Experiences of Self-Management Support Following a Stroke: A Meta-Review of Qualitative Systematic Reviews

Abstract Backgroun

The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

Experiences of Self-Management Support Following a Stroke: A Meta-Review of Qualitative Systematic Reviews

Supporting self-management in stroke patients improves psychological and functional outcomes but evidence on how to achieve this is sparse. We aimed to synthesise evidence from systematic reviews of qualitative studies in an overarching meta-review to inform the delivery and development of self-management support interventions.We systematically searched eight electronic databases including MEDLINE, EMBASE and CINAHL for qualitative systematic reviews (published January 1993 to June 2012). We included studies exploring patients', carers' or health care professionals' experiences relevant to self-management support following a stroke, including studies describing the lived experience of surviving a stroke. We meta-synthesised the included review findings using a meta-ethnographic framework.Seven reviews, reporting 130 unique studies, were included. Themes emerging from the reviews were pertinent, consistent and showed data saturation; though explicit mention of self-management support was rare. Our meta-review highlighted the devastating impact of stroke on patients' self-image; the varying needs for self-management support across the trajectory of recovery; the need for psychological and emotional support throughout recovery particularly when physical recovery plateaus; the considerable information needs of patients and carers which also vary across the trajectory of recovery; the importance of good patient-professional communication; the potential benefits of goal-setting and action-planning; and the need for social support which might be met by groups for stroke survivors.The observed data saturation suggests that, currently, no further qualitative research simply describing the lived experience of stroke is needed; we propose that it would be more useful to focus on qualitative research informing self-management support interventions and their implementation. Our findings demonstrate both the on-going importance of self-management support and the evolving priorities throughout the stages of recovery following a stroke. The challenge now is to ensure these findings inform routine practice and the development of interventions to support self-management amongst stroke survivors

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth.

Prostate cancer is the most common cancer in men and it is estimated that over 350,000 men worldwide die of prostate cancer every year. There remains an unmet clinical need to improve how clinically significant prostate cancer is diagnosed and develop new treatments for advanced disease. Aberrant glycosylation is a hallmark of cancer implicated in tumour growth, metastasis, and immune evasion. One of the key drivers of aberrant glycosylation is the dysregulated expression of glycosylation enzymes within the cancer cell. Here, we demonstrate using multiple independent clinical cohorts that the glycosyltransferase enzyme GALNT7 is upregulated in prostate cancer tissue. We show GALNT7 can identify men with prostate cancer, using urine and blood samples, with improved diagnostic accuracy than serum PSA alone. We also show that GALNT7 levels remain high in progression to castrate-resistant disease, and using in vitro and in vivo models, reveal that GALNT7 promotes prostate tumour growth. Mechanistically, GALNT7 can modify O-glycosylation in prostate cancer cells and correlates with cell cycle and immune signalling pathways. Our study provides a new biomarker to aid the diagnosis of clinically significant disease and cements GALNT7-mediated O-glycosylation as an important driver of prostate cancer progression

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth

Prostate cancer is the most common cancer in men and it is estimated that over 350,000 men worldwide die of prostate cancer every year. There remains an unmet clinical need to improve how clinically significant prostate cancer is diagnosed and develop new treatments for advanced disease. Aberrant glycosylation is a hallmark of cancer implicated in tumour growth, metastasis, and immune evasion. One of the key drivers of aberrant glycosylation is the dysregulated expression of glycosylation enzymes within the cancer cell. Here, we demonstrate using multiple independent clinical cohorts that the glycosyltransferase enzyme GALNT7 is upregulated in prostate cancer tissue. We show GALNT7 can identify men with prostate cancer, using urine and blood samples, with improved diagnostic accuracy than serum PSA alone. We also show that GALNT7 levels remain high in progression to castrate-resistant disease, and using in vitro and in vivo models, reveal that GALNT7 promotes prostate tumour growth. Mechanistically, GALNT7 can modify O-glycosylation in prostate cancer cells and correlates with cell cycle and immune signalling pathways. Our study provides a new biomarker to aid the diagnosis of clinically significant disease and cements GALNT7-mediated O-glycosylation as an important driver of prostate cancer progression

Gender and Conflict Structure in Marital Interaction: A Replication and Extension

29 married couples engaged in 2 videotaped discussions: 1 in which the husband requested a change in the wife and 1 in which the wife requested a change in the husband. Conflict behavior was assessed by self-report and observer ratings. Neither conflict structure (who requested the change) nor gender was associated with the positivity or negativity of spouses\u27 behavior. During discussions of husbands\u27 issues, wives and husbands did not differ in demand/withdraw behavior, whereas when discussing wives\u27 issues, wives were more demanding and husbands were more withdrawing. Husband-demand/wife-withdraw interaction predicted an increase in wives\u27 satisfaction 1 yr later, whereas wife-demand/husband-withdraw interaction predicted a decline in wives\u27 satisfaction 1 yr later. These results replicate and extend those of an earlier study

To beep or not to beep page 1 To beep or not to beep: Obtaining accurate reports about awareness

To beep or not to beep page 2 We begin by accepting that introspective evidence is important to cognitive science. However, as its history shows, introspection is risky, so methods should be used that minimize those risks. We argue that there are 13 ways that a beeper can reduce those risks, dividing those ways into three categories: time sampling per se, minimizing the reactive disturbance of evanescent phenomena, and aiding phenomenological fidelity. We turn aside six criticisms of beeper-based research, and describe five characteristics of a good beep. To beep or not to beep page 3 To beep or not to beep: Obtaining accurate reports about awareness Readers of this special issue will accept that awareness is worthy of scientific study, if for no other reason than because awareness has long been held to be central to the scientific study of consciousness. For example, John Dewey (1906) wrote that “conscious means aware; consciousness, the state of being aware ” (p. 40). Natsoulas (1978) discussed six meanings of the term “consciousness ” and concluded that of these meanings, awareness is central and “eminently worthy of our attention, perhaps as much as the nature of matter is worthy of the attention of other scientists ” (p. 910). More recently, Searle (1990) meant by consciousness the subjective state of awareness, and Crick (1994) wrote that he “used the terms awareness and consciousness more or less interchangeably ” (p. 10, italics in original). Thus we accept that awareness is important, but how do we gain access to it? The answer seems obvious: We need to introspect

Pristine Inner Experience and Descriptive Experience Sampling: Implications for Psychology

Pristine inner experience is that which is directly present in awareness before it is distorted by attempts at observation or interpretation. Many psychological methods, including most introspective methods, attempt to measure some aspect of pristine inner experience (thoughts, feelings, mental imagery, sensations, etc.). We believe, however, that these methods produce unspecifiable combinations of pristine inner experience, beliefs about the self, beliefs about what inner experience should be like, inaccurate recollections, miscommunications, and other confounding influences. We argue that descriptive experience sampling (DES) can produce high fidelity descriptions of pristine inner experience. These descriptions are used to create idiographic profiles, carefully crafted, in-depth characterizations of the pristine inner experience of individuals. We believe these profiles, because they are built from moments apprehended via a method that confronts the challenges inherent in examining inner experience, are uniquely valuable in advancing the science of inner experience and psychology broadly. For example, DES observations raise important questions about the veracity of results gathered via questionnaires and other introspective methods, like casual introspection. DES findings also provide high fidelity phenomenological data that can be useful for those developing psychological theories, such as theories of emotional processing. Additionally, DES procedures may allow clinicians and clients to practice valuable skills, like bracketing presuppositions and attending to internal experiences. This paper will describe difficulties inherent in the study of pristine inner experience and discuss implications of high fidelity descriptions of pristine inner experience for psychological research, theory development, and clinical practice

Measuring the Frequency of Inner-Experience Characteristics by Self-Report: The Nevada Inner Experience Questionnaire

Descriptive experience sampling has suggested that there are five frequently occurring phenomena of inner experience: inner speaking, inner seeing, unsymbolized thinking, feelings, and sensory awareness. Descriptive experience sampling is a labor- and skill-intensive procedure, so it would be desirable to estimate the frequency of these phenomena by questionnaire. However, appropriate questionnaires either do not exist or have substantial limitations. We therefore created the Nevada Inner Experience Questionnaire (NIEQ), with five subscales estimating the frequency of each of the frequent phenomena, and examine here its psychometric adequacy. Exploratory factor analysis produced four of the expected factors (inner speaking, inner seeing, unsymbolized thinking, feelings) but did not produce a sensory awareness factor. Confirmatory factor analysis validated the five-factor model. The correlation between an existing self-talk questionnaire (Brinthaupt’s Self-Talk Scale) and the NIEQ inner speaking subscale provides one piece of concurrent validation