The Effects of Postsecondary Correctional Education

Presents findings on the effect of prison-based postsecondary education on offenders during incarceration and on post-release employment and recidivism. Explores offenders' and stakeholders' views on the value and challenges of such programs

Propuesta de rediseno de procesos para las prestaciones valoradas en el Hospital Base de Curico

121 p.La presente memoria fue realizada con el propósito de identificar y analizar los procesos involucrados en el funcionamiento del Hospital Base de Curicó “San Juan de Dios”, en función de lo que dispone la Ley 19.966 para las prestaciones con Acceso Universal con Garantías Explícitas en Salud “AUGE” o Garantías Explicitas de Salud “GES” y aquellas prestaciones financiadas por el Fondo Nacional de Salud FONASA bajo el concepto de Prestaciones Valoradas, en el marco de la REFORMA DE SALUD. Esta memoria se inicia con una pequeña descripción del Establecimiento de Salud y su interrelación con las distintas Instituciones Gubernamentales, sus principales áreas y servicios. Luego, se presenta un análisis estratégico de la situación actual del Hospital que permitevisualizar las principales fortalezas y debilidades en el ambiente interno, así como lasoportunidades y amenazas que influyen desde el ambiente externo. Lo anterior permitió esposible establecer los objetivos o propósitos que motivan a la empresa y guiar el estudio en esta dirección. A continuación, se realiza un análisis de los principales procesos relativos a la atención de los pacientes, el registro de éstas y su financiamiento, para luego sugerir alternativas de mejora. Esta memoria nace gracias a las inquietudes manifestadas por el Departamento de Estadística en torno al no registro oportuno de los datos y las dificultades para su posterior Gestión

The meta book and size-dependent properties of written language

Evidence is given for a systematic text-length dependence of the power-law index gamma of a single book. The estimated gamma values are consistent with a monotonic decrease from 2 to 1 with increasing length of a text. A direct connection to an extended Heap's law is explored. The infinite book limit is, as a consequence, proposed to be given by gamma = 1 instead of the value gamma=2 expected if the Zipf's law was ubiquitously applicable. In addition we explore the idea that the systematic text-length dependence can be described by a meta book concept, which is an abstract representation reflecting the word-frequency structure of a text. According to this concept the word-frequency distribution of a text, with a certain length written by a single author, has the same characteristics as a text of the same length pulled out from an imaginary complete infinite corpus written by the same author.Comment: 7 pages, 6 figures, 1 tabl

Challenges of beef cattle production from tropical pastures

The live weight gain of cattle on tropical pastures is reviewed and found to be low and dependent on the length of the growing season. Supplements may be added to address the primary limiting nutrient, which, in the dry season, is crude protein. The response relationships of live weight gain to level of supplement (protein or energy) that have been developed for animals on pasture in Brazil and Australia have been compared and found to be very similar. This gives confidence in recommending a supplementation strategy for cattle on tropical pastures. Response in the wet season was very low and likely to be uneconomic compared with dry season supplementation. Supplementation is costly and should only be used as a last resort, but the strategy needs to be viewed in the context of a growth path to a defined market or slaughter weight. In Australia, high inputs in the first dry season are risky as subsequent compensatory growth can reduce or eliminate the weight advantage of a supplement. There is less financial risk in using supplements towards the end of the growth path. Growth paths can follow many forms and there is no need to maximise live weight gain in each period. Targeted supplements in the second dry season, leucaena based systems, other special-purpose pastures or crops, and feedlots offer the most economical way for cattle to meet market targets. The expected annual live weight gain and weaning weight are other major factors which determine the growth path, target market which can be achieved, and the level of intervention (supplements, legumes, feedlots, etc) which are required and when. Some recent results on growth paths in Australia are presented

School-based countrywide seroprevalence survey reveals spatial heterogeneity in malaria transmission in the Gambia.

BACKGROUND: As the geographical distribution of malaria transmission becomes progressively clustered, identifying residual pockets of transmission is important for research and for targeting interventions. Malarial antibody-based surveillance is increasingly recognised as a valuable complement to classic methods for the detection of infection foci especially at low transmission levels. The study presents serological evidence for transmission heterogeneity among school children in The Gambia measured during the dry, non-transmission season. METHODS: Healthy primary school children were randomly selected from 30 schools across the country and screened for malaria infection (microscopy) and antimalarial antibodies (MSP119). Antibody distribution was modelled using 2-component finite mixture model with cut-off for positivity from pooled sera set at 2-standard deviation from the mean of the first component. Factors associated with a positive serological status were identified in a univariate model and then combined in a multilevel mixed-effects logistic regression model, simultaneously adjusting for variations between individuals and school. RESULTS: A total of 4140 children, 1897 (46%) boys, were enrolled with mean age of 10.2 years (SD 2.6, range 4-20 years). Microscopy results available for 3640 (87.9%) children showed that 1.9% (69) were positive for Plasmodium falciparum infections, most of them (97.1%, 67/69) asymptomatic. The overall seroprevalence was 12.7% (527/4140) with values for the schools ranging from 0.6% to 43.8%. Age (OR 1.12, 95% CI 1.07-1.16,) and parasite carriage (OR 3.36, 95% CI 1.95-5.79) were strongly associated with seropositivity. CONCLUSION: Serological responses to malaria parasites could identify individuals who were or had been infected, and clusters of residual transmission. Field-adapted antibody tests able to guide mass screening and treatment campaigns would be extremely useful

Human helminth co-infection: no evidence of common genetic control of hookworm and Schistosoma mansoni infection intensity in a Brazilian community.

Strong statistical associations between soil-transmitted helminths and schistosomes are frequently observed in co-endemic human populations, although the underlying explanations remain poorly understood. This study investigates the contribution of host genetics and domestic environment to hookworm and Schistosoma mansoni infection intensity and evaluates the role of genetic and non-genetic factors in co-variation of infection intensity. Detailed genealogical information allowed assignment of 1303 individuals living in the Brazilian community of Americaninhas, Minas Gerais state, to 25 pedigrees (containing between two and 1159 members) residing in 303 households. The prevalence of co-infection with both hookworms and schistosomes was high (38.5%), with significant correlation between Necator americanus and S. mansoni faecal egg counts. Bivariate variance component analysis demonstrated a modest but significant species-specific heritability for intensity of N. americanus (h(2)=0.196) and S. mansoni infection (h(2)=0.230). However, after accounting for demographic, socio-economic and household risk factors, no evidence for common genetic control of intensity of hookworm and schistosome infection was observed. There was some evidence for residual clustering within households but the majority (63%) of the covariance between N. americanus and S. mansoni infection intensity remained specific to the individual and could not be explained by shared genes, shared environment or other shared demographic, socio-economic or environmental risk factors. Our results emphasize the importance of exposure to hookworm and schistosome infection in driving the association between levels of infection with these species in hosts resident in areas of high transmission and suggest that much of this common exposure occurs outside the home

Evidence of blood stage efficacy with a virosomal malaria vaccine in a Phase IIa clinical trial

Background Previous research indicates that a combination vaccine targeting different stages of the malaria life cycle is likely to provide the most effective malaria vaccine. This trial was the first to combine two existing vaccination strategies to produce a vaccine that induces immune responses to both the pre-erythrocytic and blood stages of the P. falciparum life cycle. Methods This was a Phase I/IIa study of a new combination malaria vaccine FFM ME-TRAP+PEV3A. PEV3A includes peptides from both the pre-erythrocytic circumsporozoite protein and the blood-stage antigen AMA-1. This study was conducted at the Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, UK. The participants were healthy, malaria naïve volunteers, from Oxford. The interventions were vaccination with PEV3A alone, or PEV3A+FFM ME-TRAP. The main outcome measure was protection from malaria in a sporozoite challenge model. Other outcomes included measures of parasite specific immune responses induced by either vaccine; and safety, assessed by collection of adverse event data. Results We observed evidence of blood stage immunity in PEV3A vaccinated volunteers, but no volunteers were completely protected from malaria. PEV3A induced high antibody titres, and antibodies bound parasites in immunofluorescence assays. Moreover, we observed boosting of the vaccine-induced immune response by sporozoite challenge. Immune responses induced by FFM ME-TRAP were unexpectedly low. The vaccines were safe, with comparable side effect profiles to previous trials. Although there was no sterile protection two major observations support an effect of the vaccine-induced response on blood stage parasites: (i) Lower rates of parasite growth were observed in volunteers vaccinated with PEV3A compared to unvaccinated controls (p = 0.012), and this was reflected in the PCR results from PEV3A vaccinated volunteers. These showed early control of parasitaemia by some volunteers in this group. One volunteer, who received PEV3A alone, was diagnosed very late, on day 20 compared to an average of 11.8 days in unvaccinated controls. (ii). Morphologically abnormal parasites were present in the blood of all (n = 24) PEV3A vaccinated volunteers, and in only 2/6 controls (p = 0.001). We describe evidence of vaccine-induced blood stage efficacy for the first time in a sporozoite challenge study