51 research outputs found
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S
- Adams Hieab H H
- Adeyemo Adebowale A
- Aguilar-Salinas Carlos A
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K
- Asselbergs Folkert W
- Assimes Themistocles L
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W
- Bennett David A
- Bentley Amy R
- Beulens Joline W J
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F
- Biino Ginevra
- Bis Joshua C
- Bjerregaard Anne A
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S
- Brody Jennifer A
- Brown Christopher D
- Brown Michael R
- Brown Morris
- Brumpton Ben M
- Buring Julie E
- Burtt Noël P
- Böger Carsten A
- Cade Brian E
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C
- Chandak Giriraj R
- Chang Kyong-Mi
- Chasman Daniel I
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee-Ming
- Ciullo Marina
- Clarke Shoa L
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M
- Dantoft Thomas M
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J
- de Graaf Jacqueline
- De Jager Philip L
- de Kleijn Dominique
- de Silva H Janaka
- de Vries Paul S
- Dedoussis George
- Delgado Graciela E
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P
- Elders Petra J M
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K
- Farmaki Aliki-Eleni
- Faul Jessica D
- Feitosa Mary F
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W
- Frayling Timothy M
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E
- Gao Zishan
- Gaziano John M
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E
- Grant Struan F A
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M 't
- Hattersley Andrew T
- Havulinna Aki S
- Haworth Simon
- Hayes M Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W
- Hidalgo Bertha
- Hilliard Austin T
- Hindy George
- Hirschhorn Joel N
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A
- Hunt Steven C
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D
- Ikram M Arfan
- Ingelsson Erik
- Irvin Marguerite R
- Jackson Rebecca D
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P
- Ji Yingji
- Jin Zi-Bing
- Jonas Jost B
- Joshi Peter K
- Jousilahti Pekka
- Jukema J Wouter
- Jung Bettina
- Justice Anne E
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L R
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A
- Khera Amit V
- Khor Chiea Chuen
- Kiemeney Lambertus A L M
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E
- Koh Woon-Puay
- Koistinen Heikki A
- Kolcic Ivana
- Kooner Jaspal S
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O
- Kraft Peter
- Krauss Ronald M
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L
- Laakso Markku
- Lamina Claudia
- Lange Leslie A
- Langenberg Claudia
- Launer Lenore J
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jianjun
- Liu Jun
- Lo Ken Sin
- Locke Adam E
- Loeffler Markus
- Long Jirong
- Loos Ruth J F
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian'an
- Lynch Julie A
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K E
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C
- Martin Lisa Warsinger
- Martin Nicholas G
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I
- McDaid Aaron F
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M
- Miller Jason E
- Millwood Iona Y
- Mitchell Jonathan S
- Mitchell Paul
- Mitchell Ruth E
- Mohlke Karen L
- Mook-Kanamori Dennis O
- Mori Trevor A
- Morris Andrew P
- Morrison Alanna C
- Munroe Patricia B
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E
- Nelson Christopher P
- Nethander Maria
- Neville Matt J
- Nielsen Aneta A
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S
- Noordam Raymond
- North Kari E
- Ntalla Ioanna
- Nutile Teresa
- O'Donnell Christopher J
- Obura Morgan O
- Ohlsson Claes
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J
- Oldmeadow Christopher
- Orozco Lorena
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N A
- Pandit Anita
- Parra Esteban J
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L
- Pedersen Oluf
- Peloso Gina M
- Pennell Craig E
- Penninx Brenda
- Peters Annette
- Petersen Eva R B
- Peyser Patricia A
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P
- Prasad Gauri
- Preuss Michael H
- Province Michael A
- Psaty Bruce M
- Pérusse Louis
- Qu Jia
- Rader Daniel J
- Raitakari Olli T
- Rallidis Loukianos S
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D C
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W
- Redline Susan
- Reilly Dermot F
- Reiner Alexander P
- Rhee Sang Youl
- Ridker Paul M
- Ripatti Samuli
- Ritchie Marylyn D
- Rosenthal Elisabeth A
- Rotimi Charles N
- Rotter Jerome I
- Ruggiero Daniela
- Ruotsalainen Sanni E
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B
- Schunkert Heribert
- Scott Rodney J
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C
- Smith Blair H
- Smith Jennifer A
- Smyth Laura J
- Snieder Harold
- Southam Lorraine
- Spector Tim D
- Spracklen Cassandra N
- Stark Klaus J
- Stefansson Kari
- Strachan David P
- Stringham Heather M
- Sun Yan V
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean-Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R H J
- Timpson Nicholas J
- Trembath Richard C
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L
- Tsao Philip S
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Vaccargiu Simona
- van Dam Rob M
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J
- van Dijk Ko Willems
- van Duijn Cornelia M
- van Heel David A
- van Meurs Joyce B J
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G
- Wang Carol A
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J
- Warner Sophie C
- Warren Helen R
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B
- Weir David R
- Weiss Stefan
- Whitfield John B
- Wickremasinghe Ananda R
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H
- Willemsen Allegonda H M
- Willer Cristen J
- Wilson James G
- Wilson James G
- Wilson Peter W F
- Winkler Thomas W
- Wojczynski Mary K
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R
- Wu Jer-Yuarn
- Wu Kuan-Han H
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J M
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R
- Zimmermann Martina E
- Zmuda Joseph M
- Zonderman Alan B
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2022
- Field of study
Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S
- Adams Hieab H H
- Adeyemo Adebowale A
- Aguilar-Salinas Carlos A
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K
- Asselbergs Folkert W
- Assimes Themistocles L
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W
- Bennett David A
- Bentley Amy R
- Beulens Joline W J
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F
- Biino Ginevra
- Bis Joshua C
- Bjerregaard Anne A
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S
- Brody Jennifer A
- Brown Christopher D
- Brown Michael R
- Brown Morris
- Brumpton Ben M
- Buring Julie E
- Burtt Noël P
- Böger Carsten A
- Cade Brian E
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C
- Chandak Giriraj R
- Chang Kyong-Mi
- Chasman Daniel I
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee-Ming
- Ciullo Marina
- Clarke Shoa L
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M
- Dantoft Thomas M
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J
- de Graaf Jacqueline
- De Jager Philip L
- de Kleijn Dominique
- de Silva H Janaka
- de Vries Paul S
- Dedoussis George
- Delgado Graciela E
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P
- Elders Petra J M
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K
- Farmaki Aliki-Eleni
- Faul Jessica D
- Feitosa Mary F
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W
- Frayling Timothy M
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E
- Gao Zishan
- Gaziano John M
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E
- Grant Struan F A
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M 't
- Hattersley Andrew T
- Havulinna Aki S
- Haworth Simon
- Hayes M Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W
- Hidalgo Bertha
- Hilliard Austin T
- Hindy George
- Hirschhorn Joel N
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A
- Hunt Steven C
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D
- Ikram M Arfan
- Ingelsson Erik
- Irvin Marguerite R
- Jackson Rebecca D
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P
- Ji Yingji
- Jin Zi-Bing
- Jonas Jost B
- Joshi Peter K
- Jousilahti Pekka
- Jukema J Wouter
- Jung Bettina
- Justice Anne E
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L R
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A
- Khera Amit V
- Khor Chiea Chuen
- Kiemeney Lambertus A L M
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E
- Koh Woon-Puay
- Koistinen Heikki A
- Kolcic Ivana
- Kooner Jaspal S
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O
- Kraft Peter
- Krauss Ronald M
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L
- Laakso Markku
- Lamina Claudia
- Lange Leslie A
- Langenberg Claudia
- Launer Lenore J
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jianjun
- Liu Jun
- Lo Ken Sin
- Locke Adam E
- Loeffler Markus
- Long Jirong
- Loos Ruth J F
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian'an
- Lynch Julie A
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K E
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C
- Martin Lisa Warsinger
- Martin Nicholas G
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I
- McDaid Aaron F
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M
- Miller Jason E
- Millwood Iona Y
- Mitchell Jonathan S
- Mitchell Paul
- Mitchell Ruth E
- Mohlke Karen L
- Mook-Kanamori Dennis O
- Mori Trevor A
- Morris Andrew P
- Morrison Alanna C
- Munroe Patricia B
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E
- Nelson Christopher P
- Nethander Maria
- Neville Matt J
- Nielsen Aneta A
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S
- Noordam Raymond
- North Kari E
- Ntalla Ioanna
- Nutile Teresa
- O'Donnell Christopher J
- Obura Morgan O
- Ohlsson Claes
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J
- Oldmeadow Christopher
- Orozco Lorena
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N A
- Pandit Anita
- Parra Esteban J
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L
- Pedersen Oluf
- Peloso Gina M
- Pennell Craig E
- Penninx Brenda
- Peters Annette
- Petersen Eva R B
- Peyser Patricia A
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P
- Prasad Gauri
- Preuss Michael H
- Province Michael A
- Psaty Bruce M
- Pérusse Louis
- Qu Jia
- Rader Daniel J
- Raitakari Olli T
- Rallidis Loukianos S
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D C
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W
- Redline Susan
- Reilly Dermot F
- Reiner Alexander P
- Rhee Sang Youl
- Ridker Paul M
- Ripatti Samuli
- Ritchie Marylyn D
- Rosenthal Elisabeth A
- Rotimi Charles N
- Rotter Jerome I
- Ruggiero Daniela
- Ruotsalainen Sanni E
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B
- Schunkert Heribert
- Scott Rodney J
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C
- Smith Blair H
- Smith Jennifer A
- Smyth Laura J
- Snieder Harold
- Southam Lorraine
- Spector Tim D
- Spracklen Cassandra N
- Stark Klaus J
- Stefansson Kari
- Strachan David P
- Stringham Heather M
- Sun Yan V
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean-Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R H J
- Timpson Nicholas J
- Trembath Richard C
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L
- Tsao Philip S
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Vaccargiu Simona
- van Dam Rob M
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J
- van Dijk Ko Willems
- van Duijn Cornelia M
- van Heel David A
- van Meurs Joyce B J
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G
- Wang Carol A
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J
- Warner Sophie C
- Warren Helen R
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B
- Weir David R
- Weiss Stefan
- Whitfield John B
- Wickremasinghe Ananda R
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H
- Willemsen Allegonda H M
- Willer Cristen J
- Wilson James F
- Wilson James G
- Wilson Peter W F
- Winkler Thomas W
- Wojczynski Mary K
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R
- Wu Jer-Yuarn
- Wu Kuan-Han H
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J M
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R
- Zimmermann Martina E
- Zmuda Joseph M
- Zonderman Alan B
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 27/12/2022
- Field of study
Funding GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007–2013 under grant agreement no. HEALTH-F2-2013–601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundation’s Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1–19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska Läkaresällskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Union’s Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (CP17/00142) and co-financed by the European Social Fund. Jian Yang is funded by the Westlake Education Foundation. Olga Giannakopoulou has received funding from the British Heart Foundation (BHF) (FS/14/66/3129). CHARGE Consortium cohorts were supported by R01HL105756. Study-specific acknowledgements are available in the Additional file 32: Supplementary Note. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.Peer reviewedPublisher PD
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S.
- Adams Hieab H. H.
- Adeyemo Adebowale A.
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Beulens Joline W. J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C
- Bjerregaard Anne A.
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee-Ming
- Ciullo Marina
- Clarke Shoa L.
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M.
- Dantoft Thomas M.
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Elders Petra J. M.
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K.
- Farmaki Aliki-Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F. A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson S
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M.'t
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- Hilliard Austin T.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E.
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V.
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A.
- Hunt Steven C.
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Ingelsson Erik
- Irvin Marguerite R.
- Jackson Rebecca D.
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P.
- Ji Yingji
- Jin Zi-Bing
- Jonas Jost B.
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Jung Bettina
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L. R.
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A.
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O.
- Kraft Peter
- Krauss Ronald M.
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L.
- Laakso Markku
- Lamina Claudia
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jun
- Liu Junfeng
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Long Jirong
- Loos Ruth J. F.
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian'an
- Lynch Julie A.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K. E.
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C.
- Martin Lisa Warsinger
- Martin Nicholas G.
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I.
- McDaid Aaron F.
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M.
- Miller Jason E.
- Millwood Iona Y.
- Mitchell Jonathan S.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Mori Trevor A.
- Morris Andrew P.
- Morrison Alanna C.
- Munroe Patricia B.
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T.
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A.
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Nielsen Aneta A.
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- O'Donnell Christopher J.
- Obura Morgan O.
- Ohlsson Claes
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J.
- Oldmeadow Christopher
- Orozco Lorena
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N. A.
- Pandit Anita
- Parra Esteban J.
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L.
- Pedersen Oluf
- Peloso Gina M
- Pennell Craig E.
- Penninx Brenda
- Peters Annette
- Petersen Eva R. B.
- Peyser Patricia A.
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P.
- Prasad Gauri
- Preuss Michael H.
- Province Michael A.
- Psaty Bruce M.
- Pérusse Louis
- Qu Jia
- Rader Daniel J.
- Raitakari Olli T.
- Rallidis Loukianos S.
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D. C.
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Ripatti Samuli
- Ritchie Marylyn D.
- Rosenthal Elisabeth A.
- Rotimi Charles N.
- Rotter Jerome I.
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M.
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Rodney J.
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C.
- Smith Blair H.
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stark Klaus J.
- Stefansson Kari
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean-Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Trembath Richard C.
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L.
- Tsao Philip S.
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Universitat Autònoma de Barcelona
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B. J.
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B.
- Weir David R.
- Weiss Stefan
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H. M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W. F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wu Jer-Yuarn
- Wu Kuan-Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J. M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu X
- Zhu Xiang
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S.
- Adams Hieab H.H.
- Adeyemo Adebowale A.
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Beulens Joline W.J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C.
- Bjerregaard Anne A.
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong Mi
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene E.
- Chen Yii Der Ida
- Chen Zhengming
- Cheng Ching Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee Ming
- Ciullo Marina
- Clarke Shoa L.
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne A.
- Damrauer Scott M.
- Dantoft Thomas M.
- Daviglus Martha
- Daw EWarwick W.
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Elders Petra J.M.
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K.
- Farmaki Aliki Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng Qi Ping
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F.A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M.‘t
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Heng Chew Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- Hilliard Austin T.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk Lam
- Hoefer Imo E.
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V.
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi Jen
- Hunt Karen A.
- Hunt Steven C.
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Ingelsson Erik
- Irvin Marguerite R.
- Jackson Rebecca D.
- Jang Dongkeun
- Jang Hye Mi
- Jarvelin Marjo Riitta
- Jarvik Gail P.
- Ji Yingji
- Jin Zi Bing
- Jonas Jost B.
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Jung Bettina
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L.R.
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A.
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A.L.M.
- Kim Bong Jo
- Kim Eung Kweon
- Kim Han Na
- Kim Hyung Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E.
- Koh Woon Puay
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O.
- Kraft Peter
- Krauss Ronald M.
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L.
- Laakso Markku
- Lamina Claudia
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jianjun
- Liu Jun
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Long Jirong
- Loos Ruth J.F.
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian’an
- Lynch Julie A.
- Lyssenko Valeriya
- Lyytikäinen Leo Pekka
- Magnusson Patrik K.E.
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C.
- Martin Lisa Warsinger
- Martin Nicholas G.
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I.
- McDaid Aaron F.
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M.
- Miller Jason E.
- Millwood Iona Y.
- Mitchell Jonathan S.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Mori Trevor A.
- Morris Andrew P.
- Morrison Alanna C.
- Munroe Patricia B.
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T.
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A.
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Nielsen Aneta A.
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- Obura Morgan O.
- Ohlsson Claes
- Okada Yukinori
- Oldehinkel Albertine J.
- Oldmeadow Christopher
- Orozco Lorena
- O’Donnell Christopher J.
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N.A.
- Pandit Anita
- Parra Esteban J.
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L.
- Pedersen Oluf
- Peloso Gina M.
- Pennell Craig E.
- Penninx Brenda
- Peters Annette
- Petersen Eva R.B.
- Peyser Patricia A.
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P.
- Prasad Gauri
- Preuss Michael H.
- Province Michael A.
- Psaty Bruce M.
- Pérusse Louis
- Qu Jia
- Rader Daniel J.
- Raitakari Olli T.
- Rallidis Loukianos S.
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D. C.
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Ripatti Samuli
- Ritchie Marylyn D.
- Rosenthal Elisabeth A.
- Rotimi Charles N.
- Rotter Jerome I.
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M.
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Rodney J.
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C.
- Smith Blair H.
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stark Klaus J.
- Stefansson Kari
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong S.
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R.H.J.
- Timpson Nicholas J.
- Trembath Richard C.
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L.
- Tsao Philip S.
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B.J.
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Watkins Hugh
- Wei Wei Qi
- Wei Wen B.
- Weir David R.
- Weiss Stefan
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H.M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W.F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien Yin
- Woo Jeong Taek
- Wood Andrew R.
- Wu Jer Yuarn
- Wu Kuan Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian Min
- Zajac Greg J.M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Ólafsson Ísleifur
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2022
- Field of study
Funding Information: GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007–2013 under grant agreement no. HEALTH-F2-2013–601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundation’s Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1–19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska Läkaresällskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Union’s Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (CP17/00142) and co-financed by the European Social Fund. Jian Yang is funded by the Westlake Education Foundation. Olga Giannakopoulou has received funding from the British Heart Foundation (BHF) (FS/14/66/3129). CHARGE Consortium cohorts were supported by R01HL105756. Study-specific acknowledgements are available in the Additional file : Supplementary Note. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services. Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S.
- Adams Hieab H.H.
- Adeyemo Adebowale A.
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Beulens Joline W.J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C.
- Bjerregaard Anne A.
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong Mi
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene E.
- Chen Yii Der Ida
- Chen Zhengming
- Cheng Ching Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee Ming
- Ciullo Marina
- Clarke Shoa L.
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne A.
- Damrauer Scott M.
- Dantoft Thomas M.
- Daviglus Martha
- Daw EWarwick W.
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Elders Petra J.M.
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K.
- Farmaki Aliki Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng Qi Ping
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F.A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M.‘t
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Heng Chew Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- Hilliard Austin T.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk Lam
- Hoefer Imo E.
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V.
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi Jen
- Hunt Karen A.
- Hunt Steven C.
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Ingelsson Erik
- Irvin Marguerite R.
- Jackson Rebecca D.
- Jang Dongkeun
- Jang Hye Mi
- Jarvelin Marjo Riitta
- Jarvik Gail P.
- Ji Yingji
- Jin Zi Bing
- Jonas Jost B.
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Jung Bettina
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L.R.
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A.
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A.L.M.
- Kim Bong Jo
- Kim Eung Kweon
- Kim Han Na
- Kim Hyung Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E.
- Koh Woon Puay
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O.
- Kraft Peter
- Krauss Ronald M.
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L.
- Laakso Markku
- Lamina Claudia
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jianjun
- Liu Jun
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Long Jirong
- Loos Ruth J.F.
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian’an
- Lynch Julie A.
- Lyssenko Valeriya
- Lyytikäinen Leo Pekka
- Magnusson Patrik K.E.
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C.
- Martin Lisa Warsinger
- Martin Nicholas G.
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I.
- McDaid Aaron F.
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M.
- Miller Jason E.
- Millwood Iona Y.
- Mitchell Jonathan S.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Mori Trevor A.
- Morris Andrew P.
- Morrison Alanna C.
- Munroe Patricia B.
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T.
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A.
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Nielsen Aneta A.
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- Obura Morgan O.
- Ohlsson Claes
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J.
- Oldmeadow Christopher
- Orozco Lorena
- O’Donnell Christopher J.
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N.A.
- Pandit Anita
- Parra Esteban J.
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L.
- Pedersen Oluf
- Peloso Gina M.
- Pennell Craig E.
- Penninx Brenda
- Peters Annette
- Petersen Eva R.B.
- Peyser Patricia A.
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P.
- Prasad Gauri
- Preuss Michael H.
- Province Michael A.
- Psaty Bruce M.
- Pérusse Louis
- Qu Jia
- Rader Daniel J.
- Raitakari Olli T.
- Rallidis Loukianos S.
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D. C.
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Ripatti Samuli
- Ritchie Marylyn D.
- Rosenthal Elisabeth A.
- Rotimi Charles N.
- Rotter Jerome I.
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M.
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Rodney J.
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C.
- Smith Blair H.
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stark Klaus J.
- Stefansson Kari
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong S.
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R.H.J.
- Timpson Nicholas J.
- Trembath Richard C.
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L.
- Tsao Philip S.
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B.J.
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Watkins Hugh
- Wei Wei Qi
- Wei Wen B.
- Weir David R.
- Weiss Stefan
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H.M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W.F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien Yin
- Woo Jeong Taek
- Wood Andrew R.
- Wu Jer Yuarn
- Wu Kuan Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian Min
- Zajac Greg J.M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 27/12/2022
- Field of study
Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S.
- Adams Hieab H.H.
- Adeyemo Adebowale A.
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Beulens Joline W.J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C.
- Bjerregaard Anne A.
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong Mi
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene E.
- Chen Yii Der Ida
- Chen Zhengming
- Cheng Ching Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee Ming
- Ciullo Marina
- Clarke Shoa L.
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne A.
- Damrauer Scott M.
- Dantoft Thomas M.
- Daviglus Martha
- Daw EWarwick W.
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Elders Petra J.M.
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K.
- Farmaki Aliki Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng Qi Ping
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F.A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M.‘t
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Heng Chew Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- Hilliard Austin T.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk Lam
- Hoefer Imo E.
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V.
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi Jen
- Hunt Karen A.
- Hunt Steven C.
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Ingelsson Erik
- Irvin Marguerite R.
- Jackson Rebecca D.
- Jang Dongkeun
- Jang Hye Mi
- Jarvelin Marjo Riitta
- Jarvik Gail P.
- Ji Yingji
- Jin Zi Bing
- Jonas Jost B.
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Jung Bettina
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L.R.
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A.
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A.L.M.
- Kim Bong Jo
- Kim Eung Kweon
- Kim Han Na
- Kim Hyung Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E.
- Koh Woon Puay
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O.
- Kraft Peter
- Krauss Ronald M.
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L.
- Laakso Markku
- Lamina Claudia
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jianjun
- Liu Jun
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Long Jirong
- Loos Ruth J.F.
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian’an
- Lynch Julie A.
- Lyssenko Valeriya
- Lyytikäinen Leo Pekka
- Magnusson Patrik K.E.
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C.
- Martin Lisa Warsinger
- Martin Nicholas G.
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I.
- McDaid Aaron F.
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M.
- Miller Jason E.
- Millwood Iona Y.
- Mitchell Jonathan S.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Mori Trevor A.
- Morris Andrew P.
- Morrison Alanna C.
- Munroe Patricia B.
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T.
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A.
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Nielsen Aneta A.
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- Obura Morgan O.
- Ohlsson Claes
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J.
- Oldmeadow Christopher
- Orozco Lorena
- O’Donnell Christopher J.
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N.A.
- Pandit Anita
- Parra Esteban J.
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L.
- Pedersen Oluf
- Peloso Gina M.
- Pennell Craig E.
- Penninx Brenda
- Peters Annette
- Petersen Eva R.B.
- Peyser Patricia A.
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P.
- Prasad Gauri
- Preuss Michael H.
- Province Michael A.
- Psaty Bruce M.
- Pérusse Louis
- Qu Jia
- Rader Daniel J.
- Raitakari Olli T.
- Rallidis Loukianos S.
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D. C.
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Ripatti Samuli
- Ritchie Marylyn D.
- Rosenthal Elisabeth A.
- Rotimi Charles N.
- Rotter Jerome I.
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M.
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Rodney J.
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C.
- Smith Blair H.
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stark Klaus J.
- Stefansson Kari
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong S.
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R.H.J.
- Timpson Nicholas J.
- Trembath Richard C.
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L.
- Tsao Philip S.
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B.J.
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Watkins Hugh
- Wei Wei Qi
- Wei Wen B.
- Weir David R.
- Weiss Stefan
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H.M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W.F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien Yin
- Woo Jeong Taek
- Wood Andrew R.
- Wu Jer Yuarn
- Wu Kuan Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian Min
- Zajac Greg J.M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2022
- Field of study
Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk
Additional file 28 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Academia Sinica Institute of Biomedical Sciences
- Academy of Scientific and Innovative Research (AcSIR)
- Adair Linda S.
- Adams Hieab H. H.
- Adeyemo Adebowale A.
- Agency for Science Technology and Research (A*STAR)
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Alexandria University
- Algebra University College
- Arbeeva Liubov
- Arctic Centre Univ. of Groningen
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Atlanta VA Health Care System
- Attia John
- Attikon University Hospital
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Barts and The London School of Medicine and Dentistry
- Bayyana Swati
- Bechayda Sonny Augustin
- Beijing Institute for Brain Disorders
- Beijing Tongren Hospital Capital Medical University
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Beulens Joline W. J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- BHF Glasgow Cardiovascular Research Centre Faculty of Medicine
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C.
- Bispebjerg and Frederiksberg Hospital
- Bjerregaard Anne A.
- Black Corri
- Blood Institute's and Boston University's Framingham Heart Study
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bornholms Hospital
- Boston University School of Public Health
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Broad Institute
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Capital Medical University
- Case Western Reserve University
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Center for Non-Communicable Diseases
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Charité Universitätsmedizin Berlin
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Children's Hospital Oakland Research Institute
- Children's Hospital Philadelphia and University of Pennsylvania School of Medicine
- Chinese Academy of Medical Sciences &
- Chinese National Human Genome Center at Shanghai
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christian-Albrechts-Universitaet zu Kiel
- Christofidou Paraskevi
- Chuang Lee-Ming
- Churchill Hospital
- CIBIOR
- Cincinnati Children's Hospital Medical Center
- Ciullo Marina
- Clarendon Laboratory
- Clarke Shoa L.
- Clinical Trial Service Unit and Epidemiological Studies Unit
- College of Life Sciences
- College of Medicine
- Columbia University Mailman School of Public Health
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- CSIR-Centre for Cellular and Molecular Biology
- CSIR-Institute of Genomics and Integrative Biology
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M.
- Dantoft Thomas M.
- Dasman Diabetes Institute
- Data Tecnica International
- Data Tecnica International
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- deCODE genetics/Amgen Inc.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Department of Clinical Neuroscience
- Department of Epidemiology and Data Science Amsterdam UMC
- Department of General Practice Amsterdam UMC
- Department of Nephrology Instituto de Investigaciones Biomédicas Sant Pau
- Dipartimento di Chimica e Farmacia Università di Sassari
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Dromokaiteio Psychiatric Hospital
- Duke-NUS Medical School Singapore
- DZHK (German Centre for Cardiovascular Research) Partner site Greifswald
- Ealing Hospital
- Elders Petra J. M.
- Emory University
- Emory University School of Medicine
- Engmann Jorgen
- Erasmus University Medical Center
- Erdmann Jeanette
- EURAC Research Affiliated Institute of the University of Lübeck
- Evans Michele K.
- Ewha Womans University
- Ewha Womans University School of Medicine
- Faculteit Medische Wetenschappen/UMCG
- Faisalabad Institute of Cardiology
- Farmaki Aliki-Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Fimlab Laboratories Department of Clinical Chemistry
- Finnish Institute for Health and Welfare
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Fred Hutchinson Cancer Research Center
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Fuwai Hospital Chinese Academy of Medical Sciences &
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Geisinger
- Genome Institute of Singapore
- George Institute for Global Health at Peking University Health Science Centre
- George Washington University
- George Washington University
- German Center for Diabetes Research
- German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig
- German Chronic Kidney Disease Study
- German Institute of Human Nutrition
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Glenfield Hospital
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graduate School of Medical Sciences
- Graduate School of Medicine
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F. A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Hallym University
- Han Sohee
- Hansen Torben
- Harbor-UCLA Medical Center
- Harokopio University
- Hart Leen M.‘t
- Harvard Medical School
- Harvard School of Public Health
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Helsinki University Central Hospital
- Heng Chew-Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- High Tech Campus 4
- Hilliard Austin T.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E.
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V.
- Homuth Georg
- Hospital of Southern Jutland
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huazhong University of Science and Technology
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A.
- Hunt Steven C.
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Icahn School of Medicine at Mount Sinai
- Icelandic Heart Association
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Imperial College
- Imperial College and Imperial Healthcare NHS Trust
- Imperial College London
- Ingelsson Erik
- Institute for Maternal and Child Health - IRCCS Burlo Garofolo
- Institute of Epidemiology 2
- Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” - CNR
- Institute of Molecular and Clinical Ophthalmology
- Institute of Nutrition and Functional Foods (INAF)
- Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
- Instituto Nacional de Medicina Genómica
- InstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes
- Interuniversity Cardiology Institute of The Netherlands
- IRCCS Neuromed
- Irvin Marguerite R.
- Istituto di Ricerca Genetica e Biomedica
- Jackson Rebecca D.
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P.
- Jawaharlal Nehru University
- Ji Yingji
- Jichi Medical University
- Jin Zi-Bing
- Jonas Jost B.
- Joshi Peter K.
- Jousilahti Pekka
- JSS Academy of Higher Education and Research
- Jukema J. Wouter
- Jung Bettina
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L. R.
- Karolinska University Hospital
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A.
- KfH Kidney Center Traunstein
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- King Abdulaziz University
- King's College London
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O.
- Kraft Peter
- Krauss Ronald M.
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- Kurume University School of Medicine
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- Loos Ruth J. F.
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- Ltd
- Lu Xiangfeng
- Luan Jian’an
- Lund University
- Lund University Diabetes Centre
- Lynch Julie A.
- Lyssenko Valeriya
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- Mahajan Anubha
- MAHSC University of Manchester
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
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- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C.
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- Snieder Harold
- Southam Lorraine
- Southern University of Science and Technology
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- Trivedi Bhavi
- Trompet Stella
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- Turku University Hospital and University of Turku
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- University of the Witwatersrand Faculty of Health Sciences
- University of Toronto
- University of Turku
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- University of Washington School of Medicine
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- University of Western Australia
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- Universitätsklinikum Regensburg
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- Uppsala University
- Uppsala University
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- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B. J.
- van Setten Jessica
- Vanderbilt University Medical Center
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verve Therapeutics
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Virgen de las Nieves University Hospital
- Vitart Veronique
- Vrije Universiteit Amsterdam de Boelelaan
- VU University Medical Center
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Washington University in St. Louis
- Washington University School of Medicine in St. Louis
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B.
- Weill Cornell Medicine-Qatar
- Weir David R.
- Weiss Stefan
- Wellcome Sanger Institute
- Wellcome Trust Centre for Human Genetics
- Wenzhou Medical University
- Westlake Laboratory of Life Sciences and Biomedicine
- Westlake University
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H. M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W. F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wu Jer-Yuarn
- Wu Kuan-Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yong Loo Lin School of Medicine
- Yonsei University
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J. M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- figshare
- Publication date
- 01/01/2023
- Field of study
Additional file 28: Table S18. Sex-participation association of the variants with significant sex-specific lipid results
Additional file 33 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Aberdeen Centre for Health Data Science
- Academia Sinica Institute of Biomedical Sciences
- Academy of Scientific and Innovative Research (AcSIR)
- Adair Linda S.
- Adams Hieab H. H.
- Adeyemo Adebowale A.
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Alexandria University
- Algebra University College
- Arbeeva Liubov
- Arctic Centre Univ. of Groningen
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Atlanta VA Health Care System
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Barts and The London School of Medicine and Dentistry
- Bayyana Swati
- Bechayda Sonny Augustin
- Beijing Institute for Brain Disorders
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Berlin Institute of Health
- Beulens Joline W. J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- BHF Glasgow Cardiovascular Research Centre Faculty of Medicine
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C.
- Bispebjerg and Frederiksberg Hospital
- Bjerregaard Anne A.
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bornholms Hospital
- Boston University School of Public Health
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Broad Institute
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Capital Medical University
- Case Western Reserve University
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Center for Non-Communicable Diseases
- Centre for Genomics and Oncological Research: Pfizer-University of Granada-Andalusian Regional Government
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Children's Hospital Oakland Research Institute
- Children's Hospital Philadelphia and University of Pennsylvania School of Medicine
- Chinese Academy of Medical Sciences &
- Chinese National Human Genome Center at Shanghai
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christian-Albrechts-Universitaet zu Kiel
- Christofidou Paraskevi
- Chuang Lee-Ming
- Churchill Hospital
- CIBER en Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN)
- CIBIOR
- Cincinnati Children's Hospital Medical Center
- Ciullo Marina
- Clarendon Laboratory
- Clarke Shoa L.
- Clinical Trial Service Unit and Epidemiological Studies Unit
- College of Life Sciences
- College of Medicine
- Columbia University Mailman School of Public Health
- Concas Maria Pina
- Consejo Nacional de Ciencia y Tecnología
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- CSIR-Centre for Cellular and Molecular Biology
- CSIR-Institute of Genomics and Integrative Biology
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M.
- Dantoft Thomas M.
- Dasman Diabetes Institute
- Data Tecnica International
- Data Tecnica International
- David Geffen School of Medicine at UCLA
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- deCODE genetics/Amgen Inc.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Department of Clinical Neuroscience
- Department of Epidemiology
- Department of Epidemiology and Data Science Amsterdam UMC
- Department of General Practice Amsterdam UMC
- Department of Nephrology Instituto de Investigaciones Biomédicas Sant Pau
- Deutsches Herzzentrum München
- Dipartimento di Chimica e Farmacia Università di Sassari
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Dromokaiteio Psychiatric Hospital
- Duke-NUS Medical School Singapore
- DZHK (German Centre for Cardiovascular Research) Partner site Greifswald
- Ealing Hospital
- Elders Petra J. M.
- Emory University
- Emory University School of Medicine
- Engmann Jorgen
- Erasmus University Medical Center
- Erdmann Jeanette
- EURAC Research Affiliated Institute of the University of Lübeck
- Evans Michele K.
- Ewha Womans University
- Ewha Womans University School of Medicine
- Faisalabad Institute of Cardiology
- Farmaki Aliki-Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Fimlab Laboratories Department of Clinical Chemistry
- Finnish Institute for Health and Welfare
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Fred Hutchinson Cancer Research Center
- Freie Universität Berlin
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Fuwai Hospital Chinese Academy of Medical Sciences &
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Geisinger
- Genome Institute of Singapore
- George Institute for Global Health at Peking University Health Science Centre
- George Washington University
- German Center for Diabetes Research
- German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig
- German Chronic Kidney Disease Study
- German Institute of Human Nutrition
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Glenfield Hospital
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graduate School of Medical Sciences
- Graduate School of Medicine
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F. A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Hallym University
- Han Sohee
- Hansen Torben
- Harbor-UCLA Medical Center
- Harokopio University
- Hart Leen M.‘t
- Harvard Medical School
- Harvard School of Public Health
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Helsinki University Central Hospital
- Heng Chew-Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- High Tech Campus 4
- Hilliard Austin T.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E.
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V.
- Homuth Georg
- Hospital of Southern Jutland
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huck Institutes of the Life Sciences
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A.
- Hunt Steven C.
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Icahn School of Medicine at Mount Sinai
- Icelandic Heart Association
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Imperial College
- Imperial College and Imperial Healthcare NHS Trust
- Imperial College London
- Ingelsson Erik
- Institute for Maternal and Child Health - IRCCS Burlo Garofolo
- Institute of Epidemiology 2
- Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” - CNR
- Institute of Molecular and Clinical Ophthalmology
- Institute of Nutrition and Functional Foods (INAF)
- Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
- Instituto Nacional de Medicina Genómica
- InstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes
- Interuniversity Cardiology Institute of The Netherlands
- IRCCS Neuromed
- Irvin Marguerite R.
- Istituto di Ricerca Genetica e Biomedica
- Jackson Rebecca D.
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P.
- Jawaharlal Nehru University
- Ji Yingji
- Jichi Medical University
- Jin Zi-Bing
- John Radcliffe Hospital
- Jonas Jost B.
- Joshi Peter K.
- Jousilahti Pekka
- JSS Academy of Higher Education and Research
- Jukema J. Wouter
- Jung Bettina
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L. R.
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A.
- KfH Kidney Center Traunstein
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- King Abdulaziz University
- King's College London
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E.
- Klinikum rechts der Isar der TU Muenchen
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O.
- Kraft Peter
- Krauss Ronald M.
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J.
- Kumari Meena
- Kurbasic Azra
- Kurume University School of Medicine
- Kutalik Zoltan
- Kuusisto Johanna
- Kyoto University Graduate School of Medicine
- Kyung Hee University School of Medicine
- Kähönen Mika
- Kårhus Line L.
- Laakso Markku
- Laboratory for Financial Engineering of Laval University
- Lamina Claudia
- Landspitali University Hospital
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Le Phuong
- Lee Kong Chian School of Medicine
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leiden University Medical Center
- Leipzig University Hospital
- Leonard Hampton L.
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Life Course Epidemiology (LCE)
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jianjun
- Liu Jun
- Lo Ken Sin
- Local Health Unit Toscana Centro
- Locke Adam E.
- Loeffler Markus
- London North West University Healthcare NHS Trust
- Long Jirong
- Loos Ruth J. F.
- Lorés-Motta Laura
- Loukola Anu
- Ltd
- Lu Xiangfeng
- Luan Jian’an
- Lund University
- Lund University Diabetes Centre
- Lynch Julie A.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K. E.
- Mahajan Anubha
- MAHSC University of Manchester
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C.
- Martin Lisa Warsinger
- Martin Nicholas G.
- Mashhad University of Medical Sciences School of Medicine
- MASPEC Institut
- Massachusetts General Hospital
- Massachusetts General Hospital Cancer Center
- Massachusetts Institute of Technology
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- Mayo Clinic
- McCarthy Mark I.
- McDaid Aaron F.
- McKnight Amy Jayne
- Medical University of Graz
- Medina-Gomez Carolina
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- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
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- Wu Kuan-Han H.
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- Zheng Wei
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- Publication venue
- figshare
- Publication date
- 01/01/2023
- Field of study
Additional file 33: Table S22. Mouse genes with lipid phenotypes (silver set)
Additional file 27 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
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- Atlanta VA Health Care System
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- Bennett David A.
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- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L.
- Pedersen Oluf
- Peloso Gina M.
- Pennell Craig E.
- Pennington Biomedical Research Center
- Penninx Brenda
- Pennsylvania State University
- Peters Annette
- Petersen Eva R. B.
- Peyser Patricia A.
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P.
- Prasad Gauri
- Preuss Michael H.
- Privatpraxis Prof Jonas und Dr Panda-Jonas
- Province Michael A.
- Psaty Bruce M.
- Pérusse Louis
- QIMR Berghofer Medical Research Instititute
- Qu Jia
- Quantinuum Research LLC
- Queen Mary University of London
- Queen's University
- Radboud University Nijmegen
- Rader Daniel J.
- Raitakari Olli T.
- Rallidis Loukianos S.
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D.C.
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W.
- Redline Susan
- Regeneron Genetics Center
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- RIKEN Center for Integrative Medical Sciences
- Ripatti Samuli
- Ritchie Marylyn D.
- Rollins School of Public Health
- Rosenthal Elisabeth A.
- Rotimi Charles N.
- Rotter Jerome I.
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Rush Alzheimer’s Disease Center
- Rush University Medical Center
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sahlgrenska University Hospital
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Samsung Advanced Institute of Technology
- Sattar Naveed
- Schering-Plough
- Schmidt Börge
- Schmidt Ellen M.
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- School of Clinical Medicine
- Schulze Matthias B.
- Schunkert Heribert
- Scott Rodney J.
- Sengupta Dhriti
- Sever Peter
- Shanghai Institute of Nutrition and Health
- Shimane University School of Medicine
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Singapore Eye Research Institute
- Singapore Immunology Network (SIgN) Agency for Science Technology and Research Singapore, Biopolis
- Slieker Roderick C.
- Smith Blair H.
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Southern University of Science and Technology
- Spector Tim D.
- Spracklen Cassandra N.
- St George's University of London
- St. Olavs University Hospital
- Stanford University
- Stanford University School of Medicine
- Stark Klaus J.
- Stefansson Kari
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Sung Yun Ju
- Sungkyunkwan University
- Sungkyunkwan University School of Medicine
- Surakka Ida
- Swiss Institute of Bioinformatics
- Sygehus Lillebælt
- SYNLAB Medizinisches Versorgungszentrum Weiden GmbH
- Tabara Yasuharu
- Tai EShyong
- Taichung Veterans General Hospital
- Taipei Veterans General Hospital
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tampere University Hospital
- Tampereen Yliopisto
- Tang Hua
- Tardif Jean-Claude
- Technical University of Munich
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- The Institute for Translational Genomics and Population Sciences
- The University of Newcastle
- the University of Texas Health Science
- The University of Texas Health Science Center at Houston
- The University of Tokyo
- The University of Western Australia
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Tohoku University
- Tongji Medical College
- Traunstein Hospital
- Trembath Richard C.
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L.
- Tsao Philip S.
- Turku University Hospital and University of Turku
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Universidad Adolfo Ibáñez
- Universidad Nacional Autónoma de México
- University Hospital of Southern Denmark
- University Medical Center Groningen
- University Medical Center Utrecht
- University Medicine Greifswald
- University of Aberdeen
- University of Alabama Birmingham
- University of Bergen
- University of Bristol
- University of California Los Angeles
- University of California San Francisco
- University of Cambridge
- University of College London
- University of Colorado Denver
- University of Copenhagen
- University of Copenhagen Faculty of Health Sciences
- University of Dundee
- University of Eastern Finland
- University of Edinburgh
- University of Essen
- University of Essex
- University of Exeter
- University of Exeter Medical School
- University of Gothenburg
- University of Gothenburg Sahlgrenska Academy
- University of Groningen
- University of Heidelberg
- University of Helsinki
- University of Houston
- University of Iceland
- University of Illinois College of Medicine
- University of Kelaniya
- University of Lausanne
- University of Leicester
- University of Lübeck
- University of Manchester
- University of Massachusetts
- University of Massachusetts Boston
- University of Melbourne
- University of Michigan
- University of Michigan Medical School
- University of Michigan School of Public Health
- University of Mississippi Medical Center
- University of Montreal
- University of Newcastle Faculty of Medicine and Health Sciences
- University of Newcastle Australia
- University of North Carolina
- University of Oslo
- University of Oulu
- University of Oxford Medical Sciences Division
- University of Pennsylvania
- University of Pennsylvania Perelman School of Medicine
- University of Pittsburgh
- University of Pittsburgh Graduate School of Public Health
- University of Queensland
- University of Regensburg
- University of San Carlos
- University of South Carolina
- University of Southern Denmark
- University of Split School of Medicine
- University of Surrey
- University of Sydney
- University of Texas Health Science Center at Houston
- University of the Witwatersrand
- University of the Witwatersrand Faculty of Health Sciences
- University of Toronto
- University of Turku
- University of Utah
- University of Virginia
- University of Washington School of Medicine
- University of Washington Seattle
- University of Zaragoza
- Universität Potsdam
- Universitätsklinikum Regensburg
- Université de Montréal
- Uppsala University
- Uppsala University
- VA Boston Healthcare System
- VA Palo Alto Health Care System
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B. J.
- van Setten Jessica
- Vanderbilt University Medical Center
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verve Therapeutics
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Virgen de las Nieves University Hospital
- Vitart Veronique
- Vrije Universiteit Amsterdam de Boelelaan
- VU University Medical Center
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Washington University in St. Louis
- Washington University School of Medicine in St. Louis
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B.
- Weill Cornell Medicine-Qatar
- Weir David R.
- Weiss Stefan
- Wellcome Sanger Institute
- Wellcome Trust Centre for Human Genetics
- Wenzhou Medical University
- Westlake Laboratory of Life Sciences and Biomedicine
- Westlake University
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H. M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W. F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wu Jer-Yuarn
- Wu Kuan-Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yong Loo Lin School of Medicine
- Yonsei University
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J. M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- figshare
- Publication date
- 01/01/2023
- Field of study
Additional file 27: Table S17. Sex-stratified effect sizes in UK Biobank considering all individuals or only those not on cholesterol lowering medications
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