The design and relevance of a computerised therapy program for indigenous Māori adolescents.

Background: Depression is a major health issue among Māori indigenous adolescents, yet there has been little investigation into the relevance or effectiveness of psychological treatments for them. Further, consumer views are critical for engagement and adherence to therapy. However, there is little research regarding indigenous communities’ opinions about psychological interventions for depression. Objective: The objective of this study was to conduct semistructured interviews with Māori (indigenous New Zealand) young people (taitamariki) and their families to find out their opinions of a prototype computerized cognitive behavioral therapy (cCBT) program called Smart, Positive, Active, Realistic, X-factor thoughts (SPARX), a free online computer game intended to help young persons with mild to moderate depression, feeling down, stress or anxiety. The program will teach them how to resolve their issues on their own using Cognitive Behavioural Therapy as psychotherapeutic approach. Methods: There were seven focus groups on the subject of the design and cultural relevance of SPARX that were held, with a total of 26 participants (19 taitamarki, 7 parents/caregivers, all Māori). There were five of the groups that were with whānau (family groups) (n=14), one group was with Māori teenage mothers (n=4), and one group was with taitamariki (n=8). The general inductive approach was used to analyze focus group data. Results: SPARX computerized therapy has good face validity and is seen as potentially effective and appealing for Māori people. Cultural relevance was viewed as being important for the engagement of Māori young people with SPARX. Whānau are important for young peoples’ well-being. Participants generated ideas for improving SPARX for Māori and for the inclusion of whānau in its delivery. Conclusions: SPARX computerized therapy had good face validity for indigenous young people and families. In general, Māori participants were positive about the SPARX prototype and considered it both appealing and applicable to them. The results of this study were used to refine SPARX prior to it being delivered to taitamariki and non-Māori young people

Researching with communities: towards a leading edge theory and practice for community engagement

This project seeks to determine the extent to which complexity theory might offer the most effective means for understanding how communities can be successfully engaged in and with academic research. In the project, we adopted a case study approach, working with participants in a number of projects which had significant community engagement. These projects were all supported by the UK Beacons for Public Engagement, with which we also collaborated in our work. From the outset our research was informed by a Community Advisory Group, comprising community partners and engagement specialists. The objective of our research was to identify the initial conditions that facilitated the creation of enabling environments for community engagement. A number of the research results challenged our theoretical assumptions. Revisiting these results, we were led to develop a new way of conceptualising community engagement, which we propose to call an „engagement cycle‟. We suggest that this engagement cycle comprises a number of differential „phases‟, each of which is constituted by its own characteristic processes. This notion of an engagement cycle raises further research questions relating to the applicability of complexity theory to community engagement, as well as suggesting a number of issues that may inform the future development of the Connected Communities community engagement strategy

Exploitation of nitric oxide donors to control bacterial adhesion on ready‐to‐eat vegetables and dispersal of pathogenic biofilm from polypropylene

Background Nitric oxide (NO) donors have been used to control biofilm formation. NO can be delivered in situ using organic carriers and act as a signaling molecule. Cells exposed to NO shift from biofilm to the planktonic state and are better exposed to the action of disinfectants. In this study, we investigate the capability of the NO donors molsidomine, MAHAMA NONOate, NO‐aspirin and diethylamine NONOate to act as anti‐adhesion agents on ready‐to‐eat vegetables, as well as dispersants to a number of pathogenic biofilms on plastic. Results Our results showed that 10pM molsidomine reduced the attachment of Salmonella enterica sv Typhimurium 14 028 to pea shoots and coriander leaves of about 0.5 Log(CFU/leaf) when compared with untreated control. The association of 10 pM molsidomine with 0.006% H2O2 showed a synergistic effect, obtaining a significant reduction in cell collection on the surface of the vegetable of about 1 Log(CFU/leaf). Similar results were obtained for MAHMA NONOate. We also showed that the association of diethylamine NONOate at 10 mM and 10pM with the quaternary ammonium compound diquat bromide improves the effectiveness of biofilm dispersal by 50% when compared with the donor alone. Conclusions Our findings reveal the dual role of NO compounds in biofilm control. Molsidomine, MAHMA NONOate and diethylamine NONOate are good candidates in either preventing biofilm formation or dispersing biofilm, especially when used in conjunction with disinfectants. NO compounds have the potential to be developed into tool‐kit for pro‐active practices for GAPs, HACCP and Cleaning‐in‐place (CIP) protocols in industrial settings where washing is routinely applied. This article is protected by copyright. All rights reserved

Dispersal of human and plant pathogens biofilms via nitric oxide donors at 4°C

Recent studies suggest that nitric oxide donors capable of manipulating nitric oxide-mediated signaling in bacteria could induce dispersal of biofilms. Encased in extracellular polymeric substances, human and plant pathogens within biofilms are significantly more resistant to sanitizers. This is particularly a problem in refrigerated environments where food is processed. In an exercise aimed to study the potential of nitric oxide donors as biofilm dispersal in refrigerated conditions, we compared the ability of different nitric oxide donors (SNAP, NO-aspirin and Noc-5) to dislodge biofilms formed by foodborne, human and plant pathogens treated at 4 °C. The donors SNAP and Noc-5 were efficient in dispersing biofilms formed by Salmonella enterica, pathogenic Escherichia coli and Listeria innocua. The biomasses were decreased up to 30 % when compared with the untreated controls. When the plant pathogens Pectobacterium sp. and Xanthomonas sp. were tested the dispersion was mainly limited to Pectobacterium carotovorum biofilms, decreasing up to 15 % after exposure to molsidomine. Finally, the association of selected nitric oxide donors with sanitizers (DiQuat, H2O2, peracetic acid and PhenoTek II) was effective in dispersing biofilms. The best dispersal was achieved by pre-treating P. carotovorum with molsidomine and then peracetic acid. The synergistic effect was estimated up to ~35 % in dispersal when compared with peracetic acid alone. The association of nitric oxide donors with sanitizers could provide a foundation for an improved sanitization procedure for cleaning refrigerate environments

Community? What do you mean? An investigation into how differing understandings of the term ‘community’ shapes care-leavers’ move to independence

We explored the ways in which a performance-led approach to community formation and personal development can inform care-leavers’ move to independence. We adopted a case study approach, working with two groups of participants: young people leaving care and their support workers in Devon County Council’s Children in Care team (DCCCCS). The project was co-designed and co-developed with participants from both groups and our colleagues from Exstream Theatre Company. In this action–research project all researchers acted as participant-observers. It had two key objectives: first, to better understand how the term ‘community’ shaped the processes that the participating young people engaged with, and second, to take a practice-led approach to explore if, and how, performance-based methods and principles could be used to support the participants as they left care. A number of findings challenged our early assumptions, in particular the complexity of working with people with unstable and unpredictable lives. By working with the young people and DCCCCS managers and support workers, we developed a new way of using the creation of a theatrical performance, a deeply-supportive, peer-enabled environment and a theatre company, to enable a space in which participants could reimagine both their sense of self and community. The development and implementation of this model raises further research questions relating to how new communities might be formed, as well as suggesting a number of uses that may inform the future development of the Connected Communities community engagement strategy

Community Regeneration and Complexity

Introduction Over a period of 5 years, a remarkable process of change took place on the Beacon and Old Hill estate in Falmouth, Cornwall. Overlooking the gleaming boats in the multi-million pound marina below, by 1995 the estates had come, , to be known to the other communities in Falmouth as ‘Beirut’. One of the most deprived areas in Britain, the estate was blighted by violent crime, drug dealing and intimidation. The process initiated within the community that we describe stands as one of the most extraordinary examples of neighbourhood regeneration in the whole of the UK. Perhaps most strikingly, it has led to a series of notable health outcomes. In this chapter we describe the regeneration of the Beacon and Old Hill estates and advance our initial hypotheses explaining how and why this process of regeneration occurred

Features of Severe Liver Disease With Portal Hypertension in Patients With Cystic Fibrosis

Liver disease is the third leading cause of death in patients with cystic fibrosis (CF), but features of patients with CF, severe liver disease, and portal hypertension have not been fully characterized

James Hutton’s geological tours of Scotland : romanticism, literary strategies, and the scientific quest

This article explores a somewhat neglected part of the story of the emergence of geology as a science and discourse in the late eighteenth century – James Hutton’s posthumously published accounts of the geological tours of Scotland that he undertook in the years 1785 to 1788 in search of empirical evidence in support of his theory of the Earth and that he intended to include in the projected third volume of his Theory of the Earth of 1795. The article brings some of the assumptions and techniques of literary criticism to bear on Hutton’s scientific travel writing in order to open up new connections between geology, Romantic aesthetics and eighteenth-century travel writing about Scotland. Close analysis of Hutton’s accounts of his field trips to Glen Tilt, Galloway and Arran, supplemented by later accounts of the discoveries at Jedburgh and Siccar Point, reveals the interplay between desire, travel and the scientific quest and foregrounds the textual strategies that Hutton uses to persuade his readers that they share in the experience of geological discovery and interpretation as ‘virtual witnesses’. As well as allowing us to revisit the interrelation between scientific theory and discovery, this article concludes that Hutton was a much better writer than he has been given credit for and suggests that if these geological tours had been published in 1795 they would have made it impossible for critics to dismiss him as an armchair geologist

Culture-negative bivalvular endocarditis with myocardial destruction in a patient with systemic lupus erythematosus: a case report

Culture-negative endocarditis has long been associated with systemic lupus erythematosus, but is usually asymptomatic or involves a single valve. We present a patient with destructive culture-negative endocarditis that remains without a microbial etiology despite an exhaustive workup using advanced diagnostic techniques in a patient with systemic lupus erythematosus

Non-Born-Oppenheimer calculations of the lowest vibrational energy of HD including relativistic corrections

In this work we report variational calculations of the two lowest vibrational states of the HD molecule within the framework that does not assume the Born-Oppenheimer BO approximation. The nonrelativistic energies of the states were corrected for the relativistic effects of the order of 2 where = 1 c , calculated as expectation values of the operators representing these effects with the nonrelativistic non-BO wave functions. The non-BO wave functions were expanded in terms of the one-center explicitly correlated Gaussian functions multiplied by even powers of the internuclear distance. The v=0→1 transition energy obtained in the calculations is compared with the previous calculations, as well as with the transition frequency obtained from the experimental spectra. The comparison shows the need to include corrections higher than second order in to further improve the agreement between the theory and the experimen