On the publication and pagination of Ameghino's (1894) taxonomy of Santacrucian mammals

DURING the course of our research on the paleobiology and systematics ofmammalian remains of the Santa Cruz Formation of Argentine Patagonia,we becameaware of differences in the early literature dealing with Santacrucian (late Early Miocene) mammals. Although literature errors are not uncommon, they are often only an inconvenience. However, in this case it involves an article in which numerous taxa were erected, so that particular attention must be paid to the circumstances of its publication. The article in question is Florentino Ameghino?s (1894a, b) Énumération synoptique des espèces de mammifères fossiles des formations éocènes de Patagonie. This article was published formally in 1893 in the Boletín de la Academia Nacional de Ciencias en Córdoba and also in 1894, with identical title and text but different pagination, as an offprint.Fil: De Iuliis, Gerardo. University of Toronto; Canadá. Royal Ontario Museum; CanadáFil: Fernicola, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; ArgentinaFil: Racco, Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; Argentin

Gendered Perceptions of Place on York University's Keele Campus through a Lens of Personal Safety

The York University Keele Campus is a public space that is primarily used by students, faculty, and staff and at any given moment there can be thousands of individuals on the University campus. With a student population of just over 50,000, York University is one of the largest universities in Canada and resembles a small city. Much like a city, the Keele Campus of York University has been impacted by incidents of sexual assault, robberies, hate crimes and criminal activity that have produced caution amongst those who interact with the Campus. The incidents that have occurred on the Campus have affected many individuals ability to establish a sense of place and cause them to restrict their use of space. On a university campus where incidents are publicized by the socialization between students, media reports, and notification emails, concerns regarding personal safety manifest into perceptions of place that are highly gendered. Through a lens of personal safety, this thesis seeks to understand students perceptions of place on the Keele Campus, identifying how the built environment, students gender identity, and the reputation attributed to space contribute to students perceptions. Moreover, it will explore how the perceptions of place held by students affect their daily geographies of the Keele Campus and challenge the gender normative direction of the Crime Prevention Through Environmental Design model that exists in the governing and operation of the Keele Campus

Novel schedule for treatment of inflammatory breast cancer

Inflammatory breast cancer (IBC) is the most aggressive form of this tumor, with the clinical and biological characteristics of a rapidly proliferating disease. This tumor is always diagnosed at advanced stages, atleast stage IIIB (locally advanced), so its management requires an integrated multidisciplinary approach with a systemic therapy followed by surgery and radiation therapy. Patients with IBC usually have a worse prognosis but the achievement of a pathologic complete response after neoadjuvant chemotherapy may have good rates of overall survival. We present the case of a 47 year old women with IBC, luminal B and with high proliferative index; she was successfully treated with a sequential schedule of chemotherapy (anthracyclines dose-dense/carboplatin+ taxane/Cyclophosphamide Methotrexate Fluorouracil), hormone-therapy, complementary radiotherapy and finally surgery until the achievement of a complete clinical and pathological response. Luminal B inflammatory breast cancer with high proliferation index can benefit from sequential schedules of neoadjuvant chemotherapy and hormonal treatment and this can result in pathological complete response

Metronomic chemotherapy preserves quality of life ensuring efficacy in elderly advanced non small cell lung cancer patients

Metastatic non small cell lung cancers (NSCLC) are diseases with poor prognosis and platinum-based doublet chemotherapy still remains their standard cure. Elderly patients often present comorbidities that limit the utilization of this chemotherapy; therefore these patients should have a first-line treatment with low toxicity and capable to preserve the quality of life (QoL) but, at the same time, to ensure the best possible response. Furthermore, a first-line treatment allows patients to be fit for further treatments, prolonging overall survival. At this regard, metronomic chemotherapy can be an optimal choice for elderly, able to improve QoL and to obtain an optimal palliation. We retrospectively studied a cohort of 41 elderly advanced NSCLC patients with different histotypes, treated with metronomic chemotherapy (weekly carbo-paclitaxel or vinorelbine as single agent) as first choice and we analyzed the tolerability, the impact on QoL and the efficacy of these schedules: no toxicity of 3 and 4 grade was observed, together to a clinical benefit of 43%. We administered FACT-L test to evaluate QoL at baseline and after 4 months and found a significant improvement in all FACT-L parameters: physical, social, emotional and functional, confirming a QoL improvement. At a median follow-up of 20.2 months the progression free survival was of 6 months and the overall survival was of 15 months. These results suggest that metronomic chemotherapy can be an effective choice of treatment for elderly NSCLC patients and further trials with more patients are needed to confirm this proposal

Circulating neuregulin-1 and galectin-3 can be prognostic markers in breast cancer

Background: It is important to identify novel plasmatic biomarkers that can contribute to assessing the prognosis and outcome of breast cancer patients. Neuregulin-1 (NRG1) and galectin-3 (Gal-3) are proteins that are involved in breast cancer development and patient survival; therefore, we studied whether the serum concentration of these 2 proteins can be correlated to breast cancer progression. Methods: Plasmatic NRG1 and Gal-3 were evaluated in 25 healthy controls and 50 breast cancer patients at baseline and at 3 and 6 months after treatment with anthracyclines and taxanes, with or without trastuzumab. Results: NRG1 and Gal-3 were significantly more elevated in cancer patients than in healthy controls; further- more, NRG1 and Gal-3 were significantly increased after chemotherapy and were predictive of mortality at 1 year. Conclusions: Circulating NRG1 and Gal-3 can be additional biomarkers indicative of prognosis and outcomes for breast cancer patients

The Ground Sloth, Megalonyx, from Pleistocene Deposits of the Old Crow Basin, Yukon, Canada

The bear-sized ground sloth Megalonyx, endemic to North America, was widespread during the Pleistocene, reaching as far north as Alaska, Yukon, and Northwest Territories. Twenty-two specimens collected from 10 localities in the Old Crow Basin, northern Yukon, include several bones that can be referred to Jefferson's ground sloth (Megalonyx jeffersonii) on the basis of the distinctive morphology of the upper and lower caniniform teeth. All of the Yukon specimens are relatively small, suggesting a geological age earlier than Wisconsinan - probably Sangamonian. The Alaskan, Yukon, and Northwest Territories records imply that the species occupied a broad east-west range in northwestern North America during a warm phase of the late Pleistocene. Le paresseux marcheur Megalonyx, de la taille d'un ours, qui était endémique à l'Amérique du Nord, occupait au pléistocène une vaste aire s'étendant au Nord jusqu'en Alaska, au Yukon et aux Territoires du Nord-Ouest. Vingt-deux spécimens recueillis à 10 emplacements dans le bassin de Old Crow (partie nord du Yukon), comprennent plusieurs os que l'on peut attribuer au paresseux marcheur de Jefferson (Megalonyx jeffersonii) si l'on se fie à la morphologie particulière des dents supérieures et inférieures en forme de canines. Tous les spécimens du Yukon ont une taille relativement petite, ce qui suggère qu'ils datent d'un âge géologique antérieur au wisconsinien - probablement le sangamonien. Les relevés faits en Alaska, au Yukon et dans les Territoires du Nord-Ouest laissent entendre que l'espèce occupait une vaste aire s'étendant d'est en ouest dans la partie nord-occidentale de l'Amérique du Nord durant une phase de réchauffement du pléistocène tardif.