Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants

Summary: Treatment of adult ovariectomized (OVX) rats with strontium ranelate prevented vertebral biomechanics degradation as a result of the prevention of bone loss and micro-architecture deterioration associated to an effect on intrinsic bone material quality. Strontium ranelate influenced the determinants of bone strength by prevention of ovariectomy-induced changes which contribute to explain strontium ranelate antifracture efficacy. Introduction: Strontium ranelate effects on the determinants of bone strength in OVX rats were evaluated. Methods: Adult female Sprague-Dawley rats were OVX, then treated daily for 52weeks with 125, 250, or 625mg strontium ranelate/kg. Bone strength, mass, micro-architecture, turnover, and intrinsic quality were assessed. Results: Strontium ranelate prevented ovariectomy-induced deterioration in mechanical properties with energy necessary for fracture completely maintained vs. SHAM at 625mg/kg/day, which corresponds to the clinical dose. This was related to a dose-dependent effect on bone volume, higher trabeculae number, and lower trabecular separation in strontium ranelate vs. OVX. Load and energy required to induce lamella deformation were higher with strontium ranelate than in OVX and in SHAM, indicating that the bone formed with strontium ranelate is able to withstand greater damage before fracture. Bone formation was maintained high or even increased in strontium ranelate as shown by mineralizing surfaces and alkaline phosphatase while strontium ranelate led to reductions in deoxypyridinoline. Conclusion: Strontium ranelate administered at 625mg/kg/day for 52weeks prevented OVX-induced biomechanical properties deterioration by influencing the determinants of bone strength: it prevented bone loss and micro-architecture degradation in association with an effect on intrinsic bone quality. These beneficial effects on bone contribute to explain strontium ranelate antifracture efficac

Microstructure of the Local Interstellar Cloud and the Identification of the Hyades Cloud

We analyze high-resolution UV spectra of the Mg II h and k lines for 18 members of the Hyades Cluster to study inhomogeneity along these proximate lines of sight. The observations were taken by the Space Telescope Imaging Spectrograph (STIS) instrument on board the Hubble Space Telescope (HST). Three distinct velocity components are observed. All 18 lines of sight show absorption by the Local Interstellar Cloud (LIC), ten stars show absorption by an additional cloud, which we name the Hyades Cloud, and one star exhibits a third absorption component. The LIC absorption is observed at a lower radial velocity than predicted by the LIC velocity vector derived by Lallement & Bertin (1992) and Lallement et al. (1995), (v(predicted LIC) - v(observed LIC) = 2.9 +/- 0.7 km/s), which may indicate a compression or deceleration at the leading edge of the LIC. We propose an extention of the Hyades Cloud boundary based on previous HST observations of other stars in the general vicinity of the Hyades, as well as ground-based Ca II observations. We present our fits of the interstellar parameters for each absorption component. The availability of 18 similar lines of sight provides an excellent opportunity to study the inhomogeneity of the warm, partially ionized local interstellar medium (LISM). We find that these structures are roughly homogeneous. The measured Mg II column densities do not vary by more than a factor of 2 for angular separations of < 8 degrees, which at the outer edge of the LIC correspond to physical separations of < 0.6 pc.Comment: 35 pages, 11 figures, AASTEX v.5.0 plus EPSF extensions in mkfig.sty; accepted by Ap

Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor induced growth arrest and apoptosis through NF-κB activation

Kaposi's sarcoma-associated herpesvirus (KSHV) has been linked to the development of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease (MCD). We have characterized the role of KSHV-encoded viral FLICE inhibitory protein K13 in the modulation of anti-IgM induced growth arrest and apoptosis in B cells. We demonstrate that K13 protects WEHI 231, an immature B cell line, against anti-IgM induced growth arrest and apoptosis. The protective effect of K13 was associated with the activation of the NF-κB pathway and was deficient in its mutant, K13-58AAA, and a structural homolog, vFLIP E8, which lack NF-κB activity. K13 upregulated the expression of NF-κB subunit RelB and blocked the anti-IgM induced decline in c-Myc and rise in p27(Kip1) that have been associated with growth arrest and apoptosis. K13 also upregulated the expression of Mcl-1, an anti-apoptotic member of the Bcl2 family. Finally, K13 protected the mature B cell line Ramos against anti-IgM induced apoptosis through NF-κB activation. Inhibition of anti-IgM induced apoptosis by K13 may contribute to the development of KSHV-associated lymphoproliferative disorders

Parallax of PSR J1744-1134 and the Local Interstellar Medium

We present the annual trigonometric parallax of PSR J1744-1134 derived from an analysis of pulse times of arrival. The measured parallax, pi = 2.8+/-0.3 mas ranks among the most precisely determined distances to any pulsar. The parallax distance of 357+/-39 pc is over twice that derived from the dispersion measure using the Taylor & Cordes model for the Galactic electron distribution. The mean electron density in the path to the pulsar, n_e = (0.0088 +/- 0.0009) cm^{-3}, is the lowest for any disk pulsar. We have compared the n_e for PSR J1744-1134 with those for another 11 nearby pulsars with independent distance estimates. We conclude that there is a striking asymmetry in the distribution of electrons in the local interstellar medium. The electron column densities for pulsars in the third Galactic quadrant are found to be systematically higher than for those in the first. The former correlate with the position of the well known local HI cavity in quadrant three. The excess electrons within the cavity may be in the form of HII clouds marking a region of interaction between the local hot bubble and a nearby superbubble.Comment: revised version accepted for publication in ApJ Letters; reanalysis of uncertainty in parallax measure and changes to fig

Rôle et place du riz pluvial dans les exploitations du lac Alaotra

International audienceLa région de l'Alaotra repose sur un plateau situé à 750 mètres d'altitude avec au cœur de la plaine le lac Alaotra. La surface cultivée en riziculture est estimée à 148 500 ha en 2000 (FAO/UPDR, 2000), dont 75-80 000 ha dans la cuvette du Lac et plus de 65-70 000 ha au sud et dans les zones en périphérie, qui constitue 10% de la surface rizicole nationale pour seulement 4% des riziculteurs malgaches. Cette région réalise 33% de la valeur ajoutée de l'ensemble de la filière nationale et 15% de la richesse générée par le secteur riz. Le climat irrégulier constitue une contrainte majeure pour tous les agriculteurs du lac Alaotra. Les relations agriculture-élevage sont au cœur de la problématique de développement et d'évolution des exploitations agricoles.Ainsi, avec la saturation des rizières irrigables ou à Mauvaise Maîtrise de l'Eau (RMME), la colonisation agricole des tanety anciennement dévolus aux pâturages extensifs depuis les années 1980 s'est accélérer, induisant la perturbation des activités d'élevage bovin traditionnel extensif à objectif de capitalisation qui évoluent aujourd'hui vers un élevage productif (embouche et production laitière) ou de trait. Le diagnostic réalisé en 2007 a mis en évidence 7 types d'exploitations agricoles différents. Les différents systèmes de riziculture pluviale se retrouvent sur les plateaux sommitaux et les pentes des collines (en rotation jachère culture sur les sols très pauvres), les bas de pente et les baiboho, en rotation avec d'autres cultures pluviales (maïs, manioc, pois de terre...) avec ou sans jachère, ou en système SCV depuis leur introduction au début des années 2000. L'introduction de variétés composites poly-aptitudes de type Sebota a pu lever une contrainte majeure des zones ni totalement irriguées ni totalement pluviales mais intermédiaires dans les RMME (riziculture pluviale partiellement irriguée, selon l'accès à l'eau et les caractéristiques climatiques de la saison), Les systèmes SCV mis au point sur baiboho avec des successions culturales de type riz de saison / haricot de contre saison - maïs de saison ou riz de saison puis vesce de contre saison associée ou non à des cultures maraîchères montrent également un niveau de production et de sécurité par rapport aux aléas climatiques très proche voire supérieurs à ceux obtenus en riziculture irriguée. La part du riz pluvial dans la formation du revenu et la sécurité alimentaire a été analysée pour chaque type d'exploitation et varie de 20 à 30 % du revenu riz total (avant autoconsommation), et se révèle croissante en fonction du rapport tanety / rizière dans l'exploitation. Ainsi, sur certaines zones, le riz pluvial semble avoir de beaux jours devant lui. Mots clés : Riz pluvial, exploitation agricoles, lac Alaotra, SCV, riz poly-aptitudes

Wide-field CCD imaging at CFHT: the MOCAM example

We describe a new 4096x4096 pixel CCD mosaic camera (MOCAM) available at the prime focus of the Canada-France-Hawaii Telescope (CFHT). The camera is a mosaic of four 2048x2048$Loral frontside-illuminated CCDs with 15$\mu$m pixels, providing a field of view of 14'x14' at a scale of 0.21''/pixel. MOCAM is equipped with B, V, R and I filters and has demonstrated image quality of 0.5''-0.6'' FWHM over the entire field. MOCAM will also be used with the CFHT adaptive optic bonnette and will provide a field of view of 90'' at a scale of 0.02 ''/pixel. MOCAM works within the CFHT Pegasus software environment and observers familiar with this system require no additional training to use this camera effectively. The technical details, the performance and the first images obtained on the telescope with MOCAM are presented. In particular, we discuss some important improvements with respect to the standard single-CCD FOCAM camera, such as multi-output parallel readout and dynamic anti-blooming. We also discuss critical technical issues concerning future wide-field imaging facilities at the CFHT prime focus in light of our experience with MOCAM and our recent experience with the even larger UH 8192x8192 pixel CCD mosaic camera.Comment: Accepted for publication in Publication of the Astronomical Society of the Pacific. Latex with aas2pp4.sty and epsf.sty. 12 pages, 10 figure

The political economy of the Jospin government

This article explores the political economy of the French Socialist Party (PS), beginning with the neo-liberal U-turn of 1983. It then charts the re-evaluation of the PS's political economic foundations after the 1993 defeat, the rejection of the neo-liberal 'pensée unique', and the rehabilitation of a broadly Keynesian frame of reference. The article goes on to explore how this shift has fed through into the Jospin government's policy and positions at both the national and international level. It explores aspirations to reinvent the EU as a Keynesian social democratic 'policy space', and at the national level, employment, macroeconomic, and structural policies