436 research outputs found

    Stress detection using wearable physiological sensors

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    As the population increases in the world, the ratio of health carers is rapidly decreasing. Therefore, there is an urgent need to create new technologies to monitor the physical and mental health of people during their daily life. In particular, negative mental states like depression and anxiety are big problems in modern societies, usually due to stressful situations during everyday activities including work. This paper presents a machine learning approach for stress detection on people using wearable physiological sensors with the �final aim of improving their quality of life. The presented technique can monitor the state of the subject continuously and classify it into "stressful" or "non-stressful" situations. Our classification results show that this method is a good starting point towards real-time stress detection

    Massively parallel computing on an organic molecular layer

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    Current computers operate at enormous speeds of ~10^13 bits/s, but their principle of sequential logic operation has remained unchanged since the 1950s. Though our brain is much slower on a per-neuron base (~10^3 firings/s), it is capable of remarkable decision-making based on the collective operations of millions of neurons at a time in ever-evolving neural circuitry. Here we use molecular switches to build an assembly where each molecule communicates-like neurons-with many neighbors simultaneously. The assembly's ability to reconfigure itself spontaneously for a new problem allows us to realize conventional computing constructs like logic gates and Voronoi decompositions, as well as to reproduce two natural phenomena: heat diffusion and the mutation of normal cells to cancer cells. This is a shift from the current static computing paradigm of serial bit-processing to a regime in which a large number of bits are processed in parallel in dynamically changing hardware.Comment: 25 pages, 6 figure

    Sex matters during adolescence: Testosterone-related cortical thickness maturation differs between boys and girls

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    Age-related changes in cortical thickness have been observed during adolescence, including thinning in frontal and parietal cortices, and thickening in the lateral temporal lobes. Studies have shown sex differences in hormone-related brain maturation when boys and girls are age-matched, however, because girls mature 1-2 years earlier than boys, these sex differences could be confounded by pubertal maturation. To address puberty effects directly, this study assessed sex differences in testosterone-related cortical maturation by studying 85 boys and girls in a narrow age range and matched on sexual maturity. We expected that testosterone-by-sex interactions on cortical thickness would be observed in brain regions known from the animal literature to be high in androgen receptors. We found sex differences in associations between circulating testosterone and thickness in left inferior parietal lobule, middle temporal gyrus, calcarine sulcus, and right lingual gyrus, all regions known to be high in androgen receptors. Visual areas increased with testosterone in boys, but decreased in girls. All other regions were more impacted by testosterone levels in girls than boys. The regional pattern of sex-by-testosterone interactions may have implications for understanding sex differences in behavior and adolescent-onset neuropsychiatric disorders. © 2012 Bramen et al

    The effector T cell response to influenza infection

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    Influenza virus infection induces a potent initial innate immune response, which serves to limit the extent of viral replication and virus spread. However, efficient (and eventual) viral clearance within the respiratory tract requires the subsequent activation, rapid proliferation, recruitment, and expression of effector activities by the adaptive immune system, consisting of antibody producing B cells and influenza-specific T lymphocytes with diverse functions. The ensuing effector activities of these T lymphocytes ultimately determine (along with antibodies) the capacity of the host to eliminate the viruses and the extent of tissue damage. In this review, we describe this effector T cell response to influenza virus infection. Based on information largely obtained in experimental settings (i.e., murine models), we will illustrate the factors regulating the induction of adaptive immune T cell responses to influenza, the effector activities displayed by these activated T cells, the mechanisms underlying the expression of these effector mechanisms, and the control of the activation/differentiation of these T cells, in situ, in the infected lungs

    Communities and Crime

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    ARTICLES: : 1. Editorial 2. Manuel Eisner and Per-Olof H. Wikström - Violent Crime in the Urban Community: A Comparison of Stockholm and Basel 3. J. David Hawkins - Preventing Crime and Violence through Communities That Care 4. Per-Olof H. Wikström and Marie Torstensson - Local Crime Prevention and its National Support: Organisation and Direction 5. Bram Peper and Frans Spierings - Settling Disputes Between Neighbours in the Lifeworld: An Evaluation of Experiments with Community Mediation in the Netherlands 6. Adam Crawford - Questioning Appeals to Community within Crime Prevention and Control 7. Current Issues: Martin Killias and Jacob Elfinus Sahetapy - 'Communities and Crime': the Unexpected Outcomes of an Asian Dinner 8. Frank Neubacher, Michael Walter, Helena Válková and Krzysztof Krajewski - Juvenile delinquency in Central European Cities: a Comparison of Registration and Processing Structures in the 1990

    Een sociaal-wetenschappelijke evaluatie van experimenten met Buurtbemiddeling in Nederland

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    In dit boek worden initiatieven geanalyseerd die vanaf 1996 zijn gestart in Rotterdam, Zwolle, en Gouda met vrijwillige bemiddelaars bij burenruzies. Deze vrijwillige bemiddelaars vormen een afspiegeling van de sociale en etnische samenstelling van de betreffende buurten. Naast een procesanalyse, waarin met name aandacht is voor opzet, vormgeving en verloop van het bemiddelingsproces, wordt in een effect-evaluatie nagegaan welke waarde deze initiatieven hebben voor beleidsterreinen als alternatieve conflict oplossing (ADR) en Sociale Vernieuwing

    Robustness of Cellular Automata in the Light of Asynchronous Information Transmission

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    International audienceCellular automata are classically synchronous: all cells are simultaneously updated. However, it has been proved that perturbations in the updating scheme may induce qualitative changes of behaviours. This paper presents a new type of asynchronism, the beta -synchronism, where cells still update at each time step but where the transmission of information between cells is disrupted randomly. We experimentally study the behaviour of beta-synchronous models. We observe that, although many eff ects are similar to the perturbation of the update, novel phenomena occur. We particularly study phase transitions as an illustration of a qualitative variation of behaviour triggered by continuous change of the disruption probability beta
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