9,705 research outputs found
Cricket Flour-Laden Millet Flour Blends' Physical and Chemical Composition and Adaptation in Dried Pasta Products
Increasing the protein and antioxidant content of food products is a constant challenge amongst researchers. Dried pasta products are popular amongst all groups of society. The most important factor in pasta processing is the quality of the flour. Millet (Panicum miliaceum) flour has high nutritional value, enriching it with cricket (Gryllus bimaculatus) flour is good choice to increase the quality of protein composition and antioxidant properties of products. Flour mixtures of millet and insect flours (5% and 10%) were analysed after mixing and pasta processing. Addition of wheat gluten improved both texture and nutrition value of pasta products. Total polyphenol content, antioxidant capacity, total protein content, free and total amino acid composition were studied. Quality analysis of dried pasta products were carried out according to Hungarian standards. Data was analysed with Kruskal-Wallis test, Dunn's pair-wise post hoc test was used with Bonferroni correction. The correlation was determined by Spearman's rank. Addition of cricket flour modified the pH, acid value, moisture content, and colour of the samples, these changes lasted during storage. Enrichment could increase the total phenol content significantly even at the low level of 10%. Heat treatment during pasta processing had negative effect on the antioxidant capacity except at higher cricket flour contents. Cricket flour's high protein content proportionately increased millet flour's, thus pasta products'. Dried pasta products passed all quality norms. Enrichment of millet flour with cricket flour is favourable from both nutritional and quality aspects
Sign-reversal of the in-plane resistivity anisotropy in hole-doped iron pnictides
The in-plane anisotropy of the electrical resistivity across the coupled
orthorhombic and magnetic transitions of the iron pnictides has been
extensively studied in the parent and electron-doped compounds. All these
studies universally show that the resistivity across the long
orthorhombic axis - along which the spins couple antiferromagnetically
below the magnetic transition temperature - is smaller than the resistivity
of the short orthorhombic axis , i. e. .
Here we report that in the hole-doped compounds
BaKFeAs, as the doping level increases, the
resistivity anisotropy initially becomes vanishingly small, and eventually
changes sign for sufficiently large doping, i. e. . This
observation is in agreement with a recent theoretical prediction that considers
the anisotropic scattering of electrons by spin-fluctuations in the
orthorhombic/nematic state.Comment: This paper has been replaced by the new version offering new
explanation of the experimental results first reported her
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 218, Revision 1 (FGE.218Rev1): alpha,beta-Unsaturated aldehydes and precursors from subgroup 4.2 of FGE.19: Furfural derivatives
In search of innovative capabilities of communities of practice : a systematic review and typology for future research
The concept of communities of practice has generated considerable debate among scholars of management.
Attention has shifted from a concern with the transmission and reproduction of knowledge towards their
utility for enhancing innovative potential. Questions of governance, power, collaboration and control have
all entered the debate with different theorizations emerging from a wide mix of empirical research. We
appraise these key findings through a critical review of the literature. From a divergent range of findings,
we identify four main ways in which communities of practice enable and constrain innovative capabilities
as (a) enablers of learning for innovation, (b) situated platforms for professional occupations, (c) dispersed
collaborative environments and (d) governance structures designed for purpose. Our conclusion signals the
way forward for further research that could be used to improve our understanding of different contextual
forms and how they may align with organizations in enabling rather than constraining innovative capabilities
Local and global modes of drug action in biochemical networks
It becomes increasingly accepted that a shift is needed from the traditional target-based approach of drug development to an integrated perspective of drug action in biochemical systems. We here present an integrative analysis of the interactions between drugs and metabolism based on the concept of drug scope. The drug scope represents the set of metabolic compounds and reactions that are potentially affected by a drug. We constructed and analyzed the scopes of all US approved drugs having metabolic targets. Our analysis shows that the distribution of drug scopes is highly uneven, and that drugs can be classified into several categories based on their scopes. Some of them have small scopes corresponding to localized action, while others have large scopes corresponding to potential large-scale systemic action. These groups are well conserved throughout different topologies of the underlying metabolic network. They can furthermore be associated to specific drug therapeutic properties
Back reaction, emission spectrum and entropy spectroscopy
Recently, an interesting work, which reformulates the tunneling framework to
directly produce the Hawking emission spectrum and entropy spectroscopy in the
tunneling picture, has been received a broad attention. However, during the
emission process, most related observations have not incorporated the effects
of back reaction on the background spacetime, whose derivations are therefore
not the desiring results for the real physical process. With this point as a
central motivation, in this paper we suitably adapt the \emph{reformulated}
tunneling framework so that it can well accommodate the effects of back
reaction to produce the Hawking emission spectrum and entropy spectroscopy.
Consequently, we interestingly find that, when back reaction is considered, the
Parikh-Wilczek's outstanding observations that, an isolated radiating black
hole has an unitary-evolving emission spectrum that is \emph{not} precisely
thermal, but is related to the change of the Bekenstein-Hawking entropy, can
also be reproduced in the reformulated tunneling framework, meanwhile the
entropy spectrum has the same form as that without inclusion of back reaction,
which demonstrates the entropy quantum is \emph{independent} of the effects of
back reaction. As our final analysis, we concentrate on the issues of the black
hole information, but \emph{unfortunately} find that, even including the
effects of back reaction and higher-order quantum corrections, such tunneling
formalism can still not provide a mechanism for preserving the black hole
information.Comment: 16 pages, no figure, use JHEP3.cls. to be published in JHE
Quantum corrections and black hole spectroscopy
In the work \cite{BRM,RBE}, black hole spectroscopy has been successfully
reproduced in the tunneling picture. As a result, the derived entropy spectrum
of black hole in different gravity (including Einstein's gravity,
Einstein-Gauss-Bonnet gravity and Ho\v{r}ava-Lifshitz gravity) are all evenly
spaced, sharing the same forms as , where physical process is only
confined in the semiclassical framework. However, the real physical picture
should go beyond the semiclassical approximation. In this case, the physical
quantities would undergo higher-order quantum corrections, whose effect on
different gravity shares in different forms. Motivated by these facts, in this
paper we aim to observe how quantum corrections affect black hole spectroscopy
in different gravity. The result shows that, in the presence of higher-order
quantum corrections, black hole spectroscopy in different gravity still shares
the same form as , further confirming the entropy quantum is universal
in the sense that it is not only independent of black hole parameters, but also
independent of higher-order quantum corrections. This is a desiring result for
the forthcoming quantum gravity theory.Comment: 14 pages, no figure, use JHEP3.cls. to be published in JHE
Successful Carotid Stenting for Chronic Total Occlusion of the Internal Carotid Artery
A 64-year-old man complaining of pulsatile headache was admitted. Imaging studies revealed a near-total occlusion of the right proximal internal carotid artery (ICA) with slow antegrade flow into the distal ICA. Right cerebral flow was supplied by collateral flow through the posterior communicating and ophthalmic arteries. He was successfully treated by carotid artery stenting. No new neurological deficit or transient ischemic attack occurred after treatment
Targeted knock-down of miR21 primary transcripts using snoMEN vectors induces apoptosis in human cancer cell lines
We have previously reported an antisense technology, 'snoMEN vectors', for targeted knock-down of protein coding mRNAs using human snoRNAs manipulated to contain short regions of sequence complementarity with the mRNA target. Here we characterise the use of snoMEN vectors to target the knock-down of micro RNA primary transcripts. We document the specific knock-down of miR21 in HeLa cells using plasmid vectors expressing miR21-targeted snoMEN RNAs and show this induces apoptosis. Knock-down is dependent on the presence of complementary sequences in the snoMEN vector and the induction of apoptosis can be suppressed by over-expression of miR21. Furthermore, we have also developed lentiviral vectors for delivery of snoMEN RNAs and show this increases the efficiency of vector transduction in many human cell lines that are difficult to transfect with plasmid vectors. Transduction of lentiviral vectors expressing snoMEN targeted to pri-miR21 induces apoptosis in human lung adenocarcinoma cells, which express high levels of miR21, but not in human primary cells. We show that snoMEN-mediated suppression of miRNA expression is prevented by siRNA knock-down of Ago2, but not by knock-down of Ago1 or Upf1. snoMEN RNAs colocalise with Ago2 in cell nuclei and nucleoli and can be co-immunoprecipitated from nuclear extracts by antibodies specific for Ago2
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