Buckling of conical shell with local imperfections

Small geometric imperfections in thin-walled shell structures can cause large reductions in buckling strength. Most imperfections found in structures are neither axisymmetric nor have the shape of buckling modes but rather occur locally. This report presents the results of a study of the effect of local imperfections on the critical buckling load of a specific axially compressed thin-walled conical shell. The buckling calculations were performed by using a two-dimensional shell analysis program referred to as the STAGS (Structural Analysis of General Shells) computer code, which has no axisymmetry restrictions. Results show that the buckling load found from a bifurcation buckling analysis is highly dependent on the circumferential arc length of the imperfection type studied. As the circumferential arc length of the imperfection is increased, a reduction of up to 50 percent of the critical load of the perfect shell can occur. The buckling load of the cone with an axisymmetric imperfections is nearly equal to the buckling load of imperfections which extended 60 deg or more around the circumference, but would give a highly conservative estimate of the buckling load of a shell with an imperfection of a more local nature

Radiative Models of Sagittarius A* and M87 from Relativistic MHD Simulations

Ongoing millimeter VLBI observations with the Event Horizon Telescope allow unprecedented study of the innermost portion of black hole accretion flows. Interpreting the observations requires relativistic, time-dependent physical modeling. We discuss the comparison of radiative transfer calculations from general relativistic MHD simulations of Sagittarius A* and M87 with current and future mm-VLBI observations. This comparison allows estimates of the viewing geometry and physical conditions of the Sgr A* accretion flow. The viewing geometry for M87 is already constrained from observations of its large-scale jet, but, unlike Sgr A*, there is no consensus for its millimeter emission geometry or electron population. Despite this uncertainty, as long as the emission region is compact, robust predictions for the size of its jet launching region can be made. For both sources, the black hole shadow may be detected with future observations including ALMA and/or the LMT, which would constitute the first direct evidence for a black hole event horizon.Comment: 8 pages, 2 figures, submitted to the proceedings of AHAR 2011: The Central Kiloparse

Seven steps for improving influenza vaccination rates in risk-groups: findings from a national cross sectional survey in UK general practice

The problem: Seasonal influenza vaccination rates in at-risk population in the UK are below the national and international target of 75%. Of people aged over 65 years in England 72.8% received influenza (flu) vaccine in 2010/11, just below the target of 75%. However, flu vaccination rates during 2010/11 in the under 65 year old at-risk groups was just 50.4%, which fell far short of 75%; in pregnant women who were not otherwise at risk the vaccination rate was only 36.6%, despite increasing evidence showing the beneficial effects of protection against flu for both mothers and babies. Evidence-based guidance, to advise practices how to optimise all aspects of their flu vaccination campaigns and maximise their likelihood of protecting at-risk patients against flu and its serious sequelae is greatly needed. This study sought to identify which strategies and procedures were associated with higher rates of flu vaccine uptake. The approach: An online questionnaire survey was administered to general practitioners (GPs), nursing staff and practice managers in 795 practices across England. We used logistic regression to analyse data for factors independently associated with higher practice flu vaccination rates in at-risk groups. Findings: The survey was completed by 569 practice managers, 335 nursing staff and 107 GPs. We identified seven independent factors associated with higher flu vaccination rates. Having a lead staff member for planning the flu campaign and producing a written report of practice performance predicted an 8% higher vaccination rate for at-risk patients aged <65 years (OR 1.37; 95% CI 1.10 to 1.71). These strategies, plus sending a personal invitation to all eligible patients and only stopping vaccination when Quality and Outcomes framework (QOF) targets were reached, predicted a 7% higher vaccination rate (OR 1.45; 95% CI 1.10 to 1.92) in patients aged 65 years and over. Using a lead member of staff for identifying eligible patients, with either a modified manufacturer’s or in-house search program for interrogating the practice computer system, independently predicted a 4% higher vaccination rate in patients aged 65 years and over (OR 1.22; 95% CI 1.06 to 1.41 / OR 1.20; 95% CI 1.03 to 1.40). The provision of flu vaccine by midwives was associated with a 4% higher vaccination rate in pregnant women (OR 1.19; 1.02 to 1.40). Consequences: Clear leadership, effective communication with patients, and methods used to identify and contact eligible patients were independently associated with significantly higher rates of flu vaccination. Financial targets appear to incentivise practices to work harder to maximise seasonal influenza vaccine uptake. The strategies identified here could help primary care providers to substantially increase their seasonal flu vaccination rates to meet or even exceed national targets

Wakefield damping for the CLIC crab cavity

A crab cavity is required in the CLIC to allow effective head-on collision of bunches at the IP. A high operating frequency is preferred as the deflection voltage required for a given rotation angle and the RF phase tolerance for a crab cavity are inversely proportional to the operating frequency. The short bunch spacing of the CLIC scheme and the high sensitivity of the crab cavity to dipole kicks demand very high damping of the inter-bunch wakes, the major contributor to the luminosity loss of colliding bunches. This paper investigates the nature of the wakefields in the CLIC crab cavity and the possibility of using various damping schemes to suppress them effectively

Infrared interferometry to spatially and spectrally resolve jets in X-ray binaries

Infrared interferometry is a new frontier for precision ground based observing, with new instrumentation achieving milliarcsecond (mas) spatial resolutions for faint sources, along with astrometry on the order of 10 microarcseconds. This technique has already led to breakthroughs in the observations of the supermassive black hole at the Galactic centre and its orbiting stars, AGN, and exo-planets, and can be employed for studying X-ray binaries (XRBs), microquasars in particular. Beyond constraining the orbital parameters of the system using the centroid wobble and spatially resolving jet discrete ejections on mas scales, we also propose a novel method to discern between the various components contributing to the infrared bands: accretion disk, jets and companion star. We demonstrate that the GRAVITY instrument on the Very Large Telescope Interferometer (VLTI) should be able to detect a centroid shift in a number of sources, opening a new avenue of exploration for the myriad of transients expected to be discovered in the coming decade of radio all-sky surveys. We also present the first proof-of-concept GRAVITY observation of a low-mass X-ray binary transient, MAXI J1820+070, to search for extended jets on mas scales. We place the tightest constraints yet via direct imaging on the size of the infrared emitting region of the compact jet in a hard state XRB.Comment: 12 Pages, 3 figures, accepted for publication in MNRA

Pruritus is a common feature in sheep infected with the BSE agent.

BACKGROUND: The variability in the clinical or pathological presentation of transmissible spongiform encephalopathies (TSEs) in sheep, such as scrapie and bovine spongiform encephalopathy (BSE), has been attributed to prion protein genotype, strain, breed, clinical duration, dose, route and type of inoculum and the age at infection. The study aimed to describe the clinical signs in sheep infected with the BSE agent throughout its clinical course to determine whether the clinical signs were as variable as described for classical scrapie in sheep. The clinical signs were compared to BSE-negative sheep to assess if disease-specific clinical markers exist. RESULTS: Forty-seven (34%) of 139 sheep, which comprised 123 challenged sheep and 16 undosed controls, were positive for BSE. Affected sheep belonged to five different breeds and three different genotypes (ARQ/ARQ, VRQ/VRQ and AHQ/AHQ). None of the controls or BSE exposed sheep with ARR alleles were positive. Pruritus was present in 41 (87%) BSE positive sheep; the remaining six were judged to be pre-clinically infected. Testing of the response to scratching along the dorsum of a sheep proved to be a good indicator of clinical disease with a test sensitivity of 85% and specificity of 98% and usually coincided with weight loss. Clinical signs that were displayed significantly earlier in BSE positive cases compared to negative cases were behavioural changes, pruritic behaviour, a positive scratch test, alopecia, skin lesions, teeth grinding, tremor, ataxia, loss of weight and loss of body condition. The frequency and severity of each specific clinical sign usually increased with the progression of disease over a period of 16-20 weeks. CONCLUSION: Our results suggest that BSE in sheep presents with relatively uniform clinical signs, with pruritus of increased severity and abnormalities in behaviour or movement as the disease progressed. Based on the studied sheep, these clinical features appear to be independent of breed, affected genotype, dose, route of inoculation and whether BSE was passed into sheep from cattle or from other sheep, suggesting that the clinical phenotype of BSE is influenced by the TSE strain more than by other factors. The clinical phenotype of BSE in the genotypes and breed studied was indistinguishable from that described for classical scrapie cases

Locating the intense interstellar scattering towards the inner Galaxy

We use VLBA+VLA observations to measure the sizes of the scatter-broadened images of 6 of the most heavily scattered known pulsars: 3 within the Galactic Centre (GC) and 3 elsewhere in the inner Galactic plane. By combining the measured sizes with temporal pulse broadening data from the literature and using the thin-screen approximation, we locate the scattering medium along the line of sight to these 6 pulsars. At least two scattering screens are needed to explain the observations of the GC sample. We show that the screen inferred by previous observations of SGR J1745-2900 and Sgr A*, which must be located far from the GC, falls off in strength on scales < 0.2 degree. A second scattering component closer to (< 2 kpc) or even (tentatively) within (< 700 pc) the GC produces most or all of the temporal broadening observed in the other GC pulsars. Outside the GC, the scattering locations for all three pulsars are ~2 kpc from Earth, consistent with the distance of the Carina-Sagittarius or Scutum spiral arm. For each object the 3D scattering origin coincides with a known HII region (and in one case also a supernova remnant), suggesting that such objects preferentially cause the intense interstellar scattering seen towards the Galactic plane. We show that the HII regions should contribute > 25% of the total dispersion measure (DM) towards these pulsars, and calculate reduced DM distances. Those distances for other pulsars lying behind HII regions may be similarly overestimated.Comment: 16 pages, 10 figures, MNRAS, in pres

Ethane-beta-Sultam Modifies the Activation of the Innate Immune System Induced by Intermittent Ethanol Administration in Female Adolescent Rats

Intermittent ethanol abuse or ‘binge drinking’ during adolescence induces neuronal damage, which may be associated with cognitive dysfunction. To investigate the neurochemical processes involved, rats were administered either 1 g/kg or 2 g/kg ethanol in a ‘binge drinking’ regime. After only 3 weeks, significant activation of phagocytic cells in the peripheral (alveolar macrophages) and the hippocampal brain region (microglia cells) was present,as exemplified by increases in the release of pro-inflammatory cytokines in the macrophages and of iNOS in the microglia. This was associated with neuronal loss in the hippocampus CA1 region. Daily supplementation with a taurine prodrug, ethane-β-sultam, 0.028 g/kg, during the intermittent ethanol loading regime, supressed the release of the pro-inflammatory cytokines and of reactive nitrogen species, as well as neuronal loss, particularly in the rats administered the lower dose of ethanol, 1 g/kg. Plasma, macrophage and hippocampal taurine levels increased marginally after ethane-β-sultam supplementation. The ‘binge drinking’ ethanol rats administered 1 g/kg ethanol showed increased latencies to those of the control rats in their acquisition of spacial navigation in the Morris Water Maze, which was normalised to that of the controls values after ethane-β-sultam administration. Such results confirm that the administration of ethane-β-sultam to binge drinking rats reduces neuroinflammation in both the periphery and the brain, suppresses neuronal loss, and improved working memory of rats in a water maze study

Coherent control of indirect excitonic qubits in optically driven quantum dot molecules

We propose an optoelectronic scheme to define and manipulate an indirect neutral exciton qubit within a quantum dot molecule. We demonstrate coherent dynamics of indirect excitons resilient against decoherence effects, including direct exciton spontaneous recombination. For molecules with large interdot separation, the exciton dressed spectrum yields an often overlooked avoided crossing between spatially indirect exciton states. Effective two level system Hamiltonians are extracted by Feshbach projection over the multilevel exciton configurations. An adiabatic manipulation of the qubit states is devised using time dependent electric field sweeps. The exciton dynamics yields the necessary conditions for qubit initialization and near unitary rotations in the picosecond time scale, driven by the system internal dynamics. Despite the strong influence of laser excitation, charge tunneling, and interdot dipole-dipole interactions, the effective relaxation time of indirect excitons is much longer than the direct exciton spontaneous recombination time, rendering indirect excitons as potential elemental qubits in more complex schemes.Comment: Submitted to PRB, 11 pages and 6 figure