A survey to test the story book knowledge of kindergarten children.

Thesis (Ed.M.)--Boston Universit

Altered distribution of mucosal NK cells during HIV infection.

The human gut mucosa is a major site of human immunodeficiency virus (HIV) infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells have an important role in control of HIV infection, but the mechanism(s) by which they mediate antiviral activity in the gut is unclear. Here, we show that two distinct subsets of NK cells exist in the gut, one localized to intraepithelial spaces (intraepithelial lymphocytes, IELs) and the other to the lamina propria (LP). The frequency of both subsets of NK cells was reduced in chronic infection, whereas IEL NK cells remained stable in spontaneous controllers with protective killer immunoglobulin-like receptor/human leukocyte antigen genotypes. Both IEL and LP NK cells were significantly expanded in immunological non-responsive patients, who incompletely recovered CD4+ T cells on highly active antiretroviral therapy (HAART). These data suggest that both IEL and LP NK cells may expand in the gut in an effort to compensate for compromised CD4+ T-cell recovery, but that only IEL NK cells may be involved in providing durable control of HIV in the gut

G3-homogeneous gravitational instantons

We provide an exhaustive classification of self-dual four-dimensional gravitational instantons foliated with three-dimensional homogeneous spaces, i.e. homogeneous self-dual metrics on four-dimensional Euclidean spaces admitting a Bianchi simply transitive isometry group. The classification pattern is based on the algebra homomorphisms relating the Bianchi group and the duality group SO(3). New and general solutions are found for Bianchi III.Comment: 24 pages, few correction

Relationships Between Excessive Heat and Daily Mortality over the Coterminous U.S

In the United States, extreme heat is the most deadly weather-related hazard. In the face of a warming climate and urbanization, it is very likely that extreme heat events (EHEs) will become more common and more severe in the U.S. Using National Land Data Assimilation System (NLDAS) meteorological reanalysis data, we have developed several measures of extreme heat to enable assessments of the impacts of heat on public health over the coterminous U.S. These measures include daily maximum and minimum air temperatures, daily maximum heat indices and a new heat stress variable called Net Daily Heat Stress (NDHS) that gives an integrated measure of heat stress (and relief) over the course of a day. All output has been created on the NLDAS 1/8 degree (approximately 12 km) grid and aggregated to the county level, which is the preferred geographic scale of analysis for public health researchers. County-level statistics have been made available through the Centers for Disease Control and Prevention (CDC) via the Wide-ranging Online Data for Epidemiologic Research (WONDER) system. We have examined the relationship between excessive heat events, as defined in eight different ways from the various daily heat metrics, and heat-related and all-cause mortality defined in CDC's National Center for Health Statistics 'Multiple Causes of Death 1999-2010' dataset. To do this, we linked daily, county-level heat mortality counts with EHE occurrence based on each of the eight EHE definitions by region and nationally for the period 1999-2010. The objectives of this analysis are to determine (1) whether heat-related deaths can be clearly tied to excessive heat events, (2) what time lags are critical for predicting heat-related deaths, and (3) which of the heat metrics correlates best with mortality in each US region. Results show large regional differences in the correlations between heat and mortality. Also, the heat metric that provides the best indicator of mortality varied by region. Results from this research will potentially lead to improvements in our ability to anticipate and mitigate any significant impacts of extreme heat events on health

Comparison of the in vitro and in vivo susceptibilities of Burkholderia mallei to Ceftazidime and Levofloxacin

<p>Abstract</p> <p>Background</p> <p><it>Burkholderia mallei </it>is a zoonotic Gram negative bacterium which primarily infects solipeds but can cause lethal disease in humans if left untreated. The effect of two antibiotics with different modes of action on <it>Burkholderia mallei </it>strain ATCC23344 was investigated by using <it>in vitro </it>and <it>in vivo </it>studies.</p> <p>Results</p> <p>Determination of minimal inhibitory concentrations (MICs) <it>in vitro </it>was done by the agar diffusion method and the dilution method. The MICs of levofloxacin and ceftazidime were in the similar range, 2.5 and 5.0 μg/ml, respectively. Intracellular susceptibility of the bacterium to these two antibiotics in J774A.1 mouse macrophages <it>in vitro </it>was also investigated. Macrophages treated with antibiotics demonstrated uptake of the drugs and reduced bacterial loads <it>in vitro</it>. The efficacy of ceftazidime and levofloxacin were studied in BALB/c mice as post-exposure treatment following intranasal <it>B. mallei </it>infection. Intranasal infection with 5 × 10⁵CFUs of <it>B. mallei </it>resulted in 90% death in non-treated control mice. Antibiotic treatments 10 days post-infection proved to be effective <it>in vivo </it>with all antibiotic treated mice surviving to day 34 post-infection. The antibiotics did not result in complete clearance of the bacterial infection and presence of the bacteria was found in lungs and spleens of the survivors, although bacterial burden recovered from levofloxacin treated animals appeared reduced compared to ceftazidime.</p> <p>Conclusion</p> <p>Both antibiotics demonstrated utility for the treatment of glanders, including the ability for intracellular penetration and clearance of organisms <it>in vitro</it>.</p

Factorizations of Elements in Noncommutative Rings: A Survey

We survey results on factorizations of non zero-divisors into atoms (irreducible elements) in noncommutative rings. The point of view in this survey is motivated by the commutative theory of non-unique factorizations. Topics covered include unique factorization up to order and similarity, 2-firs, and modular LCM domains, as well as UFRs and UFDs in the sense of Chatters and Jordan and generalizations thereof. We recall arithmetical invariants for the study of non-unique factorizations, and give transfer results for arithmetical invariants in matrix rings, rings of triangular matrices, and classical maximal orders as well as classical hereditary orders in central simple algebras over global fields.Comment: 50 pages, comments welcom

Reinforced composite flywheels and shafts

The maximum safe operating speed or flywheels and shafts made of low tensile strength material is often determined by the speed at which radial tensile stress exceeds a radial tensile stress limit for the material. Circumferentially wound fiber composite material, for example, has a relatively low tensile strength along the radial direction perpendicular to the fibers. To increase the maximum safe operating speed, it is therefore desirable to form a fiber composite flywheel or shaft with radial compressive prestress. Such a prestressed flywheel or shaft has an outer annulus and an inner cylinder disposed in the outer annulus, and an annular layer of solidified bonding agent within an annular region between the outer annulus and the inner cylinder, wherein the outer annulus and the inner cylinder include substantial radial prestress induced by the bonding agent. The rim portion of a flywheel, for example, is formed from an outer ring (the annulus) and an inner ring (the cylinder, which is hollow in this case). Large, thick flywheels preferably have multiple cylindrical sections joined by such layers of bonding agent, and a plurality of the cylindrical sections each including an outer layer of relatively stiff fiber-composite material, and an inner layer of relatively compliant fiber-composite material within an integral matrix material.Board of Regents, University of Texas Syste

The Application of Satellite-Derived, High-Resolution Land Use/Land Cover Data to Improve Urban Air Quality Model Forecasts

Local and state agencies are responsible for developing state implementation plans to meet National Ambient Air Quality Standards. Numerical models used for this purpose simulate the transport and transformation of criteria pollutants and their precursors. The specification of land use/land cover (LULC) plays an important role in controlling modeled surface meteorology and emissions. NASA researchers have worked with partners and Atlanta stakeholders to incorporate an improved high-resolution LULC dataset for the Atlanta area within their modeling system and to assess meteorological and air quality impacts of Urban Heat Island (UHI) mitigation strategies. The new LULC dataset provides a more accurate representation of land use, has the potential to improve model accuracy, and facilitates prediction of LULC changes. Use of the new LULC dataset for two summertime episodes improved meteorological forecasts, with an existing daytime cold bias of approx. equal to 3 C reduced by 30%. Model performance for ozone prediction did not show improvement. In addition, LULC changes due to Atlanta area urbanization were predicted through 2030, for which model simulations predict higher urban air temperatures. The incorporation of UHI mitigation strategies partially offset this warming trend. The data and modeling methods used are generally applicable to other U.S. cities