Processing Federal Document Disposal Lists During Renovations

Renovations and restoration of the Indiana State Library and Historical Building began in June 2001 and were completed in August 2003. While the building closed for only a few weeks to the public over the course of the renovations, large portions of the stacks were inaccessible for months at a time. Although this situation periodically created a challenging work environment, staff members overcame this challenge by creating new ways of working

Actvization of Self-guided Learning in Process of Implementation of Education

The topic of the research is– Activization of self-guided studies in process of implementation of education .Education is continuous process of improvement of knowledge and skills and essential means for development of personality.Self-guided learning is the outline where an individual assumes responsibility for his/her planning of work, using of knowledge,evaluation of work.The aim of the research:to find out possibilities how to promote development of self-guided learning competences based on active studies. To reach the advanced aim there is being worked out hand-outs at math and there is being done a practical probation of them paying attention to approach independent work

The Development of Youth’s Artistic Communication Underthe Influence of the Development of Science and Information and Communication Technologies

Due to the development of the ICT a new type of student is created. These students are no more passive users of the system of eduaction, they are creating it themselves.Under the influence of the ICT, students use signs, icons and symbols in their everyday communication. The aim or the work - The influence and significance of the information and communication technologies on the development of youth’s artistic communication and creation of new signs. It has been observed that visual perception dominates for majority of people. This is also the reason why visual images and symbols have served as means of communication in the history of human development. Nowadays, numbers, letters and their combinations that contain special meaning and iconic signs are often used in students’ everyday communication. The ICT have brought some changes in students’ perception of the world. The experiment, made in the Art lesson by questioning the first graders, showed that existing ideas about the styles of art that children like at this age are in the contraversion with reality

Elements of Kareem national costumes in contemporary clothing

Research idea – on the basis of the folklore research materials to promote development of ethnographic style and its inclusion in Latvian clothing culture. Aim of the research: to study Kurzeme folk costumes from different perspectives and based on insights from the research to create a set of dress variants with ethnographic elements, colour combinations/compositions, interesting elements/components of clothing and today’s needs. It could be one way of promoting the the sense of belonging to Latvians. Methods: cultural-historical material research, ancient and Kurzeme region folk costume analysis, choice and selection of interesting elements, modern dressing style analysis, and costume design creation, practical work. Result: creation of one’s own design style, based on ethnographic-style options

TARGETING LAGGING TERRITORIES WITH EU RURAL SUPPORT POLICY: CASE STUDY IN LATVIA

lagging rural areas, bi-regional CGE model, rural development policy, CAP, Agribusiness, Environmental Economics and Policy, Land Economics/Use,

Inhibition of ERK and GSK3 signalling pathways promotes development and expression of pluripotent markers in bovine blastocysts

Embryo-derived pluripotent stem cells (ePSCs) naturally derive from different founder tissues, namely the early and late epiblast, that vary in their cellular characteristics. Recent evidence in mice suggests these sources of starting material correspond with two states of pluripotency referred to as ‘naïve’ and ‘primed’, respectively. Pluripotency is defined as the ability of a cell to give rise to any foetal or subsequent adult cell type. Naïve and primed ePSCs have different fundamental properties and only naïve cells can give rise to all cell types of an animal, including functional gametes (Nichols & Smith 2009). Until recently, naïve ePSCs (also known as embryonic stem cell or ESCs) were only available in mouse. After almost 30 years, the first non-mouse ESCs were derived in rat using a combination of specific inhibitors that block the FGF-ERK differentiation pathway and simultaneously maintain self-renewal through inhibition of GSK3 (Buehr et al. 2008; Ying et al. 2008). The three inhibitor combination, or 3i, included inhibitors of the FGF receptor (PD173074), downstream ERK activity (PD0325901) and the GSK3 pathway (CHIR99021). The dual inhibition of PD0325901 and CHIR99021, termed 2i, was found to be effective for ESC culture; therefore the requirement for PD173074 became dispensable. If pluripotent mechanisms are conserved between species, we hypothesise that these inhibitors would aid the derivation of naïve ESCs in livestock species i.e. cattle. The aim of this study was to assess the effects of these inhibitors on the developing bovine embryo. We hypothesised that the use of the inhibitors in culture medium would enhance the pluripotent characteristics of blastocysts for subsequent ESC culture. To test this idea we cultured in vitro fertilised bovine embryos in the presence of the inhibitors to initially assess the effect on embryo development. To assess embryo quality, blastocysts were analysed to evaluate the total number of cell nuclei. Additionally, mRNA and protein analyses were undertaken to characterise the expression of core pluripotent genes and assess if the inhibitors had an effect on their expression. We found that culturing bovine embryos in either 3i or 2i did not influence the total number of embryos that progressed to the blastocyst stage. A significant decrease was observed in the proportion of early vs. late stage blastocysts in 2i, which suggested acceleration in the rate of development. In 2i medium, the number of cell nuclei in D7 blastocysts was significantly increased in both the inner cell mass (ICM) and the outer trophectoderm (TE). Additionally, embryos cultured in 2i showed a >2-fold increase in NANOG, a transcription factor at the core of the pluripotency network. The ICM-specific pluripotency marker SOX2 was also up-regulated in the presence of 2i. Both these genes were found to be significantly enriched in the ICM of bovine blastocysts. Overall, we conclude that bovine blastocysts differ from mouse in their response to 2i signal inhibition and molecular control of pluripotency

Ontologies of the Future in Contemporary Philosophy: Stiegler and Meillassoux

With the concept of the future understood as uncertainty at their core, both Meillassoux and Stiegler\u2019s projects ought to be read as two different solutions to the problem of correlationism: a purely speculative one, providing human mind access to the radical uncertainty (Meillassoux) and a technologically mediated, putting in question the very ontological distinction between human and reality (Stiegler). Claims of the thesis: 1) The concept of the future constitutes the heart of Meillassoux and Stiegler\u2019s ontological projects. 2) The concept of the future in Meillassoux and Stiegler ought to be understood in terms of ontological uncertainty which enriches and empowers the concept of a-venir extracted from the thought of Deleuze and Derrida. 3) Both speculative (Meillassoux) and media-oriented (Stiegler) approaches to the uncertain real require reshaping the concept and the function of imagination. 4) The projects of Stiegler and Meillassoux ought to be read as shifting from the ontology of being to what we call the ontology of may-be which is characterized by the radical openness to change of not only future but also being as such. The research is pursued as a comparative analysis of Stiegler and Meillassoux which also re-actualizes their thought in the obvious relation to Kantian legacy and in less obvious and rarely discussed relation to such representatives of 20th century continental philosophy as Deleuze, Derrida, and others, as well as contemporary thinkers of future and ontology. By re-contextualizing Meillassoux and Stiegler\u2019s ideas, the research is aimed at inquiring into Meillassoux and Stiegler\u2019s projects as a whole and, therefore, revolves around their main opuses as well as publications and talks of a smaller scale. Therefore, the research is conducted by performing four methodical steps within the hermeneutic circle of interpretation: 1. Comparative analysis of Stiegler and Meillassoux\u2019s ontological projects; 2. Re-contextualization of Stiegler and Meillassoux within the horizon of postmodern French thought, majorly represented by Deleuze and Derrida; 3. Re-evaluation of Stiegler and Meillassoux\u2019s conceptual debt to Kantian transcendentalism; 4. Contextualization of Stiegler and Meillassoux\u2019s stances on mediation by applying them to the realm of artistic practices

Sustainable 3D printed electronics with sheath conductors

Sustainable manufacturing practices have been an essential consideration in recent years. 3D printing will be a key technology in the transition towards sustainability because it minimizes material consumption and waste generation. One area that could benefit from 3D printing techniques would be the production of printed circuit boards and electronics in which most of the copper used is etched in subsequent steps. Comparatively, 3D printing minimizes waste by depositing conductive material only where desired. However, the conductive material used, commonly a silver-based printable material, is expensive and further reductions are required to ensure sustainability. In high frequency applications, owing to the skin effect, the core of a conductor carries little electrical current and thus could be replaced with a cheaper plastic. To accomplish this, custom nozzles capable of printing these sheath conductors were developed and tested by printing an embedded inductor for wireless power transfer

READING TEACHING WITH THE HELP OF SOUND GESTURES FOR PRIMARY SCHOOL CHILDREN WITH MENTAL DEVELOPMENT DISORDERS

The native language, its skills, understanding and sense are important to every member of society, it puts thinking, communicating, and text creating into order, and it indicates to educatedness. Literacy as a key skill in everyday life is essential for acquiring and implementing the nowadays’ life skills.There are situations where pupils have not yet acquired reading skills for several years, and the issue becomes topical on how to teach to read in their age and form group, and at different levels of psychological development. One of the options is to start intensive reading learning with the help of sound gestures, where each sound or letter is represented by a gesture. This approach allows pupils starting to read and understand what they read.The purpose of the study is to research the literature on reading learning possibilities and to develop didactic materials for reading teaching with the help of sound gestures for the primary school children with mental development disorders.Study methods: literature analysis, document study, observations, questionnaire, data collection and statistical processing.Based on theoretical knowledge and analysis of literature, the author of the paper has developed didactic materials for reading teaching with the help of the sound gestures for the primary school children with mental development disabilities. Taking into account the principles of special pedagogy and speech therapy, the process of reading teaching with the help of sound gestures focuses on the difficulty levels during reading, deliberate avoidance of difficulties.The research includes the seven primary school children with mental development disorders and three teachers from the mentioned school, 30 respondents from different educational institutions.At the conclusion of the research, evaluating the effectiveness of the didactic material developed, it was concluded that it is possible to contribute to reading teaching through sound gestures for the primary school age children with mental development disorders