Development of the ASQoL: a quality of life instrument specific to ankylosing spondylitis

Background: Although disease-specific health status measures are available for ankylosing spondylitis (AS), no instrument exists for assessing quality of life (QoL) in the condition. Objective: To produce an AS-specific QoL measure that would be relevant and acceptable to respondents, valid, and reliable. Methods: The ASQoL employs the needs-based model of QoL and was developed in parallel in the UK and the Netherlands (NL). Content was derived from interviews with patients in each country. Face and content validity were assessed through patient field test interviews (UK and NL). A postal survey in the UK produced a more efficient version of the ASQoL, which was tested for scaling properties, reliability, internal consistency, and validity in a further postal survey in each country. Results: A 41 item questionnaire was derived from interview transcripts. Field testing interviews confirmed acceptability. Rasch analysis of data from the first survey (n=121) produced a 26 item questionnaire. Rasch analysis of data from the second survey (UK: n=164; NL: n=154) showed some item misfit, but showed that items formed a hierarchical order and were stable over time. Problematic items were removed giving an 18 item scale. Both language versions had excellent internal consistency (α=0.89–0.91), test-retest reliability (r(s)=0.92 UK and r(s)=0.91 NL), and validity. Conclusions: The ASQoL provides a valuable tool for assessing the impact of interventions for AS and for evaluating models of service delivery. It is well accepted by patients, taking about four minutes to complete, and has excellent scaling and psychometric properties

High speed video capture for mobile phone cameras

We consider an electromechanical model for the operation of a voice coil motor in a mobile phone camera, with the aim of optimizing how a lens can be moved to a desired focusing motion. Although a methodology is developed for optimizing lens shift, there is some concern about the experimentally-determined model parameters that are at our disposal. Central to the model is the value of the estimated magnetic force constant, Kf: its value determines how far it is actually possible to move lens, but it appears that, from the value given, it would not be possible to shift the lens through the displacements desired. Furthermore, earlier experiments have also estimated the value of the back EMF constant, Kg , to be roughly five times greater than Kf, even though we present two theoretical arguments that show that Kf = Kg: a conclusion supported by readily-available manufacturers’ data

The Lazarus project: A pragmatic approach to binary black hole evolutions

We present a detailed description of techniques developed to combine 3D numerical simulations and, subsequently, a single black hole close-limit approximation. This method has made it possible to compute the first complete waveforms covering the post-orbital dynamics of a binary black hole system with the numerical simulation covering the essential non-linear interaction before the close limit becomes applicable for the late time dynamics. To determine when close-limit perturbation theory is applicable we apply a combination of invariant a priori estimates and a posteriori consistency checks of the robustness of our results against exchange of linear and non-linear treatments near the interface. Once the numerically modeled binary system reaches a regime that can be treated as perturbations of the Kerr spacetime, we must approximately relate the numerical coordinates to the perturbative background coordinates. We also perform a rotation of a numerically defined tetrad to asymptotically reproduce the tetrad required in the perturbative treatment. We can then produce numerical Cauchy data for the close-limit evolution in the form of the Weyl scalar $\psi_4$ and its time derivative $\partial_t\psi_4$ with both objects being first order coordinate and tetrad invariant. The Teukolsky equation in Boyer-Lindquist coordinates is adopted to further continue the evolution. To illustrate the application of these techniques we evolve a single Kerr hole and compute the spurious radiation as a measure of the error of the whole procedure. We also briefly discuss the extension of the project to make use of improved full numerical evolutions and outline the approach to a full understanding of astrophysical black hole binary systems which we can now pursue.Comment: New typos found in the version appeared in PRD. (Mostly found and collected by Bernard Kelly

A progressive refinement approach for the visualisation of implicit surfaces

Visualising implicit surfaces with the ray casting method is a slow procedure. The design cycle of a new implicit surface is, therefore, fraught with long latency times as a user must wait for the surface to be rendered before being able to decide what changes should be introduced in the next iteration. In this paper, we present an attempt at reducing the design cycle of an implicit surface modeler by introducing a progressive refinement rendering approach to the visualisation of implicit surfaces. This progressive refinement renderer provides a quick previewing facility. It first displays a low quality estimate of what the final rendering is going to be and, as the computation progresses, increases the quality of this estimate at a steady rate. The progressive refinement algorithm is based on the adaptive subdivision of the viewing frustrum into smaller cells. An estimate for the variation of the implicit function inside each cell is obtained with an affine arithmetic range estimation technique. Overall, we show that our progressive refinement approach not only provides the user with visual feedback as the rendering advances but is also capable of completing the image faster than a conventional implicit surface rendering algorithm based on ray casting

ICON 2019: International Scientific Tendinopathy Symposium Consensus: Clinical Terminology

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.Background Persistent tendon pain that impairs function has inconsistent medical terms that can influence choice of treatment.1 When a person is told they have tendinopathy by clinician A or tendinitis by clinician B, they might feel confused or be alarmed at receiving what they might perceive as two different diagnoses. This may lead to loss of confidence in their health professional and likely adds to uncertainty if they were to search for information about their condition. Clear and uniform terminology also assists inter-professional communication. Inconsistency in terminology for painful tendon disorders is a problem at numerous anatomical sites. Historically, the term ‘tendinitis’ was first used to describe tendon pain, thickening and impaired function (online supplementary figure S1). The term ‘tendinosis’ has also been used in a small number of publications, some of which were very influential.2 3 Subsequently, ‘tendinopathy’ emerged as the most common term for persistent tendon pain.4 5 To our knowledge, experts (clinicians and researchers) or patients have never engaged in a formal process to discuss the terminology we use. We believe that health professionals have not yet agreed on the appropriate terminology for painful tendon conditions.Peer reviewedFinal Accepted Versio

Modeling gravitational radiation from coalescing binary black holes

With the goal of bringing theory, particularly numerical relativity, to bear on an astrophysical problem of critical interest to gravitational wave observers we introduce a model for coalescence radiation from binary black hole systems. We build our model using the "Lazarus approach", a technique that bridges far and close limit approaches with full numerical relativity to solve Einstein equations applied in the truly nonlinear dynamical regime. We specifically study the post-orbital radiation from a system of equal-mass non-spinning black holes, deriving waveforms which indicate strongly circularly polarized radiation of roughly 3% of the system's total energy and 12% of its total angular momentum in just a few cycles. Supporting this result we first establish the reliability of the late-time part of our model, including the numerical relativity and close-limit components, with a thorough study of waveforms from a sequence of black hole configurations varying from previously treated head-on collisions to representative target for ``ISCO'' data corresponding to the end of the inspiral period. We then complete our model with a simple treatment for the early part of the spacetime based on a standard family of initial data for binary black holes in circular orbit. A detailed analysis shows strong robustness in the results as the initial separation of the black holes is increased from 5.0 to 7.8M supporting our waveforms as a suitable basic description of the astrophysical radiation from this system. Finally, a simple fitting of the plunge waveforms is introduced as a first attempt to facilitate the task of analyzing data from gravitational wave detectors.Comment: 23 pages, 36 figures, RevTeX

Height and risk of death among men and women: aetiological implications of associations with cardiorespiratory disease and cancer mortality

OBJECTIVES: Height is inversely associated with cardiovascular disease mortality risk and has shown variable associations with cancer incidence and mortality. The interpretation of findings from previous studies has been constrained by data limitations. Associations between height and specific causes of death were investigated in a large general population cohort of men and women from the West of Scotland. DESIGN: Prospective observational study. SETTING: Renfrew and Paisley, in the West of Scotland. SUBJECTS: 7052 men and 8354 women aged 45-64 were recruited into a study in Renfrew and Paisley, in the West of Scotland, between 1972 and 1976. Detailed assessments of cardiovascular disease risk factors, morbidity and socioeconomic circumstances were made at baseline. MAIN OUTCOME MEASURES: Deaths during 20 years of follow up classified into specific causes. RESULTS: Over the follow up period 3347 men and 2638 women died. Height is inversely associated with all cause, coronary heart disease, stroke, and respiratory disease mortality among men and women. Adjustment for socioeconomic position and cardiovascular risk factors had little influence on these associations. Height is strongly associated with forced expiratory volume in one second (FEV1) and adjustment for FEV1 considerably attenuated the association between height and cardiorespiratory mortality. Smoking related cancer mortality is not associated with height. The risk of deaths from cancer unrelated to smoking tended to increase with height, particularly for haematopoietic, colorectal and prostate cancers. Stomach cancer mortality was inversely associated with height. Adjustment for socioeconomic position had little influence on these associations. CONCLUSION: Height serves partly as an indicator of socioeconomic circumstances and nutritional status in childhood and this may underlie the inverse associations between height and adulthood cardiorespiratory mortality. Much of the association between height and cardiorespiratory mortality was accounted for by lung function, which is also partly determined by exposures acting in childhood. The inverse association between height and stomach cancer mortality probably reflects Helicobacter pylori infection in childhood resulting inor being associated withshorter height. The positive associations between height and several cancers unrelated to smoking could reflect the influence of calorie intake during childhood on the risk of these cancers

Limits on Fast Radio Burst-like Counterparts to Gamma-Ray Bursts Using CHIME/FRB

Fast radio bursts (FRBs) are a class of highly energetic, mostly extragalactic radio transients lasting for ∼milliseconds. While over 600 FRBs have been published so far, their origins are presently unclear, with some theories for extragalactic FRBs predicting accompanying high-energy emission. In this work, we use the Canadian Hydrogen Intensity Mapping Experiment (CHIME) Fast Radio Burst (CHIME/FRB) Project to explore whether any FRB-like radio emission coincides in space and time with 81 gamma-ray bursts (GRBs) detected between 2018 July 17 and 2019 July 8 by Swift/BAT and Fermi/GBM. We do not find any statistically significant coincident pairs within 3σ of each other's spatial localization regions and within a time difference of up to one week. In addition to searching for spatial matches between known FRBs and known GRBs, we use CHIME/FRB to constrain FRB-like (∼1-10 ms) radio emission before, at the time of, or after the reported high-energy emission at the position of 39 GRBs. For short gamma-ray bursts (SGRBs), we constrain the radio flux in the 400--800 MHz band to be under a few kJy for ∼5.5-12.5 hr post-high-energy burst. We use these limits to constrain models that predict FRB-like prompt radio emission after SGRBs. For long gamma-ray bursts, we constrain the radio flux to be under a few kJy from ∼6 hr pre-high-energy burst to ∼12 hr post-high-energy burst

Nonlinear Integer Programming

Research efforts of the past fifty years have led to a development of linear integer programming as a mature discipline of mathematical optimization. Such a level of maturity has not been reached when one considers nonlinear systems subject to integrality requirements for the variables. This chapter is dedicated to this topic. The primary goal is a study of a simple version of general nonlinear integer problems, where all constraints are still linear. Our focus is on the computational complexity of the problem, which varies significantly with the type of nonlinear objective function in combination with the underlying combinatorial structure. Numerous boundary cases of complexity emerge, which sometimes surprisingly lead even to polynomial time algorithms. We also cover recent successful approaches for more general classes of problems. Though no positive theoretical efficiency results are available, nor are they likely to ever be available, these seem to be the currently most successful and interesting approaches for solving practical problems. It is our belief that the study of algorithms motivated by theoretical considerations and those motivated by our desire to solve practical instances should and do inform one another. So it is with this viewpoint that we present the subject, and it is in this direction that we hope to spark further research.Comment: 57 pages. To appear in: M. J\"unger, T. Liebling, D. Naddef, G. Nemhauser, W. Pulleyblank, G. Reinelt, G. Rinaldi, and L. Wolsey (eds.), 50 Years of Integer Programming 1958--2008: The Early Years and State-of-the-Art Surveys, Springer-Verlag, 2009, ISBN 354068274

Magnetic Field Generation in Stars

Enormous progress has been made on observing stellar magnetism in stars from the main sequence through to compact objects. Recent data have thrown into sharper relief the vexed question of the origin of stellar magnetic fields, which remains one of the main unanswered questions in astrophysics. In this chapter we review recent work in this area of research. In particular, we look at the fossil field hypothesis which links magnetism in compact stars to magnetism in main sequence and pre-main sequence stars and we consider why its feasibility has now been questioned particularly in the context of highly magnetic white dwarfs. We also review the fossil versus dynamo debate in the context of neutron stars and the roles played by key physical processes such as buoyancy, helicity, and superfluid turbulence,in the generation and stability of neutron star fields. Independent information on the internal magnetic field of neutron stars will come from future gravitational wave detections. Thus we maybe at the dawn of a new era of exciting discoveries in compact star magnetism driven by the opening of a new, non-electromagnetic observational window. We also review recent advances in the theory and computation of magnetohydrodynamic turbulence as it applies to stellar magnetism and dynamo theory. These advances offer insight into the action of stellar dynamos as well as processes whichcontrol the diffusive magnetic flux transport in stars.Comment: 41 pages, 7 figures. Invited review chapter on on magnetic field generation in stars to appear in Space Science Reviews, Springe