Synthesis of the ?-Rhamnopyranosides and the 6-Deoxy-?-mannoheptopyranosides

A review is presented of the development of methods for the synthesis of ?-rhamnopyranosides and the related 6-deoxy-?-mannoheptopyranosides based on the 4,6-O-alkylidene directed synthesis of mannopyranosides and their 6-thia derivatives followed by selective reduction at the 6-position. Applications to total synthesis of complex bacterial oligosaccharides containing the title moieties are presented

Mechanistic Investigations into the Application of Sulfoxides in Carbohydrate Synthesis

The utility of sulfoxides in a diverse range of transformations in the field of carbohydrate chemistry has seen rapid growth since the first introduction of a sulfoxide as a glycosyl donor in 1989. Sulfoxides have since developed into more than just anomeric leaving groups, and today have multiple roles in glycosylation reactions. These include as activators for thioglycosides, hemiacetals, and glycals, and as precursors to glycosyl triflates, which are essential for stereoselective β- mannoside synthesis, and bicyclic sulfonium ions that facilitate the stereoselective synthesis of α-glycosides. In this review we highlight the mechanistic investigations undertaken in this area, often outlining strategies employed to differentiate between multiple proposed reaction pathways, and how the conclusions of these investigations have and continue to inform upon the development of more efficient transformations in sulfoxide based carbohydrate synthesis

“Everything from sadness…to absolute delirium”: Exploring the perspectives and experiences of key professional groups supporting live music services in UK care homes

Within UK care homes, live music programmes are promoted for the care and wellbeing of residents with dementia. These programmes are delivered via charitable music organisations and established orchestra outreach departments that specialise in providing live music sessions within this setting. However, the perspectives and experiences of key professional groups involved in the provision of these live music services are underrepresented within research. Namely, performing musicians, care assistants, activity coordinators and care home managers. To supplement this gap in research, this thesis aimed to explore the perspectives and experiences of these professional groups, with a focus on their views of the occupational factors, collaborative working and training of their work with care home live music programmes. These perspectives were explored through a series of nine ethnographic observations of live music programmes in UK care homes and in-depth semi-structured interviews with a total of 30 performing musicians and 44 care home staff. These data sets were subject to thematic analysis. The main thematic findings revealed a need for enhanced organisational approaches to live music programme delivery supplemented by a more extensive research evidence base and showed promise for approaching live music services as a multi-professional collaborative practice that is actively developed and realised from within the context of care homes and promotes shared learning of music and care-based occupations across these professional groups

Relaxometric investigations addressing the determination of intracellular water lifetime : a novel tumour biomarker of general applicability

This project has received funding from the European Union’s Horizon 2020 (H2020 Health) research and innovation programme under grant agreement No 668119 (project ‘IDentIFY’). This article is based upon work from COST Action EURELAX, CA15209, supported by COST (European Cooperation in Science and Technology).Peer reviewedPublisher PD

A propos of glycosyl cations and the mechanism of chemical glycosylation

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