Yüksek enerjili travma nedeni ile oluşmuş ekstremite defektlerinin tedavisinde negatif basınçlı terapi kullanılması]

Aim: Defects of the extremities due to high-energy trauma are common and it is necessary to repair these defects. Reconstruction is possible with simple surgeries using skin grafts and negative pressure therapy (NPT). In this study, we present our results of the reconstruction of extremity defects caused by high-energy trauma with a simple surgical procedure using NPT. Methods: Patients with soft tissue defects of the upper and lower extremities caused by high energy trauma, who were treated with NPT between November 2009 and June 2015, were included in the study. Results: NPT was performed in 63 patients. The average defect size was 60 cm(2). The patients underwent an average of nine sessions. The average length of hospital stay was 26 days. The defects were reconstructed using skin grafts and local flaps in 58 and two patients, respectively. None of the patients required free flaps. Conclusion: Extremity defects occurring due to high energy trauma can be closed by simple surgical techniques using NPT, patients can be protected from the complications of free tissue transfer, and also treatment is possible at much lower costs

L’image du héros populaire en Asie Mineure : l’exemple de Tchakidji (1872-1912)

Présentation de Tchakidji, bandit social ayant vécu autour de 1900. L’auteur en analyse la présence dans la tradition héroïque, qu’il affilie à l’archétype du bandit d’honneur Köroğlu.Setting out of Tchakidji, a social bandit who lived around 1900. the author analyzes its figure in the heroic tradition by affiliation to the outlaw archetype, Köroğlu

A small cell carcinoma in the testis associated with testicular teratoma

[Abtract Not Available

Changes on soil properties associated with soil depth in eroded areas: a case study of Pamukcular watershed

This study was carried out to investigate changes on soil properties associated with soil depth in eroded areas under semi-arid climate conditions. Pamukcular Watershed (Yusufeli-Artvin-Turkey), with total annual rain amount of 250- 400 mm and alluvial soils formed especially by sudden floods, was chosen as the study area. Due to poor vegetation cover, continuous surface erosion was observed for most of the year in the research area, leading us to predict that negative changes may have occurred in soil physical and chemical properties. In order to determine these changes, disturbed and undisturbed soil samples were taken at two depths (0-10 ve 10-20 cm) in 12 parcels with about 3% slope. When soil samples were taken, it was observed that vegetation cover rate was low (20%-30%). The results show that clay content, moisture, aggregate stability, pH, bulk density and dispersion rate of soils was significantly different between soil depths. However, silt, sand, lime and organic matter contents along with air and hydraulic conductivity did not show significant differences

Effect of urolithiasis in the differential diagnosis of acute abdominal pain in pediatric age population

Amaç: Akut karın ağrısı çocuklarda acil servise en sık başvuru sebeplerinden biridir. the most common reason of admission to emerKarın ağrısı, enfeksiyon gibi kolay tedavi edigency in children. Acute abdomimal pain may lebilir nedenlerden olabileceği gibi ciddi morbidite ve mortalite nedeni olabilecek durumlardan da kaynaklanabilir. Bu durumların sık resulted in severe morbidity or mortality. Urolitgörülenlerinden biri de üriner sistem taş hashiasis is one of these commonly seen conditions.talığıdır (ÜSTH).Gereç ve Yöntemler: Akut karın ağrısı ren presented to the emergency service with acute abdominal pain were reviewed. Routine şikayeti ile acil servise başvuran 442 hasta çalışmaya dahil edildi. Tüm hastalara rutin fizik physical examination and abdominal ultrasomuayene ve batın ultrasonografisi yapıldı.nography were performed.Bulgular: Karın ağrısının en sık saptanan medikal nedenleri sıklık sırasına göre, üriner minal pain are, urinary infection (n=55, 12.4%), enfeksiyon n=55 %12.4, üriner sistem taş hasurolithiasis n=38, 8.6%, mesenteric lymphadenitalığı n= 38 %8,6 mezenterik lenfadenit n=34 tis n=34, 7.7%, problems of hepatobiliary system %7.7, hepatobilier sistem kaynaklı problemler n=22, 5%, urinary tract anomalies n=12, 2.7% n=22 ( %5), üriner sistem anomalileri n=12 and idiopathic abdominal pains n=11, 2.5%. %2.7 ve nedeni belirlenemeyen karın ağrısı Surgical reasons were 6.1% n=27. Abdominal n=11 %2.5 idi. Cerrahi nedenler n=27 %6,1 ultrasonography was normal in 243 children.vakada karın ağrısı sebebi olarak saptandı. 243 hastada yapılan tüm batın ultrasonografi tetkiki normal sınırlarda bulundu.Sonuç: Çocuklarda ÜSTH böbrek yetmezliğine kadar varabilen ciddi morbidite nedenidir. ÜSTH'nin ilk ve en sık klinik prezentasyonu karın ağrısıdır. Bu sebeple hastaneye karın abdominal pain.ağrısı şikayeti ile başvuran çocuklarda ÜSTH ön planda düşünülmelidirObjectives: Acute abdominal pain is one of the most common reason of admission to emergency in children. Acute abdomimal pain may be a symptom of simple conditions such as infections or due to serious conditions which can be resulted in severe morbidity or mortality. Urolithiasis is one of these commonly seen conditions. Material and Methods: A total of 442 children presented to the emergency service with acute abdominal pain were reviewed. Routine physical examination and abdominal ultrasonography were performed. Results: The most common causes of abdominal pain are, urinary infection (n=55, 12.4%), urolithiasis n=38, 8.6%, mesenteric lymphadenitis n=34, 7.7%, problems of hepatobiliary system n=22, 5%, urinary tract anomalies n=12, 2.7% and idiopathic abdominal pains n=11, 2.5%. Surgical reasons were 6.1% n=27. Abdominal ultrasonography was normal in 243 children. Conclusion: Pediatric urolithiasis is a serious condition which can cause severe morbidity. Acute abdominal pain is the first and most common sypmtom of urolithiasis, therefore urolithiasis must be primarily in mind in children presented to the emergency room with acute abdominal pai

Treatment of renal stones with flexible ureteroscopy in preschool age children

WOS: 000336383500008PubMed ID: 24374900The aim of the study is to evaluate the efficacy and safety of retrograde intrarenal surgery (RIRS) to treat renal stones in preschool age ( 4 mm, a second-stage RIRS was performed. The pre-operative, operative and post-operative data of the patients were retrospectively analyzed. A total of 65 patients with a mean age of 4.31 +/- A 1.99 years (6 months-7 years) were included in the present study. The mean stone size was 14.66 +/- A 6.12 mm (7-30 mm). The mean operative time was 46.47 +/- A 18.27 min. In 5 (7.69 %) patients, the initial procedure failed to reach the renal collecting system and ended with the insertion of a pigtail stent. The stone-free rates were 83.07 and 92.3 % after the first and second procedures, respectively. Complications were observed in 18 (27.7 %) patients and classified according to the Clavien system. Post-operative hematuria (Clavien I) occurred in 6 (9.2 %) patients, post-operative urinary tract infection with fever (Clavien II) was observed in 10 (15.4 %) patients, and ureteral wall injury (Clavien III) was noted in 2 (3 %) patients. RIRS is an effective and safe procedure that can be used to manage renal stones in preschool age children

Developing a scoring function for NMR structure-based assignments using machine learning

Determining the assignment of signals received from the ex- periments (peaks) to speci_c nuclei of the target molecule in Nuclear Magnetic Resonance (NMR1) spectroscopy is an important challenge. Nuclear Vector Replacement (NVR) ([2, 3]) is a framework for structure- based assignments which combines multiple types of NMR data such as chemical shifts, residual dipolar couplings, and NOEs. NVR-BIP [1] is a tool which utilizes a scoring function with a binary integer programming (BIP) model to perform the assignments. In this paper, support vector machines (SVM) and boosting are employed to combine the terms in NVR-BIP's scoring function by viewing the assignment as a classi_ca- tion problem. The assignment accuracies obtained using this approach show that boosting improves the assignment accuracy of NVR-BIP on our data set when RDCs are not available and outperforms SVMs. With RDCs, boosting and SVMs o_er mixed results

KRAS Mutation in Small Cell Lung Carcinoma and Extrapulmonary Small Cell Cancer

Background: Lung cancer is one of the most lethal cancers. It is mainly classified into 2 groups: non-small cell lung can-cer (NSCLC) and small cell lung cancer (SCLC). Extrapul-monary small cell carcinomas (EPSCC) are very rare. The Ras oncogene controls most of the cellular functions in the cell. Overall, 21.6% of human cancers contain a Kirsten Ras (KRAS) mutation. SCLC and EPSCC have several similar features but their clinical course is different.Aims: We investigated the KRAS mutation status in SCLC and EPSCC.Study design: Mutation research.Methods: Thirty-seven SCLC and 15 EPSCC patients were included in the study. The pathological diagnoses were confirmed by a second pathologist. KRAS analysis was performed in our medical genetic department. DNA isola-tion was performed with primary tumor tissue using the QIAamp DNA FFPE Tissue kit (Qiagen; Hilden, Germany) in all patients. The therascreen KRAS Pyro Kit 24 V1 (Qia-gen; Hilden, Germany) was used for KRAS analyses. Results: Thirty-four (91.9%) of the SCLC patients were male, while 11 (73.3%) of the EPSCC l patients were fe-male. SCLC was more common in males, and EPSCC in females (p=0.001). A KRAS mutation was found in 6 (16.2%) if SCLC patients. The most common mutation was Q61R (CAA>CGA). Among the 15 EPSCC patients, 2 had a KRAS mutation (13.3%). When KRAS mutant and wild type patients were compared in the SCLC group, no differ-ence was found for overall survival (p=0.6).Conclusion: In previous studies, the incidence of KRAS mutation in SCLC was 1-3%; however, it was 16.2% in our study. Therefore, there may be ethnic and geographical differences in the KRAS mutations of SCLC. As a result, KRAS mutation should not be excluded in SCL