1,168 research outputs found
A thermal simulation process based on electrical modeling for complex interconnect, packaging, and 3DI structures
To reduce the product development time and achieve first-pass silicon success, fast and accurate estimation of very-large-scale integration (VLSI) interconnect, packaging and 3DI (3D integrated circuits) thermal profiles has become important. Present commercial thermal analysis tools are incapable of handling very complex structures and have integration difficulties with existing design flows. Many analytical thermal models, which could provide fast estimates, are either too specific or oversimplified. This paper highlights a methodology, which exploits electrical resistance solvers for thermal simulation, to allow acquisition of thermal profiles of complex structures with good accuracy and reasonable computation cost. Moreover, a novel accurate closed-form thermal model is developed. The model allows an isotropic or anisotropic equivalent medium to replace the noncritical back-end-of-line (BEOL) regions so that the simulation complexity is dramatically reduced. Using these techniques, this paper introduces the thermal modeling of practical complex VLSI structures to facilitate thermal guideline generation. It also demonstrates the benefits of the proposed anisotropic equivalent medium approximation for real VLSI structures in terms of the accuracy and computational cost. © 2006 IEEE.published_or_final_versio
How uncertainty enables non-classical dynamics
The uncertainty principle limits quantum states such that when one observable
takes predictable values there must be some other mutually unbiased observables
which take uniformly random values. We show that this restrictive condition
plays a positive role as the enabler of non-classical dynamics in an
interferometer. First we note that instantaneous action at a distance between
different paths of an interferometer should not be possible. We show that for
general probabilistic theories this heavily curtails the non-classical
dynamics. We prove that there is a trade-off with the uncertainty principle,
that allows theories to evade this restriction. On one extreme, non-classical
theories with maximal certainty have their non-classical dynamics absolutely
restricted to only the identity operation. On the other extreme, quantum theory
minimises certainty in return for maximal non-classical dynamics.Comment: 4 pages + 4 page technical supplement, 2 figure
Leucine‐Rich Amelogenin Peptide: A Candidate Signaling Molecule During Cementogenesis
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141564/1/jper1126.pd
A violation of the uncertainty principle implies a violation of the second law of thermodynamics
Uncertainty relations state that there exist certain incompatible
measurements, to which the outcomes cannot be simultaneously predicted. While
the exact incompatibility of quantum measurements dictated by such uncertainty
relations can be inferred from the mathematical formalism of quantum theory,
the question remains whether there is any more fundamental reason for the
uncertainty relations to have this exact form. What, if any, would be the
operational consequences if we were able to go beyond any of these uncertainty
relations? We give a strong argument that justifies uncertainty relations in
quantum theory by showing that violating them implies that it is also possible
to violate the second law of thermodynamics. More precisely, we show that
violating the uncertainty relations in quantum mechanics leads to a
thermodynamic cycle with positive net work gain, which is very unlikely to
exist in nature.Comment: 8 pages, revte
The urologic epithelial stem cell database (UESC) – a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder
Background: Public databases are crucial for analysis of high-dimensional gene and protein expression data. The Urologic Epithelial Stem Cells (UESC) database http://scgap.systemsbiology.net/ is a public database that contains gene and protein information for the major cell types of the prostate, prostate cancer cell lines, and a cancer cell type isolated from a
primary tumor. Similarly, such information is available for urinary bladder cell types.
Description: Two major data types were archived in the database, protein abundance localization data from immunohistochemistry images, and transcript abundance data principally from DNA microarray analysis. Data results were organized in modules that were made to operate independently but built upon a core functionality. Gene array data and immunostaining images for human and mouse prostate and bladder were made available for interrogation. Data analysis
capabilities include: (1) CD (cluster designation) cell surface protein data. For each cluster designation molecule, a data summary allows easy retrieval of images (at multiple magnifications). (2) Microarray data. Single gene or batch search can be initiated with Affymetrix Probeset ID, Gene Name, or Accession Number together with options of coalescing probesets and/or replicates.
Conclusion: Databases are invaluable for biomedical research, and their utility depends on data quality and user friendliness. UESC provides for database queries and tools to examine cell typespecific gene expression (normal vs. cancer), whereas most other databases contain only whole tissue expression datasets. The UESC database provides a valuable tool in the analysis of differential
gene expression in prostate cancer genes in cancer progression.This work was supported by grant 1U01 DK63630 from NIDDK. Additional funding came from grants CA85859, CA98699 and CA111244 from NCI
Annotation of two large contiguous regions from the Haemonchus contortus genome using RNA-seq and comparative analysis with Caenorhabditis elegans
The genomes of numerous parasitic nematodes are currently being sequenced, but their complexity and size, together with high levels of intra-specific sequence variation and a lack of reference genomes, makes their assembly and annotation a challenging task. Haemonchus contortus is an economically significant parasite of livestock that is widely used for basic research as well as for vaccine development and drug discovery. It is one of many medically and economically important parasites within the strongylid nematode group. This group of parasites has the closest phylogenetic relationship with the model organism Caenorhabditis elegans, making comparative analysis a potentially powerful tool for genome annotation and functional studies. To investigate this hypothesis, we sequenced two contiguous fragments from the H. contortus genome and undertook detailed annotation and comparative analysis with C. elegans. The adult H. contortus transcriptome was sequenced using an Illumina platform and RNA-seq was used to annotate a 409 kb overlapping BAC tiling path relating to the X chromosome and a 181 kb BAC insert relating to chromosome I. In total, 40 genes and 12 putative transposable elements were identified. 97.5% of the annotated genes had detectable homologues in C. elegans of which 60% had putative orthologues, significantly higher than previous analyses based on EST analysis. Gene density appears to be less in H. contortus than in C. elegans, with annotated H. contortus genes being an average of two-to-three times larger than their putative C. elegans orthologues due to a greater intron number and size. Synteny appears high but gene order is generally poorly conserved, although areas of conserved microsynteny are apparent. C. elegans operons appear to be partially conserved in H. contortus. Our findings suggest that a combination of RNA-seq and comparative analysis with C. elegans is a powerful approach for the annotation and analysis of strongylid nematode genomes
Hybrid Mechanical Systems
We discuss hybrid systems in which a mechanical oscillator is coupled to
another (microscopic) quantum system, such as trapped atoms or ions,
solid-state spin qubits, or superconducting devices. We summarize and compare
different coupling schemes and describe first experimental implementations.
Hybrid mechanical systems enable new approaches to quantum control of
mechanical objects, precision sensing, and quantum information processing.Comment: To cite this review, please refer to the published book chapter (see
Journal-ref and DOI). This v2 corresponds to the published versio
Towards Quantum Repeaters with Solid-State Qubits: Spin-Photon Entanglement Generation using Self-Assembled Quantum Dots
In this chapter we review the use of spins in optically-active InAs quantum
dots as the key physical building block for constructing a quantum repeater,
with a particular focus on recent results demonstrating entanglement between a
quantum memory (electron spin qubit) and a flying qubit (polarization- or
frequency-encoded photonic qubit). This is a first step towards demonstrating
entanglement between distant quantum memories (realized with quantum dots),
which in turn is a milestone in the roadmap for building a functional quantum
repeater. We also place this experimental work in context by providing an
overview of quantum repeaters, their potential uses, and the challenges in
implementing them.Comment: 51 pages. Expanded version of a chapter to appear in "Engineering the
Atom-Photon Interaction" (Springer-Verlag, 2015; eds. A. Predojevic and M. W.
Mitchell
Quantum Communication
Quantum communication, and indeed quantum information in general, has changed
the way we think about quantum physics. In 1984 and 1991, the first protocol
for quantum cryptography and the first application of quantum non-locality,
respectively, attracted a diverse field of researchers in theoretical and
experimental physics, mathematics and computer science. Since then we have seen
a fundamental shift in how we understand information when it is encoded in
quantum systems. We review the current state of research and future directions
in this new field of science with special emphasis on quantum key distribution
and quantum networks.Comment: Submitted version, 8 pg (2 cols) 5 fig
Targeting VIP and PACAP receptor signalling: new therapeutic strategies in multiple sclerosis
MS (multiple sclerosis) is a chronic autoimmune and neurodegenerative pathology of the CNS (central nervous system) affecting approx. 2.5 million people worldwide. Current and emerging DMDs (disease-modifying drugs) predominantly target the immune system. These therapeutic agents slow progression and reduce severity at early stages of MS, but show little activity on the neurodegenerative component of the disease. As the latter determines permanent disability, there is a critical need to pursue alternative modalities. VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase-activating peptide) have potent anti-inflammatory and neuroprotective actions, and have shown significant activity in animal inflammatory disease models including the EAE (experimental autoimmune encephalomyelitis) MS model. Thus, their receptors have become candidate targets for inflammatory diseases. Here, we will discuss the immunomodulatory and neuroprotective actions of VIP and PACAP and their signalling pathways, and then extensively review the structure–activity relationship data and biophysical interaction studies of these peptides with their cognate receptors
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