (26%). The s2/m1 genotype was not found in this study. The relation of the presence of cagA and the development of cases to gastritis and ulcer was statistically significant (P < 0.05). The study showed a significant correlation between the vacA s1/m2 genotype and gastritis cases, and a significant correlation between vacA s1/m1 genotype and peptic ulcer cases. The results of this study might be used for the identification of high-risk patients who are infected by vacA s1/m1 genotype of H. pylori strains. In conclusion, H. pylori strains of vacA type s1 and the combination of s1/m1 were associated with peptic ulceration and the presence of cagA gene