Caregivers’ knowledge and attitude scale towards drug: development and validation

Background: Drug abuse is a prevalent issue in society, often used to reduce stress and improve mental health. It is often seen as a personal disorder, causing harm to users and their loved ones. In today’s globalized world, society strives for better care, emphasizing the importance of solving problems and emphasizing the role of caregivers in supporting drug addicts. Methods: A standardized knowledge and attitude scale was developed to assess 60 caregivers of drug addicts in Kolkata, India. The scale was self-administered and tested at 21-day intervals. The Pearson’s correlation coefficient method was applied for questionnaire validity. The scale was used to eliminate poor items and ensure reliability. Results: The tool primarily consists of twenty-two (22) knowledge and twenty-two (22) attitude items towards drug. Following item analysis, four (4) distracting items from the knowledge scale are dropped in accordance with the difficulty index and discrimination index. The discrimination indices from the attitude scale were used to eliminate 1 distracting item.  As a result, 18 items for the knowledge scale and 21 items for the attitude scale were retained. The knowledge and attitude tools’ final form has found high significant correlation. Conclusions: The study explained how to create a standardized scale with good items and significant reliability to evaluate knowledge and attitude towards drug addicts

Insect growth regulatory activity of Thevetia nerifolia Juss. against Spodoptera litura (Fab.)

Screening for insect growth regulatory activity (IGR) of Thevetia nerifolia leaf extracts were evaluated against Spodoptera litura (Fab.). Methanol extract of leaves provided 53.8 % larval mortality, 29.6 % pupation and 22.3 % adult emergence at 2.5 % concentration level. The extract was further subfractioned with solvents of different polarity in search of better IGR activity and chloroform extract was found to be most active in terms of larval mortality (27.5-61.5 %), pupation (28.4-60.2 %) and adult emergence (19.8-52.8 %). GI50 of the extract was recorded to be 3.02 %. Activity was attributed to the glycosides present in the extract

Effect of lac treatment on mechanical properties of jute fabric /polyester resin based biocomposite

An attempt has been made to dissolve lac in methanol / sodium hydroxide solution and to use this lac solution as a coupling agent for jute fabric. Lac treated jute fabric has been used to reinforce the unsaturated polyester resin (USP). Flexural strength and inter-laminar shear strength (ILSS) of lac modified jute/USP biocomposite have been evaluated and then compared with sodium hydroxide treated jute as well as untreated jute based biocomposites. Lac treated jute fabric shows higher flexural properties of the biocomposite than that of untreated jute fabric, which infers that lac acts as a good compatibliser between jute fibre and USP. Lac treatment on jute fabric enhances the flexural properties of biocomposite better in alkaline medium than in solvent medium. It is concluded that lac treatment can be used to improve the flexural and ILSS properties of jute / thermoset resin based biocomposite

SoCCAR: Detecting System-on-Chip Security Violations Under Asynchronous Resets

Modern SoC designs include several reset domains that enable asynchronous partial resets while obviating complete system boot. Unfortunately, asynchronous resets can introduce security vulnerabilities that are difficult to detect through traditional validation. In this paper, we address this problem through a new security validation framework, SoCCCAR, that accounts for asynchronous resets. The framework involves (1) efficient extraction of reset-controlled events while avoiding combinatorial explosion, and (2) concolic testing for systematic exploration of the extracted design space. Our experiments demonstrate that SoCCAR can achieve almost perfect detection accuracy and verification time of a few seconds on realistic SoC designs

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

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Not AvailableNatural colorants are emerging globally as the safer and eco-friendly leaving synthetic colorant behind in the race. An attempt has been made to extract the dye from fresh, shade dried; field dropped and sun dried flowers of Butea monosperma (Palas). A good quantity of crude dye was recovered to the extent of 4, 18 and 9 per cent respectively on weight basis. The compounds present in the flowers were analyzed through spectral means and identified as Chalcone, butein (C15H12O5), orange yellow needles and a small quantities of colourless isomeric flavanone, butin (C15H12O5), and its glycoside, butrin. The crude dye after further purification and refining has tremendous scope as a medicine or ingredient for other medicine and can also serve as colouring material in soft drinks and other food products like ham/sausages, jam, chowmin noodles etc. Highlights • Method of palas dye extraction methodology have been standardized • The yield of dye using cold percolation and soxhlet method of extraction were 4% and 2%, respectively • The dye extract was fractionated through solvent extraction techniques using solvent like hexane, chloroform, ethyl acetate and n-butanol • The separated constituents were characterized through physical determination of melting points, boiling points and instrumental methods like UV and Infra red (IR) and GC-MS • Compounds identified from the palas dye were chalcone, small quantities of colourless isomeric flavanone, butin and its glycoside, butrin

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Not AvailableJute is an eco-friendly, cheap and excellent fibre, traditionally used for sacking and hessian. India produces 80% of jute of total global demand. Owing to environment friendly properties, this ‘golden fiber’ has been used as a safe material for packing and transport. However, dilution of JPM act coupled with competition from synthetic/ man-made fibres, demand of jute for traditional usages i.e. sacking and hessian has decreased over past five years. Under such circumstances, application of jute for diversified product has become necessary for survival of around 44 lakhs direct and indirectly related workers (covering farmers and mill workers) associated with the jute industry. Jute diversified products like shopping bags, wall hangings, floor covering, non-ovens, geo-textiles, composites etc has opened up a new realm beyond traditional application of jute. Export of jute diversified products has increased from INR 363.593 to 590.215 corers during 2012-13 to 2016-17. Present status paper reports various type of jute diversified products along with their market scope, performance and opportunity across the world.Not Availabl