Tracing early evolutionary stages of high-mass star formation with molecular lines

Despite its major role in the evolution of the interstellar medium, the formation of high-mass stars (M > 10 Msol) is still poorly understood. Two types of massive star cluster precursors, the so-called Massive Dense Cores (MDCs), have been observed, which differ in their mid-infrared brightness. The origin of this difference is not established and could be the result of evolution, density, geometry differences, or a combination of these. We compare several molecular tracers of physical conditions (hot cores, shocks) observed in a sample of mid-IR weak emitting MDCs with previous results obtained in a sample of exclusively mid-IR bright MDCs. The aim is to understand the differences between these two types of object. We present single-dish observations of HDO, H2O-18, SO2 and CH3OH lines at lambda = 1.3 - 3.5 mm. We study line profiles and estimate abundances of these molecules, and use a partial correlation method to search for trends in the results. The detection rates of thermal emission lines are found to be very similar between mid-IR quiet and bright objects. The abundances of H2O, HDO (1E-13 to 1E-9 in the cold outer envelopes), SO2 and CH3OH differ from source to source but independently of their mid-IR flux. In contrast, the methanol class I maser emission, a tracer of outflow shocks, is found to be strongly anti-correlated with the 12 micron source brightnesses. The enhancement of the methanol maser emission in mid-IR quiet MDCs may indicate a more embedded nature. Since total masses are similar between the two samples, we suggest that the matter distribution is spherical around mid-IR quiet sources but flattened around mid-IR bright ones. In contrast, water emission is associated with objects containing a hot molecular core, irrespective of their mid-IR brightness. These results indicate that the mid-IR brightness of MDCs is an indicator of their evolutionary stage.Comment: 15 pages, 6 figures, 11 tables, accepted for publication in A&A the 11/06/201

La grille au service du développement médical en Afrique

PCSV, présenté par F. Jacq, pas de proceedingsObjectives: Telemedicine networks allow to train local physicians and to improve diagnosis by exchanging medical data. But the set-up of multipoint dynamic telemedicine requires moving towards GRID technologies. The objective is to develop telemedicine services for physicians from Burkina Faso and France with the perspective of setting up a grid infrastructure between the participating medical sites. Methods: A web site to exchange diagnosis on diabetic retinopathy was developed in PHP. Another application using web services was developed to exchange patient information on ophthalmology between two databases. Results: The main difficulty comes from limited resources in developing countries including staff skills, bandwidth and funding. But the collaboration with dispensaries opened a door to enhanced collaboration between physicians of France and Burkina Faso Conclusions: These applications are designed with the aim of their use on grids which opens the perspective of multipoint dynamic telemedicine. We are developing a new generation of telemedicine service using experience acquired in the last two years

Detection of water at z = 0.685 towards B0218+357

We report the detection of the H_2O molecule in absorption at a redshift z = 0.68466 in front of the gravitationally lensed quasar B0218+357. We detect the fundamental transition of ortho-water at 556.93 GHz (redshifted to 330.59 GHz). The line is highly optically thick and relatively wide (15 km/s FWHM), with a profile that is similar to that of the previously detected CO(2--1) and HCO^+(2--1) optically thick absorption lines toward this quasar. From the measured level of the continuum at 330.59 GHz, which corresponds to the level expected from the power-law spectrum $S(\nu) \propto \nu^{-0.25}$ already observed at lower frequencies, we deduce that the filling factor of the H_2O absorption is large. It was already known from the high optical thickness of the CO, ^{13}CO and C^{18}O lines that the molecular clouds entirely cover one of the two lensed images of the quasar (all its continuum is absorbed); our present results indicate that the H_2O clouds are covering a comparable surface. The H_2O molecules are therefore not confined to small cores with a tiny filling factor, but are extended over parsec scales. The H_2O line has a very large optical depth, and only isotopic lines could give us the water abundance. We have also searched for the 183 GHz line in absorption, obtaining only an upper limit; this yields constraints on the excitation temperature.Comment: 4 pages, 3 figures, accepted in ApJ Letter

Les grilles pour le développement médical

PCSV, présenté par V. Breton, à paraître dans les Comptes-Rendu de la ConférenceLe développement récent des sciences et technologies de l'information et de la communication permet aujourd'hui la création de véritables infrastructures pour le calcul et le stockage de données hétérogènes à l'échelle régionale, nationale et internationale. Ces infrastructures, appelées grilles informatiques, permettront bientôt d'utiliser les ressources informatiques mutualisées avec autant de facilité que nous utilisons aujourd'hui l'électricité. L'utilisation des grilles afin d'accélérer la découverte de médicaments est une voie très prometteuse pour l'avenir. Par cette approche in silico, le nombre de molécules ainsi que la vitesse de test peuvent être grandement augmentés induisant un coût moindre de développement de médicaments. Du 11 Juillet au 31 Août 2005, l'expérience WISDOM (Wide In Silico Docking On Malaria) a permis de tester rien moins qu'un million de ligands (médicaments potentiels) pour le traitement du paludisme: 1700 ordinateurs à travers le monde ont ainsi été associés à cette démarche permettant de réaliser en un mois ce qui aurait nécessité 80 ans sur un ordinateur classique. L'analyse des résultats est en cours. Par cette approche, on peut souhaiter également que les maladies orphelines puissent bénéficier d'un intérêt nouveau de la part des industries pharmaceutiques, à travers notamment la baisse du coût de développement d'un médicament, principal obstacle actuellement à leur mobilisation

Selective Methylation of Arenes: A Radical C−H Functionalization/Cross‐Coupling Sequence

A selective, nonchelation‐assisted methylation of arenes has been developed. The overall transformation, which combines a C−H functionalization reaction with a nickel‐catalyzed cross‐coupling, offers rapid access to methylated arenes with high para selectivity. The reaction is amenable to late‐stage methylation of small‐molecule pharmaceuticals

The Water Vapor Abundance in Orion KL Outflows

We present the detection and modeling of more than 70 far-IR pure rotational lines of water vapor, including the 18O and 17O isotopologues, towards Orion KL. Observations were performed with the Long Wavelength Spectrometer Fabry-Perot (LWS/FP; R~6800-9700) on board the Infrared Space Observatory (ISO) between ~43 and ~197 um. The water line profiles evolve from P-Cygni type profiles (even for the H2O18 lines) to pure emission at wavelengths above ~100 um. We find that most of the water emission/absorption arises from an extended flow of gas expanding at 25+-5 kms^-1. Non-local radiative transfer models show that much of the water excitation and line profile formation is driven by the dust continuum emission. The derived beam averaged water abundance is 2-3x10^-5. The inferred gas temperature Tk=80-100 K suggests that: (i) water could have been formed in the "plateau" by gas phase neutral-neutral reactions with activation barriers if the gas was previously heated (e.g. by shocks) to >500 K and/or (ii) H2O formation in the outflow is dominated by in-situ evaporation of grain water-ice mantles and/or (iii) H2O was formed in the innermost and warmer regions (e.g. the hot core) and was swept up in ~1000 yr, the dynamical timescale of the outflow.Comment: Accepted for publication in ApJ letters [2006 August 7] (5 pages 2, figures, not edited

Multi-line Herschel/HIFI observations of water reveal infall motions and chemical segregation around high-mass protostars

(Abridged) We use HIFI maps of the 987 GHz H2O 2(02)-1(11) emission to measure the sizes and shapes of 19 high-mass protostellar envelopes. To identify infall, we use HIFI spectra of the optically thin C18O 9-8 and H2O-18 1(11)-0(00) lines. The high-J C18O line traces the warm central material and redshifted H2O-18 1(11)-0(00) absorption indicates material falling onto the warm core. We probe small-scale chemical differentiation by comparing H2O 752 and 987 GHz spectra with those of H2O-18. Our measured radii of the central part of the H2O 2(02)-1(11) emission are 30-40% larger than the predictions from spherical envelope models, and axis ratios are <2, which we consider good agreement. For 11 of the 19 sources, we find a significant redshift of the H2O-18 1(11)-0(00) line relative to C18O 9-8. The inferred infall velocities are 0.6-3.2 km/s, and estimated mass inflow rates range from 7e-5 to 2e-2 M0/yr, with the highest mass inflow rates occurring toward the sources with the highest masses, and possibly the youngest ages. The other sources show either expanding motions or H2O-18 lines in emission. The H2O-18 1(11)-0(00) line profiles are remarkably similar to the "differences" between the H2O 2(02)-1(11) and 2(11)-2(02) profiles, suggesting that the H2O-18 line and the H2O 2(02)-1(11) absorption originate just inside the radius where water evaporates from grains, typically 1000-5000 au from the center. In some sources, the H2O-18 line is detectable in the outflow, where no C18O emission is seen. Together, the H2O-18 absorption and C18O emission profiles show that the water abundance around high-mass protostars has at least three levels: low in the cool outer envelope, high within the 100 K radius, and very high in the outflowing gas. Thus, despite the small regions, the combination of lines presented here reveals systematic inflows and chemical information about the outflows.Comment: Accepted for publication in Astronomy & Astrophysics; 10 pages body + 10 pages appendi

Demonstration of In Silico docking at a large scale on grid infrastructure

présenté par N. Jac