11 research outputs found
No Child Left Behind: Implications for Career and Technical Education
High school principals and career and technical education (CTE) teachers throughout Illinois were subjects of this study which described principals\u27 and CTE teachers\u27 perceptions of the impact the No Child Left Behind Act of2001 has had on high school CTE programs. Findings indicated principals and teachers collectively disagreed with No Child Left Behind has had a positive impact on the image ofCTE at your school. Both groups also agreed CTE courses can help schools meet the goals of all students will reach high standards, at a minimum of attaining proficiency or better in reading and mathematics and all students will graduate from high school. However, a statistically significant difference between the groups was found with No Child Left Behind has had a positive impact on CTE enrollment at your school. Findings indicated while the principals agree, the teachers conversely disagreed with the statement
An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression
Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use of whole-blood transcriptomics for stratification of patients with severe infection by integrating data from 3149 samples from patients with sepsis due to community-acquired pneumonia or fecal peritonitis admitted to intensive care and healthy individuals into a gene expression reference map. We used this map to derive a quantitative sepsis response signature (SRSq) score reflective of immune dysfunction and predictive of clinical outcomes, which can be estimated using a 7- or 12-gene signature. Last, we built a machine learning framework, SepstratifieR, to deploy SRSq in adult and pediatric bacterial and viral sepsis, H1N1 influenza, and COVID-19, demonstrating clinically relevant stratification across diseases and revealing some of the physiological alterations linking immune dysregulation to mortality. Our method enables early identification of individuals with dysfunctional immune profiles, bringing us closer to precision medicine in infection.peer-reviewe
Professional Development: Implications for Illinois Career and Technical Education Teachers
No Child Left Behind: Implications for Career and Technical Education
High school principals and career and technical education (CTE) teachers throughout Illinois were subjects of this study which described principals\u27 and CTE teachers\u27 perceptions of the impact the No Child Left Behind Act of2001 has had on high school CTE programs. Findings indicated principals and teachers collectively disagreed with No Child Left Behind has had a positive impact on the image ofCTE at your school. Both groups also agreed CTE courses can help schools meet the goals of all students will reach high standards, at a minimum of attaining proficiency or better in reading and mathematics and all students will graduate from high school. However, a statistically significant difference between the groups was found with No Child Left Behind has had a positive impact on CTE enrollment at your school. Findings indicated while the principals agree, the teachers conversely disagreed with the statement
Piloting a Patient-based Questionnaire to Assess Patient Satisfaction with the Process of Orthodontic Treatment
O-mannosylation of the Mycobacterium tuberculosis Adhesin Apa Is Crucial for T Cell Antigenicity during Infection but Is Expendable for Protection
Synthesis and Mass Spectral Characterization of Mycobacterial Phosphatidylinositol and Its Dimannosides
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31â127 anaesthetic procedures in 30â874 children with a mean age of 6·35 years (SD 4·50) were included. The incidence of perioperative severe critical events was 5·2% (95% CI 5·0â5·5) with an incidence of respiratory critical events of 3·1% (2·9â3·3). Cardiovascular instability occurred in 1·9% (1·7â2·1), with an immediate poor outcome in 5·4% (3·7â7·5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10â000. This was independent of type of anaesthesia. Age (relative risk 0·88, 95% CI 0·86â0·90; p<0·0001), medical history, and physical condition (1·60, 1·40â1·82; p<0·0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0·99, 0·981â0·997; p<0·0048 for respiratory critical events, and 0·98, 0·97â0·99; p=0·0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia. Funding European Society of Anaesthesiology