The Energetic Gamma-Ray Experiment Telescope (EGRET) Science Symposium

The principle purpose of this symposium is to provide the EGRET (Energetic Gamma-Ray Experiment Telescope) scientists with an opportunity to study and improve their understanding of high energy gamma ray astronomy. The Symposium began with the galactic diffusion radiation both because of its importance in studying galactic cosmic rays, galactic structure, and dynamic balance, and because an understanding of its characteristics is important in the study of galactic sources. The galactic objects to be reviewed included pulsars, bursts, solar flares, and other galactic sources of several types. The symposium papers then proceeded outward from the Milky Way to normal galaxies, active galaxies, and the extragalactic diffuse radiation

Gravitons and Dark Matter in Universal Extra Dimensions

Models of Universal Extra Dimensions (UED) at the TeV scale lead to the presence of Kaluza Klein (KK) excitations of the ordinary fermions and bosons of the Standard Model that may be observed at hadron and lepton colliders. A conserved discrete symmetry, KK-parity, ensures the stability of the lightest KK particle (LKP), which, if neutral, becomes a good dark matter particle. It has been recently shown that for a certain range of masses of the LKP a relic density consistent with the experimentally observed one may be obtained. These works, however, ignore the impact of KK graviton production at early times. Whether the G^1 is the LKP or not, the G^n tower thus produced can decay to the LKP, and depending on the reheating temperature, may lead to a modification of the relic density. In this article, we show that this effect may lead to a relevant modification of the range of KK masses consistent with the observed relic density. Additionally, if evidence for UED is observed experimentally, we find a stringent upper limit on the reheating temperature depending on the mass of the LKP observed.Comment: References added. 38 pages, 18 figures. Submitted to Phys. Rev.

<i>De novo</i> transcriptome profiling unveils the regulation of phenylpropanoid biosynthesis in unripe <i>Piper nigrum</i> berries

BACKGROUND: Black pepper (Piper nigrum L.) is rich in bioactive compounds that make it an imperative constituent in traditional medicines. Although the unripe fruits have long been used in different Ayurvedic formulations, the mechanism of gene regulation resulting in the production of the bioactive compounds in black pepper is not much investigated. Exploring the regulatory factors favouring the production of bioactive compounds ultimately help to accumulate the medicinally important content of black pepper. The factors that enhance the biosynthesis of these compounds could be potential candidates for metabolic engineering strategies to obtain a high level production of significant biomolecules. RESULTS: Being a non-model plant, de novo sequencing technology was used to unravel comprehensive information about the genes and transcription factors that are expressed in mature unripe green berries of P. nigrum from which commercially available black pepper is prepared. In this study, the key gene regulations involved in the synthesis of bioactive principles in black pepper was brought out with a focus on the highly expressed phenylpropanoid pathway genes. Quantitative real-time PCR analysis of critical genes and transcription factors in the different developmental stages from bud to the mature green berries provides important information useful for choosing the developmental stage that would be best for the production of a particular bioactive compound. Comparison with a previous study has also been included to understand the relative position of the results obtained from this study. CONCLUSIONS: The current study uncovered significant information regarding the gene expression and regulation responsible for the bioactivity of black pepper. The key transcription factors and enzymes analyzed in this study are promising targets for achieving a high level production of significant biomolecules through metabolic engineering. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12870-022-03878-1

A comparison of 64Cu-labeled bi-terminally PEGylated A20FMDV2 peptides targeting integrin ανβ6

Expression of epithelial-specific integrin

On the viability of holistic cosmic-ray source models

We consider the energy spectrum of cosmic-rays (CRs) from a purely phenomenological point of view and investigate the possibility that they all be produced by the same type of sources with a single power-law spectrum, in E^{-x}, from thermal to ultra-high energies. We show that the relative fluxes of the Galactic (GCR) and extra-galactic (EGCR) components are compatible with such a holistic model, provided that the index of the source spectrum be x \simeq 2.23\pm 0.07. This is compatible with the best-fit indices for both GCRs and EGCRs, assuming that their source composition is the same, which is indeed the case in a holistic model. It is also compatible with theoretical expectations for particle acceleration at relativistic shocks.Comment: 5 pages, 1 figure, Accepted for publication in Astronomy and Astrophysic

Out-of-plane mosaic of single-wall carbon nanotube films

For single-wall carbon nanotube (SWNT) films deposited from suspension onto filter membranes, or by drop casting or spin coating onto flat substrates, the tube axes lie preferentially in the film plane. Using x-ray scattering and a two-dimensional detector, we show that this out-of-plane mosaic spread can be easily and accurately quantified. It varies significantly with deposition conditions, and the aligning effects of deposition and external force in the film plane (e.g., magnetic field) are additive. Films from well-dispersed tubes show better alignment than from poor dispersions. The finite out-of-plane mosaic in C60@SWNT films enables quantitative separation of one-dimensional diffraction (chains of C60 peas) from the 2D rope lattice diffraction

Rapid X-ray Variability of the BL Lacertae Object PKS 2155-304

(Abridged) We present a detailed power density spectrum and cross-correlation analysis of the X-ray light curves of the BL Lac object PKS 2155-304, observed with BeppoSAX in 1997 and 1996, aimed at exploring the rapid variability properties and the inter-band cross correlations in the X-rays. We also perform the same analysis on the (archival) X-ray light curve obtained with ASCA in 1994.Comment: 47 pages, 11 figures, AAS Latex macros V4.0, accepted for publication in the Astrophysical Journa

Mass limits for heavy neutrinos

Neutrinos heavier than $M_Z/2\sim 45$ GeV are not excluded by particle physics data. Stable neutrinos heavier than this might contribute to the cosmic gamma ray background through annihilation in distant galaxies as well as to the dark matter content of the universe. We calculate the evolution of the heavy neutrino density in the universe as a function of its mass, $M_N$, and then the subsequent gamma ray spectrum from annihilation of distant $N\bar{N}$ (from $0<z<5$). The evolution of the heavy neutrino density in the universe is calculated numerically. In order to obtain the enhancement due to structure formation in the universe, we approximate the distribution of $N$ to be proportional to that of dark matter in the GalICS model. The calculated gamma ray spectrum is compared to the measured EGRET data. A conservative exclusion region for the heavy neutrino mass is 100 to 200 GeV, both from EGRET data and our re-evalutation of the Kamiokande data. The heavy neutrino contribution to dark matter is found to be at most 15%.Comment: 8 pages, 10 figures (Major revision

High-Energy Cosmology: gamma rays and neutrinos from beyond the galaxy

Our knowledge of the high-energy universe is undergoing a period of rapid change as new astronomical detectors of high-energy radiation start to operate at their design sensitivities. Now is a boomtime for high-energy astrophysics, with new discoveries from Swift and HESS, results from MAGIC and VERITAS starting to be reported, the upcoming launches of the gamma-ray space telescopes GLAST and AGILE, and anticipated data releases from IceCube and Auger. A formalism for calculating statistical properties of cosmological gamma-ray sources is presented. Application is made to model calculations of the statistical distributions of gamma-ray and neutrino emission from (i) beamed sources, specifically, long-duration GRBs, blazars, and extagalactic microquasars, and (ii) unbeamed sources, including normal galaxies, starburst galaxies and clusters. Expressions for the integrated intensities of faint beamed and unbeamed high-energy radiation sources are also derived. A toy model for the background intensity of radiation from dark-matter annihilation taking place in the early universe is constructed. Estimates for the gamma-ray fluxes of local group galaxies, starburst, and infrared luminous galaxies are briefly reviewed. Because the brightest extragalactic gamma-ray sources are flaring sources, and these are the best targets for sources of PeV -- EeV neutrinos and ultra-high energy cosmic rays, rapidly slewing all-sky telescopes like MAGIC and an all-sky gamma-ray observatory beyond Milagro will be crucial for optimal science return in the multi-messenger age.Comment: 10 pages, 3 figs, accepted for publication in the Barcelona Conference on Multimessenger Astronomy; corrected eq. 27, revised Fig. 3, added 2 ref

Preclinical efficacy of a PARP-1 targeted Auger-emitting radionuclide in prostate cancer

There is an unmet need for better therapeutic strategies for advanced prostate cancer. Poly (ADP-ribose) polymerase-1 (PARP-1) is a chromatin-binding DNA repair enzyme overexpressed in prostate cancer. This study evaluates whether PARP-1, on account of its proximity to the cell\u27s DNA, would be a good target for delivering high-linear energy transfer Auger radiation to induce lethal DNA damage in prostate cancer cells. We analyzed the correlation between PARP-1 expression and Gleason score in a prostate cancer tissue microarray. A radio-brominated Auger emitting inhibitor (