17,284 research outputs found
The structure of a <i>Trypanosoma cruzi</i> glucose-6-phosphate dehydrogenase reveals differences from the mammalian enzyme
Kinetic Theory of Collisionless Self-Gravitating Gases: II. Relativistic Corrections in Galactic Dynamics
In this paper we study the kinetic theory of many-particle astrophysical
systems imposing axial symmetry and extending our previous analysis in Phys.
Rev. D 83, 123007 (2011). Starting from a Newtonian model describing a
collisionless self-gravitating gas, we develop a framework to include
systematically the first general relativistic corrections to the matter
distribution and gravitational potentials for general stationary systems. Then,
we use our method to obtain particular solutions for the case of the Morgan &
Morgan disks. The models obtained are fully analytical and correspond to the
post-Newtonian generalizations of classical ones. We explore some properties of
the models in order to estimate the importance of post-Newtonian corrections
and we find that, contrary to the expectations, the main modifications appear
far from the galaxy cores. As a by-product of this investigation we derive the
corrected version of the tensor virial theorem. For stationary systems we
recover the same result as in the Newtonian theory. However, for time dependent
backgrounds we find that there is an extra piece that contributes to the
variation of the inertia tensor.Comment: 30 pages, 8 figures. v2: Minor corrections and references added.
Conclusions unchanged. v3: Version published in PR
Simulated Performance of 3-DTI Gamma-Ray Telescope Concepts
We present Monte Carlo simulations of two astronomical gamma-ray telescope concepts based on the ThreeDimensional Track Imager (3- DTI) detector. The 3-DTI consists of a time projection chamber with two-dimensional, crossedstrip micro-well detector readout. The full three- dimensional reconstruction of charged-particle tracks in the gas volume is obtained from transient digitizers, which record the time signature of the charge collected in the wells of each strip. Such detectors hold great promise for advanced Compton telescope (ACT) and advanced pair telescope (APT) concepts due to the very precise measurement of charged particle momenta that is possible (Compton recoil electrons and electron-positron pairs, respectively). We have investigated the performance of baseline ACT and APT designs based on the 3-DTI detector using simulation tools based on GEANT3 and GEANT4, respectively. We present the expected imaging, spectroscopy, polarimetry, and background performance of each design
On the Nonlocal Equations and Nonlocal Charges Associated with the Harry Dym Hierarchy
A large class of nonlocal equations and nonlocal charges for the Harry Dym
hierarchy is exhibited. They are obtained from nonlocal Casimirs associated
with its bi-Hamiltonian structure. The Lax representation for some of these
equations is also given.Comment: to appear in Journal of Mathematical Physics, 17 pages, Late
T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions.
T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo. T cells entered into and actively migrated within lymphatic capillaries but were passively transported in contractile collecting vessels. Intralymphatic T cell number and motility were increased during contact-hypersensitivity-induced inflammation and dependent on ICAM-1/LFA-1 interactions. In vitro, blockade of endothelial cell-expressed ICAM-1 reduced T cell adhesion, crawling, and transmigration across lymphatic endothelium and decreased T cell advancement from capillaries into lymphatic collectors in skin explants. In vivo, T cell migration to draining lymph nodes was significantly reduced upon ICAM-1 or LFA-1 blockade. Our findings indicate that T cell migration through LVs occurs in distinct steps and reveal a key role for ICAM-1/LFA-1 interactions in this process
The distribution of H13CN in the circumstellar envelope around IRC+10216
H13CN J=8-7 sub-millimetre line emission produced in the circumstellar
envelope around the extreme carbon star IRC+10216 has been imaged at
sub-arcsecond angular resolution using the SMA. Supplemented by a detailed
excitation analysis the average fractional abundance of H13CN in the inner wind
(< 5E15 cm) is estimated to be about 4E-7, translating into a total HCN
fractional abundance of 2E-5 using the isotopic ratio 12C/13C=50.
Multi-transitional single-dish observations further requires the H13CN
fractional abundance to remain more or less constant in the envelope out to a
radius of about 4E16 cm, where the HCN molecules are effectively destroyed,
most probably, by photodissociation. The large amount of HCN present in the
inner wind provides effective line cooling that can dominate over that
generated from CO line emission. It is also shown that great care needs to be
taken in the radiative transfer modelling where non-local, and non-LTE, effects
are important and where the radiation field from thermal dust grains plays a
major role in exciting the HCN molecules. The amount of HCN present in the
circumstellar envelope around IRC+10216 is consistent with predicted
photospheric values based on equilibrium chemical models and indicates that any
non-equilibrium chemistry occurring in the extended pulsating atmosphere has no
drastic net effect on the fractional abundance of HCN molecules that enters the
outer envelope. It further suggests that few HCN molecules are incorporated
into dust grains.Comment: Accepted for publication in ApJ. 20 pages, 7 figure
Medium-Energy Gamma-Ray Astrophysics with the 3-DTI Gamma-Ray Telescope
Gamma-ray observations in the medium energy range (0.50-50.0 MeV) are central to unfolding many outstanding questions in astrophysics. The challenges of medium-energy gamma-ray observations, however, are the low photon statistics and large backgrounds. We review these questions, address the telescope technology requirements, and describe our development of the 3-Dimensional Track Imaging (3-DTI) Compton telescope and its performance for a new mediumenergy gamma-ray mission. The 3-DTI is a large-volume time projection chamber (TPC) with a 2-dimensional gas micro-well detector (MWD) readout
Recommended from our members
Dynamical system modeling via signal reduction and neural network simulation
Many dynamical systems tested in the field and the laboratory display significant nonlinear behavior. Accurate characterization of such systems requires modeling in a nonlinear framework. One construct forming a basis for nonlinear modeling is that of the artificial neural network (ANN). However, when system behavior is complex, the amount of data required to perform training can become unreasonable. The authors reduce the complexity of information present in system response measurements using decomposition via canonical variate analysis. They describe a method for decomposing system responses, then modeling the components with ANNs. A numerical example is presented, along with conclusions and recommendations
Clustered Star Formation in W75 N
We present 2" to 7" resolution 3 mm continuum and CO(J=1-0) line emission and
near infrared Ks, H2, and [FeII] images toward the massive star forming region
W75 N. The CO emission uncovers a complex morphology of multiple, overlapping
outflows. A total flow mass of greater than 255 Msun extends 3 pc from
end-to-end and is being driven by at least four late to early-B protostars.
More than 10% of the molecular cloud has been accelerated to high velocities by
the molecular flows (> 5.2 km/s relative to v{LSR}) and the mechanical energy
in the outflowing gas is roughly half the gravitational binding energy of the
cloud. The W75 N cluster members represent a range of evolutionary stages, from
stars with no apparent circumstellar material to deeply embedded protostars
that are actively powering massive outflows. Nine cores of
millimeter-wavelength emission highlight the locations of embedded protostars
in W75 N. The total mass of gas & dust associated with the millimeter cores
ranges from 340 Msun to 11 Msun. The infrared reflection nebula and shocked H2
emission have multiple peaks and extensions which, again, suggests the presence
of several outflows. Diffuse H2 emission extends about 0.6 parsecs beyond the
outer boundaries of the CO emission while the [FeII] emission is only detected
close to the protostars. The infrared line emission morphology suggests that
only slow, non-dissociative J-type shocks exist throughout the pc-scale
outflows. Fast, dissociative shocks, common in jet-driven low-mass outflows,
are absent in W75 N. Thus, the energetics of the outflows from the late to
early B protostars in W75 N differ from their low-mass counterparts -- they do
not appear to be simply scaled-up versions of low-mass outflows.Comment: Astrophysical Journal, in press. 23 pages plus 10 figures (jpg
format). See http://www.aoc.nrao.edu/~dshepher/science.shtml for reprint with
full resolution figure
Recommended from our members
Application of the bootstrap to the analysis of vibration test data
Structural dynamic testing is concerned with estimation of system properties, including frequency response functions and modal characteristics. These properties are derived from tests on the structure of interest, during which excitations and responses are measured and Fourier techniques are used to reduce the data. The inputs used in a test are frequently radom and excite random responses in the structure of interest. When these random inputs and responses are analyzed they yield estimates of system properties that are random variable and random process realizations. Of course, such estimates of system properties vary randomly from one test to another, but even when deterministic inputs are used to excite a structure, the estimated properties vary from test to test. When test excitations and responses are normally distributed, classical techniques permit us to statistically analyze inputs, responses, and system parameters. However, when the input excitations are non-normal, the system is nonlinear, and/or the property of interest is anything but the simplest, the classical analyses break down. The bootstrap is a technique for the statistical analysis of data that are not necessarily normally distributed. It can be used to statistically analyze any measure of input excitation on response, or any system property, when data are available to make an estimate. It is designed to estimate the standard error, bias, and confidence intervals of parameter estimates. This paper shows how the bootstrap can be applied to the statistical analysis of modal parameters
- …