Molecular biologic substaging of non-small cell lung cancer

AbstractJ Thorac Cardiovasc Surg 2002;123:409-1

Local control without resection

AbstractJ Thorac Cardiovasc Surg 2003;125:787-

Grado de motivación frente a la actividad física extracurricular de adolescentes de 14 años de género masculino y femenino en tres colegios particulares del sector oriente de Santiago

Tesis (Profesor de Educación Física, Licenciado en Educación)El presente trabajo de investigación, tiene como eje investigativo la motivación frente a la actividad física extracurricular en adolescentes de 14 años. Para llevar a cabo este proceso investigativo, se intervino en tres Colegios Particulares de la Zona Oriente, Saint Gabriel´s School, Licée Antoine de Saint- Exupéry y Lincoln International Academy, para poder obtener la información necesaria, se realizó una encuesta a un total de 85 adolescentes, 48 varones y 37 damas. La encuesta se basa en 12 preguntas de carácter objetivo, validada por la Profesora Lucia Illanes. Una vez obtenidos los datos, se tabularon mediante gráficos, separados por género y establecimientos. Posteriormente se realizaron análisis, en algunos casos validados mediante citas del marco teórico. Por último se realiza un análisis comparativo de los resultados obtenidos dentro de los tres establecimientos intervenidos

Pattern of Recurrence after Curative Resection of Local (Stage I and II) Non-Small Cell Lung Cancer: Difference According to the Histologic Type

The aim of the present study was to evaluate the pattern of recurrence after complete resection of pathological stage I, II non-small cell lung cancer, especially according to the cell type. We reviewed the clinical records of 525 patients operated on for pathologic stage I and II lung cancer. The histologic type was found to be squamous in 253 and non-squamous in 229 patients. Median follow-up period was 40 months. Recurrences were identified in 173 (36%) of 482 enrolled patients; distant metastasis in 70%, distant and local recurrence in 11%, and local recurrence in 19%. Distant metastasis was more common in non-squamous than in squamous cell carcinoma (p=0.044). Brain metastasis was more frequently identified in non-squamous mthan in squamous cell carcinoma (24.2% vs. 7.3%. p=0.005). Multivariate analyses showed that cell type is the significant risk factor for recurrence-free survival in stage I and stage II non-small cell lung cancer. Recurrence-free survival curves showed that non-squamous cell carcinoma had similar risks during early periods of follow-up and more risks after 2 yr from the operation compared to squamous cell carcinoma. Pathological stage and histologic type significantly influence recurrence-free survival

Personalized and targeted therapy of esophageal squamous cell carcinoma: an update: Personalized and targeted therapy of esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is a deadly disease that requires extensive research. In this review, we update recent progress in the research area of targeted therapy for ESCC. Sox2 and its associated proteins (e.g., ΔNp63α), which regulate lineage survival of ESCC cells, are proposed as therapeutic targets. It is believed that targeting the lineage-survival mechanism may be more effective than targeting other mechanisms. With the advent of a new era of personalized targeted therapy, there is a need to move from the tumor-centric model into an organismic model

Radio Emission as a Test of the Existence of Intermediate Mass Black Holes in Globular Clusters and Dwarf Spheroidal Galaxies

We take the established relation between black hole mass, X-ray luminosity, and radio luminosity and show that intermediate mass black holes, such as those predicted to exist at the centers of globular clusters, will be easily identifiable objects in deep radio observations. We show that the radio observations will be far more senstive than any possible X-ray observations. We also discuss the likely optical photometric and spectroscopic appearance of such systems in the event that radio detections are made.Comment: 6 pages, no figures, accepted to MNRA

Personalized targeted therapy for esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial