Antibacterial properties of phosphine gold(i) complexes with 5-fluorouracil

New gold(I) complexes with coordination to 5-fluorouracil (5-FU), an anticancer drug with antibacterial properties, have been synthesised and characterised, and are the first reported examples of 5-FU–Au compounds. These new complexes show high solution stability, even in the presence of a cysteine derivative, and so were evaluated as antibacterial compounds against model Gram-positive and Gram-negative bacteria. All the complexes show excellent antibacterial activity against Gram-positive B. subtilis, most of them improving the activity of 5-FU alone. Furthermore, these new complexes are also active against Gram-negative E. coli, where [Au(5-FU)(PTA)], the complex with the smallest phosphane, is the most bactericidal, 32 times more active than 5-FU on its own

A synthesis of the prehistory of Madrid trough the revision of the bento collection

El trabajo ofrece una revisión de la Prehistoria Reciente de la Cuenca Baja del Manzanares que sintetiza el proceso histórico desde el Neolítico hasta el Bronce Final en elinterior peninsular. Para ello se han reinterpretado los datos que ofrecen los numerosos yacimientos de la zona y algunos de los materiales más significativos depositados en el Museo Arqueológico de Barcelona, que forman parte de la Colección Bento.This paper offers a revision oftheRecient Prehistoryin LoverManzanares Valley, with a syntesis of historical process from Neolithic to Final Bronze Age development in the Center of Iberian Peninsula. With this purpouse we have reinterpreted the data offered by the sites of the area, and most significative materialsincluded in Bento Collection, stored in ArchaeologicalMuseum of Catalonia in Barcelona

Aplicación de técnicas de minería de datos en redes sociales/web

[ES Las técnicas de minería de datos permiten obtener información de redes sociales como Twitter. Su análisis correcto proporciona un valor adicional a la recuperación de información. El procesado de lenguaje natural, así como la delimitación geográfica del origen de sus mensajes, se convierte en un objetivo fundamental y punto de partida de cualquier investigación. Por ello, nuestro estudio se basa en la realización de una aplicación que gestione y obtenga datos sobre el uso de los lenguajes oficiales de las comunidades autonómicas en Twitter.[CA] Les tècniques de mineria de dades permeten obtenir informació de xarxes socials com Twitter. La seua anàlisi correcta proporciona un valor addicional a la recuperació d'informació. El processat de llenguatge natural, així com la delimitació geogràfica de l'origen dels seus missatges, es converteix en un objectiu fonamental i punt de partida de qualsevol investigació. Per això, el nostre estudi es basa en la realització d'una aplicació que gestione i done dades sobre l'ús dels llenguatges oficials de les comunitats autonòmiques a Twitter.[EN] Data mining techniques obtain information from social networks like Twitter. The correct analysis of this data can provide useful and valuable knowledge. Natural language processing and geolocation of messages have become fundamental tools and a starting point of many investigations. This study addresses the development of an application to obtain and analyse Twitter data about the use of the official languages of the autonomous regions of Spain.Asensio Blasco, E. (2015). Aplicación de técnicas de minería de datos en redes sociales/web. http://hdl.handle.net/10251/56102.TFG

Violencias "por odio" y discriminación motivadas por SOGIESC: estudio de caso: la Comunidad Autónoma de Madrid

[ES]El objeto de este trabajo de investigación es conocer, a través del análisis cuantitativo de los datos y el cualitativo de los testimonios de las víctimas, una realidad y una tendencia hasta el momento no analizada, como es la relativa a las violencias (y discriminaciones) de carácter prejuicioso e intolerante que se enmarcan dentro de lo que popularmente se conoce como “delitos de odio” motivados por la orientación sexual y/o identidad de género de la personas o grupo de personas que las padecen y con ellas, con las violencias, la conculcación de sus derechos constitucionale

Special contribution: Small questionnaire for the trade union action in the domestic work sector

El día 14 de noviembre de 2018, se celebró el II Seminario General de Trabajo Doméstico, en el marco del Seminario Permanente con idéntico nombre. A las 16. 00 se previó una mesa redonda en la que estaban representadas CCOO, UGT y USO. Moderaba el acto la profesora Patricia Nieto Rojas. El objeto del debate se centró en uno de los Retos futuros del Trabajo de Servicio Doméstico, el de la representación colectiva de las trabajadoras del hogar. La moderadora plantearía algunas preguntas que se debatirían por la mesa entre sí, y con el público. A esas preguntas responde Doña Elena Blasco, cuyas consideraciones se traducen aquíOn November 14, 2018, the II General Seminar on Domestic Work was held, within the framework of the Permanent Seminar with the same name. At 16.00 a round table was planned in which CCOO, UGT and USO were represented. The act was moderated by Professor Patricia Nieto Rojas. The subject of the debate focused on one of the future Challenges of Domestic Service Work, that of the collective representation of domestic workers. The moderator would ask some questions that would be discussed by the table among themselves, and with the audience. Doña Elena Blasco answers those questions, whose considerations are translated here.Universidad Pablo de Olavid

Arc welding of Dissimilar Metals:FEA and Experiments

Assuming an elliptical disk heat source, several results of theoretical and experimental investigations on heat transfer in copper - low carbon steel welded joints are presented in the first part of the paper. Using thin sheets, temperature variation in the thickness direction is negligible and heat flow is considered two-dimensional. Convection and radiation influence, and thermo-physical properties depending on the temperature are considered in the model. Measurements and visualization of the temperatures distribution have been made during welding using infrared thermography. The proposed theoretical method using finite element analysis was validated for the temperatures prediction in the welded joint. In the second part of the paper, the influence of the welding process on the structural modifications and grains’ size in the heat affected zone (HAZ) of both base materials (BM) is described. Discussion on the graphs of temperatures variation vs. microstructural analysis enables conclusions on the potential undesired structural changes and related preventing measures. The asymmetric position of the heat source closer to the material having a higher thermal conductivity is an effective method for controlling the temperature field

SIOS-m: desarrollo y simulación de un sistema Inteligente orientado a servicios móviles

El proyecto SIOS-m ha consistido principalmente en la creación de una plataforma de simulación orientada a servicios móviles. Para el desarrollo de la plataforma más idónea ha sido necesaria una investigación previa de las tecnologías propias de estos servicios. Y, partiendo de esta base, construir una aplicación inteligente que sea capaz de centralizar el proceso de comunicación entre el usuario final y los servicios ofrecidos por el proveedor, adaptándose en cada caso a las necesidades del usuario. [ABSTRACT] The SIOS-m project has consisted primarily on the creation of a simulation platform oriented to mobile services. In order to develop the ideal platform for the project it has been necessary to perform a prior study of the technologies associated to these services and based on these studies, build an intelligent application. This application is capable of centralizing the Communication process between the end-user and the services offered by the service provider, and furthermore adapt itself to the needs of each user

Complement Mediated Endothelial Damage in Thrombotic Microangiopathies

Thrombotic microangiopathies (TMA) constitute a group of different disorders that have a common underlying mechanism: the endothelial damage. These disorders may exhibit different mechanisms of endothelial injury depending on the pathological trigger. However, over the last decades, the potential role of the complement system (CS) has gained prominence in their pathogenesis. This is partly due to the great efficacy of complement-inhibitors in atypical hemolytic syndrome (aHUS), a TMA form where the primary defect is an alternative complement pathway dysregulation over endothelial cells (genetic and/or adquired). Complement involvement has also been demonstrated in other forms of TMA, such as thrombotic thrombocytopenic purpura (TTP) and in Shiga toxin-producing Escherichia coli hemolytic uremic syndrome (STEC-HUS), as well as in secondary TMAs, in which complement activation occurs in the context of other diseases. However, at present, there is scarce evidence about the efficacy of complement-targeted therapies in these entities. The relationship between complement dysregulation and endothelial damage as the main causes of TMA will be reviewed here. Moreover, the different clinical trials evaluating the use of complement-inhibitors for the treatment of patients suffering from different TMA-associated disorders are summarized, as a clear example of the entry into a new era of personalized medicine in its management

Integrating HBIM models in the management of the public use of heritage buildings

[Otros] Le plus grand défi à relever pour bien gérer l¿accès du public aux édifices patrimoniaux et assurer la faisabilité à long terme de leur réutilisation est d¿établir une relation durable entre les visiteurs et les biens. L¿objectif de ce document est donc d¿identifier le rôle potentiel de la modélisation des données sur les bâtiments historiques (MDBH) pour l¿usage du public dans les bâtiments patrimoniaux. L¿étude, qui fait partie d¿un projet de recherche en science de la conception, limite sa portée à l¿élaboration des deux premières étapes d¿un protocole de MDBH complet pour l¿utilisation publique du patrimoine, en mettant l¿accent sur la gestion des visiteurs, la programmation de la conservation préventive et de l¿interprétation et de la diffusion du patrimoine afin de résoudre les difficultés décelées dans la gestion de ces quatre domaines. La méthodologie suivie comprend une revue de la littérature, une analyse d¿études de cas, des entrevues avec des intervenants, des visites sur le terrain et l¿analyse de documents techniques. Les résultats indiquent que la MDBH peut aider à améliorer et à optimiser la gestion de l¿utilisation des bâtiments historiques par le public.[EN] The greatest challenge in managing public access to heritage buildings and ensuring the long-term feasibility of their reuse is to establish a sustainable relationship between visitors and assets. The aim of this paper is thus to identify the potential role of Historic Building Information Modelling (HBIM) for public use in heritage buildings. The study, which is part of a design science research project, limits its scope to the development of the two first stages of a comprehensive HBIM protocol for the public use of heritage, focusing on visitor management, programming preventative conservation, and heritage interpretation and dissemination to solve the difficulties detected in the management of these four areas. The methodology followed involves a literature review, case study analysis, interviews with stakeholders, field visits, and analysis of technical documents. Results indicate that HBIM can help to improve and optimize the management of the public use of historic buildings.Authors thank the Editorial Board of the Canadian Journal of Civil Engineering and the reviewers at the 6th BIM-Lean workshop held at the University of Huddersfield for their reviews and useful comments. In addition, we also thank the experts in public use management for the data provided in the interviews, as well as the San Juan del Hospital, Monastery of the Descalzas Reales, and Cerralbo Museum for allowing us to use them as case studies.Salvador-García, E.; G-Valldecabres, J.; Viñals Blasco, MJ. (2020). Integrating HBIM models in the management of the public use of heritage buildings. Canadian Journal of Civil Engineering. 47(2):228-235. https://doi.org/10.1139/cjce-2018-0338S228235472Alonso-Monasterio, P. 2014. Análisis de la eficiencia comunicativa y las funciones interpretativas de los mapas turísticos para la visita de espacios con patrimonio. Doctoral thesis, Universitat Politècnica de València.Baik, A., and Boehm, J. 2017. Jeddah heritage building information modelling (JHBIM). In Heritage building information modelling. Routledge Taylor & Francis Group, London and New York. pp. 133–153.Barazzetti, L., Banfi, F., Brumana, R., Oreni, D., Previtali, M., and Roncoroni, F. 2015. HBIM and augmented information: towards a wider user community of image and range-based reconstructions. In The international archives of the photogrammetry, remote sensing and spatial information sciences. Vol. XL-5/W7, pp. 35–42.British Standards Institution (BSI). 2013. BS: 7913: Guide to the conservation of historic buildings.Bruno, S., De Fini, M., and Fatiguso, F. 2018. Historic building information modelling: performance assessment for diagnosis-aided information modelling and management. In Automation in Construction. Vol. 86, pp. 256–276.Casu, P., and Pisu, C. 2016. BIM application in documenting and recreating lost architectural heritage. In Handbook of research on visual computing and emerging geometrical design tools. IGI Global. pp. 144–173.Cos-Gayón López, F., Cordón Llácer, J., Anquela Julián, A.B., and Bonet Edesa, J.A. 2016. Aplicacions de realidad virtual inmersiva en el Teatro Romano de Sagunto (Valencia, España). In EUBIM. Universitat Politècnica de València, Valencia, Spain. pp. 138–149.Counsell, J., and Taylor, T. 2017. What are the goals of HBIM. In Heritage building information modelling. Routledge Taylor & Francis Group, London and New York.Edwards, J. 2017. It’s BIM but not as we know it! In Heritage building information modelling. Routledge Taylor & Francis Group, London and New York.Garagnani, S., and Manferdini, A.M. 2013. Parametric accuracy: Building information modeling process applied to the cultural heritage preservation. In 3DArch2013. The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Trento, Italia. pp. 87–92.García Hernández, M. 2003. Turismo y conjuntos monumentales: capacidad de acogida turística y gestión de flujos de visitantes. Tirant lo Blanch. València.Ham, S. 1992. Environmental interpretation. A practical guide for people with big ideas and small budgets. North American Press.Hawas, S., and Marzouk, M. 2017. Integrating value map with building information modelling approach for documenting historic buildings in Egypt. In Heritage building information modelling. Routledge Taylor & Francis Group, London & New York.Hegazy, Y.S. 2017. HBIM applications in Egyptian heritage sites. In Heritage building information modelling. Routledge Taylor & Francis Group, London & New York.Hilfert, T., & König, M. (2016). Low-cost virtual reality environment for engineering and construction. Visualization in Engineering, 4(1). doi:10.1186/s40327-015-0031-5Jordan-Palomar, I., Tzortzopoulos, P., García-Valldecabres, J., & Pellicer, E. (2018). Protocol to Manage Heritage-Building Interventions Using Heritage Building Information Modelling (HBIM). Sustainability, 10(4), 908. doi:10.3390/su10040908Ministerio de Educación, Cultura y Deporte de España. 2011. Plan nacional de conservación preventiva. Secretaría General Técnica. Centro de publicaciones. Edited by Ministerio de Educación Cultura y Deporte.Salvador García, E., García-Valldecabres, J., & Viñals Blasco, M. J. (2018). The use of HBIM models as a tool for dissemination and public use management of historical architecture: A review. International Journal of Sustainable Development and Planning, 13(01), 96-107. doi:10.2495/sdp-v13-n1-96-107UNESCO. 2014. 37 C/4 Estrategia a medio plazo. Paris, France.(2004). Journal of Management Studies, 41(2). doi:10.1111/joms.2004.41.issue-2Viñals, M.J., and Alonso-Monasterio, P. 2013. Analysis of the spatial standards and perceptual components of the recreational carrying capacity applied to archaeological sites. Case study of Castellet de Bernabé (Lliria, Spain). In Methods and analysis on tourism and environment. Edited in Mondejar. Nova Science, New York. pp. 109–120.Viñals, M.J., Morant, M., and Alonso-Monasterio, P. 2013. Key issue in the ancient theatres recreational carrying capacity assessment studies. In Prototype of management plan for enhancement of new actualities. Juan, F. (coord.), Universitat Politècnica de València. pp. 89–96.Viñals, M. J., Martínez, I., Abdennadher, A., & Teruel, L. (2014). A recreational carrying capacity assessment of the 16th century Spanish Fort of Santiago on the Island of Chikly, Tunisia. Defence Sites II. doi:10.2495/dshf140161Viñals, M.J., Mayor, M., Martínez-Sanchis, I., Alonso-Monasterio, P., and Morant, M. 2017. Turismo sostenible y patrimonio: herramientas para la puesta en valor y planificación. Universitat Politècnica de València

El agua: una reina en peligro

Textos de las páginas 18 a 23, Luisa Hurtado González.El Agua es alegre y divertida; le encanta juguetear y disfrazarse de nube, lluvia o nieve... A veces se enfada y puede resultar terrible y cruel. Aprende a conocerla y a respetarla en este cuento