Treating Obesity in Latino Children: A Systematic Review of Current Interventions

Childhood obesity remains a significant public health issue in the U.S. and globally. Rates are disproportionately higher in Latinos than other ethnic groups. This review provides a qualitative synthesis of the current evidence for childhood obesity treatment interventions among Latino children. A systematic search was performed in PubMed, Web of Science and Google Scholar for articles published from September 2010 to December 2015. Randomized controlled trials treating childhood overweight/obesity in Latino children ages 5-19 focused on diet and/or physical activity (PA) behaviors were included. Of the records initially identified (n=1,592), 11 studies met the inclusionary criteria. The majority included a family-based component (n=8; 73%). Nearly half (n=5) focused on children ages 5-12, with three specifically developed for the pre-adolescence stage (ages 8-12). Nine studies acknowledged cultural tailoring, most frequently by seeking input from their intended population and utilizing bilingual delivery staff. Improvements in anthropometric measures (e.g. body mass index (BMI) z-score) were observed in 55% of the studies (n=6). Many interventions with a combined focus of diet and PA, in the form of nutrition education in a group setting and in-person activity/exercise sessions and incorporated a parent/family component reported positive anthropometric results. Three (27%) studies included a follow-up period, all of which observed a sustained decrease in BMI over time. Overall, family-based interventions focusing on both diet and PA demonstrated promising results. However, additional research incorporating a follow-up period is warranted to assess sustainability of these outcomes. Additionally, more interventions could be developed specifically for the critical developmental stage of pre-adolescence

The effect of potash on liver function of wistar rats

This study was aimed at investigating the effect of potash on liver function of wistar rats. Thirty two adult albino wistar rats divided into eight (8) groups were used for this study. Group A was the control, while B, C and D were test groups given 0.4g/ml, 0.6g/ml, and 0.8g/ml of potash respectively for 21 days. The weights of both the test animals and the control were monitored. The results on acute toxicity tests showed that LD50 was greater than 2.5g/kg body weight. The activities of GGT increased in group B (1.63 ± 0.54 U/L), C (3.20 ±0.92 U/L) and D (3.41 ±0.81 U/L) when compared with the control (1.00 ±0.36 U/L). The activities of AST increased in group B (0.83 ±0.09 U/L), C (0.90 ±0.05 U/L) and D (0.93 ±0.09 U/L) when compared with the control (0.76 ±0.13 U/L). ALT activities in group B (0.57 ±0.18 U/L), C (0.67 ±0.14 U/L) and D (0.87 ±0.07 U/L) increased in comparison with the control (0.55 ±0.17 U/L). ALP activities increased in group B (4.18 ±1.99 U/L), C (6.86 ±2.04 U/L) and D (6.00 ±1.34 U/L), in comparison with control (3.80 ±1.83 U/L). Our study revealed that Potash altered the functionality of the liver as well as the physical activity of the wistar rats and that the effect is dosage dependent.Keywords: Potash, Liver, Toxicity, Rats, Dos

Review of adult head injury admissions into the intensive care unit of a tertiary hospital in Nigeria

Background: Head injury is frequently associated with death and disability and imposes considerable demands on health services. Outcome after head injury is closely related to prompt management, including prevention of secondary brain injury and intensive care unit (ICU) management. This study aimed at determining the aetiological spectrum, injury characteristics, ICU admission patterns, and treatment outcomes of adult head-injured patients at a sub-Saharan tertiary hospital.Methods: A retrospective study on adult head-injured patients admitted to the ICU of a sub-Saharan tertiary hospital between July 2000 and June 2010.Results: A total of 198 head-injured adult patients were managed in the ICU during the study period. This included 128 males and 70 females with a male-to-female ratio of 1.8:1. The most common mode of injury was road traffic accident. All the patients admitted to ICU had either moderate or severe head injury, with 73.7% having severe head injury. About 26.3% of the patients had associated cervical spine injuries and 50% had various musculoskeletal and soft tissue injuries. Cranial computed tomography findings included brain contusions and intracranial haematomas. Mean duration of ICU stay was 18 days (range 24 hours-42 days), with 89.9% discharged out of ICU care. The overall mortality was 10.1%, although only 36.9% had satisfactory outcomes, as determined by the Glasgow Outcome Scale. Outcome had statistically significant (P < 0.05) relationship with severity of head injury and surgical intervention.Conclusions: Head injury management in the ICU requires an approach to ensure prevention of secondary brain injury; appropriate and early neuroimaging to diagnose lesions that would benefit from timely surgical intervention; as well as management of fluid, electrolyte and haematological derangements.Keywords: head injury; admissions; IC

Infant feeding choices practiced among HIV positive mothers attending a prevention of mother to child transmission (PMTCT) of HIV Program in Nnewi, Nigeria

Background: The HIV epidemic has significantly altered the context within which women make decisions about how they will feed their infants. This study examined the antenatal infant feeding choices and actual infant feeding practices of HIV-positive mothers in order to assess adherence to the 2010 WHO national infant feeding guidelines in Nnewi, Nigeria. Methods: The study was conducted between January 2012 and February 2013 at Nnamdi-Azikiwe University Teaching Hospital (NAUTH) in Nnewi-Anambra State, Nigeria. It was a prospective cohort study of HIV positive women attending the Prevention of Mother-To-Child Transmission (PMTCT) clinic in NAUTH. Women received HIV Counseling and Testing (HCT) from trained HIV positive women working in the hospital and from members of HIV support groups. The women made an informed decision on their infant feeding choice and received antiretroviral (ARV) treatment or prophylaxis (WHO option B) following WHO 2010 guidelines. Each mother-baby pair was followed up until the HIV sero-status of the baby was determined by DNA PCR (6-8weeks after cessation of breastfeeding). Results: The overall HIV MTCT rate was 19 of 583 (3.3%; 95% confidence interval (CI): 2.0 - 5.0). Only 94 (16.1%; 95% CI: 13.2 - 19.4) mothers complied with the WHO 2010 recommendation of exclusive breastfeeding (EBF) and ARV treatment or prophylaxis. Overall, 431 (73.9%) mother-baby pairs received prophylactic ARV intervention; in 88 (15.1%) pairs, the baby or the mother received ARV; while in 64 (11.0%) pairs, neither mother nor baby received ARV. When the mother-baby pair received ARV, MTCT was 0.8%, 1.7% and 5.9% for Exclusive Formular Feeding (EFF), EBF and Mixed Feeding (MF), respectively. When either mother or baby received intervention, MTCT rates increased to 3.3%, 4.8% and 7.7% for EFF, EBF and MF, respectively. The rate of MTCT was further increased to 5.1%, 6.7% and 23.5% when neither mother nor baby received intervention for EFF, EBF and MF respectively. Conclusion: EFF is still the infant feeding option preferred and practiced by majority of our HIV positive mothers despite the promotion of the safety of EBF with ARV interventions according to WHO 2010 guideline. It will take some time to change existing belief in EFF for us to achieve the required shift to EBF in our practice area. We also demonstrated that ARV treatment/chemoprophylaxis for both mother and baby is an important measure for achieving the reduction of MTCT of HIV in breastfeeding setting mixed feeding practice is associated with an increased rate of MTCT and should be strongly discouraged. Increasing the uptake of ARV treatment/ chemoprophylaxis and ensuring appropriate counseling about infant feeding practices have the potential to markedly decrease the rate of MTCT of HIV in developing countries

Coherent Parton Showers with Local Recoils

We outline a new formalism for dipole-type parton showers which maintain exact energy-momentum conservation at each step of the evolution. Particular emphasis is put on the coherence properties, the level at which recoil effects do enter and the role of transverse momentum generation from initial state radiation. The formulated algorithm is shown to correctly incorporate coherence for soft gluon radiation. Furthermore, it is well suited for easing matching to next-to-leading order calculations.Comment: 24 pages, 3 figure

Comparative Study on Liver Enzymes Activity and Blood Group Variations

The aim of this study is to determine the activities of some selected liver enzymes amongst apparently healthy subjects of different blood groups. The study involved 95 apparently healthy students of Ambrose Alli University, Ekpoma, Edo State, Nigeria, between the ages of 18-30, and distributed as follows; blood group O (30), group AB (18), group A (22) and blood group B (25). Blood samples were collected from the antecubital vein and separated to obtain serum. The activities of Alkaline phosphatase (ALP), Aspartate amino transferase (AST) and Alanine amino transferase (ALT) in the serum were determined using the spectrophometric method and the results were compared using SPSS (version 15). The results showed that the activities of AST and ALT were not significantly different (p>0.05) among the blood groups. However, the activity of ALP was significantly different (p<0.05) from those of blood group A, AB and O. Based on the findings of this study therefore, ABO blood group variations may have an influence on some liver enzymes activity.Keywords: ABO Blood Groups, Liver enzymes, Liver functio

Quantifying traffic, biomass burning and secondary source contributions to atmospheric particle number concentrations at urban and suburban sites

In this study, we propose a new approach to determine the contributions of primary vehicle exhaust (N-1(ff)), primary biomass burning (N-1(bb)) and secondary (N-2) particles to mode segregated particle number concentrations. We used simultaneous measurements of aerosol size distribution in the 12-600 nm size range and black carbon (BC) concentration obtained during winter period at urban and suburban sites influenced by biomass burning (BB) emissions. As expected, larger aerosol number concentrations in the 12-25 and 25-100 nm size ranges are observed at the urban site compared to the suburban site. However, similar concentrations of BC are observed at both sites due to the larger contribution of BB particles to the observed BC at suburban (34%) in comparison to urban site (23%). Due to this influence of BB emissions in our study area, the application of the Rodriguez and Cuevas (2007) method, which was developed for areas mainly influenced by traffic emissions, leads to an overestimation of the primary vehicle exhaust particles concentrations by 18% and 26% in urban and suburban sites, respectively, as compared to our new proposed approach. The results show that (1) N-2 is the main contributor in all size ranges at both sites, (2) N-1(ff) is the main contributor to primary particles (>70%) in all size ranges at both sites and (3) N-1(bb) contributes significantly to the primary particles in the 25-100 and 100-600 nm size ranges at the suburban (24% and 28%, respectively) and urban (13% and 20%, respectively) sites. At urban site, the N-1(ff) contribution shows a slight increase with the increase of total particle concentration, reaching a contribution of up to 65% at high ambient aerosol concentrations. New particle loination events are an important aerosol source during summer noon hours but, on average, these events do not implicate a considerable contribution to urban particles. (C) 2021 Elsevier B.V. All rights reserved.Peer reviewe