h-Discrete Fractional Model of Tumor Growth and Anticancer Effects of Mono and Combination Therapies

In this thesis, we focus on h–discrete and h–discrete fractional representation of a pharmacokinetics-pharmacodynamics (PK-PD) model which describes tumor growth considering time on hNa, where h\u3e0. First, we introduce some definitions, lemmas and theorems on both h–discrete and h–discrete fractional calculus in the preliminary section. In Chapter 3, we work on the PD model with delay by exam ining nabla h–discrete equations and nabla h–discrete fractional equations as well as variation of constants formulas, accordingly. We introduce our model and solve it using theorems we proved in the last section of the indicated chapter. When we do simulation for the solutions we found that jumps occur when drug was given the first time. Therefore, we decide to work on PD model without delay in Chapter 4. We also obtain theorems regarding nabla h–discrete equations and nabla h–discrete fractional equations ignoring delay. We apply our results to the tumor growth model to find solutions. We observe that jumps disappear on this model once we put new solutions into code. Although, we do not attain our wanted goal for tumor growth model having delay, we decide to write it as a chapter in this thesis because the theorems and lemmas found in Chapter 3 might be useful for another research work in the future. In Chapter 5, we give our PK model considering both delay and without delay case, then solutions of the models are stated accordingly. In the last chapter, we summarize what we have done so far and mention future works regarding continuation of this work

Auto-translation and Nabokov’s autobiography

Este artigo busca explorar a identidade própria de autores em autobiografias autotraduzidas por meio da leitura de textos de Nabókov em duas línguas, apresentados de três formas diferentes com três títulos diversos. A autobiografia de Nabokov é, por um lado, uma tradução dupla, e, por outro, três life writings diferentes. A primeira versão foi escrita em inglês e é intitulada Conclusive evidence. Nela, o autor parece estar tentando prover evidências para seu lugar em uma cultura estrangeira. O segundo livro é a tradução do supracitado, mas feita pelo próprio autor, que teve uma abordagem muito criativa nesse processo, adaptando-o corajosamente a um novo público. Essa versão russa foi intitulada Druguie beregá, e nela Nabókov fala a seus compatriotas sobre sua vida em outras cercanias. O livro não inclui todas as partes da primeira versão, e o autor escolhe informações convenientes para causar efeito sobre o espírito russo. A terceira versão, Speak memory, é a forma mais madura de life writing do autor, e investiga sua identidade em duas línguas, mas com fontes quase idênticas para fomentar seu talento. O artigo analisa as buscas de identidade nas autobiografias de Nabókov, comparando-as onde se faz relevante.This paper tries to explore authors’ self-identity in their self-translated autobiographies through a reading of Vladimir Nabokov’s self-writing in two languages and presented in three different forms with three different titles. Nabokov’s autobiography is a twofold translation on the one hand and three different life-writings on the other hand. The first version was written in English and entitled Conclusive Evidence, in which the author seems to be trying to provide evidence for his place in a foreign culture. The second book is the translation of the above-mentioned book, but it was done by the author himself, he approached to this process very creatively, courageously adapting it to a new audience. This Russian version was entitled Druqie bereqa, where Nabokov discuss his life in other shores to his compatriots. This book does not include all parts of the first version, and the author chooses suitable information to affect on Russian soul. The third version Speak Memory is the most mature form of the author’s life writing, who has investigated his identity in two languages, which were almost equal sources to nourish his talent. The article investigates identity searches in Nabokov’s autobiographies, contrasting them where relevant

Estimations of Dzjadyk-Tamrazov type in L_{p}

In the given paper we give auxiliary results allowing proving the main theorem connecting weight norms of derivatives of polynomials with weight norms of polynomials themselves

Взаємозв’язок монетарної та фіскальної політик в Україні

In this study, the results of monetary and fiscal policies in Ukraine during 1991–2014 are analyzed. In particular, interconnections between the National Bank and the government regulation of the economy are investigated. 7 key phases in monetary and fiscal policies interconnections are distinguished. Effects of regulatory actions during these phases allow defining governmental regulation features in Ukraine. Combination of moderate monetary expansion and balanced fiscal restriction is proven to be most favorable for economic growth.У статті представлено результати аналізу проведення монетарної та фіскальної політик в Україні протягом 1991-2014 років. Досліджено напрями взаємоузгодження заходів НБУ та уряду. Виявлено 7 основних етапів розвитку взаємозв’язків грошово-кредитної та бюджетно-податкової політик, наслідки яких на макрорівні суттєво різняться та дають підставу робити висновки щодо особливостей державного регулювання економіки в Україні. Доведено, що найбільш сприятливим для економічного розвитку є поєднання помірної монетарної експансії зі збалансованим фіскальним обмеженням

Atomoxetine treatment for nicotine withdrawal: a pilot double-blind, placebo-controlled, fixed-dose study in adult smokers

<p>Abstract</p> <p>Background</p> <p>Many effective treatments for nicotine addiction inhibit noradrenaline reuptake. Three recent studies have suggested that another noradrenaline reuptake inhibitor, atomoxetine, may reduce smoking behaviors.</p> <p>Methods</p> <p>The present double-blind, placebo-controlled, fixed-dose study was carried out over 21 days during which administration of 40 mg atomoxetine was compared to placebo in 17 individuals. Of these, nine were randomized to atomoxetine and eight to placebo. Baseline and weekly measurements were made using the Cigarette Dependence Scale (CDS), Cigarette Withdrawal Scale (CWS), Questionnaire of Smoking Urges (QSU), reported number of cigarettes smoked, and salivary cotinine levels.</p> <p>Results</p> <p>The study results showed that all those on placebo completed the study. In marked contrast, of the nine individuals who started on atomoxetine, five dropped out due to side effects. In a completer analysis there were statistically significant differences at 14 and 21 days in several measures between the atomoxetine and placebo groups, including CDS, CWS, QSU, number of cigarettes smoked (decreasing to less than two per day in the treatment group who completed the study), and a trend towards lower mean salivary cotinine levels. However, these differences were not seen in a last observation carried forward (LOCF) analysis.</p> <p>Conclusions</p> <p>In summary, this is the first study to examine the use of atomoxetine in non-psychiatric adult smokers for a period of more than 7 days, and the findings suggest that atomoxetine might be a useful treatment for nicotine addiction. However, the dose used in the current study was too high to be tolerated by many adults, and a dose-finding study is required to determine the most appropriate dose for future studies of this potential treatment for smoking cessation.</p

Моделювання монетарного сектора україни на основі динамічної системи симультативних рівнянь

The paper presents a concept of the Ukrainian monetary sector modeling with the use of a dynamic system of simultaneous equations that differs from existing models by the inclusion of the deviations from a long term balance correction mechanism. Therefore, it includes a Ukrainian monetary sector model developed basing on this approach. For the representation of the interest rate channel of the transmission mechanism in the model the main regulatory instruments of the National bank of Ukraine were defined and the combined index of the interest rates on them was calculated with the use of vector autoregressional models. The evaluation of the model allowed for the both representations of the long term interrelations between variables and detection of the potential ability of the indicators to restore balance or to destabilize macroeconomic environment. The most sensitive to the changes in the monetary sector are proved to be the interest rates on short-term deposits and exchange rate. In general, developed model has high explanatory capacity and forecasting precision. Made scenario analysis demonstrates the advantages of the complex economic interrelations representation and the usage of proposed methodology for macroeconomic modelling. The paper presents a concept of the Ukrainian monetary sector modeling with the use of a dynamic system of simultaneous equations that differs from existing models by the inclusion of the deviations from a long term balance correction mechanism. Therefore, it includes a Ukrainian monetary sector model developed basing on this approach. For the representation of the interest rate channel of the transmission mechanism in the model the main regulatory instruments of the National bank of Ukraine were defined and the combined index of the interest rates on them was calculated with the use of vector autoregressional models. The evaluation of the model allowed for the both representations of the long term interrelations between variables and detection of the potential ability of the indicators to restore balance or to destabilize macroeconomic environment. The most sensitive to the changes in the monetary sector are proved to be the interest rates on short-term deposits and exchange rate. In general, developed model has high explanatory capacity and forecasting precision. Made scenario analysis demonstrates the advantages of the complex economic interrelations representation and the usage of proposed methodology for macroeconomic modelling.  Article received 25.03.2016У статті подано концепцію моделювання монетарного сектора України на основі динамічної системи симультативних рівнянь, яка відрізняється від наявних включенням механізму коригування відхилення від довгострокової рівноваги та розроблену на основі запропонованого підходу модель монетарного сектору України. Для представлення процентного каналу трансмісійного механізму в моделі з використанням векторних авторегресійних моделей визначено основні інструменти регулювання Національного банку України та розраховано комбінований показник зміни рівня ставок за ними. Оцінювання моделі дало змогу описати не тільки довгострокові взаємозв’язки між її змінними, а й визначити потенційну здатність окремих показників у перспективі до відновлення рівноваги або до дестабілізації макроекономічного середовища. Найбільш чутливими до змін у монетарному секторі виявилися рівень ставок за короткостроковими депозитами та валютний курс. Загалом розроблена модель має високу пояснювальну здатність і прогнозну точність. Проведений на її основі сценарний аналіз демонструє переваги комплексного відображення взаємозв’язків між економічними показниками та використання цієї методології для моделювання макроекономічних явищ.Матеріал надійшов 25.03.201

Simulation Study of the Effect of Decreasing Truck Traffic Flow on Safety on Almeria-Barcelona Corridor

[EN] In this paper the effect of truck traffic on road safety has been analyzed through simulation study. The main objective of the study is to quantify the effect of the decreasing average annual daily traffic of heavy duty vehicles (trucks) on road safety. As the road safety indicators the frequency road accidents is considered. The data used in the study were collected from one of the most crowded routes in Spain which connects Almeria (south-east) with Barcelona (northeast). The observed data covers year 2010 and were classified into 2 road types: dual carriageways and toll roads. The estimation was carried out using negative binomial model and Markov Chain Monte Carlo simulation. Using the estimation results new traffic scenarios were proposed where the traffic flow is assumed to change its values. A total of 33 scenarios were proposed and new accidents data were generated through MCMC sampling. The comparison of the simulated and observed accident data shows that the effect of decreasing truck traffic flow could meliorate road safety in the route. The simulation tool could be applied to evaluate the effects of freight modal shift from road to rail.This work has been carried out in the framework of the MODALTRAM - TRA2011- 28647-C02-01 Research Project "Development of an integrated methodology for the assessment of effects on Safety and Environment, for the road and rail modal shift", of the Spanish National Research Plan 2011-2014, Ministry of Economy and Competitiveness (MINECO). The authors would also like to thanks the Community of Madrid, that contributed to this work through the SEGVAUTO-TRIES-CM (S2013-MIT2713) Programme.Dadashova, B.; Arenas Ramirez, B.; González Fernandez, C.; Aparicio Izquierdo, F. (2016). Simulation Study of the Effect of Decreasing Truck Traffic Flow on Safety on Almeria-Barcelona Corridor. En XII Congreso de ingeniería del transporte. 7, 8 y 9 de Junio, Valencia (España). Editorial Universitat Politècnica de València. 1649-1659. https://doi.org/10.4995/CIT2016.2016.4214OCS1649165