Looptop Hard X-Ray Emission in Solar Flares: Images and Statistics

The discovery of hard X-ray sources near the top of a flaring loop by the HXT instrument on board the YOHKOH satellite represents a significant progress towards the understanding of the basic processes driving solar flares. In this paper we extend the previous study of limb flares by Masuda (1994) by including all YOHKOH observations up through August 1998. We report that from October 1991 to August 1998, YOHKOH observed 20 X-ray bright limb flares (where we use the same selection criteria as Masuda), of which we have sufficient data to analyze 18 events, including 8 previously unanalyzed flares. Of these 18 events, 15 show detectable impulsive looptop emission. Considering that the finite dynamic range (about a decade) of the detection introduces a strong bias against observing comparatively weak looptop sources, we conclude that looptop emission is a common feature of all flares. We summarize the observations of the footpoint to looptop flux ratio and the spectral indices. We present light curves and images of all the important newly analyzed limb flares. Whenever possible we present results for individual pulses in multipeak flares and for different loops for multiloop flares. We then discuss the statistics of the fluxes and spectral indices of the looptop and footpoint sources taking into account observational selection biases. The importance of these observations (and those expected from the scheduled HESSI satellite with its superior angular spectral and temporal resolution) in constraining acceleration models and parameters is discussed briefly.Comment: 27 pages (13 embedded figures). Accepted for publication in Ap

A multi-data source surveillance system to detect a bioterrorism attack during the G8 summit in Scotland

In 18 weeks, Health Protection Scotland (HPS) deployed a syndromic surveillance system to early-detect natural or intentional disease outbreaks during the G8 Summit 2005 at Gleneagles, Scotland. The system integrated clinical and non-clinical datasets. Clinical datasets included Accident and Emergency (A and E) syndromes, and General Practice (GPs) codes grouped into syndromes. Non-clinical data included telephone calls to a nurse helpline, laboratory test orders, and hotel staff absenteeism. A cumulative sum-based detection algorithm and a log-linear regression model identified signals in the data. The system had a fax-based track for real-time identification of unusual presentations. Ninety-five signals were triggered by the detection algorithms and four forms were faxed to HPS. Thirteen signals were investigated. The system successfully complemented a traditional surveillance system in identifying a small cluster of gastroenteritis among the police force and triggered interventions to prevent further cases

On the Spatial Distribution of Hard X-Rays from Solar Flare Loops

The aim of this paper is to investigate the spatial structure of the impulsive phase hard X-ray emission from solar flares. This work is motivated by the YOHKOH and the forthcoming HESSI observations. Summarizing past results, it is shown that the transport effects can account for the observations by inhomogeneous loops where there is a strong field convergence and/or density enhancement at the top of the flaring loop. Scattering by plasma turbulence at the acceleration site or pancake type pitch angle distribution of the accelerated electrons can also give rise to enhanced emission at the loop tops. These could be a natural consequence of acceleration by plasma waves. This paper considers a general case of stochastic scattering and acceleration that leads to an isotropic pitch angle distribution and an enhanced emission from the loop tops or the acceleration site. Following the formalism developed in earlier papers the strength and the spectrum of the radiation expected from the acceleration site and the foot points are evaluated and their dependence on the parameters describing the acceleration process and the flare plasma are determined. The theoretical ratio of these two intensities and relative values of their spectral indices are compared with the YOHKOH observations, demonstrating that the above mentioned parameters can be constrained with such observations. It is shown that future high spatial and spectral resolution observations, for example those expected from HESSI, can begin to distinguish between different models and constrain their parameters.Comment: 37 pages with 20 figures. Accepted for publication in ApJ http://www.astronomy.stanford.ed

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction

The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling cascade including MEK1 and MEK2 and ERK1 and ERK2 but their role in platelet function and haemostasis is ambiguous as previous reports have been contradictory. It is therefore unclear if MEK inhibitors might be causing platelet dysfunction and contributing to increased hemorrhage. In the present study we performed pharmacological characterisation of cobimetinib and trametinib in vitro to investigate potential for MEK inhibitors to cause platelet dysfunction. We report that whilst both cobimetinib and trametinib are potent inhibitors of platelet MEK activity, treatment with trametinib did not alter platelet function. Treatment with cobimetinib results in inhibition of platelet aggregation, integrin activation, alpha-granule secretion and adhesion but only at suprapharmacological concentrations. We identified that the inhibitory effects of high concentrations of cobimetinib are associated with off-target inhibition on Akt and PKC. Neither inhibitor caused any alteration in thrombus formation on collagen under flow conditions in vitro. Our findings demonstrate that platelets are able to function normally when MEK activity is fully inhibited, indicating MEK activity is dispensable for normal platelet function. We conclude that the MEK inhibitors cobimetinib and trametinib do not induce platelet dysfunction and are therefore unlikely to contribute to increased incidence of bleeding reported during MEK inhibitor therapy

Comparative effects of ASI and APR sire breeding values on the lactation profile of pasture-based Holstein-Friesian cows

Estimated Breeding Values (EBVs) of bulls are useful indicators of the genetic transmission ability of an animal of desirable traits to their progeny. Lactation profile differs between different merit cows but for pasture-based production systems, the impact of emerging EBV evaluation methods remains largely unpublished. In this study, Wood’s incomplete gamma model (Y(t) = atbe−ct ) was utilised to compare the effects of the Australian Selection Index (ASI) and Australian Profit Ranking (APR) EBVs on the shape of the lactation profile of first-parity, pasture-based Holstein-Friesian cows. Initial yield and the rate of increase to peak were significantly influenced by EBV choice, although peak yield was not. It was concluded that Wood’s incomplete gamma function adequately modelled the lactation profile of pasture-based cows explaining over 90% of the observed variation irrespective of using ASI or APR sire breeding values

A qualitative study of primary care professionals’ views of case finding for depression in patients with diabetes or coronary heart disease in the UK

<p>Background Routinely conducting case finding (also commonly referred to as screening) in patients with chronic illness for depression in primary care appears to have little impact. We explored the views and experiences of primary care nurses, doctors and managers to understand how the implementation of case finding/screening might impact on its effectiveness.</p> <p>Methods Two complementary qualitative focus group studies of primary care professionals including nurses, doctors and managers, in five primary care practices and five Community Health Partnerships, were conducted in Scotland.</p> <p>Results We identified several features of the way case finding/screening was implemented that may lead to systematic under-detection of depression. These included obstacles to incorporating case finding/screening into a clinical review consultation; a perception of replacing individualised care with mechanistic assessment, and a disconnection for nurses between management of physical and mental health. Far from being a standardised process that encouraged detection of depression, participants described case finding/screening as being conducted in a way which biased it towards negative responses, and for nurses, it was an uncomfortable task for which they lacked the necessary skills to provide immediate support to patients at the time of diagnosis.</p> <p>Conclusion The introduction of case finding/screening for depression into routine chronic illness management is not straightforward. Routinized case finding/screening for depression can be implemented in ways that may be counterproductive to engagement (particularly by nurses), with the mental health needs of patients living with long term conditions. If case finding/screening or engagement with mental health problems is to be promoted, primary care nurses require more training to increase their confidence in raising and dealing with mental health issues and GPs and nurses need to work collectively to develop the relational work required to promote cognitive participation in case finding/screening.</p&gt

Implications of using an extended lactation to change from a spring-calving to an autumn-calving farm system in South Taranaki

Recent changes to pasture-supply curves in South Taranaki, and the availability of winter milk premiums have increased farmer interest in changing from a spring-calving to an autumn-calving farm system. One approach to changing the season of calving from spring to autumn is to extend the calving interval (CI) by delaying the mating period by ~8 months, so that they next calve in autumn and undertake an extended lactation [>305 days in milk (DIM)]. A large-scale farmlet experiment was established in South Taranaki to investigate the production and reproduction responses of cows using this approach. In June 2017, 602 springcalving cows were allocated to two farmlets. In one farmlet (SPR) 301 cows were mated in October to maintain a 12-month CI spring-calving pattern. In the other farmlet (AUT, n=301 cows), mating was delayed for eight months, and cows underwent an extended lactation (mean DIM, 488; max DIM, 577) to calve next in autumn 2019. The experiment analysed two lactations for the AUT farmlet and two and a half lactations for the SPR farmlet. Across the total experimental period, milksolids (MS) production was similar between farmlets (1,194 vs. 1,174 kg MS/cow), however, cows in the AUT farmlet were fed more supplementary feed [2,371 vs. 1,951 kg dry matter (DM)/cow]. The extended lactation changed the relationship between feed supply and herd demand, which led to excessive BCS gain and ryegrass staggers for AUT farmlet cows. Further research is required to examine grazing management during extended lactations and to assess the economic implications of this approach.fals

The influence of riparian woodland on the spatial and temporal variability of stream water temperatures in an upland salmon stream

International audienceThe spatio-temporal variability of stream water temperatures was investigated at six locations on the Girnock Burn (30km2 catchment), Cairngorms, Scotland over three hydrological years between 1998 and 2002. The key site-specific factors affecting the hydrology and climatology of the sampling points were investigated as a basis for physical process inference. Particular emphasis was placed on assessing the effects of riparian forest in the lower catchment versus the heather moorland riparian zones that are spatially dominant in the upper catchment. The findings were related to river heat budget studies that provided process detail. Gross changes in stream temperature were affected by the annual cycle of incoming solar radiation and seasonal changes in hydrological and climatological conditions. Inter-annual variation in these controlling variables resulted in inter-annual variability in thermal regime. However, more subtle inter-site differences reflected the impact of site-specific characteristics on various components of the river energy budget. Inter-site variability was most apparent at shorter time scales, during the summer months and for higher stream temperatures. Riparian woodland in the lower catchment had a substantial impact on thermal regime, reducing diel variability (over a period of 24 hours) and temperature extremes. Observed inter-site differences are likely to have a substantial effect on freshwater ecology in general and salmonid fish in particular. Keywords: temperature, thermal regime, forest, salmon, hydrology, Girnock Burn, Cairngor

Validation of simple epidemiological or clinical methods for the measurement of body composition in young children

The present study aimed to determine the validity of simple epidemiological and clinical methods for the assessment of body fatness in preschool children. In 89 children (42 boys, 47 girls; mean age 4.1 SD 1.3y) measures of body fatness were made using total body water (TBW), dual energy x-ray absorptiometry (DXA), air displacement plethysmography (BODPOD) and skinfold thickness. Methods were compared by Bland–Altman analysis using TBW as the reference method, and by paired comparisons and rank order correlations. Bias for DXA was +1.8% body fat percentage units (limits of agreement +15.5% to -11.9%), bias for BODPOD was -3.5% (limits of agreement +18.9% to -5.9%) and bias for skinfolds using the Slaughter equations was -6.5% (limits of agreement +10.0% to –23.1%). Significant rank order correlations with TBW measures of fatness were obtained for DXA estimates of fatness (r=0.54, P=0.01), but not for estimates of fat by skinfold thickness (r=0.20, P=0.2) or BODPOD (r=0.25, P=0.1). Differences between both DXA and BODPOD and the reference TBW estimates of body fatness were not significant (P=0.06 and P=0.1 respectively); however, the difference in estimated body fatness between skinfold thickness and TBW was significant (P<0.001). Estimates of body fatness in preschool children were inaccurate at the level of the individual child using all the methods, but DXA might provide unbiased estimates and a means of making relative assessments of body fatness