RSAT: regulatory sequence analysis tools

The regulatory sequence analysis tools (RSAT, http://rsat.ulb.ac.be/rsat/) is a software suite that integrates a wide collection of modular tools for the detection of cis-regulatory elements in genome sequences. The suite includes programs for sequence retrieval, pattern discovery, phylogenetic footprint detection, pattern matching, genome scanning and feature map drawing. Random controls can be performed with random gene selections or by generating random sequences according to a variety of background models (Bernoulli, Markov). Beyond the original word-based pattern-discovery tools (oligo-analysis and dyad-analysis), we recently added a battery of tools for matrix-based detection of cis-acting elements, with some original features (adaptive background models, Markov-chain estimation of P-values) that do not exist in other matrix-based scanning tools. The web server offers an intuitive interface, where each program can be accessed either separately or connected to the other tools. In addition, the tools are now available as web services, enabling their integration in programmatic workflows. Genomes are regularly updated from various genome repositories (NCBI and EnsEMBL) and 682 organisms are currently supported. Since 1998, the tools have been used by several hundreds of researchers from all over the world. Several predictions made with RSAT were validated experimentally and published

Regional Sanctions Against Burundi: A Powerful Campaign and Its Unintended Consequences

This paper examines the impact of regionally imposed sanctions on the trajectory of the Burundian regime and its involvement in the peace process following the 1996 coup in the country. Despite the country's socioeconomic and geopolitical vulnerability, the Buyoya government withstood the pressure from the sanctions. Through a vocal campaign against these sanctions, the new government mitigated the embargo's economic consequences and partially reestablished its international reputation. Paradoxically, this campaign planted the seed for comprehensive political concessions in the long term. While previous literature has attributed the sanctions' success in pressuring the government into negotiations to their economic impact, the government actually responded to the sanction senders' key demand to engage in unconditional, inclusive peace talks under the auspices of the regional mediator once the economy had already started to recover. The regime's anti-sanctions campaign, with its emphasis on the government's willingness to engage in peace talks, backfired, with Buyoya forced to negotiate after having become entrapped in his own rhetoric

Turbulent Flame Sub-Grid Scale Modeling with High-Order Spectral Difference

International audienc

A Scalar Limiting Algorithm for High-Order Methods

International audienc

Turbulent Flame Sub-Grid Scale Modeling with High-Order Spectral Difference

International audienc

Déchets, effluents et pollution

NGO, Christian. REGENT, Alain . Déchets, effluents et pollution. Impact sur l'environnement et la santé. Paris: Dunod, 2008. Coll. UniverSciences Aujourd'hui, le volume et le rythme de production des déchets et de la pollution mettent en péril les grands équilibres naturels. Les auteurs font le point sur les différentes sources de pollution et de déchets et proposent des solutions pour une maîtrise efficace. En effet, les communautés modernes doivent réagir et imaginer des solutions pour ..

A Scalar Limiting Algorithm for High-Order Methods

International audienc

A new approach to secure scalar boundedness in flame simulation with high-order spectral difference methods on unstructured meshes

International audienc

A new approach to secure scalar boundedness in flame simulation with high-order spectral difference methods on unstructured meshes

International audienc